Derivados de Quinazolina y Quinolina
Las quinazolinas y quinolinas son compuestos heterocíclicos nitrogenados con estructuras aromáticas que desempeñan un papel clave en la síntesis de fármacos con actividad anticancerígena, antimicrobiana y antiinflamatoria. Sus derivados presentan modificaciones estructurales que optimizan su biodisponibilidad y selectividad, lo que permite el desarrollo de nuevos principios activos para diversas aplicaciones terapéuticas. Estos compuestos se utilizan en la fabricación de APIs destinados al tratamiento de cáncer, infecciones, enfermedades neurodegenerativas y cardiovasculares. Además, los derivados de quinazolina y quinolina son esenciales en la investigación de inhibidores enzimáticos y en el diseño de moléculas bioactivas innovadoras. En CymitQuimica disponemos de derivados de quinazolina y quinolina de alta pureza para aplicaciones en síntesis química, desarrollo farmacéutico y biotecnología.
Se han encontrado 65924 productos de "Derivados de Quinazolina y Quinolina"
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Isoniazid
CAS:Producto controlado<p>Applications Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. Antibacterial (tuberculostatic).<br>References Brewer, G.A., et al.: Anal. Profiles Drug Subs., 6, 183 (1977), Weber, W.W., et al.: Clin. Pharmacokinet., 4, 401 (1979)<br></p>Fórmula:C6H7N3OForma y color:NeatPeso molecular:137.14Ketoconazole-d8
CAS:Producto controlado<p>Applications Deuterated Ketoconazole, an inhibitor of cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986), Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989), Nardone, P.A., et al.: . Surg. Res., 44, 425 (1988), Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986)<br></p>Fórmula:C26H20D8Cl2N4O4Forma y color:White To BeigePeso molecular:539.48Amisulpride-d5 N-Oxide
CAS:Producto controlado<p>Applications Labelled Amisulpride N-Oxide (A633265). Amisulpride N-Oxide is an impurity of Amisulpride (A633250). Amisulpride N-Oxide was identified as a photodegradation product of Amisulpride.<br>References Moulin, A., et al.: Eur. J. Drug Metab. Pharmcokinet., 3, 507 (1991), Chatterjee, B., et al.: J. Biotechnol., 3, 235 (2008), Breier, A., et al.: J. Pharm. Biomed. Anal., 46, 250 (2008),<br></p>Fórmula:C17H22D5N3O5SForma y color:WhitePeso molecular:390.514-(3-((4-Chloro-7-methoxyquinazolin-6-yl)oxy)propyl)morpholine
CAS:Pureza:95+%Forma y color:SolidPeso molecular:337.79998779296875(S)-2-Aminobutanoic Acid Hydrochloride
CAS:Producto controlado<p>Applications (S)-2-Aminobutanoic Acid Hydrochloride is an intermediate in the synthesis of Levetiracetam (L331500), which is used as an anticonvulsant.<br>References Gower, A.J., et al.: Eur. J. Pharmacol., 222, 193 (1992); Kasteleijn-Noist Trenite, D.G.A., et al.: Epilepsy Res., 25, 225 (1996); Patsalos, P.N., et al.: Pharmacol. Ther., 85, 77 (2000)<br></p>Fórmula:C4H10ClNO2Forma y color:NeatPeso molecular:139.58L-Lysine Clonixinate
CAS:<p>Applications L-Lysine Clonixinate is a non-morphinic andalgesic.<br>References Krymchantowski, A., et al.: Curr. Ther. Res., 64, 505 (2003), Di Girolamo, G., et al.: Brit. J. Pharmacol., 141, 1234 (2004),<br></p>Fórmula:C13H11ClN2O2·C6H14N2O2Forma y color:Off WhitePeso molecular:408.884-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluorobenzamide
CAS:Fórmula:C20H14F4N4O2SForma y color:NeatPeso molecular:450.41Des(R)-3-Aminopiperidine Linagliptin
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications 7-(2-Butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dione is an impurity of Linagliptin (L465900), a novel potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor with potential use in the treatment of type 2 diabetes.<br>References Prabavathy, N. et al.: Int. J. Pharm. Bio. Sci., 2, 438 (2011); Deacon, C.F.: Diab. Obes. Metab., 13, 7 (2011);<br></p>Fórmula:C20H18N6O2Forma y color:NeatPeso molecular:374.4(3’S,3R,4S)-Desfluoro Ezetimibe
