Derivados de Quinazolina y Quinolina
Las quinazolinas y quinolinas son compuestos heterocíclicos nitrogenados con estructuras aromáticas que desempeñan un papel clave en la síntesis de fármacos con actividad anticancerígena, antimicrobiana y antiinflamatoria. Sus derivados presentan modificaciones estructurales que optimizan su biodisponibilidad y selectividad, lo que permite el desarrollo de nuevos principios activos para diversas aplicaciones terapéuticas. Estos compuestos se utilizan en la fabricación de APIs destinados al tratamiento de cáncer, infecciones, enfermedades neurodegenerativas y cardiovasculares. Además, los derivados de quinazolina y quinolina son esenciales en la investigación de inhibidores enzimáticos y en el diseño de moléculas bioactivas innovadoras. En CymitQuimica disponemos de derivados de quinazolina y quinolina de alta pureza para aplicaciones en síntesis química, desarrollo farmacéutico y biotecnología.
Se han encontrado 65630 productos de "Derivados de Quinazolina y Quinolina"
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Indomethacin Ethyl Ester
CAS:Producto controladoFórmula:C21H20ClNO4Forma y color:Off-WhitePeso molecular:385.842-Acetylbenzothiophene
CAS:Producto controlado<p>Applications A novel anti-osteoporosis agent, by enhansing expression of the BMP-2 gene.<br>References Horiguchi, Y., et al.: Chem. Pharm. Bull., 52, 214 (2004), Joshi, E., et al.: Chem. Res. Toxicol., 17, 137 (2004), Liu, Z., et al.: Bioorg. Med. Chem. Lett., 19, 4167 (2009),<br></p>Fórmula:C10H8OSForma y color:NeatPeso molecular:176.231-(4-(4-(tert-Butyl)phenyl)-4-hydroxybutyl)-4-piperidinecarboxylic Acid Ethyl Ester
CAS:Producto controladoFórmula:C22H35NO3Forma y color:NeatPeso molecular:361.52N,N’-Desethylene Levofloxacin Hydrochloride
CAS:<p>Impurity Levofloxacin USP Related Compound E<br>Applications Levofloxacin (L360000) impurity. A photodegradation product of Levofloxacin (L360000) in aqueous solution. Levofloxacin USP Related Compound E.<br>References Yoshida, Y., et al.: Arzneim.-Forsch., 43, 601 (1993),<br></p>Fórmula:C16H18FN3O4·ClHForma y color:Off White SolidPeso molecular:371.796-Oxo-(S,S)-Palonosetron (~90%)
CAS:Producto controlado<p>Applications 6-Oxo-(S,S)-Palonosetron is an impurity of (S,S)-Palonosetron (P165800), a serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.<br>References Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993), Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995), Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003), Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004), Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004),<br></p>Fórmula:C19H22N2O2Pureza:~90%Forma y color:NeatPeso molecular:310.39N-Des(4-Fluorophenyl)-N-(3-chlorophenyl)-ezetimibe
CAS:Producto controladoFórmula:C24H21ClFNO3Forma y color:NeatPeso molecular:425.88Loxapine N-Glucuronide Chloride
CAS:Producto controladoFórmula:C24H27ClN3O7·ClForma y color:NeatPeso molecular:540.393(E/Z)-Chlorprothixene-d6 Hydrochloride(Mixture)
CAS:Producto controlado<p>Applications Labelled cis/trans-Chlorprothixene (C424850). Antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rudy, B.C., et al.: Anal. Profiles Drug Subs., 2, 63 (1973), Bagli, M., et al.: Arzneim.-Forsch., 46, 247 (1996),<br></p>Fórmula:C18H13D6Cl2NSForma y color:NeatPeso molecular:358.36N-Ethyl-3-buteno-o-toluidide
CAS:Producto controladoFórmula:C13H17NOForma y color:NeatPeso molecular:203.28Bis(3-methylthien-2-yl)methanone
CAS:Producto controlado<p>Applications Bis(3-methylthien-2-yl)methanone is an impurity of Tiagabine (T436400), a GABA uptake inhibitor and nticonvulsant agent.<br>References Zhang, J.G., et al.: Chem. Res. Chin. Uni., 22, 351 (2006); Callen, G., et al.: Heterocycles., 39, 293 (1994);<br></p>Fórmula:C11H10OS2Forma y color:NeatPeso molecular:222.33N-Desmesthyl N-Nitroso-Telmisartan
Producto controladoFórmula:C32H27N5O3Forma y color:NeatPeso molecular:529.6Zuclopenthixol (1 mg/mL In Methanol)
CAS:Fórmula:C22H25ClN2OSForma y color:Single SolutionPeso molecular:400.96Ethionamide Sulfoxide-D3
