Derivados de Quinazolina y Quinolina
Las quinazolinas y quinolinas son compuestos heterocíclicos nitrogenados con estructuras aromáticas que desempeñan un papel clave en la síntesis de fármacos con actividad anticancerígena, antimicrobiana y antiinflamatoria. Sus derivados presentan modificaciones estructurales que optimizan su biodisponibilidad y selectividad, lo que permite el desarrollo de nuevos principios activos para diversas aplicaciones terapéuticas. Estos compuestos se utilizan en la fabricación de APIs destinados al tratamiento de cáncer, infecciones, enfermedades neurodegenerativas y cardiovasculares. Además, los derivados de quinazolina y quinolina son esenciales en la investigación de inhibidores enzimáticos y en el diseño de moléculas bioactivas innovadoras. En CymitQuimica disponemos de derivados de quinazolina y quinolina de alta pureza para aplicaciones en síntesis química, desarrollo farmacéutico y biotecnología.
Se han encontrado 65580 productos de "Derivados de Quinazolina y Quinolina"
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2,6-Di(1H-benzo[d]imidazol-2-yl)pyridine
CAS:Pureza:95.0%Forma y color:SolidPeso molecular:311.34799194335943-Methyl Adenine-d3
CAS:Producto controlado<p>Applications 3-Methyl Adenine-d3 is labelled 3-Methyl Adenine (M275904). 3-Methyl Adenine is a selective autophagy and phosphoinositide 3-kinase (PI3K) inhibitor (1,2,3). 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K).<br>References (1) Munafo, D., et al.: J. Cell Sci., 114, 3619 (2001) (2) Aggarwal, B., et al.: Biochem. Pharmacol., 71, 1397 (2006) (3) Hayat, M., et al.: Oncologist, 12, 20 (2007)<br></p>Fórmula:C62H3H4N5Forma y color:NeatPeso molecular:152.173-[4-(2-Methoxyphenyl)piperazin-1-yl]propan-1-amine
CAS:Producto controlado<p>Applications 3-[4-(2-methoxyphenyl)piperazin-1-yl]propan-1-amine (cas# 20529-23-1) is a useful research chemical.<br></p>Fórmula:C14H23N3OForma y color:NeatPeso molecular:249.35Telmisartan-d4
CAS:Producto controlado<p>Applications Telmisartan-d4 is deuterium labelled Telmisartan (T017000). Telmisartan is an angiotensin II receptor antagonist.<br>References Wienen, W. et al.: Br. J. Pharmacol., 110, 245 (1993); Neutel, J.M. et al: Adv. Therap., 15, 206 (1998)<br></p>Fórmula:C33D4H26N4O2Forma y color:NeatPeso molecular:518.64Genfatinib-d3 (Imatinib-d3)
CAS:Producto controlado<p>Applications Genfatinib-d3 (Imatinib-d3) is the labeled analogue of Genfatinib, a treatment of chronic myeloid leukemia (CML). It is a COVID19-related research product.<br>References Helmann, R., et. al.: J. Clin. Oncol., 32, 415 (2014)<br></p>Fórmula:C29D3H28N7OForma y color:NeatPeso molecular:496.62DL-Fenfluramine Hydrochloride
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications N-Ethyl-α-methyl-3-(trifluoromethyl)-benzeneethanamine hydrochloride has been used in case studies for the study of impulsivity, motor skills, and anxiogenic effects in the neuroscience community.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Whitney, K.N., et al.: Exp. Clin. Psychopharm., 21, 345-54 (2013); Arrant, A.E., et al.: Neuropharmacology, 65, 213-22 (2013)<br></p>Fórmula:C12H16F3N·ClHForma y color:WhitePeso molecular:267.724-methoxy-7-methyl-N-(pyridin-3-ylmethyl)-1,3-benzothiazol-2-amine
CAS:Pureza:95.0%Peso molecular:285.36999511718752-(Pyridin-4-ylmethyl)-2,3-dihydro-1H-isoindole-1,3-dione dihydrate
CAS:Pureza:98.0%Peso molecular:274.27600097656251-Chloro-2,4-dinitrobenzene
CAS:Producto controlado<p>Applications 1-Chloro-2,4-dinitrobenzene is a benzene derivative and is used in biochemical research as a substrate for glutathione S-transferase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Viswanathan, R., et al.: BIoconjugate. Chem., 24, 571 (2013); Ormazabal-Toledo, R., et al.: J. Org. Chem., 78, 1091 (2013);<br></p>Fórmula:C6H3ClN2O4Forma y color:NeatPeso molecular:202.55Famotidine Amide Impurity Hydrochloride
CAS:<p>Applications Famotidine impurity.<br>References Junnarkar, G., et al.: Pharm. Res., 12, 599 (1995), Singh, S., et al.: J. Pharm. Sci., 91, 253 (2002),<br></p>Fórmula:C8H14ClN5OS2Forma y color:White SolidPeso molecular:295.81Tert-Butyl 4-(2-morpholino-2-oxoethyl)piperazine-1-carboxylate
