Derivados de Quinazolina y Quinolina
Las quinazolinas y quinolinas son compuestos heterocíclicos nitrogenados con estructuras aromáticas que desempeñan un papel clave en la síntesis de fármacos con actividad anticancerígena, antimicrobiana y antiinflamatoria. Sus derivados presentan modificaciones estructurales que optimizan su biodisponibilidad y selectividad, lo que permite el desarrollo de nuevos principios activos para diversas aplicaciones terapéuticas. Estos compuestos se utilizan en la fabricación de APIs destinados al tratamiento de cáncer, infecciones, enfermedades neurodegenerativas y cardiovasculares. Además, los derivados de quinazolina y quinolina son esenciales en la investigación de inhibidores enzimáticos y en el diseño de moléculas bioactivas innovadoras. En CymitQuimica disponemos de derivados de quinazolina y quinolina de alta pureza para aplicaciones en síntesis química, desarrollo farmacéutico y biotecnología.
Se han encontrado 65924 productos de "Derivados de Quinazolina y Quinolina"
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Gabapentin-d4
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Used as an anticonvulsant.<br>References Vollmer, K.-O. et al.: Arzneimittel-Forshc., 36, 830 (1986), Saletu, B., et al.: Int. J. Clin. Pharmacol. Ther. Toxicol., 24, 362 (1986)<br></p>Fórmula:C9D4H13NO2Forma y color:Off-WhitePeso molecular:175.26Celecoxib
CAS:Producto controlado<p>Applications Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in treatment of familial adenomatous polyposis. Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body.Celecoxib is used to treat pain or inflammation caused by many conditions such as arthritis, ankylosing spondylitis, and menstrual pain. Celecoxib is also used in the treatment of hereditary polyps in the colon<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Simon, L.S., et al.: Arthritis Rheum., 41, 1591 (1998), Silverstein, F.E., et al.: J. Am. Med. Assoc., 284, 1247 (2000), Steinbach, G., et al.: N. Engl. J. Med., 342, 1946 (2000),<br></p>Fórmula:C17H14F3N3O2SForma y color:NeatPeso molecular:381.37Dolutegravir O-b-D-Glucuronide Sodium salt
Fórmula:C26H26F2N3NaO11Forma y color:White To Off-WhitePeso molecular:617.49(S)-Naproxen
CAS:<p>Applications (S)-Naproxen is a a nonsteroidal anti-inflammatory compound with analgesic and antipyretic properties (1,2). (S)-Naproxen is also a potent COX1 inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References (1) Harrison, I.T., et al.: J. Med. Chem., 13, 203 (1970)(2) Scott, W. W., et al.: World Neurosurg. 82, e633 (2014)<br></p>Fórmula:C14H14O3Forma y color:Off-WhitePeso molecular:230.266-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole
CAS:Producto controlado<p>Applications An Intermediate in the synthesis of risperidone and iloperidone.<br></p>Fórmula:C12H13FN2OForma y color:NeatPeso molecular:220.245-Aminoimidazole-4-carboxamide
CAS:<p>Applications A metabolite of Temozolomide.<br>References Jaeken, J., et al.: Lancet, 2, 1058 (1984), Baggott, J., et al.: Biochem. J., 236, 193 (1986), Baggott, J., et al.: Arch. Dermatol., 135, 813 (1999),<br></p>Fórmula:C4H6N4OForma y color:White To Off-WhitePeso molecular:126.122,2'-Dithiobis[N-methyl-benzamide]
CAS:<p>Applications Benzamide, 2,2'-dithiobis[N-methyl- (cas# 2527-58-4) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Fórmula:C16H16N2O2S2Forma y color:Light Yellow To Light BeigePeso molecular:332.444-Anilino-4-oxobutanoic Acid
