Derivados de Quinazolina y Quinolina
Las quinazolinas y quinolinas son compuestos heterocíclicos nitrogenados con estructuras aromáticas que desempeñan un papel clave en la síntesis de fármacos con actividad anticancerígena, antimicrobiana y antiinflamatoria. Sus derivados presentan modificaciones estructurales que optimizan su biodisponibilidad y selectividad, lo que permite el desarrollo de nuevos principios activos para diversas aplicaciones terapéuticas. Estos compuestos se utilizan en la fabricación de APIs destinados al tratamiento de cáncer, infecciones, enfermedades neurodegenerativas y cardiovasculares. Además, los derivados de quinazolina y quinolina son esenciales en la investigación de inhibidores enzimáticos y en el diseño de moléculas bioactivas innovadoras. En CymitQuimica disponemos de derivados de quinazolina y quinolina de alta pureza para aplicaciones en síntesis química, desarrollo farmacéutico y biotecnología.
Se han encontrado 65630 productos de "Derivados de Quinazolina y Quinolina"
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1,4,8,11-Tetraazacyclotetradecane
CAS:Producto controlado<p>Applications 1,4,8,11-Tetraazacyclotetradecane is macrocyclic ligand that is used as an antioxidant in rubber and has been shown to suppress oxidation catalyzed by some metal ions.<br>References Goh, S.H.: Poly, Degrad, Stab., 8, 123 (1984);<br></p>Fórmula:C10H24N4Forma y color:NeatPeso molecular:200.32N-Nitroso Amodiaquine-D10
Producto controladoFórmula:C20D10H11ClN4O2Forma y color:NeatPeso molecular:394.921rac-trans-7-Hydroxy Pramipexole
CAS:Producto controlado<p>Impurity Pramipexole Related Compound F<br>Applications Pramipexole derivative used for the preparation of (S)-Pramipexole via resolution of 2,6-diamino-7-hydroxy-4,5,6,7-tetrahydrobenzothiazole derivatives.<br>References Validation of a column liquid chromatographic method for the analysis of pramipexole and its 5 impurities. Journal of AOAC International (2010), 93(4), 1102-1112. Gegoe, Csaba Lehel; Fejes, Imre; Garaczi, Sandor; Kovacs, Imre; Lukacs, Ferenc; Majercsik, Orsolya; Schneider, Geza. Process for preparation of (S)-pramipexole via resolution of 2,6-diamino-7-hydroxy-4,5,6,7-tetrahydrobenzothiazole derivatives. Eur. Pat. Appl. (2008), 26pp. CODEN: EPXXDW EP 1878731<br></p>Fórmula:C10H17N3OSForma y color:NeatPeso molecular:227.332-Fluoro-4-desfluoro Bicalutamide
CAS:Producto controlado<p>Impurity Bicalutamide EP Impurity B<br>Applications Bicalutamide impurity. Bicalutamide derivative.<br>References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988),<br></p>Fórmula:C18H14F4N2O4SForma y color:NeatPeso molecular:430.3734Cibenzoline
CAS:Producto controlado<p>Applications Cibenzoline acts as a highly active class I antiarrhythmic agent.<br>References Xie, C. et al.: Handbook. Metab. Pathway. Xenobio., 3, 1110 (2014);<br></p>Fórmula:C18H18N2Forma y color:NeatPeso molecular:262.354'-Desmethoxy Omeprazole
CAS:Producto controlado<p>Applications 4'-Desmethoxy Omeprazole is one of two impurities in the synthesis of Esomeprazole, an anti-ulcerative drug for treatment of acid-related diseases.<br>References Liu, X., et al.: Lat. Am. J. Pharm., 34, 1265-1268 (2015);<br></p>Fórmula:C16H17N3O2SForma y color:NeatPeso molecular:315.39Ibudilast
CAS:Producto controlado<p>Applications A leukotriene D4 antagonist. Used as an antiallergic, antiasthmatic, and vasodilator (cerebral). PDE inhibitor (non-selective).<br>References Nishino, K., et al.: Japan J. Pharmacol., 33, 267 (1983), Ohashi, M., et al.: Arch. Int. Pharmacodyn., 280, 216 (1986), Armstead, W.M., et al.: J. Pharmacol., Exp. Ther., 244, 138 (1988),<br></p>Fórmula:C14H18N2OForma y color:NeatPeso molecular:230.31Bis(3-methylthien-2-yl)methanone
CAS:Producto controlado<p>Applications Bis(3-methylthien-2-yl)methanone is an impurity of Tiagabine (T436400), a GABA uptake inhibitor and nticonvulsant agent.<br>References Zhang, J.G., et al.: Chem. Res. Chin. Uni., 22, 351 (2006); Callen, G., et al.: Heterocycles., 39, 293 (1994);<br></p>Fórmula:C11H10OS2Forma y color:NeatPeso molecular:222.33Sulcotrione-d7
CAS:Producto controladoFórmula:C14D7H6ClO5SForma y color:Light Yellow SolidPeso molecular:335.813-(Trifluoromethoxy)aniline
CAS:Producto controlado<p>Applications 3-(Trifluoromethoxy)aniline is reactant in the synthesis of pyrazolone-quinazolone hybrids as human hydroxyphenylpyruvate dioxygenase inhibitors which is a potential treatment for type I tyrosinemia.<br>References Xu, Y., et. al.: Bioorg. Med. Chem., 22, 5194 (2014)<br></p>Fórmula:C7H6F3NOForma y color:NeatPeso molecular:177.125-(Chloromethyl)-α1,α1,α3,α3-tetramethyl-1,3-benzenediacetonitrile