CAS:Pureza:98%Peso molecular:313.398010253906255-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
CAS:Fórmula:C10H10N2OPureza:95%Forma y color:SolidPeso molecular:174.203Arotinolol
CAS:Producto controlado<p>Applications Arotinolol is both and alpha- and beta-adrenoceptor antagonist and is used to treat essential tremors and hypertension.<br>References Kuroda, Y., et al.: Neurology, 38, 650 (1988); Miyagishi, A., et al.: Arch. Pharmacodyn. Ther., 271, 249 (1984); Wu, H., et al.: Hypertens. Res.: Off. J. Jpn. Soc. Hypertens., 24, 605 (2001)<br></p>Fórmula:C15H21N3O2S3Forma y color:NeatPeso molecular:371.541-Bis(4-fluorophenyl)methyl Piperazine
CAS:Producto controlado<p>Impurity Flumazenil EP Impurity A<br>Stability Hygroscopic<br>Applications 1-Bis(4-fluorophenyl)methyl Piperazine (Flumazenil EP Impurity A) is a chemical reagent used in the synthesis of novel tubulin polymerization inhibitors. Also used in the synthesis of novel benzhydrylpiperazine carboxamide derivatives. Impurity of F455200<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yin, Y. et al.: Bioorg. Med. Chem., 22, 2409 (2014); Gurdal, E. et al.: J. Enz. Inhib. Med. Chem., 29, 205 (2014);<br></p>Fórmula:C17H18F2N2Forma y color:White To Light YellowPeso molecular:288.343-Acetylthio-2-methylpropionic Acid
CAS:Producto controlado<p>Impurity Captopril EP Impurity G<br>Applications 3-Acetylthio-2-methylpropionic Acid (Captopril EP Impurity G) is a key intermediate for Captopril (C175750) and other hypertension drugs.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cushman, D., et al.: Biochem., 16, 5484 (1977), Ondetti, M., et al.: J. Med. Chem., 24, 355 (1981), Tseng, T., et al.: Cancer Lett., 62, 233 (1992),<br></p>Fórmula:C6H10O3SForma y color:NeatPeso molecular:162.21N- Hydro Ranitidine
CAS:Producto controlado<p>Impurity Ranitidine EP Impurity B<br>Applications 2-[[5-(Dimethylaminomethyl)-2-furanyl]methylthio]ethylamine (Ranitidine EP Impurity B) is an impurity of Ranitidine (R120000).<br>References Evans, M., et al.: J. Pharm. Biomed. Anal., 7, 1 (1989), Plumb, R., et al.: Analyst., 130, 844 (2005),<br></p>Fórmula:C10H18N2OSForma y color:NeatPeso molecular:214.332-Benzylacrylic Acid
CAS:Producto controlado<p>Stability Light Sensitive<br>Applications 2-Benzylacrylic Acid (cas# 5669-19-2) is a compound useful in organic synthesis.<br></p>Fórmula:C10H10O2Forma y color:NeatPeso molecular:162.195-Desbromo, 5-Chloro Brimonidine
CAS:Producto controlado<p>Impurity Brimonidine EP Impurity H<br>Applications UK 14819 is a quinoxalinyl imidazolidine α2-adrenoceptor agonist and is structurally related to Brimonidine (B677520).<br>References Thaina, P., et al.: J. Auton. Pharmacol., 19, 185 (1999)<br></p>Fórmula:C11H10ClN5Forma y color:Light Yellow To YellowPeso molecular:247.68362-Hydroxy Felbamate
CAS:<p>Applications A metabolite of the antiepileptic drug Felbamate (F231000).<br>References Yang, J.T. et al.: Drug Metab. Disp., 19, 1126 (1991); Roller, S.G. et al.: Chem. res. Toxicol., 15, 815 (2002);<br></p>Fórmula:C11H14N2O5Forma y color:NeatPeso molecular:254.24Loxapine-d8 Hydrochloride (Major)
CAS:Producto controladoFórmula:C18H10D8ClN3O·xHClForma y color:White To Off-WhitePeso molecular:372.322,6-Dichloro-4-phenyl-quinazoline
CAS:Pureza:95.0%Forma y color:SolidPeso molecular:275.13000488281252-Methyl-5-morpholin-4-ylmethyl-furan-3-carboxylic acid
CAS:Fórmula:C11H15NO4Pureza:98%Forma y color:SolidPeso molecular:225.2442-Isoniazid
CAS:Producto controlado<p>Applications An impurity of Isoniazid (I821450), which is an antibiotic for treatment of Mycobacterium tuberculosis and inhibits mycolic acid biosynthesis. Intermediate used for the synthesis of analogs of antitumor agent 1-acetyl-2-picolinoylhydrazine.<br>References Brewer, G.A., et al.: Anal. Profiles. Drug. Subs., 6, 183 (1977), Weber, W.W., et al.: Clin. Pharmacokinet., 4, 401 (1979); Rutner, H., et al.: Cancer. Chem. Rep., 58, 803 (1974)<br></p>Fórmula:C6H7N3OForma y color:WhitePeso molecular:137.14(+/-)-4-Hydroxy Mephenytoin-d3
CAS:Producto controlado<p>Applications A deuterated CYP2C19 metabolite of Mephenytoin.<br>References Karlaganis, G., et al.: Drug Metab. Dispos., 8, 173 (1980)<br></p>Fórmula:C12H11D3N2O3Forma y color:White To Off-WhitePeso molecular:237.27Ethyl 2-(2-(4-methoxyphenoxy)acetamido)-4-methyl-5-(o-tolylcarbamoyl)thiophene-3-carboxylate
CAS:Pureza:98%Peso molecular:482.54998779296875Isoniazid-d4
CAS:Producto controlado<p>Applications Labelled Isoniazid. Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. Antibacterial (tuberculostatic).<br>References Brewer, G.A., et al.: Anal. Profiles Drug Subs., 6, 183 (1977), Weber, W.W., et al.: Clin. Pharmacokinet., 4, 401 (1979)<br></p>Fórmula:C62H4H3N3OForma y color:White To Light BeigePeso molecular:141.16Dehydro Amlodipine Oxalate
CAS:Producto controladoFórmula:C20H23ClN2O5·C2H2O4Forma y color:White To Off-WhitePeso molecular:496.895-(Dimethylaminomethyl)-2-furfuryl Alcohol Hydrochloride
CAS:Producto controlado<p>Impurity Ranitidine EP Impurity F<br>Stability Hygroscopic<br>Applications 5-(Dimethylaminomethyl)-2-furfuryl Alcohol Hydrochloride (Ranitidine EP Impurity F) is an intermediate in the synthesis of Ranitidine hydrochloride (R120000).<br>References Salameh, A., et al.: J. Food Sci., 71, 10 (2006), Guerrieri, P., et al.: Pharm. Res., 24, 147 (2007),<br></p>Fórmula:C8H13NO2·ClHForma y color:BrownPeso molecular:191.66Omeprazole sulfide N-Oxide
CAS:<p>Applications 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]thio]-1H-benzimidazole N-Oxide is a metabolite of Omeprazole (O635000), an proton inhibitor used as an antiulcerative agent.<br>References Muller, P., et al.: Arzneimittel-Forsch., 33, 1685 (1983), Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984), Morii, M., et al.: J. Biol. chem., 268, 21553 (1993), Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)<br></p>Fórmula:C17H19N3O3SForma y color:Off-WhitePeso molecular:345.42Dehydro Aripiprazole
CAS:Producto controlado<p>Impurity Aripiprazole EP Impurity E; Aripiprazole USP Related Compound G<br>Applications Dehydro Aripiprazole (Aripiprazole EP Impurity E; Aripiprazole USP Related Compound G) is an impurity of Aripiprazole (A771000), a selective dopamine D2-receptor antagonist with dopamine autoreceptor agonist activity.<br>References Zeidan, T.A., et al.: Crystal. Growth. Design., 13, 2036 (2013); Nagasaka, Y., et al.: Biopharma. Drug. Dispo., 33, 304 (2012); Chen, X., et al.: J. Med. Chem., 55, 7141 (2012);<br></p>Fórmula:C23H25Cl2N3O2Forma y color:Off-WhitePeso molecular:446.37Semicarbazide Hydrochloride
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Semicarbazide Hydrochloride is a metabolite of Nitrofuran (N493840), a minor antimicrobial used in veterinary medicine affecting semicarbazide-sensitive amine oxidase (SSAO) activity (1). Semicarbazide may be found in from nitrofuran residues in honey extracts (2) as well as milk from dairy cows (3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.Environmental contaminants; Food contaminants; Heat processing contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Elliott J. et al.: J Pharm Pharmacol. 1989 Jan;41(1):37-41. 2. Tribalat L. et al.: Anal Bioanal Chem. 2006 Dec;386(7-8):2161-8. 3. Chu, P. et al.: J. Agric. Food Chem. 2007 Feb:55(6);2129-2135<br></p>Fórmula:CH5N3O·ClHForma y color:NeatPeso molecular:111.53Axitinib Iodo Tetrahydropyran
Producto controlado<p>Applications Axitinib Iodo Tetrahydropyran is an analog of Axitinib (A794650). Axitinib (A794650) is a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.<br>References Wasser, K., et al.: Eur. Radiol., 13, 80 (2003);Park, J., et al.: Clin. Cancer Res., 8, 1172 (2002); Bergers, G., et al.: J. Clin. Invest., 111, 1287 (2003);<br></p>Fórmula:C19H20IN3OForma y color:NeatPeso molecular:433.2862-(2,6-Dimethylbenzoyl)-5-(1,3-dioxolan-2-yl)thiophene
CAS:Pureza:97.0%Peso molecular:288.3599853515625
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