Esteroides y derivados
Los esteroides son compuestos orgánicos que poseen una estructura de cuatro anillos fusionados, conocida como el núcleo esteroídico. Este núcleo puede unirse a varios grupos funcionales que modifican sus propiedades y funciones biológicas. Los esteroides tienen un papel clave en la regulación de procesos metabólicos y hormonales. Se utilizan en medicina para tratar trastornos inflamatorios, autoinmunes y desequilibrios hormonales. Además, algunos derivados esteroides tienen propiedades antiinflamatorias potentes, como los corticosteroides. En terapias específicas, se usan para reducir la inflamación y controlar el dolor en diversas enfermedades.
En CymitQuimica contamos con una variedad de esteroides y sus derivados para investigación y desarrollo farmacéutico.
Se han encontrado 4962 productos de "Esteroides y derivados"
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Calcipotriol Monohydrate
CAS:Producto controlado<p>Applications Calcipotriol Monohydrate is a synthetic derivative of calcitriol, which is a biologically active form of Vitamin D3 (1). Calcipotriol Monohydrate can be used to treat psoriasis (2).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References (1) Kim, D. H., et al.: Ann Dermatol. 24, 341 (2012) (2) Queille-Roussel, C., et al.: Clin Drug Investig (2016)<br></p>Fórmula:C27H40O3·H2OForma y color:NeatPeso molecular:430.62Estriol Methyl Ether
CAS:<p>Impurity Estriol EP Impurity C<br>Applications Estriol Methyl Ether (Estriol EP Impurity C) is a metabolite (1,2) of Estriol (E888960), which is a produced naturally and also a metabolite of Estradiol (E888000). Estriol is a GPR3 antagonist in estrogen receptor-negative breast cancer cells displaying anti-proliferative effects (3).<br>References 1. Marrian, G. et al.: Biochem. J. 1929;23(5):1090-8.2. Rogerson, B. et al.: Arch. Biochem. Biophys. 1986 Oct;250(1):70-85.3. Lappano, R. et al.: Mol Cell Endocrinol. 2010 May 14;320(1-2):162-70.<br></p>Fórmula:C19H26O3Forma y color:NeatPeso molecular:302.41Betamethasone 17-Propionate-d5
CAS:Producto controladoFórmula:C25H28D5FO6Forma y color:NeatPeso molecular:453.5621-Deoxy Cortisone
CAS:Producto controlado<p>Applications A Cortisone derivative, a glucocorticoid.<br>References Mickelson, K., et al.: Biochemistry, 20, 6211 (1981), Westphal, U., et al.: J. Steroid Biochem., 19, 1 (1983),<br></p>Fórmula:C21H28O4Forma y color:NeatPeso molecular:344.44Desonide 21-Acetate
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Desonide 21-Acetate is a reactant in the synthesis of 7α-halogenocorticosteroids with anti-inflammatory activity.<br>References De, K., et. al.: J. Indian Chem. Soc., 79, 513 (2002)<br></p>Fórmula:C26H34O7Forma y color:NeatPeso molecular:458.54trans-Latanoprost
CAS:<p>Impurity Latanoprost USP Related Compound A<br>Stability Temperature Sensitive<br>Applications Prostaglandin analog; prodrug of active acid metabolite. It is a synthetic derivative of the natural prostaglandin PGF2α, used as an anti-glaucoma agent that is effective in various types of glaucoma and ocular hypertension. Latanoprost USP Related Compound A.<br>References Resul, B., et al.: J. Med. Chem., 36, 2242 (1993), Toris, C., et al.: Ophthalmology, 100, 1297 (1993), Holmstrom, S., et al.: Curr. Med. Res. Op., 21, 1875 (2005),<br></p>Fórmula:C26H40O5Forma y color:ColourlessPeso molecular:432.5921-Dehydrocorticosterone (mixture of the aldehyde and the hydrated form)