CAS:Producto controladoFórmula:C15H17ClN2Forma y color:NeatPeso molecular:260.76(7-(4-{4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butoxy}butoxy)-3,4-dihydroquinolin-2(1H)-one)
CAS:Producto controlado<p>Impurity Aripiprazole USP Related Compound H<br>Applications (7-(4-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}butoxy)-3,4-dihydroquinolin-2(1H)-one) is an impurity of Aripiprazole (A771000), a selective dopamine D2-receptor antagonist with dopamine autoreceptor agonist activity. Aripiprazole USP Related Compound H.<br>References Zeidan, T.A., et al.: Crystal. Growth. Design., 13, 2036 (2013); Nagasaka, Y., et al.: Biopharma. Drug. Dispo., 33, 304 (2012); Chen, X., et al.: J. Med. Chem., 55, 7141 (2012);<br></p>Fórmula:C27H35Cl2N3O3Forma y color:WhitePeso molecular:520.49Desfluoro Bicalutamide
CAS:Producto controlado<p>Impurity Bicalutamide EP Impurity A<br>Applications Desfluoro Bicalutamide (Bicalutamide EP Impurity A) is an impurity of Bicalutamide, a nonsteroidal antiandrogen.<br>References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988),<br></p>Fórmula:C18H15F3N2O4SForma y color:NeatPeso molecular:412.38Loratadine Impurity F
CAS:Producto controlado<p>Impurity Loratadine EP Impurity F; Loratadine USP Related Compound G Impurity<br>Applications Loratadine Impurity F (Loratadine EP Impurity F; Loratadine USP Related Compound G Impurity) is a fluorinated analog of Loratadine (L469575), which is a nonsedating-type histamine H1-receptor.<br>References Bruttmann, G., et al.: J. Allergy Clin. Immunol., 83, 411 (1989), Haria, M., et al.: Drugs, 48, 617 (1994)<br></p>Fórmula:C22H24ClFN2O2Forma y color:White To Off-WhitePeso molecular:402.89rac-7-Oxo-pramipexole Dihydrochloride
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications An impurity of Pramipexole production.<br>References Jancic, B., et al.: Acta Chim. Slov., 54, 49 (2007),<br></p>Fórmula:C10H17Cl2N3OSForma y color:NeatPeso molecular:225.31 + 2(36.46)β-Tetralone
CAS:Producto controlado<p>Applications β-Tetralone is the 2-keto derivative of Tetralin. β-Tetralone was initially reported to be a metabolite of Tetralin but was later found to be just an artifact in the metabolism process. β-Tetralone is known to be biological marker in fossil fuels.<br>References Elliott, T.H. et al.: Biochem. J., 108, 551 (1968); Armstrong, D. et al.: Microchem. J., 57, 149 (1997);<br></p>Fórmula:C10H10OForma y color:NeatPeso molecular:146.195-Ethoxy-2-pyrrolidone
CAS:Producto controlado<p>Applications 5-Ethoxy-2-pyrrolidone is an intermediate in the synthesis of rac-Vigabatrin (V253005), a novel antiepileptic drug. Antidepressant; antipsychotic; anxiolytic.<br>References Vajda, F., et al.: Clin. Neurosci., 7, 88 (2000), Beghi, E., et al.: Lancet. Neurol., 3, 618 (2004), Sagirli, O., et al.: J. Pharmaceut. Biomed., 42, 618 (2006),<br></p>Fórmula:C6H11NO2Pureza:>90%Forma y color:NeatPeso molecular:129.162,3,3a,12b-Tetradehydro Asenapine
CAS:Producto controladoFórmula:C17H12ClNOForma y color:NeatPeso molecular:281.74Diphenhydramine-d6 N-Oxide
CAS:Producto controlado<p>Applications A labelled metabolite of Diphenhydramine (D486900) in humans.<br>References Breyer-Pfaff, U., et al.: Drug Metab. Dispos., 25, 340 (1997),<br></p>Fórmula:C17H15D6NO2Forma y color:NeatPeso molecular:277.39Varenicline Carbamoyl β-D-Glucuronide
CAS:Producto controlado<p>Applications A metabolite of Varenicline.<br>References Toide, K., et al.: Biochem. Pharmacol., 67, 1269 (2004), Coe, J., et al.: J. Med. Chem., 48, 3474 (2005), Doll, R., et al.: Br. J. Cancer, 92, 426 (2005), Obach, R., et al.: Drug Metab. Dispos., 33, 262 (2005),<br></p>Fórmula:C20H21N3O8Forma y color:NeatPeso molecular:431.43-(2-Chloroethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
CAS:<p>Applications An intermediate in the synthesis of Risperidone (R525000), which is a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Brown, T., et al.: J. Med. Chem., 33, 527 (1990), Yapi, A., et al.: Chem. Pharm. Bull., 48, 1886 (2000), Yapi, A., et al.: Arch. Pharm., 339, 201 (2006); Jannssen, P.A.J., et al.: J. Pharmacol. Exp. Ther., 244, 685 (1988); Gelders, Y.G., et al.: Pharmacopsychiatry, 23, 206 (1990); Green, B.: Curr. Med. Res. Opin., 16, 57 (2000);<br></p>Fórmula:C11H11ClN2OForma y color:NeatPeso molecular:222.6710-Acetyloxy Oxcarbazepine