CAS:Producto controlado<p>Applications The metabolite (MII) of Suberoylanilide Hydroxamic Acid (S688700).<br>References Sun, W.S., et al.: J. Med. Chem., 46, 5619 (2003)<br></p>Fórmula:C10H11NO3Forma y color:NeatPeso molecular:193.20Maraviroc
CAS:Producto controladoFórmula:C29H41F2N5OForma y color:White To Off-WhitePeso molecular:513.67Methyl 4’-[[2-n-Propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]methyl]biphenyl-2-ca
CAS:Fórmula:C34H32N4O2Forma y color:YellowPeso molecular:528.64Nifursol (~90%)
CAS:Producto controlado<p>Applications A medicinal, prophylactic additive in animal feeds, protecting poultry from histomoniasis.Environmental contaminants; Food contaminants; Heat processing contaminants<br>References Kowalski, P., et al.: J. Pharm. Biomed. Anal., 32, 937 (2003), Khlebnikov, A., et al.: Bioorg. Med. Chem., 16, 9302 (2008), Schepetkin, I., et al.: Mol. Pharmacol., 74, 392 (2008),<br></p>Fórmula:C12H7N5O9Pureza:~90%Forma y color:NeatPeso molecular:365.21Vildagliptin Amide
CAS:Producto controlado<p>Impurity Vildagliptin Amide Impurity<br>Applications N-(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)glycyl-L-prolinamide is an impurity of Vildagliptin (V305000) which is an oral anti-hyperglycemic agent that inhibit dipeptidyl peptidase 4 (DPP-4).<br>References Ahren, B., et al.: J. Clin. Endocrinol. Metab., 89, 2078 (2004), Ahren, B., et al.: Diabetes Care, 27, 2874 (2004), Barlocco, D., et al.: Curr. Opin. Invest. Drugs, 5, 1094 (2004),<br></p>Fórmula:C17H27N3O3Forma y color:Off-WhitePeso molecular:321.41Felbamate-d4
CAS:Producto controlado<p>Applications Antiepileptic, structurally similar to meprobamate.<br>References Swinyard, E.A., et al.: Epilepsia, 27, 27 (1986), Remmel, R.P., et al.: Ther. Drug Monit., 12, 90 (1990), Sofia, R.D., et al.: Epilepsy Res. Suppl., 3, 103 (1991),<br></p>Fórmula:C11H10D4N2O4Forma y color:NeatPeso molecular:242.267Irbesartan-d4
CAS:Producto controlado<p>Applications Irbesartan-d4 is the labeled analogue of Irbesartan (I751000), an angiotensin II type 1 (AII1)-receptor antagonist.<br>References Gillis, J.C. and Markham, A.: Drugs, 54, 885 (1997); Chando, T.J., et al.: Drug. Metabol. Dispos., 26, 408 (1998); Massie, B., et al.: New Eng. J. Med., 359, 2456 (2008); Ren, X., et al.: Pharmacol., 83, 80 (2009)Aromatics, Heterocycles, Inhibitors, Isotope Labelled Compounds, Pharmaceuticals, Intermediates & Fine Chemicals<br></p>Fórmula:C25H24D4N6OForma y color:NeatPeso molecular:432.55Trametinib
CAS:Producto controlado<p>Applications Used in the systematic treatment of advanced cutaneous melanoma. An EGFR kinase inhibitor and potent MEK inhibitor.<br>References Ercan, D. et al.: Canc. Disc., 2, 934 (2012); Mackiewicz-Wysocka, M. et al.: Exp. Opin. Investig. Drugs., 22, 181 (2013);<br></p>Fórmula:C26H23FIN5O4Forma y color:Off-WhitePeso molecular:615.39Alogliptin-d3
CAS:Producto controlado<p>Applications Labelled Alogliptin (A575425). It is an oral antihyperglycemic agent that is a selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4). Antidiabetic agent.<br>References Lynn, F., et al.: Diabetes, 50, 1004 (2001), Trumper, A., et al.: J. Endocrinol., 174, 233 (2002), Vollmer, K., et al.: J. Clin. Endocrinol. Metab., 94, 1379 (2009),<br></p>Fórmula:C182H3H18N5O2Forma y color:NeatPeso molecular:342.41Vismodegib
CAS:Producto controlado<p>Applications Vismodegib targets the Hedgehog (Hh) pathway. Inhibition of the Hh signaling may be effective in the treatment and prevention of many types of human cancers. Potent Hedgehog inhibitor.<br>References Gupta, S. et al.: Ther. Advances in Med. Oncology 2,237(2010)<br></p>Fórmula:C19H14Cl2N2O3SForma y color:Off-WhitePeso molecular:421.30Nimodipine