CAS:Producto controladoFórmula:C8D3H7N2OSForma y color:NeatPeso molecular:185.26rac N-Desmethyl Mephenytoin-D5 (Major)
CAS:Producto controlado<p>Applications An anticonvulsant, hypnotic. A labelled metabolite of Mephentoin.A representative lot was 85% d5; 15% d4 1% d3 with no detectable d0.<br>References Karlaganis, G., et al.: Drug Metab. Dispos., 8, 173 (1980), Knabe, J., et al.: Arch. Phar., 313, 538 (1980),<br></p>Fórmula:C112H5H7N2O2Forma y color:NeatPeso molecular:209.262-Amino-3-hydroxypyridine
CAS:Producto controlado<p>Applications 2-Amino-3-hydroxypyridine (cas# 16867-03-1) is a compound useful in organic synthesis.<br></p>Fórmula:C5H6N2OForma y color:NeatPeso molecular:110.114'-Nitro-3'-(trifluoromethyl)acetanilide
CAS:<p>Applications 4’-Nitro-3’-(trifluoromethyl)acetanilide is a metabolite of the nonsteroidal antiandrogen drug, Flutamide (F598850).<br>References Kang, P. et al.: Drug Metab. Dispos., 36, 1425 (2008); Takashima, E. et al.: Biol. Pharmac. Bull., 26, 1455 (2003); Katchen, B. et al.: J. Invest. Dermatol., 66, 379 (1976);<br></p>Fórmula:C9H7F3N2O3Forma y color:NeatPeso molecular:248.16Haloperidol Octanoate
CAS:Producto controladoFórmula:C29H37ClFNO3Forma y color:NeatPeso molecular:502.063-Amino-2-chloro-propenal
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications 3-Amino-2-chloro-propenal is a chemical reagent in the synthesis of a COX-2 specific inhibitor.<br>References Davies, I. et al.: J. Org. Chem., 65, 8415 (2000);<br></p>Fórmula:C3H4ClNOForma y color:NeatPeso molecular:105.527,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
CAS:Producto controlado<p>Applications 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is a substituted benzazepinonee derivative used in the preparation of bradycardic agents as well as isoform-selective f-current blockers.<br>References Liang, H.-Y. et al.: Arch. Pharm., 343, 114 (2010); Reiffen, M. et al.: J. Med. Chem., 33, 1496 (1990); Melchiorre, M. et al.: J. Med. Chem., 53, 6773 (2010);<br></p>Fórmula:C12H13NO3Forma y color:Off-WhitePeso molecular:219.244-Hydroxy Tolvaptan (Mixture of Diastereomers)
CAS:Producto controlado<p>Applications Diastereomeric mixture of 4-Hydroxy Tolvaptan is an impurity of Tolvaptan (T536650), a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).<br>References Ohtani, T., et al.: Heterocycles, 69, 333 (2006);<br></p>Fórmula:C26H25ClN2O4Forma y color:NeatPeso molecular:464.942-Amino-3-benzyloxypyridine
CAS:Producto controlado<p>Applications 2-Amino-3-benzyloxypyridine is used in preparation of pyridinyl/pyridazinyloxymethyl substituted Raf kinase inhibitors.<br>References Jen, T., et al.: J. Med. Chem., 20, 1258 (1977), Chung, D., et al.: Antican. Res., 11, 1373 (1991),<br></p>Fórmula:C12H12N2OForma y color:NeatPeso molecular:200.24Ethyl 2-[N-[(2'-Cyanobiphenyl-4-yl)methyl]amino]-3-nitrobenzoate
CAS:<p>Applications Ethyl 2-[N-[(2'-Cyanobiphenyl-4-yl)methyl]amino]-3-nitrobenzoate is a useful reagent in synthesis of candesartan cilexitil.<br>References Zhu, Y., et al.: Zhongguo Yaowu Huaxue Zazhi, 13, 31 (2003); Cao, R., et al.: Zhongguo Yiyao Gongye Zazhi, 34, 425 (2003);<br></p>Fórmula:C23H19N3O4Forma y color:NeatPeso molecular:401.41Isoproturon-d3
CAS:Producto controlado<p>Applications Labelled Isoproturon. Pre-and post-emergence herbicide for control of annual grasses and broad-leaved weeds. Herbicide.<br>References Fournier, J.-C., et al.: Chemosphere, 4, 207 (1975), Gonzales, P., et al.: Weed Res., 23, 39 (1983),<br></p>Fórmula:C122H3H15N2OForma y color:White To Off-WhitePeso molecular:209.304-Desisopropyl-4-ethyl Nateglinide
CAS:Producto controlado<p>Applications D-phenylanaline derivative and an analog Nateglinide (N379375) with similar hypoglycemic activity.<br>References Shinkai, H. et al.: J. Med. Chem., 32, 1436 (1989);<br></p>Fórmula:C18H25NO3Forma y color:NeatPeso molecular:303.403-Isoniazid
CAS:Producto controlado<p>Applications An impurity of Isoniazid (I821450), potent antitubercular agent against M. tuberculosis.<br>References Brewer, G.A., et al.: Anal. Profiles. Drug. Subs., 6, 183 (1977), Andrade, C., et al.: Lett. Drug. Des. Discov., 5, 377 (2008)<br></p>Fórmula:C6H7N3OForma y color:Off White PowderPeso molecular:137.143-Hydroxy-4-methoxybenzaldehyde