CAS:Producto controlado<p>Applications An intermediate in the preparation of Carbamazepine metabolites.<br>References Heckendorn, R., et al.: Helv. Chimica Acta, 70, 1955 (1987),<br></p>Fórmula:C17H14N2O4Forma y color:NeatPeso molecular:310.304-Hydroxy Flecainide
CAS:Producto controlado<p>Applications 4-Hydroxy Flecainide is an analogue of Flecainide (F390000).<br>References Blom, Y., et al.: J. Chromatogr., 653, 138 (1993),<br></p>Fórmula:C17H20F6N2O4Forma y color:NeatPeso molecular:430.34(R)-Desmethyl Citalopram Hydrochloride
CAS:Fórmula:C19H19FN2O·ClHForma y color:NeatPeso molecular:346.83Efavirenz 3-Desoxy
CAS:<p>Applications Efavirenz 3-Desoxy is an analog of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>Fórmula:C15H11ClF3NOForma y color:Off White SolidPeso molecular:313.70Dimenhydrinate
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications An antihistamine with antiemetic properties used to prevent nausea and motion sicknes composed of two drugs 8-Chlorotheophylline (C411440) and Diphenhydramine (D486900).<br>References Sibel, K. et al.: Arzneim.-Forsch. , 52, 529 (2002); Pytel, J. et al.: Clin. Therap., 29, 84 (2007); Scholtz, A.W. et al.: Clin. Therap., 26, 866 (2004);<br></p>Fórmula:C17H21NO·C7H7ClN4O2Forma y color:NeatPeso molecular:469.96Indomethacin Acyl-β-D-glucuronide (>90%)
CAS:Producto controlado<p>Applications Indomethacin Acyl-β-D-glucuronide is a metabolite of Indomethacin (I641000). Acyl glucuronides have been implicated in the toxicity of many xenobiotics and marketed drugs.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Abid, A., et al.: Biochem. Pharmacol., 50, 557 (1995), Gamage, N., et al.: Toxicol. Sci., 90, 5 (2006), Cerveny, L., et al.: Drug Metab. Dispos., 35, 1032 (2007), Hayeshi, R., et al.: Eur. J. Pharm. Sci., 35, 383 (2008),<br></p>Fórmula:C25H24ClNO10Forma y color:NeatPeso molecular:533.91Homopiperazine
CAS:Producto controlado<p>Applications Homopiperazine acts as a corrosion inhibitor for iron. It has also been used in the preparation of potent H3 receptor antagonists for use as treatments for neurodegenerative conditions such as Alzheimer’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Granese, S. et al.: Corrosion., 44, 322 (1988); Pippel, D. et al.: Org. Proc. Res. Devel., 15, 638 (2011);<br></p>Fórmula:C5H12N2Forma y color:NeatPeso molecular:100.16Des(methylpiperazinyl-N-methyl) Imatinib Dimer Impurity
CAS:<p>Applications Des(methylpiperazinyl-N-methyl) Imatinib Dimer is an impurity of Imatinib (Gleevec) (G407000). Imatinib impurity E. It is a COVID19-related research product.<br></p>Fórmula:C52H48N12O2Forma y color:White To Off-WhitePeso molecular:873.02N-[4-(Aminocarbonyl)-3-fluorophenyl]-2-methylalanine Methyl Ester
CAS:Producto controladoFórmula:C12H15FN2O3Forma y color:NeatPeso molecular:254.262,5-Bis-(3,4-dihydroxyphenyl)piperazine Dihydrochloride
Producto controladoFórmula:C16H18N2O4•2(HCl)Forma y color:BrownPeso molecular:302.33236463-(2-Chloroethyl)-2-methyl-9-(benzyloxy)-4H-pyrido[1,2a]pyrimidin-4-one
CAS:Producto controlado<p>Applications 3-(2-Chloroethyl)-2-methyl-9-(benzyloxy)-4H-pyrido[1,2a]pyrimidin-4-one (cas# 147687-17-0) is a compound useful in organic synthesis.<br></p>Fórmula:C18H17ClN2O2Forma y color:NeatPeso molecular:328.794-(1-Methylethenyl)-2-propyl-1H-imidazole-5-carboxylic Acid Ethyl Ester
CAS:Producto controlado<p>Applications Olmesartan intermediate.<br>References Yanagisawa, H., et al.: J. Med. Chem., 39, 323 (1996),<br></p>Fórmula:C12H18N2O2Forma y color:NeatPeso molecular:222.28N-Nitroso-(1S,2R)-ephedrine
CAS:Producto controladoFórmula:C10H14N2O2Forma y color:NeatPeso molecular:194.23N-Methyl-2-[[3-[(1Z)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide
CAS:Producto controlado<p>Applications N-Methyl-2-[[3-[(1Z)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide is an impurity of Axitinib (A794650), a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.<br>References Wasser, K., et al.: Eur. Radiol., 13, 80 (2003), Park, J., et al.: Clin. Cancer Res., 8, 1172 (2002), Bergers, G., et al.: J. Clin. Invest., 111, 1287 (2003),<br></p>Fórmula:C22H18N4OSForma y color:NeatPeso molecular:386.4695Pamapimod
CAS:Producto controlado<p>Applications A selective inhibitor of the α-isoform of p38 MAP kinase. It is used in in treatment of patient with rheumatoid arthritis. Pamapimod was tolerable but not effective as Methotrexate.<br>References Guan, Z., et al.: J. Biol. Chem., 273, 12901 (1998), Lee, J., et al.: Pharmacol. Ther., 82, 389 (1999), Korb, A., et al.: Arthritis Rheum., 54, 2745 (2006),<br></p>Fórmula:C19H20F2N4O4Forma y color:WhitePeso molecular:406.382’-Des(1-hydroxy-1-methylethyl)-2’-methycarboxy Montelukast Hydrochloride