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications (3’S,3R,4S)-Desfluoro Ezetimibe is an impurity of the cholesterol absorption inhibitor Ezetimibe (E975000).<br>References Gajjar, A.K., Open. Con. Proceed. J., 2, 108 (2011);<br></p>Fórmula:C24H22FNO3Forma y color:NeatPeso molecular:391.43Topiramate-13C6
CAS:Producto controlado<p>Applications Topiramate-13C6 is the labeled compound of Topiramate (T540250). Topiramate is used as an anticonvulsant.<br>References Maryanoff, B.E., et al.: J. Med. Chem., 30, 880 (1987); Bialer, M.: Clin. Pharmacokinet., 24(6), 441-52 (1993)<br></p>Fórmula:C6C6H21NO8SForma y color:NeatPeso molecular:345.3184-[4-[(5S)-5-Phthalimidomethyl-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone
CAS:Producto controladoFórmula:C22H19N3O6Forma y color:NeatPeso molecular:421.40Trimetazidine N-Carboxylic Acid Ethyl Ester
CAS:Producto controlado<p>Impurity Trimetazidine EP impurity H<br>Applications Trimetazidine N-Carboxylic Acid Ethyl Ester is impurity of Trimetazidine (T795610). Trimetazidine impurity H.<br>References Szwed, H., et al.: Clin. Drug Invest., 19, 1 (2000), Thoppil, S., et al.: J. Pharm. Biomed. Anal., 25, 15 (2001), Wang, Z., et al.: Pharmazie, 62, 27 (2007),<br></p>Fórmula:C17H26N2O5Forma y color:NeatPeso molecular:338.403-Hydroxy Citalopram
CAS:<p>Impurity Citalopram EP Impurity B<br>Applications 3-Hydroxy Citalopram (Citalopram EP Impurity B) is a Citalopram (C505000) impurity.<br></p>Fórmula:C20H21FN2O2Forma y color:NeatPeso molecular:340.391-(8-Chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethanone
CAS:Fórmula:C20H21ClN4OForma y color:White To Off-WhitePeso molecular:368.86Norfloxacin Nicotinate
CAS:Producto controlado<p>Applications Norfloxacin nicotinate is a fluoroquinolone antibacterial agent that is a norfloxacin derivative with improved solubility in water.<br></p>Fórmula:C16H18FN3O3·C6H5NO2Forma y color:NeatPeso molecular:319.33 + (123.11)Latrepirdine dihydrochloride
CAS:Latrepirdine dihydrochloride (Dimebolin dihydrochloride) is an orally active, and neuroactive antagonist of multiple drug targets.Fórmula:C21H25N3·2HClPureza:98.45%Forma y color:SolidPeso molecular:392.376-Methoxy-2-naphthol
CAS:Producto controlado<p>Stability Light Sensitive<br>Applications 6-Methoxy-2-naphthol is a reactant in the development of sirtuin inhibitors from pyrazolone and isoxazol-5-one cambinol analogs.<br>References Mahajan, S.S., et. al.: J. Med. Chem., 57, 3283 (2014)<br></p>Fórmula:C11H10O2Forma y color:NeatPeso molecular:174.20Benzocaine
CAS:Producto controlado<p>Applications Benzocaine is used as an anesthetic (local).<br>References Kholod, Y., et al.: Environ. Sci. Technol., 43, 9208 (2009), Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Perez-Garrido, Alfonso; Helguera, A., et al.: J. Pharm. Sci., 98, 4557 (2009), Onoue, S., et al.: J. Pharm. Sci., 98, 3647 (2009),<br></p>Fórmula:C9H11NO2Forma y color:NeatPeso molecular:165.19N-Nitrosocarvedilol
CAS:Producto controladoFórmula:C24H25N3O5Forma y color:NeatPeso molecular:435.4722'-[(1H-Tetrazol-5-yl)biphenyl-4-yl]methanol
CAS:Producto controlado<p>Applications Losartan (L470500) impurity.<br>References Huskey, S., et al.: Drug Metab. Dispos., 22, 651 (1994), Herr, R., et al.: Bioorg. Med. Chem., 10, 3379 (2002),<br></p>Fórmula:C14H12N4OForma y color:NeatPeso molecular:252.27Roflumilast
CAS:<p>Applications Roflumilast is a selective phosphodiesterase 4(PDE4) inhibitor. Antiasthmatic; used in treatment of chronic obstructive pulmonary disease.<br>References Hatzelmann, A., et al.: J. Pharmacol. Exp. Ther., 297, 267 (2001); Schmidt, B.M.W., et al.: J. Allergy Clin. Immunol., 108, 530 (2001); Timmer, W., et al.: J. Clin. Pharmacol., 42, 297 (2002); Rabe, K.F., et al.: Lancet, 366, 563 (2005);<br></p>Fórmula:C17H14Cl2F2N2O3Forma y color:NeatPeso molecular:403.21Rivaroxaban Pseudodimer