CAS:Producto controladoFórmula:C8H8O3Forma y color:NeatPeso molecular:152.15Diphenhydramine-d6 N-β-D-Glucuronide
CAS:Producto controlado<p>Applications A labelled glucuronide metabolite of Diphenhydramine (D486900) in humans.<br>References Breyer-Pfaff, U., et al.: Drug Metab. Dispos., 25, 340 (1997),<br></p>Fórmula:C23H23D6NO7Forma y color:NeatPeso molecular:437.523-Amino-5-chloro Salicylic Acid Methyl Ester
CAS:<p>Applications Intermediate in the preparation of Azasetron.<br>References Kawakita, T., et al.: Chem. Pharm. Bull., 40, 624 (1992),<br></p>Fórmula:C8H8ClNO3Forma y color:NeatPeso molecular:201.61N-De[2-(methylsulfonyl)ethyl] Lapatinib
CAS:Producto controlado<p>Applications A reactive metabolite of Lapatinib (L175800) which is associated with various drug toxicities. Lapatinib is metabolized mainly by P450 3A4 to form O- and N-dealkylated metabolites.<br>References He, K., et al.: Chem. Res. Toxicol., 11, 252 (1998), Rusnuk, D., et al.: Cancer Res., 61, 7196 (2001), Li, X., et al.: Drug Metab. Dispos., 37, 1242 (2009),<br></p>Fórmula:C26H20ClFN4O2Forma y color:NeatPeso molecular:474.91Valsartan Decarboxylic Acid
CAS:Producto controladoFórmula:C23H29N5OForma y color:NeatPeso molecular:391.5093O-Desethyl Resiquimod-d6
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications O-Desethyl Resiquimod-d6 is the labelled analogue of O-Desethyl Resiquimod (D228575), which is derived from its parent compound Resiquimod (R144680), which is an imidazoquinoline derivative that acts as an immune response modifier. Resiquimod shows antitumor and antiviral activity and is used in the treatment of skin lesions such as herpes simplex virus. Resiquimod is a toll-like receptor 9 (TLR7) agonist.<br>References Wu, J.J. et al.: Antivir. Res., 64, 79 (2004); Fife, K.H. et al.: Antimicrob. Agents Chemother., 52, 477 (2008); Szeimies, R.M. et al.: Brit. J. Dermatol., 159, 205 (2008);<br></p>Fórmula:C15H12D6N4O2Forma y color:NeatPeso molecular:292.37Fenpropimorph
CAS:Producto controlado<p>Applications Systemic fungicide for control of powdery mildew, rust in cereal crops.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Baloch, R.I., et al.: Phytochemistry, 23, 2219 (1984), Pommer, E.-H., et al.: Pestic. Sci., 15, 285 (1984),<br></p>Fórmula:C20H33NOForma y color:ColourlessPeso molecular:303.48Dacomitinib
CAS:Producto controlado<p>Applications Dacomitinib is an Erb-inhibitor, or an inhibitor of the members of the epidermal growth factor receptor family. Used as an ant-cancer agent due to observation of over-expressed epidermal growth factor receptor in nearly all cases of squamous cell carcinoma in the head and neck.<br>References Williams, J. et al.: PLoS., 9, e98557 (2014); Peters, S. et al.: Canc. Treatment Rev., 40, 917 (2014);<br></p>Fórmula:C24H25ClFN5O2Forma y color:NeatPeso molecular:469.944-[[3-(4-Methylphenyl)-3-oxo-1-(trifluoromethyl)propylidene]amino]benzenesulfonamide
CAS:Producto controlado<p>Applications 4-[[3-(4-Methylphenyl)-3-oxo-1-(trifluoromethyl)propylidene]amino]benzenesulfonamide, is an impurity of Celecoxib (C251000), which is a selective cyclooxygenase-2 (COX-2) inhibitor, an anti-inflammatory agent. It is also used in treatment of familial adenomatous polyposis.<br>References Simon, L.S., et al.: Arthritis Rheum., 41, 1591 (1998), Silverstein, F.E., et al.: J. Am. Med. Assoc., 284, 1247 (2000), Steinbach, G., et al.: N. Engl. J. Med., 342, 1946 (2000),<br></p>Fórmula:C17H15F3N2O3SForma y color:YellowPeso molecular:384.37Lonafarnib
CAS:Producto controlado<p>Applications Lonafarnib is an orally bioavailable tricyclic inhibitor of farnesyl protein transferase. It inhibits Rheb farnesylation and mTOR signaling and enhances taxane and tamoxifen antitumor activity. Studies show that it induces CCAAT/enhancer-binding protein homologous protein-dependent expression of death receptor 5, leading to induction of apoptosis in human cancer cells<br>References Liu, M. et al.: Cancer Res., 58, 4947 (1998); Basso, A. et al.: J. Biol. Chem., 280, 31101 (2005); Sun, S. et al.: J. Biol. Chem., 282, 18800 (2007);<br></p>Fórmula:C27H31Br2ClN4O2Forma y color:NeatPeso molecular:638.82Sitagliptin N-Sulfate Sodium Salt