CAS:Producto controlado<p>Applications 2’-Des(1-hydroxy-1-methylethyl)-2’-methycarboxy Montelukast Hydrochloride is an impurity of Montelukast (M568000), a selective leukotriene D4-receptor antagonist.<br>References Kumar, I.V. et al.: Asian J. Chem., 23, 4536 (2011)<br></p>Fórmula:C34H33Cl2NO4SForma y color:NeatPeso molecular:622.6(R)-Afatinib
CAS:Producto controlado<p>Applications (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide, is an impurity of Afatinib (A355300) an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.<br></p>Fórmula:C24H25ClFN5O3Forma y color:NeatPeso molecular:485.945'-Hydroxyphenyl Carvedilol-d5
CAS:Producto controlado<p>Applications A Labelled metabolite of Carvedilol which is a multiple-action, neurohormonal antagonist that is used in the treatment of hypertension.<br>References Schaefer, W.H., et al.: Drug Metab. Dispos., 26, 958 (1998).<br></p>Fórmula:C24H21D5N2O5Forma y color:NeatPeso molecular:427.5(S)-Hydroxy Timolol
CAS:Producto controlado<p>Applications (S)-(-)-Hydroxy Timolol is a metabolite of the non-selective beta-adrenergic receptor blocker, Timolol (T443710).<br>References Volotinen, M. et al.: Basic Clin. Pharmacol. Toxicol., 106, 302 (2010);<br></p>Fórmula:C13H24N4O4SForma y color:NeatPeso molecular:332.4210-Methoxy-5H-dibenz[b,f]azepine-5-carbonyl chloride
CAS:Producto controladoFórmula:C16H12ClNO2Forma y color:NeatPeso molecular:286.00Fingolimod Stearoate Amide
CAS:Producto controlado<p>Applications Fingolimod Stearoate Amide is an impurity of Fingolimod (F805000, HCl salt), a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),<br></p>Fórmula:C37H67NO3Forma y color:NeatPeso molecular:573.93Ethyl 4-(8-chloro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate
CAS:Producto controlado<p>Applications Ethyl 4-(8-chloro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate is an impurity of loratadine (L469575), which is a nonsedating-type histamine H1-receptor.<br>References Bruttmann, G., et al.: J. Allergy Clin. Immunol., 83, 411 (1989), Haria, M., et al.: Drugs, 48, 617 (1994)<br></p>Fórmula:C22H21ClN2O2Forma y color:NeatPeso molecular:380.874-Amino-2-fluoro-N-methylbenzamide
CAS:Producto controlado<p>Stability Moisture Sensitive<br>Applications 4-Amino-2-fluoro-N-methylbenzamide acts as a reagent in the design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists. Also, in the preparation and structure-activity relationship of chiral benzyloxypyridinone derivatives as c-Met kinase inhibitors<br>References Ivachtchenko, A. V., et al.: Eur. J. Med. Chem., 99, 51 (2015); Zhang, D., et al.: Bioorg. Med. Chem. Lett., 23, 2408 (2013)<br></p>Fórmula:C8H9FN2OForma y color:NeatPeso molecular:168.17N-Aminocarbonyl Felbamate
CAS:Producto controlado<p>Applications N-Aminocarbonyl Felbamate is an impurity of Felbamate (F231000), an antiepileptic, structurally similar to meprobamate.<br></p>Fórmula:C12H15N3O5Forma y color:NeatPeso molecular:281.26Asenapine-d7 (Major)
CAS:Producto controlado<p>Applications Labelled Asenapine. Asenapine is a combined serotonin (5HT2) and dopamine (D2) receptor antagonist; structurally related to Mianserin. Antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Meltzer, H. et al.: J. Pharmacol. Exp. Ther., 251, 238 (1989); Schotte, A. et al.: Brain Res., 631, 191 (1993); Andree, B. et al.: Psychopharmacology, 131, 339 (1997); Richelson, E. et al.: Life Sci., 68, 29 (2000);<br></p>Fórmula:C17D7H9ClNOForma y color:NeatPeso molecular:292.81Dinaciclib
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Dinaciclib is a potent and selective inhibitor of cyclin-dependent kinases which is undergoing development as oncology therapeutics.<br>References Paruch, K., et al.: ACS. Med. Chem. Lett., 1, 204 (2010); Zhang, Da., et al.: Cancer. Chemotherap. Pharmacol., 70, 891 (2012); Chen, S., et al.: Cancer. Res., 72, 4225 (2012);<br></p>Fórmula:C21H28N6O2Forma y color:NeatPeso molecular:396.49Montelukast Cyclized Ether impurity
CAS:Producto controlado<p>Applications A cyclic ether impurity of antiasthmatic Montelukast (M568000).<br>References Egekeze, J.O. et al.: Anal. Chem., 67, 2292 (1995);<br></p>Fórmula:C29H26ClNOForma y color:NeatPeso molecular:439.984’-Fluoroacetophenone