CAS:Fórmula:C21H28O4Forma y color:NeatPeso molecular:344.445,6-trans Travoprost
CAS:<p>Applications An 5,6-trans isomeric impurity of the selective FP prostaglandin receptor agonist Travoprost (T715600).<br></p>Fórmula:C26H35F3O6Forma y color:NeatPeso molecular:500.555-ANDROSTEN-3,17-DIONE
CAS:Producto controlado<p>Applications 5-Androsten-3,17-dione has been used in the synthetic preparation of androstenediones for treatment of hormone-related disorders.<br>References Davies, H., et al.: U.S. (2011), WO 2011127232 A2<br></p>Fórmula:C19H26O2Pureza:>90%Forma y color:NeatPeso molecular:286.4116a-Butyloxyprednisolone(Budenoside Impurity)
CAS:Producto controlado<p>Impurity Budesonide EP Impurity I<br>Applications 16α-Butyloxyprednisolone (Budesonide EP Impurity I) is an impurity of Budesonide (B689460), a non-halogenated glucocorticoid intended for the local treatment of lung disease.<br>References Ryrfeldt, Å., et al.: Eur. J. Respir. Dis., 122, 86 (1981); Vestbo, J., et al.: Lancet, 353, 1819 (1999)<br></p>Fórmula:C25H34O7Forma y color:NeatPeso molecular:446.53(17α)-13-Ethyl-3-methoxy-18,19-dinorpregna-3,5-dien-20-yn-17-ol
CAS:Producto controlado<p>Applications Norgestrel (N689500) impurity.<br>References Gorog, S., et al.: J. Chromatogr., 400 177 (1987),<br></p>Fórmula:C22H30O2Forma y color:NeatPeso molecular:326.477,7’-Nonane-1,9-diylbis[estra-1,3,5(10)-triene-3,17β-diol](Mixture of Diastereomers)
Producto controlado<p>Applications Fulvestrant (F862500) impurity D.<br></p>Fórmula:C45H64O4Forma y color:NeatPeso molecular:668.9917β-Estradiol-d3 17-Acetate 3-β-D-Glucuronide
Producto controlado<p>Applications A labelled Estradiol (E888000) derivative.<br></p>Fórmula:C26H31D3O9Forma y color:NeatPeso molecular:493.56(20S)-Dexamethasone Epimeric Glycolic Acid
CAS:Fórmula:C22H29FO6Forma y color:NeatPeso molecular:408.4621-Dehydro Budesonide
CAS:Producto controlado<p>Impurity Budesonide EP Impurity D<br>Stability Hygroscopic<br>Applications 21-Dehydro Budesonide (Budesonide EP Impurity D) is a Budesonide (B689490) impurity.<br>References Backes, S., et al.: Drug Metab. Rev., 34, 157 (2002), Vermeer, H., et al.: Clin. Endocrinol., 59, 49 (2003), Assi, K., et al.: J. Pharm. Biomed. Anal., 41, 325 (2006),<br></p>Fórmula:C25H32O6Forma y color:NeatPeso molecular:428.523-Keto Fluvastatin Sodium Salt
CAS:Producto controlado<p>Stability Light Sensitive<br>Applications An impurity of Fluvastatin.<br></p>Fórmula:C24H23FNO4·NaForma y color:NeatPeso molecular:431.43Betamethasone-∆17,20 21-Aldehyde(Mixture of Isomers)
CAS:Producto controlado<p>Applications A degradation and metabolic intermediate of Betamethasone (B3270000).<br></p>Fórmula:C22H27FO4Forma y color:NeatPeso molecular:374.45Fulvestrant
CAS:Producto controladoFórmula:C32H47F5O3SForma y color:White To Off-WhitePeso molecular:606.77Pregna-4,9(11)-diene-3,20-dione (90%)