CAS:Producto controlado<p>Applications A metabolite of Sitagliptin.<br>References Beconi, M.G. , et al.: Drug Metab. Dispos., 35, 525 (2007),<br></p>Fórmula:C16H15F6NaN5O4SForma y color:NeatPeso molecular:509.36O-Desmorpholinopropyl-O-methyl-gefitinib
CAS:Producto controlado<p>Applications O-Desmorpholinopropyl-O-methyl-gefitinib is a anilinoquinazoline derivative of which acts as an inhibitor of tyrosine kinases and found to be allosteric inhibitors of the enzyme frutose 1,6-bisphosphatase. It serves as a lead to further drug design.<br>References Wright, S. W., Bioorganic & Medicinal Chemistry Letters, 11, 17-21, (2000)<br></p>Fórmula:C16H13ClFN3O2Forma y color:White To Off-WhitePeso molecular:333.74Apatinib-d8 25-N-Oxide Dihydrochloride
CAS:Producto controlado<p>Applications Labelled Apatinib 25-N-Oxide (A726160). Apatinib 25-N-Oxide is a metabolite of the antiangiogenic agent and selective VEGFR2 inhibitor Apatinib (A726150).<br>References Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);<br></p>Fórmula:C24H15D8N5O2•2HClForma y color:NeatPeso molecular:421.52236464-Fluoro-2-(hydroxymethyl)phenylboronic Acid
CAS:Producto controlado<p>Applications 4-Fluoro-2-(hydroxymethyl)phenylboronic Acid is a compound used in the preparation of 4,5-dihydro-1H-pyrazole derivatives as cholesterol 24 hydroxylase inhibitors.<br>References Kaku, T., et al.: Preparation of 4,5-dihydro-1H-pyrazole derivatives as cholesterol 24 hydroxylase inhibitors, WO 2010110400 (2010);<br></p>Fórmula:C7H8BFO3Forma y color:NeatPeso molecular:169.952-Methylisoindole-1,3-dione
CAS:Producto controlado<p>Applications Photoreduction of N-methylphthalimide (NMP) with 2,3-dimethyl-2-butene h and the selective electroreduction of N-methylphthalimide to 3-hydroxy-2-methyl-isoindolin-1-one have been studied.<br>References Mazzocchi, P., et al.: J. Am. Chem. Soc., 106, 7567 (1984); Villagran, C., et al.: Ultrasonics Sonochemistry, 12, 423 (2005)<br></p>Fórmula:C9H7NO2Forma y color:NeatPeso molecular:161.163-Bromo-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one
CAS:Fórmula:C16H11BrN2OForma y color:Light Brown To Dark BrownPeso molecular:327.18rac Timolol Maleate
CAS:Producto controlado<p>Applications Antihypertensive; antiarrhythmic (class II); antianginal; antiglaucoma agent.<br>References Wasson, et al.: J. Med. Chem., 15, 651 (1972), Franciosa, et al.: Clin. Pharmacol. Ther., 13, 138 (1972), Heel, R.C., et al.: Drugs, 17, 38 (1979), Rofman, B.A., et al.: Hypertension, 2, 643 (1980), Mazzo, D.J., et al.: Anal. Profiles Drug Subs., 16, 641 (1987),<br></p>Fórmula:C13H24N4O3S·C4H4O4Forma y color:NeatPeso molecular:432.49Nitrofurantoin Monohydrate
CAS:Producto controlado<p>Applications 1-(((5-Nitrofuran-2-yl)methylene)amino)-imidazolidine-2,4-dione hydrate (CAS# 17140-81-7) is a useful research chemical compound.<br></p>Fórmula:C8H8N4O6Forma y color:YellowPeso molecular:256.18Hydroxy Saxagliptin
CAS:Producto controlado<p>Applications Hydroxy Saxagliptin is a metabolite of Saxagliptin (S143500).<br>References Patel, C. et al.: J. Clinic. Pharmacol., 50, 1211 (2010); Feng, J., et al.: J. Med. Chem., 50, 2297 (2007),:Rosenstock, J., et al.: Diabetes Obes. Metab., 10, 376 (2008);<br></p>Fórmula:C18H25N3O3Forma y color:NeatPeso molecular:331.41(Z)-4-Hydroxy Tamoxifen O-β-D-Glucuronide (~90%)
CAS:Producto controlado<p>Applications (Z)-4-Hydroxy Tamoxifen O-β-D-Glucuronide is an active metabolite of Tamoxifen (T006000).<br>References Ogura, K. et al.: Biochem. Pharmacol., 71, 1358 (2006); Nishiyama, T. et al.: Biochem. Pharmacol., 63, 1817 (2002); McCague, R. et al.: Biochem. Pharmacol., 39, 1459 (1990);<br></p>Fórmula:C32H37NO8Pureza:~90%Forma y color:NeatPeso molecular:563.641-[6-(2-propenyl)-ergoline-8β-carbonyl]-3-methyl-perhydropyrimidine-2-one Methanolate
Producto controladoFórmula:C24H32N4O3Forma y color:NeatPeso molecular:424.54N,N'-bis(2,6-Dimethylphenyl)-1,4-piperazinediacetamide