CAS:<p>Applications Rivaroxaban Pseudodimer is an impurity of Rivaroxaban (R538000), a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Fórmula:C38H36Cl2N6O10S2Forma y color:NeatPeso molecular:871.766-chloro-2-(3-hydroxyphenyl)quinoline-4-carboxylic acid
CAS:Pureza:95.0%Peso molecular:299.7099914550781Lercanidipine-d3
CAS:Producto controlado<p>Applications Lercanidipine-d3 is a labeled dihydropyridine calcium channel blocker.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bianchi, G., et al.: Pharmacol. Res., 21, 193 (1989); Rimoldi, E., et al.: Acta Therap., 200, 23 (1994)<br></p>Fórmula:C36H38D3N3O6Forma y color:NeatPeso molecular:614.752-[[(3-Methyl-4-nitro-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
CAS:Producto controlado<p>Applications 2-[[(3-Methyl-4-nitro-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole is a drug impurity of Lansoprazole, which is a proton pump inhibitor and used to treat stomach and intestinal ulcers.<br>References Figgitt, D., et al.: Drugs, 60, 925 (2000); Katsuki, H., et al.: Eur. J. Clin. Pharmacol., 57, 709 (2001); Barradell, L.B., et al.: Drugs, 44, 225 (1992); Kim, K., et al.: Clin. Pharmacol. Ther., 72, 90 (2002); Niioka, T., et al.: Ther. Drug Monit., 28, 321 (2006)<br></p>Fórmula:C14H12N4O3SForma y color:NeatPeso molecular:316.34Paliperidone E-oxime
CAS:Producto controlado<p>Applications Paliperidone E-oxime is an impurity of Paliperidone (P141000), a known orally active antipsychotic agent.<br>References Rao, J., et al.: Pharmacia Lettre, 3, 240 (2011);<br></p>Fórmula:C23H28F2N4O3Forma y color:NeatPeso molecular:446.49Des-4-fluorobenzyl Mosapride
CAS:Producto controlado<p>Applications The major metabolite of Mosapride (M731000).<br>References Somogyi, A., et al.: Clin. Pharmacokinet., 8, 463 (1983), Cashman, J., et al.: Drug Metab. Dispos., 21, 587 (1993), Berkman, C., et al.: Biochem. Pharmacol., 50, 565(1995), Blake, B., et al.: Xenobiotica, 25, 377 (1995),<br></p>Fórmula:C14H20ClN3O3Forma y color:NeatPeso molecular:313.78Ranitidine N-Oxide
CAS:Producto controlado<p>Impurity Ranitidine EP Impurity E<br>Stability Very Hygroscopic<br>Applications Ranitidine N-Oxide (Ranitidine EP Impurity E) is a metabolite of Ranitidine (R120000).<br></p>Fórmula:C13H22N4O4SForma y color:BeigePeso molecular:330.40((3S,4R)-4-(4-Fluorophenyl)piperidin-3-yl)methanol
CAS:Producto controlado<p>Applications ((3s,4r)-4-(4-Fluorophenyl)Piperidin-3-Yl)Methanol (cas# 125224-43-3) is a useful research chemical.<br></p>Fórmula:C12H16FNOForma y color:Light YellowPeso molecular:209.26Chlorpromazine N-Oxide Maleic Acid Salt
CAS:Producto controlado<p>Applications Chlorpromazine N-Oxide Maleic Acid Salt is an impurity of Chlorpromazine (C424750) which has antiemetic; antipsychotic properties.<br>References Anden, N.-E., et al.: Eur. J. Pharmacol., 11, 303 (1970), Curzon, G., et al.: Trends Pharmacol. Sci., 11, 61 (1990)<br></p>Fórmula:C21H23ClN2O5SForma y color:NeatPeso molecular:450.94(3’R)-Ezetimibe
CAS:Producto controlado<p>Applications Azetidinone Ezetimibe (E975000) analog. A cholesterol absorption inhibitor.<br>References Hauser, H., et al.: Biochemistry, 37, 17843 (1998), Davis, et al.: Metabolism, 50, 1234 (2001), Berger., et al.: Therapeutics, 4, 163 (2002),<br></p>Fórmula:C24H21F2NO3Forma y color:Off-WhitePeso molecular:409.433-Picoline
CAS:Producto controlado<p>Applications A useful precursor to agrochemicals and antidotes for organophosphate poisoning.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Qiao, L., et al.: Bioorg. Med. Chem. Lett., 19, 6122 (2009), Giri, A., et al.: Food Chem., 120, 621 (2010), Farrer, N., et al.: Chem. Res. Toxicol., 23, 413 (2010),<br></p>Fórmula:C6H7NForma y color:ColourlessPeso molecular:93.13Cimetidine Sulfoxide