CAS:Producto controlado<p>Applications Pregna-4,9(11)-diene-3,20-dione is a Progesterone (P755900) impurity, a steroid hormone produced by the corpus luteum. Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.<br>References Thomas, P. et al.: Endocrinol., 148, 705 (2007); Anderson, E., et al.: Breast Cancer Res., 4, 197 (2002), Lanari, C., et al.: Breast Cancer Res., 4, 240 (2002), Albrecht, E.D., et al.: Front. Biosci., 8, 416 (2003), Qiu, M., et al.: J. Steroid Biochem. Mol. Biol., 85, 147 (2003),<br></p>Fórmula:C21H28O2Pureza:90%Forma y color:NeatPeso molecular:312.45Digoxigenin Bisdigitoxoside
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications A metabolite of Digoxin (Dx) (D446575).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fujii, Y., et al.: Clin. Chem., 37, 476 (1991), Salphati, L., et al.: Xenobiotica, 29, 171 (1999), Song, S., et al.: Drug Metab. Dispos., 27, 689 (1999),<br></p>Fórmula:C35H54O11Forma y color:NeatPeso molecular:650.8017α-Hydroxy Pregnenolone-d3
CAS:Producto controlado<p>Applications A labelled metabolite of Pregnenolone (P712200).<br>References Kramer, R., et al.: J. Steroid Biochemi., 18, 715 (1983), Hiwatashi, A., et al.: J. Biochem., 98, 619 (1985), Eiichi, T., et al.: J. Pharmacol. Sci., 95, 140 (2004),<br></p>Fórmula:C212H3H29O3Forma y color:NeatPeso molecular:335.50Betamethasone 21-Acetate 17-Propionate
CAS:<p>Impurity Betamethasone Dipropionate EP Impurity D<br>Applications Betamethasone 21-acetate-17-propionate (Betamethasone Dipropionate EP Impurity D) is a related compound of Betamethasone dipropionate (B327005).<br>References Grootveld, M., et al.: Biochem. Pharmacol., 37, 271 (1988), Chen, B., et al.: Steriods, 74, 30 (2009), Mikami, E., et al.: J. Pharm. Biomed. Anal., 28, 261 (2002),<br></p>Fórmula:C27H35FO7Forma y color:NeatPeso molecular:490.56117,21-Dihydroxy-16a-methylpregna-1,4,9(11)-triene-3,20-dione 21-Acetate
CAS:Producto controlado<p>Applications 17,21-Dihydroxy-16α-methylpregna-1,4,9(11)-triene-3,20-dione 21-Acetate is an intermediate in the synthesis of Mometasone Furoate (M490000), a tropical corticosteroid used as an anti-inflammatory agent.<br>References Spangler, M., et al.: Chromatograph., 54, 329 (2001); Reeves, E.K., et al.: Bioorg. Med. Chem., 21, 2241 (2013);<br></p>Fórmula:C24H30O5Forma y color:White To Light YellowPeso molecular:398.49Testosterone-2,2,4,6,6-d5
CAS:Producto controladoFórmula:C192H5H23O2Forma y color:White To Off-WhitePeso molecular:293.463-O-Methyl Estradiol
CAS:Producto controlado<p>Applications Estradiol derivative which shows antioxidant activity.<br>References Fotsis, T., et al.: J. Steroid. Biochem., 28, 215 (1987), Sack, M., et al.: Lancet, 343, 269 (1994), Brunelli, R., et al.: Biochemistry, 39, 13897 (2000), Li, A., et al.: Nat. Med., 8, 1235 (2002),<br></p>Fórmula:C19H26O2Forma y color:White To Light YellowPeso molecular:286.41Ospemifene
CAS:Producto controlado<p>Applications Ospemifene is used to treat dyspareunia. It is a selective estrogen receptor modulator (SERM) acting similarly to an estrogen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rutanen, E., et al.: Menopause, 10, 433 (2003);<br></p>Fórmula:C24H23ClO2Forma y color:White To Off-WhitePeso molecular:378.89δ-5(6)-Norethindrone Acetate