CAS:Producto controlado<p>Impurity Ranolazine USP Related Compound D<br>Applications N,N'-bis(2,6-Dimethylphenyl)-1,4-piperazinediacetamide is an intermediate of Ranolazine (R122500), an anti-ischemic agent which modulates myocardial metabolism. Ranolazine is also known to exert antianginal activities.<br>References Sampath, A., et al.: Org. Proc. Rsch. Dev., 16, 748 (2012); Chaitman, B.R., et al.: J. Am. Coll. Cardial., 43, 1375 (2004); McCormack, J.G., et al.: Gen. Pharmacol., 30, 639 (1998); Schofield, J.A.H., et al.: Expert Opin. Invest. Drugs, 11, 117 (2002)<br></p>Fórmula:C24H32N4O2Forma y color:NeatPeso molecular:408.54Losartan Carboxylic Acid Acyl-β-D-Glucuronide, 90%
CAS:Producto controlado<p>Applications A metabolite of Losartan (L470500).<br></p>Fórmula:C28H29ClN6O8Pureza:90%Forma y color:NeatPeso molecular:613.02β-Tetralone
CAS:Producto controlado<p>Applications β-Tetralone is the 2-keto derivative of Tetralin. β-Tetralone was initially reported to be a metabolite of Tetralin but was later found to be just an artifact in the metabolism process. β-Tetralone is known to be biological marker in fossil fuels.<br>References Elliott, T.H. et al.: Biochem. J., 108, 551 (1968); Armstrong, D. et al.: Microchem. J., 57, 149 (1997);<br></p>Fórmula:C10H10OForma y color:NeatPeso molecular:146.192-Chloromethyl-4-methoxy-3-methylpyridine Hydrochloride
CAS:Producto controlado<p>Applications A pyridine derivative used in the preparation of anti-ulcerative agents and other pharmaceutical compounds.<br>References Kuehler, T.C. et al.: J. Med. Chem., 38, 4906 (1995);<br></p>Fórmula:C8H10ClNO·ClHForma y color:NeatPeso molecular:208.08Ibrutinib Dimer (~90%)
CAS:<p>Applications Ibrutinib Dimer is a dimer impurity of Ibrutinib (I124970), a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.<br>References MacGlashan, D., et. al.: Int. Immunol., 11, 475 (2011)<br></p>Fórmula:C50H48N12O4Pureza:~90%Forma y color:NeatPeso molecular:880.99rac 4-(3-Aminobutyl)phenol
CAS:Producto controlado<p>Applications A metabolite of the antihypertensive agent, Labetalol (L096500).<br>References Gal, J., et al.: Res. Comm. Chem. Pathol. Pharmacol., 62, 3 (1988),<br></p>Fórmula:C10H15NOForma y color:NeatPeso molecular:165.23Ezetimibe Hydroxy β-D-Glucuronide
CAS:Producto controlado<p>Applications A metabolite of Ezetimibe. Antilipemic.<br>References Shah, V., et al.: J. Pharm. Sci., 17, 1551 (2000), Van Heek, M., et al.: Br. J. Pharmacol., 134, 409 (2001), Patrick, J., et al.: Drug Metab. Dispos., 30, 430 (2002),<br></p>Fórmula:C30H29F2NO9Forma y color:NeatPeso molecular:585.55Lodoxamide-15N2,d2
CAS:Producto controlado<p>Applications Lodoxamide-15N2,d2 is the labelled form of Lodoxamide which is an antiallergic drug that acts as a mast cell stabilizer. It is effective in the treatment of allergic conjunctivitis and in decreasing vascular permeability.<br>References Ciprandi, G., et al.: Allergy, 51(12), 946-951 (1996); Bayer, Atilla., et al.: Ophthalmologica, 217(2), 119-123 (2003)<br></p>Fórmula:C11H4D2ClN15N2O6Forma y color:NeatPeso molecular:315.63Zomepirac Sodium Salt
CAS:Producto controlado<p>Applications Zomepirac is an analgesic, anti-inflammatory drug.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sofia, R., et al.: Pharmacol. Res. Commun., 11, 179 (1979), Grindel, J.M., et al.: Drug Metab. Dispos., 8, 343 (1980), Steele, C.E., et al.: Curr. Med. Res. Opin., 8, 382 (1983),<br></p>Fórmula:C15H13ClNO3·NaForma y color:Off White SolidPeso molecular:313.71Isopropyl 4-Hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-Dioxide (Piroxicam Impurity I)
CAS:Producto controlado<p>Impurity Piroxicam EP Impurity I<br>Applications Piroxicam impurity I.<br>References Lombardino, J., et al.: J. Med. Chem., 14, 1171 (1971), Turck, D., et al.: Clin. Drug Invest., 9, 270 (1995),<br></p>Fórmula:C12H13NO5SForma y color:NeatPeso molecular:283.3rac Dropropizine
CAS:Producto controlado<p>Applications Dropropizine is a cough suppressant and central sedative therapeutic agent.<br>References Bakken, G., et al.: J. Med. Chem., 43, 4534 (2000), Salunkhe, M., et al.: Enz. Microb. Technol., 28, 333 (2001), Atul, B., et al.: J. Pharm. Sci., 91, 2067 (2002),<br></p>Fórmula:C13H20N2O2Forma y color:WhitePeso molecular:236.31N-Sulfamoylethyl Naratriptan Pyridinium Chloride