CAS:<p>Applications A dihydropyridine calcium channel blocker. It is used as a vasodilator (cerebral). Neuroprotective & Neuroresearch products.<br>References Allen, G.S., et al.: N. Engl. J. Med., 308, 619 (1983), Schluter, H.: Arzneim.-Forsch., 36, 1733 (1986), Deyo, R.A., et al.: Science, 243, 809 (1989),<br></p>Fórmula:C21H26N2O7Forma y color:NeatPeso molecular:418.44N-Chloro Ethyl ThioTEPA
CAS:Producto controlado<p>Stability Hygroscopic, Moisture Sensitive<br>Applications N-Chloro Ethyl ThioTEPA is an impurity of ThioTEPA which is an alkylating agent used to treat cancer.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Maanen, M., et al.: Cancer Treatment Rev., 26, 257 (2000); Sykes, M., et al.: Cancer, 6, 142 (1953)<br></p>Fórmula:C6H13ClN3PSForma y color:White To Off-WhitePeso molecular:225.68O3-Desethyl Apremilast
CAS:Producto controladoFórmula:C20H20N2O7SForma y color:NeatPeso molecular:432.45Riociguat-13C-d3
CAS:Producto controlado<p>Applications Riociguat-13C-d3 is the labelled analogue of Riociguat (R520000), which is used in the treatment for pulmonary hypertension.<br>References Frey, R. et al.: J. Clin. Pharmacol., 51, 1051 (2011);<br></p>Fórmula:C1913CH16D3FN8O2Forma y color:NeatPeso molecular:426.43Netupitant
CAS:Producto controlado<p>Applications Netupitant is a potent and selective neurokinin-1 receptor (NK1) receptor antagonist. It is achiral and orally active.<br>References Hoffmann, T., et al.: Bioorg. Med. Chem. Lett., 16, 1362 (2006); Di Fabio, R., et al.: Bioorg. Med. Chem., 21, 6264 (2013)<br></p>Fórmula:C30H32F6N4OForma y color:NeatPeso molecular:578.59Butoxy Olopatadine Hydrochloride
CAS:Producto controladoFórmula:C25H31NO3•HClForma y color:NeatPeso molecular:429.98Irbesartan-d6
CAS:Producto controlado<p>Applications Irbesartan-d6 is deuterium labelled Irbesartan (I751000) which is an angiotensin II type 1 (AII1)-receptor antagonist.<br>References Gillis, J.C. and Markham, A.: Drugs, 54, 885 (1997); Chando, T.J., et al.: Drug. Metabol. Dispos., 26, 408 (1998),<br></p>Fórmula:C25D6H22N6OForma y color:White SolidPeso molecular:434.57N-Demethyl Ondansetron
CAS:<p>Applications A metabolite of Ondansetron (O655000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bayliss, M., et al: Xenobiotica, 24, 231 (1994), Atkins, W., et al.: J. Biol. Chem., 277, 33258 (2002), De Graaf, I., et al.: Drug Metab. Dispos., 30, 1129 (2002),<br></p>Fórmula:C17H17N3OForma y color:White To BrownPeso molecular:279.342-(Chloromethyl)-4-methylquinazoline
CAS:Producto controlado<p>Impurity Linagliptin 2-Chloromethyl Impurity<br>Applications 2-(Chloromethyl)-4-methylquinazoline, is a building block used for the preparation of Linagliptin (L465900), and its impurities, acting as type 2 diabetes drugs.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Prabavathy, N. et al.: Int. J. Pharm. Bio. Sci., 2, 438 (2011); Deacon, C.F.: Diab. Obes. Metab., 13, 7 (2011);<br></p>Fórmula:C10H9ClN2Forma y color:NeatPeso molecular:192.64Oxaprozin-d10
CAS:Producto controlado<p>Applications Oxaprozin-d10 is the labeled analogue of Oxaprozin (O845400), an anti-inflammatory drug. Oxaprozin was comparable to Aspirin (A687780).<br>References Whitehouse, M.W., et al.: Biochem. Pharmacol., 20, 2309 (1971); Janssen, F.W., et al.: Drug Metab. Dispos., 6, 465 (1978); Shriver, D.A., et al.: Toxicol. Appl. Pharmacol., 42, 75 (1977)<br></p>Fórmula:C18H5D10NO3Forma y color:NeatPeso molecular:303.38Ethyl 6-(4-Aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
CAS:Producto controlado<p>Applications Ethyl 6-(4-Aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate is an impurity of Apixaban (A726700), A potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.<br>References Nevuluri, N. et al.: Monat. fuer Chem., 148, 1477 (2017);<br></p>Fórmula:C22H22N4O4Forma y color:NeatPeso molecular:406.43C-Desmethyl Metoprolol
CAS:Producto controlado<p>Impurity Metoprolol EP Impurity A<br>Applications C-Desmethyl Metoprolol (Metoprolol EP Impurity A) is a new byproduct detected in Metoprolol tartrate. Metoprolol impurity.<br>References Erickson, M., et al.: J. Pharma. Biomed. Analysis, 13, 567 (1995), Phinney, K., et al.: Chirality, 15, 287 (2003), Zheng, J., et al.: Anal. Chem., 78, 1535 (2006),<br></p>Fórmula:C14H23NO3Forma y color:NeatPeso molecular:253.34Hydroxynorketamine-d6 Hydrochloride
CAS:Producto controlado<p>Applications Hydroxynorketamine-d6 Hydrochloride, is labelled Hydroxynorketamine (H949680, HCl salt), a metabolite of Ketamine (K165300, HCl salt) which is a medication used mainly for starting and maintaining anesthesia.<br>References Adams, J., et al.: Biomed. Mass Spec., 11, 527 (1981); Sass, W.C., et al.: Anal. Profiles Drug Subs., 6, 297 (1977); Reich, D.L., et al.: Can. J. Anaesth., 36, 186 (1989)<br></p>Fórmula:C12H8D6ClNO2•HClForma y color:NeatPeso molecular:282.24-Methyl-1-(3-methyl-2-pyridinyl)-2-phenylpiperazine
CAS:<p>Applications 4-Methyl-1-(3-methyl-2-pyridinyl)-2-phenylpiperazine is an impurity of Mirtazapine (M365000). Mirtazapine impurity E.<br>References De Boer, T., et al.: Neuropharmacology, 27, 399 (1988), Wynia, G., et al.: J. Chromatography, A 773, 339 (1997),<br></p>Fórmula:C17H21N3Forma y color:NeatPeso molecular:267.37Delamanid
CAS:<p>Stability Hygroscopic<br>Applications Delamanid is a novel anti-tuberculosis medication that inhibits mycolic acid synthesis and shows potent in vitro and in vivo activity against drug-resistant strains of Mycobacterium tuberculosis.<br>References Gler, M.T., et al.: New Engl. J. Med., 366, 2151 (2012); Skripconoka, V., et al.: Eur. Respir. J., 41, 1393 (2012); Diacon, A.H., et al.: Int. J. Tuberc. Lung D., 15, 949 (2011); Zhang, Q., et al.: Cell Biochem. Biophys., 67, 957 (2013)<br></p>Fórmula:C25H25F3N4O6Forma y color:NeatPeso molecular:534.481-epi-Darunavir
CAS:Producto controlado<p>Applications Stereoisomer to Darunavir (D193500), a second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. It is a COVID19-related research product.<br>References Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003), Arasteh, K., et al.: AIDS, 19, 943 (2005), Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2005),<br></p>Fórmula:C27H37N3O7SForma y color:White To Off-WhitePeso molecular:547.66Ticagrelor
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Ticagrelor, the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>Fórmula:C23H28F2N6O4SForma y color:WhitePeso molecular:522.57Pomalidomide
CAS:<p>Applications Pomalidomide is a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.<br>References Ruchelman, A. et al.: Bioorg. Med. Chem. Lett., 23, 360 (2013); Latif, T. et al.: Exp. Hematol. Oncol., 1, 27 (2012); Man, H. et al.: Bioorg. Med. Chem. Lett., 13, 3415 (2003); Muller, G. et al.: Bioorg. Med. Chem. Lett., 9, 1625 (1999)<br></p>Fórmula:C13H11N3O4Forma y color:YellowPeso molecular:273.243-Hydroxy Phenytoin
CAS:Producto controlado<p>Applications A major metabolite of Phenytoin, an anticonvulsant.<br>References Bowmer, C., et al.: Biochem. Pharmacol., 27, 937 (1978), Kober, A., et al.: Mol. Pharmacol., 18, 237 (1980), Dasgupta, A., et al.: Ther. Drug Monit., 21, 625 (1999),<br></p>Fórmula:C15H12N2O3Forma y color:NeatPeso molecular:268.27trans-Hydroxy Praziquantel
CAS:Producto controlado<p>Applications The main trans-monohydroxylated metabolite of Praziquantel (P702095).<br>References Buehring, K., et al.: Eur. J. Drug Metab. Pharm., 3, 179 (1978), Moldeus, P., et al.: Methods Enzymol., 52, 60 (1978), Cioli, D., et al.: Pharmacol. Ther., 68, 35 (1995),<br></p>Fórmula:C19H24N2O3Forma y color:NeatPeso molecular:328.412-(3-(tert-Butylamino)-2-hydroxypropyl)-4-morpholino-1,2,5-thiadiazol-3(2H)-one (>90%)
CAS:<p>Impurity Timolol EP Impurity H<br>Applications 2-(3-(tert-Butylamino)-2-hydroxypropyl)-4-morpholino-1,2,5-thiadiazol-3(2H)-one is a impurity of Timolol (T443710), an antihypertensive; antiarrhythmic (class II); antianginal; antiglaucoma agent.<br>References Lacroix, P.M., et. al.: Chirality, 6, 484 (1994); Wasson, et al.: J. Med. Chem., 15, 651 (1972); Franciosa, et al.: Clin. Pharmacol. Ther., 13, 138 (1972); Heel, R.C., et al.: Drugs, 17, 38 (1979); Rofman, B.A., et al.: Hypertension, 2, 643 (1980); Mazzo, D.J., et al.: Anal. Profiles Drug Subs., 16, 641 (1987)<br></p>Fórmula:C13H24N4O3SPureza:>90%Forma y color:NeatPeso molecular:316.42(R)-Desmethyl Atomoxetine Hydrochloride
CAS:Producto controladoFórmula:C16H19NO·HClForma y color:Off-WhitePeso molecular:277.79(Z)-Sulindac Sulfone
CAS:<p>Stability Hygroscopic<br>Applications An active metabolite of Sulindac. Inducer of apoptosis independent of cyclooxygenase inhibition. Inhibits cell growth by inducing apoptosis.<br>References Piazza, G.A., et al.: Cancer Res., 55, 3310 (1995)<br></p>Fórmula:C20H17FO4SForma y color:NeatPeso molecular:372.41(R)-O-Desmethyl Naproxen
CAS:Producto controlado<p>Applications A metabolite of Naproxen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rettie, A., et al.: Chem. Res. Toxicol., 5, 54 (1992), Tracy, T., et al.: Biochem. Pharmacol., 52, 1305 (1996), Bonnabry, P., et al.: Eur. J. Clin. Pharmacol., 49, 305 (1996), Rao, S., et al.: J. Med. Chem., 43, 2789 (2000), Hutzler, J., et al.: Drug Metab. Dispos., 29, 1029 (2001),<br></p>Fórmula:C13H12O3Forma y color:NeatPeso molecular:216.235-Hydroxyhydantoin
CAS:Producto controlado<p>Applications 5-Hydroxyhydantoin (cas# 29410-13-7) is a compound useful in organic synthesis.<br></p>Fórmula:C3H4N2O3Forma y color:WhitePeso molecular:116.082-Thiopheneethanol Tosylate
CAS:Producto controlado<p>Applications Intermediate in the preparation of Rotigotine<br>References Janssens, F., et al.: J. Med. Chem., 29, 2290 (1986),<br></p>Fórmula:C13H14O3S2Forma y color:NeatPeso molecular:282.382-Methoxy-4-amino-5-ethylsulfonylbenzoic Acid
CAS:Producto controlado<p>Impurity Amisulpride EP Impurity E<br>Applications An impurity found in amisulpride (A633250). Amisulpride EP Impurity E<br></p>Fórmula:C10H13NO5SForma y color:WhitePeso molecular:259.28Ivacaftor
CAS:<p>Applications Ivacaftor is used in the treatment of cystic fibrosis.<br>References Clancy, J. et al.: Am. J. Resp. Crit. Care. Med., 186, 593 (2012);<br></p>Fórmula:C24H28N2O3Forma y color:Off-WhitePeso molecular:392.49
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