CAS:Producto controlado<p>Impurity Norethindrone Acetate EP Impurity C<br>Applications Δ-5(6)-Norethindrone Acetate (Norethindrone Acetate EP Impurity C) is an impurity of Norethindrone Acetate (N675990).<br></p>Fórmula:C22H28O3Forma y color:NeatPeso molecular:340.46Dexamethasone 21-Mesylate
CAS:Producto controlado<p>Stability Moisture Sensitive<br>Applications Dexamethasone 21-Mesylate is a derivative of Dexamethasone (D298800), a glucocorticoid used as an anti-inflammatory agent.<br>References Kim, T.H., et al.: J. Nanosci. Nanotech., 13, 7325 (2013); Joshi, T., et al.: Brit. J. Pharmacol., 172, 1360 (2015);<br></p>Fórmula:C23H31FO7SForma y color:NeatPeso molecular:470.552-Methyl-N-[3-(trifluoromethyl)phenyl]propanamide
CAS:Producto controladoFórmula:C11H12F3NOForma y color:NeatPeso molecular:231.21Pregna-4,14-diene-3,20-dione
CAS:Producto controlado<p>Impurity Progesterone EP Impurity A<br>Applications Pregna-4,14-diene-3,20-dione (Progesterone EP Impurity A) is a Progesterone derivative<br>References Wilks, J., et al.: Steroids, 35, 697 (1980), Templeton, J., et al.: J. Med. Chem., 30, 1502 (1987), Blackmore, P., et al.: Mol. Pharmacol., 49, 727 (1996),<br></p>Fórmula:C21H28O2Forma y color:NeatPeso molecular:312.45Testosterone Undecanoate-d3
CAS:Producto controlado<p>Applications A Labelled metabolite of Testosterone (T155000). It is a promising androgen for male hormonal contraception.CONTROLLED SUBSTANCE<br>References Glass, A., et al.: J. Clin. Endocrinol. Metab., 45, 1211 (1977), Behre, H., et al.: Eur. J. Endocrinol., 140, 414 (1999), Nieschlag, E., et al.: Steroids, 68, 965 (2003), Wang, C., et al.: J. Clin. Endocrinol. Metab., 91, 460 (2006),<br></p>Fórmula:C30H45D3O3Forma y color:NeatPeso molecular:459.729,11-Didehydrooestriol
CAS:Producto controlado<p>Impurity Estriol EP Impurity A<br>Stability Hygroscopic<br>Applications 9,11-Didehydrooestriol (Estriol EP Impurity A) is an impurity of Estriol (E888960), a metabolite of Estradiol (E888000). An estrogenic metabolite considerably less potent than the hormone Estradiol (E888000).<br>References Marrian, et al.: Biochem. J., 23,1090 (1929), Huffman, et al.: J. Biol. Chem., 169, 167 (1947),<br></p>Fórmula:C18H22O3Forma y color:Off-WhitePeso molecular:286.3719-Hydroxy Cholesterol
CAS:<p>Applications A metabolite of Cholesterol. Cholesterol oxidation product having cytotoxicity effects.<br>References Higley, N., et al.: Food Chem. Toxicol., 22, 983 (1984), Emanuel, H., et al.: J. Food Sci., 56, 843 (1991), Kilsdonk, E., et al.: J. Lipid Res., 36, 505 (1995), Cantwell, H., et al.: Cell Biol. Toxicol., 14, 401 (1998),<br></p>Fórmula:C27H46O2Forma y color:NeatPeso molecular:402.65cis-Diethyl Stilbestrol
CAS:<p>Stability Isomerizes rapidly in Benzene, Chloroform, and Ether.Keep Shielded from light.<br>Applications A synthetic, nonsteroidal estrogen.Recomended solvents are DMSO, DMF and ethanol, even in these solvents do not store in solution for any prolonged period of time.<br>References White, W. A. et. al.: J. Agric. Food Chem. 19(2), 388-390 (1971).<br></p>Fórmula:C18H20O2Forma y color:NeatPeso molecular:268.35Digitoxin