CAS:Producto controlado<p>Impurity Naratriptan Impurity F<br>Stability Hygroscopic<br>Applications 4-[1,5-Bis-(2-methylsulfamoylethyl)-1H-indol-3-yl]-1-methylpyridinium Chloride is an impurity of Naratriptan (N378730).<br></p>Fórmula:C20H27ClN4O4S2Forma y color:NeatPeso molecular:487.044-Hydroxy-2-methyl- 1,1-dioxide-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide
CAS:Producto controladoFórmula:C8H8N2O4S2Forma y color:NeatPeso molecular:260.29Decarboxyl Norfloxacin
CAS:Producto controladoFórmula:C15H18FN3OForma y color:NeatPeso molecular:275.32Diclazuril 6-Carboxylic Acid Butyl Ester
CAS:Producto controlado<p>Applications Diclazuril 6-carboxylic acid butyl ester is an impurity of Diclazuril (D436200), a nucleotide analog with broad-spectrum anticoccidial activity. Coccidiostat.<br>References Maes, L., et al.: J. Parasitol., 74, 931 (1988),<br></p>Fórmula:C22H17Cl3N4O4Forma y color:NeatPeso molecular:507.757,7'-[1,4-Piperazinediylbis(4,1-butanediyloxy)]bis-2(1H)-quinolinone
CAS:Producto controladoFórmula:C30H36N4O4Forma y color:NeatPeso molecular:516.63(R)-5-Chloro-α-(cyclopropylethynyl)-2-amino-α-(trifluoromethyl) benzenemethanol
CAS:Producto controladoFórmula:C13H11ClF3NOForma y color:NeatPeso molecular:289.68Asenapine-d7 (Major)
CAS:Producto controlado<p>Applications Labelled Asenapine. Asenapine is a combined serotonin (5HT2) and dopamine (D2) receptor antagonist; structurally related to Mianserin. Antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Meltzer, H. et al.: J. Pharmacol. Exp. Ther., 251, 238 (1989); Schotte, A. et al.: Brain Res., 631, 191 (1993); Andree, B. et al.: Psychopharmacology, 131, 339 (1997); Richelson, E. et al.: Life Sci., 68, 29 (2000);<br></p>Fórmula:C17D7H9ClNOForma y color:NeatPeso molecular:292.81Desmethyl Nintedanib Carboxylic Acid (Nintedanib Impurity A)
Producto controlado<p>Applications Desmethyl Nintedanib Carboxylic Acid is an impurity of Intedanib (I666650), which is an indolinone derivative potently blocking VEGF-, PDGF-, and FGF-receptor kinases. it is an indolinone as triple angiokinase inhibitors and an antitumor agent.<br>References Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)<br></p>Fórmula:C29H29N5O5Forma y color:NeatPeso molecular:527.57Defluoro-MDV 3100 (Defluoro-enzalutamide)
CAS:Producto controlado<p>Applications Defluoro-MDV 3100 (Defluoro-enzalutamide) is an impurity of Enzalutamide (M199800), which is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. Enzalutamide has been shown to induce tumor cell apoptosis, and is used for the treatment of castration-resistant prostate cancer.<br>References Scher, H.I. et al.: Lancet, 375, 1437 (2010); Bellmunt, J. et al.: Ther. Adv. Med. Oncol., 2, 189 (2010); Ryan, C.J. et al.: J. Clin. Oncol., 29, 3651 (2011); Ma, X., et al.: J. Pharm. Biomed. Anal., 131, 436 (2016);<br></p>Fórmula:C21H17F3N4O2SForma y color:Light YellowPeso molecular:446.45N-Isopropyl Carvedilol
CAS:Producto controlado<p>Applications Carvedilol (C184625) derivative.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Fórmula:C27H32N2O4Forma y color:White To Off-WhitePeso molecular:448.55(E,Z)-Tamoxifen-d5 N-β-D-Glucuronide (~90%)
CAS:Producto controlado<p>Applications Α labelled metabolite of Tamoxifen (T006000).<br>References Sun, D., et al.: Breast Cancer Res., 8(4), (2006), Zheng, Y., et al.: Drug Metab. Dispos., 35, 1942 (2007),<br></p>Fórmula:C32H33D5NO7Pureza:~90%Forma y color:NeatPeso molecular:553.68Afatinib Impurity AFT-8
CAS:Producto controlado<p>Applications Afatinib Impurity AFT-8 is an impurity of its parent compound Afatinib (A355300), which is an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.<br></p>Fórmula:C24H27ClFN5O4Forma y color:NeatPeso molecular:503.954Indomethacin 1-Menthol ester
CAS:Producto controlado<p>Applications Indomethacin terpenoids' esters were synthesized and assessed both in vitro and in vivo as indomethacin dermal prodrugs.<br>References Bonina,, Francesco. , et al.: European Journal of Pharmaceutical Sciences, 14, 123 (2001),<br></p>Fórmula:C29H34ClNO4Forma y color:NeatPeso molecular:496.0384-Cyano Loratadine