CAS:<p>Applications 4’-Fluoroacetophenone is an intermediate used for the synthetic preparation of various pharmaceutical good and agricultural products.<br>References Xiao, Z.J., et al.: Chem. Eng. Sci., 84, 695 (2012); Vitale, P., et al.: Tetrahedron., 22, 1985 (2011); Kawano, S., et al.: Biosci. Biotech. Biochem., 75, 1055 (2011);<br></p>Fórmula:C8H7FOForma y color:NeatPeso molecular:138.149-Acridinecarboxylic acid
CAS:Producto controlado<p>Applications 9-Acridinecarboxylic acid is used in the synthesis of short DNA-binding peptides.<br></p>Fórmula:C14H9NO2Forma y color:YellowPeso molecular:223.23Chlorpromazine-d6 Hydrochloride
CAS:Producto controlado<p>Applications Labelled Chlorpromazine (C424750). Used as an antiemetic; antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anden, N.-E., et al.: Eur. J. Pharmacol., 11, 303 (1970), Curzon, G., et al.: Trends Pharmacol. Sci., 11, 61 (1990),<br></p>Fórmula:C172H6H13ClN2S·ClHForma y color:White To Light YellowPeso molecular:361.36Niclosamide Piperazinesalt
CAS:Producto controladoFórmula:C13H8Cl2N2O4·C4H10N2Forma y color:NeatPeso molecular:413.26R-Amisulpride
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications R-Amisulpride is an isomer of the antipsychotic Amisulpride (A633250). R-Amisulprideis a potential antidiabetic agent.<br>References Roix, J.J., et. al.: Diabetes Obesity Metab., 14, 329 (2012)<br></p>Fórmula:C17H27N3O4SForma y color:NeatPeso molecular:369.483-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS:Producto controlado<p>Applications 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine is a useful synthetic intermediate in the synthesis of Ibrutinib (I124970); a highly selective Bruton’s tyrosine kinase (BTK) irreversible inhibitor.<br>References MacGlashan, D., et. al.: Int. Immunol., 11, 475 (2011); Li, X., et al.: J. Med. Chem., 58, 9625 (2015)<br></p>Fórmula:C17H13N5OForma y color:Light Brown To BrownPeso molecular:303.322,2'-Ethylenedianiline
CAS:Producto controlado<p>Applications 2,2'-Ethylenedianiline is used as a reagent to synthesize Oxcarbazepine (O869250), a broad-specturm, second-generation anticonvulsant drug that is used to treat partial and complex partial seizures in children and adults. 2,2'-Ethylenedianiline is also used as a reagent to prepare a series of triterpines (e.g. Lupeol [L474850]), compounds that have chemopreventative activity.<br>References Asmaa, M., et al.: Pac. J. Cancer Prevent., 15, 475 (2014); Kalis, M. & Huff, N.: Clin. Ther., 23, 680 (2001); Malke, S., et al.: Pharm. Sci., 69, 211 (2007); Schmidt, D. & Elger, C.: Epil. Beh., 5, 627 (2004)<br></p>Fórmula:C14H16N2Forma y color:NeatPeso molecular:212.29Deshydroxymethyl Losartan Trifluoroacetic Acid Salt
CAS:Producto controlado<p>Applications Losartan Impurity C.<br>References Duncia, J.V., et al.: J. Med. Chem., 33, 1312 (1990),<br></p>Fórmula:C21H21ClN6·C2HF3O2Forma y color:White To Off-WhitePeso molecular:506.91rac Pimobendan
CAS:Producto controlado<p>Applications Pimobendan is a cardiotonic agent. The study of the cardiotonic mechanism of Pimobendan using ventricular muscles from rabbits and guinea pigs suggests that Pimobendan acts by inhibiting phosphodiesterase III and potassium channel. The potent venodilating action of Pimobendan makes it a suitable treatment option for patients with congestive heart failure (CHF) as it also improves systemic vasoconstriction.<br>References Yokota, S. et al.: Yakuri Chiryo, 20, 1143 (1992); Yamamoto, M. et al.: Kank. Igaku Ken. Nenpo, 47, 155 (1996); Matsumoto, A. et al.: Cardiovas. Drugs Ther., 12, 595 (1998);<br></p>Fórmula:C19H18N4O2Forma y color:NeatPeso molecular:334.374-Methyl Irinotecan
Producto controlado<p>Applications 4-Methyl Irinotecan, is an impurity of Irinotecan (I767500), a DNA topoisomerase inhibitor.<br>References Kunimoto, T., et al.: Cancer Res., 47, 5944 (1987), Shimada, Y., et al.: J. Clin. Oncol., 11, 909 (1993)<br></p>Fórmula:C34H40N4O6Forma y color:NeatPeso molecular:600.70N-(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)-β-alanine-d4
CAS:Producto controladoFórmula:C17H13D4ClN2O4SForma y color:NeatPeso molecular:384.87N-Desmesthyl N-Nitroso-Telmisartan
Producto controladoFórmula:C32H27N5O3Forma y color:NeatPeso molecular:529.6Lodoxamide-15N2,d2
CAS:Producto controlado<p>Applications Lodoxamide-15N2,d2 is the labelled form of Lodoxamide which is an antiallergic drug that acts as a mast cell stabilizer. It is effective in the treatment of allergic conjunctivitis and in decreasing vascular permeability.<br>References Ciprandi, G., et al.: Allergy, 51(12), 946-951 (1996); Bayer, Atilla., et al.: Ophthalmologica, 217(2), 119-123 (2003)<br></p>Fórmula:C11H4D2ClN15N2O6Forma y color:NeatPeso molecular:315.634-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