CAS:<p>Stability Hygroscopic<br>Applications Cardiotonic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Foerster, et al.: Arch. Int. Pharmacodyn. Ther., 159, 1 (1966), Jakovljevic, I.M., Anal. Profiles Drug Subs., 3, 149 (1974)<br></p>Fórmula:C41H64O13Forma y color:White To Off-WhitePeso molecular:764.9420(α)-Dihydro Pregnenolone
CAS:<p>Applications 20α-Dihydro Pregnenolone is a metabolite of Pregnenolone (P712200).<br>References Purdy, R., et al.: J. Med. Chem., 33, 1572 (1990), Bixo, M., et al.: Brain Res., 764, 173 (1997), Huang, X., et al.: J. Biol. Chem., 275, 29452 (2000),<br></p>Fórmula:C21H34O2Forma y color:NeatPeso molecular:318.4917β-Hydroxyprogesterone
CAS:Producto controladoFórmula:C21H30O3Forma y color:NeatPeso molecular:330.46Hydroxy Flutamide-d6
CAS:Producto controladoFórmula:C11H5D6F3N2O4Forma y color:Light Yellow SolidPeso molecular:298.254-Hydroxy Atorvastatin-d5 Hemicalcium Salt
CAS:Producto controlado<p>Applications di(4-Hydroxy Atorvastatin-d5) Calcium Salt is a labeled metabolite of Atorvastatin Calcium Salt (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.<br>References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993); Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996); Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000)<br></p>Fórmula:C66H58D10CaF2N4O12Forma y color:Beige SolidPeso molecular:1197.4β-Methyl Digoxin
CAS:<p>Applications Cardiotonic. Obtained by the O-methylation of Digoxin.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hunter, J., et al.: J. Biol. Chem., 268, 14991 (1993), Greiner, B., et al.: J. Clin. Invest., 104, 147 (1999), Jun, A., et al.: J. Pharm.Pharm. Sci., 4, 263 (2001), Sugiyama, D., et al.: Drug Metab. Dispos., 30, 220 (2002),<br></p>Fórmula:C42H66O14Forma y color:NeatPeso molecular:794.97Dexamethasone Acid Ethyl Ester
CAS:<p>Applications Dexamethasone Acid Ethyl Ester is a derivative of Dexamethasone (D298800), a glucocorticoid used as an anti-inflammatory agent. Dexamethasone regulates T cell survival, growth, and differentiation. Dexamethasone inhibits the induction of nitric oxide synthase.<br>References Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995), Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999), Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999)<br></p>Fórmula:C23H31FO5Forma y color:Off-WhitePeso molecular:406.49(24R)-Calcipotriene
CAS:Producto controlado<p>Impurity Calcipotriol EP Impurity D<br>Applications (24R)-Calcipotriene (Calcipotriol EP Impurity D) is a synthetic analogs of vitamin D that was studied for its potential antitumor effects. Studies has shown the combined treatment with vitamin D analog (24R)-Calcipotriene was more effective than the treatment with cytostatics applied alone. (24R)-Calcipotriene is also the 24-R epimer of Calcipotriene (C144200).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wietrzyk, J., et al.: Anticancer. Res., 27, 3387 (2007); Tien, X.Y., et al.: Am. J. Physiol., 265, 143 (1993); Wietrzyk, J., et al.: Anti-Cancer. Drugs., 18, 447 (2007);<br></p>Fórmula:C27H40O3Forma y color:NeatPeso molecular:412.60517β-Estradiol-d3 3-β-D-Glucuronide
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications A labelled metabolite of Estradiol (E888000).<br>References Agasan, A., et al.: J. