Derivados de Quinazolina y Quinolina
Las quinazolinas y quinolinas son compuestos heterocíclicos nitrogenados con estructuras aromáticas que desempeñan un papel clave en la síntesis de fármacos con actividad anticancerígena, antimicrobiana y antiinflamatoria. Sus derivados presentan modificaciones estructurales que optimizan su biodisponibilidad y selectividad, lo que permite el desarrollo de nuevos principios activos para diversas aplicaciones terapéuticas. Estos compuestos se utilizan en la fabricación de APIs destinados al tratamiento de cáncer, infecciones, enfermedades neurodegenerativas y cardiovasculares. Además, los derivados de quinazolina y quinolina son esenciales en la investigación de inhibidores enzimáticos y en el diseño de moléculas bioactivas innovadoras. En CymitQuimica disponemos de derivados de quinazolina y quinolina de alta pureza para aplicaciones en síntesis química, desarrollo farmacéutico y biotecnología.
Se han encontrado 65630 productos de "Derivados de Quinazolina y Quinolina"
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2,6-Dichloroformanilide
CAS:Producto controlado<p>Applications 2,6-Dichloroformanilide is an intermediate in the synthesis of N-(2,6-Dichlorophenyl)-carbonimidic Dichloride (D436565). N-(2,6-dichlorophenyl)-carbonimidic Dichloride is an impurity of clonidine (C587130). Chlonidine is α2-Adrenergic agonist. Antihypertensive; analgesic for neuropathic pain.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Roach, A.G., et al.: J. Pharmacol. Exp. Ther., 227, 421 (1983), Glassman, A.H., et al.: Science, 226, 864 (1984), Abounassif, A.M., et al.: Anal. Profiles Drug Subs. Excip., 21, 109 (1992),<br></p>Fórmula:C7H5Cl2NOForma y color:NeatPeso molecular:190.03Sulindac Sulfone Acyl-β-D-Glucuronide
CAS:Producto controlado<p>Applications Sulindac Sulfone Acyl-β-D-Glucuronide is the major metabolite of the non-steroidal anti-inflammatory drug Sulindac (S699215) in plasma and urine.<br>References Hucker, H.B., et al.: Drug Metab. Dispos., 1, 721 (1973),<br></p>Fórmula:C26H25FO10SForma y color:NeatPeso molecular:548.53[1-(2-Chloro-pyridine-3-carbonyl)-piperidin-3-ylmethyl]-carbamic acid tert-butyl ester
CAS:Pureza:95.0%Peso molecular:353.8500061035156t-Butylnorsynephrine
CAS:<p>Impurity Salbutamol EP Impurity B<br>Applications t-Butylnorsynephrine (Salbutamol EP Impurity B) is a derivative of norsynephrine, an endogenous biogenic amine that is closely related to norepinephrine, which has effects on the adrenergic and dopaminergic system. Structure and activity tudies have shown that t-Butylnorsynephrine may also exhibit effects towards β-adrenergic receptors and β-adrenergic receptor-coupled adenylate cyclase.<br>References Wong, A., et al.: Molec. Pharmacol., 31, 368 (1987); Constanzi, S., et al.: J. Comp. Chem., 33, 561, (2012);<br></p>Fórmula:C12H19NO2Forma y color:YellowPeso molecular:209.283-(1-benzofuran-2-yl)-1H-pyrazole
CAS:Pureza:95.0%Forma y color:Solid, Beige powderPeso molecular:184.197998046875Prochlorperazine Dimaleate
CAS:Producto controladoFórmula:C20H24ClN3S·2C4H4O4Forma y color:Off-WhitePeso molecular:606.091-(4-Bromophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid hydrazide
CAS:Fórmula:C11H11BrN4OPureza:95.0%Peso molecular:295.142-(2,5-Dichlorobenzoyl)-5-(1,3-dioxolan-2-yl)thiophene
CAS:Pureza:97.0%Peso molecular:329.19000244140625Famotidine-d4 (Major)
CAS:Producto controlado<p>Applications Famotidine-d4 is the labeled analogue of Famotidine (F102250), a histamine H2-receptor antagonist. Antiulcerative.<br>References Takeda, M., et al.: Arzneim.-Forsch., 32, 734 (1982); Miwa, M., et al.: J. Clin. Pharmacol. Ther. Toxicol., 22, 214 (1984); Takabatke, T., et al.: Eur. J. Clin. Pharmacol., 28, 327 (1985)<br></p>Fórmula:C8H11D4N7O2S3Forma y color:NeatPeso molecular:341.474,4'-(3',4',5',6'-Tetrakis(4-(pyridin-4-yl)phenyl)-[1,1':2',1''-terphenyl]-4,4''-diyl)dipyridine
CAS:Pureza:98%Forma y color:SolidPeso molecular:997.218Captopril Disulfide
CAS:<p>Impurity Captopril EP Impurity A<br>Applications Captopril Disulfide (Captopril EP Impurity A) is a metabolite of Captopril. A new antihypertensive agent.<br>References Sprague, P., et al.: Perspect. Drug Discovery Des., 3, 21 (1995), Cushman, D., et al.: Nat. Med., 5, 1110 (1999), Jacoby, E., et al.: Drug News Perspect., 16, 93 (2003), Lengauer, T., et al.: Drug Discovery Today, 9, 27 (2004),<br></p>Fórmula:C18H28N2O6S2Forma y color:WhitePeso molecular:432.55Nor Mianserin
CAS:Producto controlado<p>Applications The active metabolites of Miansein (M341500) in plasma, an antidepressant.<br>References Kent, J., et al.: Lancet, 355, 911 (2000), Maurer, H., et al.: Ther. Drug Monit., 24, 117 (2002),<br></p>Fórmula:C17H18N2Forma y color:NeatPeso molecular:250.344-Bromo-2-chloro-3-iodopyridine
CAS:Fórmula:C5H2BrClINPureza:98%Forma y color:Brown powderPeso molecular:318.342-Des(acetylthiomethyl)-2-methylene Racecadotril
CAS:Producto controlado<p>Applications An impurity of the antidiarrheal Racecadotril (R070600).<br>References Reddy, K.M. et al.: Pharmazie, 61, 994 (2006);<br></p>Fórmula:C19H19NO3Forma y color:NeatPeso molecular:309.36Nifuroxazide
CAS:Producto controlado<p>Applications Nifuroxazide is an intestinal antiseptic. Nifuroxazide, is still used as a veterinary drug illegally in some countries. SEE H829102 as a test for antibiotic in broiler chickens.<br>References Carron, M.C.E., et al.: Ann. Pharm. Fr., 21, 287 (1963), Thabaut, A., et al.: Gaz. Med. Fr., 85, 4516 (1978), Residue depletion of nifuroxazide in broiler chicken. Gao F. et al, J Sci Food Agric. 2013 Jul;93(9):2172-8<br></p>Fórmula:C12H9N3O5Forma y color:YellowPeso molecular:275.22rac Phenylephrine Hydrochloride
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Phenylephrine is a selective α1-adrenergic receptor agonist used as a decongestant. Phenylephrine lowers intraocular pressure and is used as an agent to dilate the pupil.<br>References Lorenzetti, O.J. et al.: Exp. Eye Res., 12, 80 (1971); Ando, J. et al.: Nip. Yakur. Zas., 61, 471 (1965);<br></p>Fórmula:C9H14ClNO2Forma y color:NeatPeso molecular:203.67Ketoconazole
CAS:Producto controlado<p>Applications Inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor. Inhibitor of exosome secretion.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986), Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989), Nardone, P.A., et al.: . Surg. Res., 44, 425 (1988), Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986); Scientific Reports 8: 8161 (2018)<br></p>Fórmula:C26H28Cl2N4O4Forma y color:NeatPeso molecular:531.43Tazarotene
CAS:<p>Applications An acetylenic retinoid prodrug converted to the active metabolite, Tazarotenic acid, with selective affinity for retinoic acid receptors RARβ and RARγ. Antiacne; antipsoriatic. Used in treatment of photodamaged skin.<br>References Tang-Liu, D.D.-S., et al.: Clin. Pharmacokinet., 37, 273 (1999), Roeder, A., et al.: Skin Pharmacol. Physiol., 17, 111 (2004),<br></p>Fórmula:C21H21NO2SForma y color:Light YellowPeso molecular:351.46Etoricoxib-d6
CAS:Producto controlado<p>Applications Etoricoxib-d6 is the labelled analog of Etoricoxib (E934100), a specific inhibitor of COX-2 .<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References McGeer, P.L., et al.: Exp. Gerontol., 37, 925 (2002), Chenevard, R., et al.: Circulation, 107, 405 (2003)<br></p>Fórmula:C18H9D6ClN2O2SForma y color:NeatPeso molecular:364.888-Hydroxy Loxapine
CAS:<p>Stability Light Sensitive<br>Applications The inactive metabolite of Loxapine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bradford, M., et al.: Anal. Biochem., 72, 248 (1976), Fitton, A., et al.: Drugs, 40, 722 (1990), Jann, M., et al.: Clin. Pharmacokinet., 24, 161 (1993), Jennison, T., et al.: J. Anal. Toxicol., 21, 73 (1997),<br></p>Fórmula:C18H18ClN3O2Forma y color:NeatPeso molecular:343.81Deschloro Dasatinib
CAS:Producto controladoFórmula:C22H27N7O2SForma y color:BrownPeso molecular:453.56A 77-1726
CAS:<p>Impurity Leflunomide EP Impurity B<br>Applications A77 1726 (Leflunomide EP Impurity B) is the active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function. The second Phase III study evaluating the efficacy of Genzyme’s teriflunomide therapy against relapsing forms of multiple sclerosis found the once-daily oral drug to be no less effective than injectable interferon beta 1a (Rebif®).<br>References Kirsch, B.M., et al.: Arthritis Research and Therapy, 7, 3, R694, (2005)<br></p>Fórmula:C12H9F3N2O2Forma y color:White To Off-WhitePeso molecular:270.211-Cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
CAS:Pureza:95.0%Forma y color:SolidPeso molecular:295.24200439453125Raloxifene
CAS:<p>Raloxifene (LY139481) is an estrogen receptor modulator exhibiting estrogen agonist and antagonist activity at different sites, with antiviral activity.</p>Fórmula:C28H27NO4SPureza:99.39%Forma y color:Light-Yellow SolidPeso molecular:473.58Terfenadine
CAS:Producto controlado<p>Applications Nonsedating-type histamine H1-receptor antagonist. Antihistaminic.<br>References Carr, A.A., et al.: Arzneim. Forsch., 32, 1157 (1982), Badwan, A.A., et al.: Anal. Profiles Drug Subs., 19, 627 (1990), Masheter, H.C., et al.: Clin. Rev. Allergy, 11, 5 (1993), Jurima-Romet, M., et al.: Drug Metab. Dispos., 22, 849 (1994),<br></p>Fórmula:C32H41NO2Forma y color:White To Off-WhitePeso molecular:471.67(R)-Naproxen Acyl-β-D-glucuronide
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications A metabolite of Naproxen.<br>References Boynton, C., et al.: J. Clin. Pharmacol., 28, 512 (1988), Jin, C., et al.: J. Pharmacol. Exp. Ther., 264, 475 (1993),King, C., et al.: Toxicol. Sci., 61, 49 (2001), Aresta, A., et al.: J. Pharm. Biomed. Anal., 39, 643 (2005),<br></p>Fórmula:C20H22O9Forma y color:NeatPeso molecular:406.383-[2-(Diaminomethyleneamino)-1,3-thiazol-4-ylmethylsulphinyl]-N-sulphamoylpropanamide (Famotidine Metabolite)