CAS:Producto controlado<p>Applications 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine is a reagent in the synthesis of (+)-tofacitinib, a selective Janus kinase 3 inhibitor (JAK3) and an immunosuppressant drug.<br>References Liao, H., et al.: Tetrahedron: Asymmetry, 28, 105, (2017)<br></p>Fórmula:C13H10ClN3O2SForma y color:NeatPeso molecular:307.76(S)-α-Hydroxy-β-methoxy-β-phenyl-benzenepropanoic Acid Methyl Ester
CAS:Producto controlado<p>Impurity Ambrisentan Hydroxyester Impurity<br>Applications (S)-α-Hydroxy-β-methoxy-β-phenyl-benzenepropanoic Acid Methyl Ester is an impurity in the synthesis of Ambrisentan (A575860), a nonpeptide endothelin ETA receptor antagonist. Antihypertensive. (Ambrisentan Hydroxyester Impurity)<br>References Riechers, H., et al.: J. Med. Chem., 39, 2123 (1996), Billman, G.E., et al.: Curr. Opin. Invest. Drugs, 3, 1483 (2002), Vatter, H., et al.: Clin. Neuropharmacol., 26, 73 (2003),<br></p>Fórmula:C17H18O4Forma y color:NeatPeso molecular:286.327,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
CAS:Producto controlado<p>Applications 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is a substituted benzazepinonee derivative used in the preparation of bradycardic agents as well as isoform-selective f-current blockers.<br>References Liang, H.-Y. et al.: Arch. Pharm., 343, 114 (2010); Reiffen, M. et al.: J. Med. Chem., 33, 1496 (1990); Melchiorre, M. et al.: J. Med. Chem., 53, 6773 (2010);<br></p>Fórmula:C12H13NO3Forma y color:Off-WhitePeso molecular:219.242-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole
CAS:<p>Impurity Nizatidine EP Impurity D<br>Applications 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole (Nizatidine EP Impurity D) is a Nizatidine intermediate.<br></p>Fórmula:C9H17N3S2Forma y color:NeatPeso molecular:231.38rac trans-2-Phenylcyclopropylamine Hydrochloride
CAS:Producto controlado<p>Applications Non-selective MAO-A/B inhibitor.<br>References Stout, S.C., et al.: J. Pharmacol. Exp. Ther., 300, 1085 (2002),<br></p>Fórmula:C9H11N·ClHForma y color:NeatPeso molecular:169.652-(1-Amino-1-methylethyl)-N-(4-fluorobenzyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide
CAS:Producto controlado<p>Applications An intermediate in the preparation of HIV-integrase inhibitors<br>References Summa, V., et al.: J. Med. Chem., 51, 5843 (2008),<br></p>Fórmula:C16H19FN4O3Forma y color:NeatPeso molecular:334.35Repirinast (>80%)
CAS:Producto controladoFórmula:C20H21NO5Pureza:>80%Forma y color:NeatPeso molecular:355.38o-Nitrofluorobenzene
CAS:Producto controlado<p>Applications o-Nitrofluorobenzene is an intermediate in the synthetic preparations of various pharmaceutical goods.<br>References Ma. W., et al.: QSAR. Combin. Sci., 25, 895 (2006); Sutton, P.G., et al.: Analyst., 124, 877 (1999); Yi, W.B., et al.: J. Fluorine. Chem., 129, 524 (2008);<br></p>Fórmula:C6H4FNO2Forma y color:NeatPeso molecular:141.1Ketoconazole N-Oxide
CAS:Producto controlado<p>Applications Ketoconazole N-Oxide is an impure analogue of Ketoconazole (K186000) which inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor.<br>References Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986), Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989), Nardone, P.A., et al.: . Surg. Res., 44, 425 (1988), Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986)<br></p>Fórmula:C26H28Cl2N4O5Forma y color:Off-WhitePeso molecular:547.43Dasatinib-d8 N-Oxide
CAS:Producto controlado<p>Applications The labelled oxidative metabolite of Dasatinib (M5 metabolite). It is a COVID19-related research product.<br>References Cashman, J.R., et al.: Chem. Res. Toxicol., 8, 165 (1995), Aasmoe, L., et al.: Toxicol. Appl. Pharmacol., 150, 86 (1998), Galetin, A., et al.: J. Pharmacol. Exp. Ther., 314, 180 (2005), Christopher, L.J., et al.: Drug Metab. Dispos., 36, 1357 (2008),<br></p>Fórmula:C22H18D8ClN7O3SForma y color:NeatPeso molecular:512.05Haloperidol Octanoate
CAS:Producto controladoFórmula:C29H37ClFNO3Forma y color:NeatPeso molecular:502.06N-Benzyl Epinephrine-d3
CAS:Producto controlado<p>Applications Labelled analogue of N-Benzyl Epinephrine, an impurity of Epinephrine (E588580).<br></p>Fórmula:C16H16D3NO3Forma y color:NeatPeso molecular:276.351-(4-(4-(tert-Butyl)phenyl)-4-hydroxybutyl)-4-piperidinecarboxylic Acid Ethyl Ester
CAS:Producto controladoFórmula:C22H35NO3Forma y color:NeatPeso molecular:361.52Famotidine Acetaldehyde Adduct Maleate
CAS:Producto controladoFórmula:C10H17N7O2S3·C4H4O4Forma y color:NeatPeso molecular:479.55Bicalutamide Sulfoxide
CAS:Producto controlado<p>Impurity Bicalutamide USP Related Compound A<br>Applications Bicalutamide Sulfoxide is a derivative of Bicalutamide (B382000), non-steroidal peripherally active antiandrogen. Used as an antiandrogen, antineoplastic (hormonal).<br>References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988), Cockshott, I.D., et al.: Eur. Urol., 18, Suppl. 3, 10 (1990), Cockshott, I., et al.: Br. J. Clin. Pharm., 36, 339 (1993), McKillop, D., et al.: Xenobiotica, 25, 623 (1995),<br></p>Fórmula:C18H14F4N2O3SForma y color:NeatPeso molecular:414.37Desmethyl 7-Methoxycarbonyl Nintedanib (Nintedanib Impurity C)
Producto controlado<p>Applications Desmethyl 7-Methoxycarbonyl Nintedanib is an impurity of Intedanib (I666650), which is an indolinone derivative potently blocking VEGF-, PDGF-, and FGF-receptor kinases. it is an indolinone as triple angiokinase inhibitors and an antitumor agent.<br>References Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)<br></p>Fórmula:C30H31N5O4Forma y color:NeatPeso molecular:525.598N-Nitrososotalol-d6
CAS:Producto controladoFórmula:C12D6H13N3O4SForma y color:Off-WhitePeso molecular:307.399O-Desmethylsulpiride
CAS:Producto controladoFórmula:C14H21N3O4SForma y color:NeatPeso molecular:327.40Loratadine-d5
CAS:Producto controlado<p>Applications Loratadine-d5 is the labeled analogue of Loratadine (L469575), a nonsedating-type histamine H1-receptor.<br>References Bruttmann, G., et al.: J. Allergy Clin. Immunol., 83, 411 (1989); Haria, M., et al.: Drugs, 48, 617 (1994)<br></p>Fórmula:C22H18D5ClN2O2Forma y color:NeatPeso molecular:387.91Vortioxetine Lactose Adduct
Producto controlado<p>Stability Hygroscopic<br>Applications Vortioxetine Lactose Adduct, is an impurity of Vortioxetine (V766000), a multimodal serotonergic agent that inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT (1,2,3).<br>References Paunovic, A. et al.: ACS Chem. Biol., 12, 132 (2017);<br></p>Fórmula:C30H42N2O10SForma y color:NeatPeso molecular:622.738-Bromo-3,9-dihydro-3-methyl-1H-purine-2,6-dione
CAS:<p>Applications 8-Bromo-3,9-dihydro-3-methyl-1H-purine-2,6-dione, is a substituted derivative of Xanthine (X499950), found in animal organs, yeast, potatoes, coffee beans, tea. It can also be used for the synthesis of Linagliptin (L465900), which is a novel potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor with potential use in the treatment of type 2 diabetes.<br>References Mueller, C. et. al: Handbook Exp. Pharmacol. 200,151(2011); Prabavathy, N. et al.: Int. J. Pharm. Bio. Sci., 2, 438 (2011); Deacon, C.F.: Diab. Obes. Metab., 13, 7 (2011); Mtthias E., et. al: J. Med. Chem., 50, 6450 (2007);<br></p>Fórmula:C6H5BrN4O2Forma y color:NeatPeso molecular:245.03(2R,6S)-rel-2,6-Dimethyl-4-(2-methyl-3-phenylpropyl)morpholine Hydrochloride
CAS:<p>Impurity Amorolfine EP Impurity C<br>Stability Hygroscopic<br>Applications (2R,6S)-rel-2,6-Dimethyl-4-(2-methyl-3-phenylpropyl)morpholine Hydrochloride (1:1), is used in the preparation of Amorolfine (A634170), a morpholine antifungal drug.<br>References Rotta, I., et al.: JAMA Dermatol., 149, 341 (2013); Espinel-Ingroff, A., et al.: Antimicrob. Agents Ch., 26, 5 (1984)<br></p>Fórmula:C16H26ClNOForma y color:NeatPeso molecular:283.84Methyl 4-Methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]benzoate
CAS:Producto controlado<p>Applications Methyl 4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]benzoate is an intermediate used in the synthesis of 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzamide (M326838), which is an impurity of Nilotinib (N465300), a possible agent in the treatment of chronic myelogenous leukemia.<br>References Corbin, A., et al.: J. Biol. Chem., 277, 32214 (2002); Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005); Gleixner, K., et al.: Blood, 107, 752 (2006); Nicolini, F., et al.: Leukemia, 20, 1061 (2006)<br></p>Fórmula:C18H16N4O2Forma y color:NeatPeso molecular:320.35ZK 159222
CAS:Producto controlado<p>Stability Light Sensitive, Temperature Sensitive<br>Applications ZK 159222 is a vitamin D receptor antagonist. It is a derivative of Vitamin D3 (V676045).<br>References Mizwicki, M., et al.: J. Bio. Chem., 284, 36292 (2009); Ochiai, E., et al.: Mol. Endocrinol., 19, 1147 (2005)<br></p>Fórmula:C32H48O5Forma y color:NeatPeso molecular:512.72rac erythro-Dihydro Bupropion-d9
CAS:Producto controlado<p>Applications A labelled metabolite of the drug Bupropion (B689625).<br>References Hsyu, P-H., et al.: J. Clin. Pharmacol., 37, 737 (1997)<br></p>Fórmula:C13H11D9ClNOForma y color:NeatPeso molecular:250.81(alphaR)-α-Methyl-N-[3-[4-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine Hydrochloride Salt
CAS:Producto controladoFórmula:C22H22F3N·ClHForma y color:NeatPeso molecular:393.873-Bromo-2-methylpropionic Acid
CAS:<p>Impurity Captopril EP Impurity D<br>Stability Hygroscopic<br>Applications 3-Bromo-2-methylpropionic Acid (Captopril EP Impurity D) is used in the preparation of captopril selenium analogs as antioxidants and ACE inhibitors used as antihypertensive drugs.<br>References Bhuyan, B. et al.: Org. Biomol. Chem., 9, 1356 (2011);<br></p>Fórmula:C4H7BrO2Forma y color:Colourless LiquidPeso molecular:167.00Loratadine-d5 (ethyl-d5)
CAS:Producto controlado<p>Applications Loratadine-d5 (ethyl-d5) (CAS# 1398065-63-8) is a useful isotopically labeled research compound.<br></p>Fórmula:C22D5H18ClN2O2Forma y color:NeatPeso molecular:387.922-Methyl-5-nitroaniline
CAS:Producto controlado<p>Applications 2-Methyl-5-nitroaniline is used as a reagent in the synthesis of imatinib base derivatives which show antibacterial and antifungal activity. Also used as a reagent in the synthesis of pyrimidinylaminobenzene derivatives which exhibit antiproliferative activity against melanoma. Dyes and metabolites, Environmental Testing. It is a COVID19-related research product.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Patoliya, M.J., et al.: J. Chem., no vol., no pp. (2013); Kim, H.J., et al.: B. Korean Chem. Soc., 34, 2311 (2013)<br></p>Fórmula:C7H8N2O2Forma y color:YellowPeso molecular:152.154-Hydroxy-2-methyl- 1,1-dioxide-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide
CAS:Producto controladoFórmula:C8H8N2O4S2Forma y color:NeatPeso molecular:260.29Diclazuril 6-Carboxylic Acid Butyl Ester
CAS:Producto controlado<p>Applications Diclazuril 6-carboxylic acid butyl ester is an impurity of Diclazuril (D436200), a nucleotide analog with broad-spectrum anticoccidial activity. Coccidiostat.<br>References Maes, L., et al.: J. Parasitol., 74, 931 (1988),<br></p>Fórmula:C22H17Cl3N4O4Forma y color:NeatPeso molecular:507.754-Hydroxy Phenylbutazone
CAS:<p>Applications Impurity in the production of Phenylbutazone (P319570)<br>References Fricoteaux, R., et al.: J. Pharm. Biomed. Anal., 7, 1585 (1989), Segrestaa, J., et al.: Chem. Pharm. Bull., 50, 744 (2002),<br></p>Fórmula:C19H20N2O3Forma y color:White To Off-WhitePeso molecular:324.37(4-Methyl-1H-imidazol-5-yl)methanol Hydrochloride
CAS:Producto controlado<p>Applications (4-Methyl-1H-imidazol-5-yl)methanol hydrochloride (cas# 38585-62-5) is a useful research chemical.<br></p>Fórmula:C5H8N2O·ClHForma y color:NeatPeso molecular:148.59(3S)-1-[2-(3-Ethenyl-4-hydroxyphenyl)ethyl]-α,α-diphenyl-3-pyrrolidineacetamide
CAS:Producto controladoFórmula:C28H30N2O2Forma y color:NeatPeso molecular:426.552-(2,4-Difluorophenyl)-1,2,3-propanetriol
CAS:<p>Applications 2-(2,4-Difluorophenyl)-1,2,3-propanetriol is used as a reagent in the synthesis of glycerol derivatives as intermediates for antifungal phenyltriazolylpropanediol derivatives. Also an impurity of the antifungal agent Fluconazole (F421000).<br>References Richard, K. et al.: Antimicrob. Ag. Chemother., 27, 832 (1985); Yasohara, Y., et al.: PCT Int. Appl. WO 9528374 A1 19951026. Oct 26, 1995<br></p>Fórmula:C9H10F2O3Forma y color:NeatPeso molecular:204.173-Des(2-methoxyethyl) 3-(1-Methylethyl) Ester Nimodipine
CAS:Producto controlado<p>Impurity Nimodipine EP Impurity B<br>Applications 3-Des(2-methoxyethyl) 3-(1-Methylethyl) Ester Nimodipine (Nimodipine EP Impurity B) can be used in synthetic preparation of dihydropyridinedicarboxylic acid esters by methylimidazolium trifluoroacetate-catalyzed Hantzsch cyclocondensation reaction of oxo-carboxylic acid esters with aldehydes and ammonium acetate. It can also be used as an analyte for analytical study in developing and optimizing a validated isocratic reversed-phase high-performance liquid chromatograhy separation of nimodipine and impurities in tablets using experimental. design methodology. It is an impurity of the drug Nimodipine (N478200).<br>References Avalani, J. R., et al.: J. Chem. Sci., 124, 1091-1096 (2012); Barmpalexis, P., et al.: J. Pharmaceut. Biomed., 49, 1192-1202 (2009)<br></p>Fórmula:C21H26N2O6Forma y color:NeatPeso molecular:402.44
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