CAS:Producto controlado<p>Impurity Cimetidine EP Impurity E<br>Applications Cimetidine Sulfoxide (Cimetidine EP Impurity E) is a metabolite of the H2-receptor antagonist Cimetidine (C441650). Cimetidine Sulfoxide is detected in the blood and urine of patients with kidney diseases.<br>References Luksa, J. et al.: J. Chrom. B Biomed. Appl., 667, 321 (1995); Lee, R.M. et al.: J. Chrom. Biomed. Appl., 146, 354 (1978);<br></p>Fórmula:C10H16N6OSForma y color:NeatPeso molecular:268.34Danofloxacin
CAS:<p>Applications Danofloxacin is a broad spectrum fluoroquinolone antibacterial compound.<br>References Golet, E., et al.: Anal. Chem., 73, 3632 (2001); Golet, E., et al.: Environ. Sci. Technol., 36, 3645 (2002); Huet, A., et al.: J. Agric. Food Chem., 54, 2822 (2006);<br></p>Fórmula:C19H20FN3O3Forma y color:Off-WhitePeso molecular:357.38Methyl 4-Acetamido-5-bromo-2-methoxybenzoate
CAS:Producto controlado<p>Applications Methyl 4-Acetamido-5-bromo-2-methoxybenzoate is an impurity of bromopride (B686645), which is an antimetic.<br>References Fontaine, J., et al.: Arch. Int. Pharmacodyn. Ther., 213, 322 (1975), Lucker, P.W., et al.: Arzneim.-Forsch., 33, 453 (1983)<br></p>Fórmula:C11H12BrNO4Forma y color:Off-WhitePeso molecular:302.12Apixaban PG Ester-II
CAS:Producto controlado<p>Applications Apixaban PG Ester-II is one of the multiple constituents extracted from Biebersteinia multifida, that exhibits inhibitory activity on acetylcholinesterase.<br>References Xiang, F., et al.: Faming Zhuanli Shenqing (2019), CN 109432093 A 20190308.<br></p>Fórmula:C28H30N4O6Forma y color:NeatPeso molecular:518.56Sarafloxacin
CAS:<p>Applications Sarafloxacin is a quinolone antibiotic drug that was discontinued in 2001. Useful for biological studies and can be detected with colloidal gold test strips.<br>References Jia, F., et al.: Agric. Biotechnol., 8, 172 (2019)<br></p>Fórmula:C20H17F2N3O3Forma y color:Light YellowPeso molecular:385.36(R,R)-Montelukast Bis-sulfide (~90%)
CAS:<p>Impurity Montelukast EP Impurity D; Montelukast USP Related Compound C<br>Applications (R,R)-Montelukast Bis-sulfide (Montelukast EP Impurity D; Montelukast USP Related Compound C) is an impurity of Montelukast and is a part of the diastereomer mixture Montelukast Bis-Sulfide (M567985).<br></p>Fórmula:C41H46ClNO5S2Pureza:~90%Forma y color:Light YellowPeso molecular:732.39N,N-Didesmethyl Diltiazem Hydrochloride
CAS:Producto controlado<p>Applications A metabolite of Diltiazem (D460620).<br>References Sugawara, Y., et al.: J. Pharmacobio-Dynamics, 11, 211 (1988),<br></p>Fórmula:C20H23ClN2O4SForma y color:NeatPeso molecular:422.933,5-Dinitrosalicylhydrazide-15N2
CAS:Producto controlado<p>Applications Labelled Nifursol (N458700) metabolite.<br>References Shen, Y. et al.: Faming Zhuanli Shenqing 13 (2009)<br></p>Fórmula:C7H6N215N2O6Forma y color:Light YellowPeso molecular:244.13Pefloxacin Mesylate Dihydrate
CAS:Producto controlado<p>Applications Pefloxacin Mesylate Dihydrate is an analog of norfloxacin that inhibits topoisomerase.<br></p>Fórmula:C17H20FN3O3·CH4O3S·2H2OForma y color:Light YellowPeso molecular:465.49Dehydronitrendipine
CAS:Producto controlado<p>Applications Dehydronitrendipine is a derivative of Nitrendipine (N490150), a dihydropyridine calcium channel blocker. Nitrendipine is used in the treatment of primary (essential) hypertension to decrease blood pressure. Antihypertensive.<br>References Ventura, H.O., et al.: Am. J. Cardiol., 51, 783 (1983); Kann, J. et al.: Brit. J. Clin. Pharmacol., 33, 51 (1992);<br></p>Fórmula:C18H18N2O6Forma y color:NeatPeso molecular:358.35Nadolol-d9
CAS:Producto controlado<p>Applications Labelled Nadolol (N201052). β-Adrenergic blocker. Antihypertensive; antianginal.<br>References Dreyfuss, J., et al.: J. Clin. Pharmacol., 17, 300 (1977), Sibley, P.L., et al.: Toxicol. Appl. Pharmacol., 44, 379 (1978), Slusarek, L., et al.: Anal. Profiles Drug Subs., 9, 455 (1980),<br></p>Fórmula:C17H18D9NO4Forma y color:NeatPeso molecular:318.46
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