CAS:Producto controlado<p>Impurity Famotidine EP Impurity I<br>Stability Light Sensitive<br>Applications 3-[2-(Diaminomethyleneamino)-1,3-thiazol-4-ylmethylsulphinyl]-N-sulphamoyl propanamide (Famotidine EP Impurity I) is a metabolite of the drug Famotidine.<br></p>Fórmula:C8H14N6O4S3Forma y color:NeatPeso molecular:354.431-Ethyl-2-((Z)-((Z)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)pyridin-1-ium chloride
CAS:Pureza:95.0%Peso molecular:432.0rac-Propranolol-d7
CAS:Producto controladoFórmula:C162H7H14NO2Forma y color:WhitePeso molecular:266.39(S)-Lisinopril-d5 Sodium
CAS:Producto controladoFórmula:C21H26D5N3NaO5Forma y color:NeatPeso molecular:433.511-(5-Fluoropyridin-2-yl)-1,4-diazepane dihydrochloride
CAS:Pureza:95.0%Peso molecular:268.1600036621094(S)-Naproxen Sodium Salt
CAS:<p>Applications An anti-inflammatory, analgesic, antipyretic. A non-steroidal anti-inflammatory.<br>References Harrison, I.T., et al.: J. Med. Chem., 13, 203 (1970)<br></p>Fórmula:C14H13O3·NaForma y color:Off White SolidPeso molecular:252.24p-Chlonixin
CAS:<p>Applications p-Chlonixin may be used in pharmaceutical tablet dosage formulations.<br>References Kumar, M. N., et al.: I. J. Pharm., 5, 170-179 (2015)<br></p>Fórmula:C13H11ClN2O2Forma y color:NeatPeso molecular:262.691-(4-Chlorophenyl)-5-(furan-2-yl)-1h-pyrazole-3-carboxylic acid
CAS:Pureza:95%Peso molecular:288.690002441406253-Phenoxyphenylacetonitrile
CAS:Producto controlado<p>Applications 3-PHENOXYPHENYLACETONITRILE (cas# 51632-29-2) is a useful research chemical.<br></p>Fórmula:C14H11NOForma y color:NeatPeso molecular:209.242-[5-(3-bromophenyl)-1H-pyrazol-3-yl]-5-methylphenol
CAS:Pureza:95.0%Peso molecular:329.1969909667969Ibrutinib-d4 (Major)
CAS:Producto controlado<p>Applications Ibrutinib-d4 is the labelled analogue of Ibrutinib (I124970). Ibrutinib is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.<br>References MacGlashan, D., et. al.: Int. Immunol., 11, 475 (2011)<br></p>Fórmula:C25H20D4N6O2Forma y color:NeatPeso molecular:444.52Eltrombopag Ethyl Ester
Producto controlado<p>Applications Eltrombopag Ethyl Ester, is a metabolite of Eltrombopag (E508000), which is an agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia.<br>References Bussel, J., et al.: New Eng. J. Med., 357, 2237 (2007), Marsilje, T., et al.: Bioorg. Med. Chem. Lett., 18, 5259 (2008), Alper, P., et al.: Bioorg. Med. Chem. Lett., 18, 5255 (2008),<br></p>Fórmula:C27H26N4O4Forma y color:NeatPeso molecular:470.52(S)-2-Aminobutyramide Hydrochloride
CAS:Producto controlado<p>Impurity Levetiracetam USP Related Compound B<br>Applications Levetiracetam USP Related Compound B<br></p>Fórmula:C4H10N2O·ClHForma y color:White To Off-WhitePeso molecular:138.60Trametinib-13C6
CAS:Producto controlado<p>Applications Trametinib-13C6 is the labelled compound form of Trametinib (C988930), which is used in the systematic treatment of advanced cutaneous melanoma. An EGFR kinase inhibitor and potent MEK inhibitor.<br>References Ercan, D., et al.: Canc. Disc., 2, 934 (2012); Mackiewicz-Wysocka, M., et al.: Exp. Opin. Investig. Drugs., 22, 181 (2013);<br></p>Fórmula:C6C20H23FIN5O4Forma y color:NeatPeso molecular:621.351Axitinib Tetrahydro-2H-pyran
CAS:Producto controladoFórmula:C27H26N4O2SForma y color:NeatPeso molecular:470.586
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