CAS:Producto controlado<p>Applications Intermediate for the synthesis of 4-Hydroxymethyl Loratadine.<br>References Cerrada, V., et al.: ARKIVOC, 9, 200 (2005).<br></p>Fórmula:C23H22ClN3O2Forma y color:NeatPeso molecular:407.89N-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl] Rabeprazole Sulfide
CAS:Producto controlado<p>Applications Rabeprazole (R070500) N-aralkyl impurity.<br>References Fujisaki, H., et al.: Biochem. Pharmacol., 42, 321 (1991), Morri, M., et al.: J. Biol. Chem., 268, 21553 (1993), Pingili, R., et al.: Pharmazie, 60, 814 (2005),<br></p>Fórmula:C29H36N4O4SForma y color:NeatPeso molecular:536.691-(2,4-Bis(benzyloxy)phenyl)ethanone
CAS:Producto controlado<p>Applications 1-(2,4-Bis(benzyloxy)phenyl)ethanone is a useful research chemical for organic synthesis and other chemical processes.<br>References Chen, D., et al.: Eur. J. Med. Chem., 87, 765 (2014); Malik, N., et al.: Tetrahedron Lett., 54, 4121 (2013)<br></p>Fórmula:C22H20O3Forma y color:NeatPeso molecular:332.39L-Valinol
CAS:Producto controlado<p>Applications L-Valinol is used as a reagent in the synthesis of simple 1,3-thiazolidine-2-thione derivatives which can exhibit fungicidal activity. L-Valinol is also used as a reagent in the synthesis of small-molecule inhibitors of MDM2-p53 protein-protein interaction (MDM2 inhibitors) in clinical trials for the treatment of cancer.<br>References Chen, N., et al.: Phosphorus Sulfur, 190, 112 (2015); Zhao, Y., et al.: J. Med. Chem., 58, 1038 (2015)<br></p>Fórmula:C5H13NOForma y color:WhitePeso molecular:103.163N-[(2R)-2-Hydroxy-2-(3-hydroxyphenyl)ethyl]-N-methyl-glycine Sodium Salt
CAS:Producto controlado<p>Applications N-[(2R)-2-Hydroxy-2-(3-hydroxyphenyl)ethyl]-N-methyl-glycine Sodium salt is the sodium salt of H943135, which is an impurity of Phenylephrine (P320640), an α-Adrenergic agonist. Mydriatic; decongestant.<br>References Warren, M.R., et al.: J. Pharmacol. Exp. Ther., 86, 284 (1946), Gaglia, C.A., et al.: Anal. Profiles Drug Subs., 3, 483 (1974)<br></p>Fórmula:C11H14NNaO4Forma y color:NeatPeso molecular:247.223-[(1E)-2-[4-[[(2-Carboxyethyl)amino]carbonyl]phenyl]diazenyl] Balsalazide Sodium Salt (>90%)
CAS:Producto controlado<p>Applications An impurity of the anti-inflammatory drug Balsalazide (B116300).<br></p>Fórmula:C27H24N6O9xNaPureza:>90%Forma y color:NeatPeso molecular:576.51(free acid)N-Ethyl-N-nitroso-2-propanamine (100 μg/mL in Methanol)
CAS:Producto controladoFórmula:C5H12N2OForma y color:ColourlessPeso molecular:116.1616MRX-2843
CAS:Producto controlado<p>Applications MRX-2843, is an orally available small-molecule inhibitor of both MERTK and FLT3.<br>References Minson, K. A. et al.: JCI Insight. 2016 Mar;1(3):e85630.;<br></p>Fórmula:C29H40N6OForma y color:NeatPeso molecular:488.671-Nitroso-4-phenylpiperazine
CAS:Producto controlado<p>Applications Metabolite of N-Phenylpiperazine (P336040) found in wastewater treatment facilities.<br>References Jung, C. et al., Appl. Environ. Microb., 74, 6147 (2008)<br></p>Fórmula:C10H13N3OForma y color:NeatPeso molecular:191.2310-Acetyloxy Oxcarbazepine
CAS:Producto controlado<p>Applications An intermediate in the preparation of Carbamazepine metabolites.<br>References Heckendorn, R., et al.: Helv. Chimica Acta, 70, 1955 (1987),<br></p>Fórmula:C17H14N2O4Forma y color:NeatPeso molecular:310.30N-[4-Cyano-3-(trifluoromethyl)phenyl]-2,3-dihydroxy-2-methylpropanamide
CAS:Producto controlado<p>Applications N-[4-Cyano-3-(trifluoromethyl)phenyl]-2,3-dihydroxy-2-methylpropanamide is used as a reagent in the preparation of bicalutamide by coupling with sodium p-fluorobenzenesulfinate.<br>References Thijs, L., et al.: U.S. Pat. Appl. Publ. 23pp. (2004)<br></p>Fórmula:C12H11F3N2O3Forma y color:NeatPeso molecular:288.22(1S,3S)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl
CAS:Producto controlado<p>Applications Tadalafil (T004500) derivative. Used in the preparation of pyrazinopyridoindole derivatives for their PDE5 inhibitory activity.<br>References Beghyn, T. et al.: Bioorgan. Med. Chem. Lett. 17, 789(2007)<br></p>Fórmula:C20H18N2O4Forma y color:Off White SolidPeso molecular:350.377,8-Dihydro-1-naphthalenol
CAS:<p>Stability Light Sensitive, Air (oxygen) Sensitive<br>Applications 7,8-Dihydro-1-naphthalenol can be used as reagent/reactant in stereoselective preparation of indanes via chiral hypervalent iodine - mediated ring contraction of dihydronaphthalenes<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ahmed, A., & Silva, L. F,: J. Org. Chem., 81, 2174-2181 (2016)<br></p>Fórmula:C10H10OForma y color:White To Light YellowPeso molecular:146.19N-Formyl Carvedilol
Producto controlado<p>Applications N-Formyl Cardevilol is an impurity of Carvedilol (C184625).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Fórmula:C25H26N2O5Forma y color:NeatPeso molecular:434.48Chlorpromazine-d6 Hydrochloride
CAS:Producto controlado<p>Applications Labelled Chlorpromazine (C424750). Used as an antiemetic; antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anden, N.-E., et al.: Eur. J. Pharmacol., 11, 303 (1970), Curzon, G., et al.: Trends Pharmacol. Sci., 11, 61 (1990),<br></p>Fórmula:C172H6H13ClN2S·ClHForma y color:White To Light YellowPeso molecular:361.36(2S,4S)-Argatroban
CAS:Producto controlado<p>Applications Synthetic thrombin inhibitor. Antithrombotic.<br>References Abiko, Y., et al.: Thromb. Res., 24, 285 (1981), Kikumoto, R., et al.: Biochemistry, 23, 85 (1984),<br></p>Fórmula:C23H36N6O5SForma y color:NeatPeso molecular:508.633-Deschloro-3,4-difluoro Gefitinib
CAS:<p>Applications 3-Deschloro-3,4-difluoro gefitinib, is an impurity of Gefitinib (G304000), an antineoplastic.<br>References Anderson, N.G., et al.: Int. J. Cancer, 94, 774 (2001), Hirata, A., et al.: Cancer Res., 62, 2554 (2002), Kris, M.G., et al.: J. Am. Med. Assoc., 290, 2149 (2003), Tamura, K., et al.: Expert Opin. Pharmacother., 6, 985 (2005),<br></p>Fórmula:C22H24F2N4O3Forma y color:Off-White To Light YellowPeso molecular:430.448Montelukast Cyclized Ether impurity
CAS:Producto controlado<p>Applications A cyclic ether impurity of antiasthmatic Montelukast (M568000).<br>References Egekeze, J.O. et al.: Anal. Chem., 67, 2292 (1995);<br></p>Fórmula:C29H26ClNOForma y color:NeatPeso molecular:439.98N-Nitroso-(1S,2R)-ephedrine
CAS:Producto controladoFórmula:C10H14N2O2Forma y color:NeatPeso molecular:194.23Hydroxy Varenicline N-Trifluoroacetic Acid Salt
CAS:Producto controlado<p>Applications Protected Varenicline metabolite.<br></p>Fórmula:C15H12F3N3O2Forma y color:NeatPeso molecular:323.27trans-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolane-4-methanol
CAS:Producto controlado<p>Applications trans-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolane-4-methanol is an impurity of Ketoconazole (K186000).<br>References Ryu, J., et al. Bull. Korean Chem. Soc., 24, 460 (2003)<br></p>Fórmula:C14H14Cl2N2O3Forma y color:NeatPeso molecular:329.18(S)-4-Hydroxy Propranolol Hydrobromide
CAS:Producto controlado<p>Applications (S)-4-Hydroxy Propranolol is the main metabolite of (S)-Propranolol (P831795).<br>References Shwed, J., et al.: Xenobiotica, 22, 973 (1992), Fujita, K., et al.: Biol. Pharm. Bull., 22, 446 (1999), Walle, U., et al.: Drug Metab. Dispos., 30, 564 (2002),<br></p>Fórmula:C16H21NO3·ClHForma y color:NeatPeso molecular:311.80Des-6-[4-(2-hydroxyethyl)-1-piperazinyl]-6-chloro Dasatinib
CAS:Producto controlado<p>Applications Intermediate in the preparation of Dasatinib metabolite, used in the treatment of cancers and immune diseases. It is a COVID19-related research product.<br></p>Fórmula:C16H13Cl2N5O2SForma y color:NeatPeso molecular:410.28(S)-Rivastigmine
CAS:<p>Applications S-Rivastigmine is an isomer of Rivastigmine ( an acetylcholinesterase inhibitor used in the treatment of neurological disorders such as Alzheimer’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Howes, L et al.: Drug. Safe., 37, 391 (2014); Shahar, O. et al.: Nucl. Acids Res., 42, 5869 (2014);<br></p>Fórmula:C14H22N2O2Forma y color:ColourlessPeso molecular:250.34
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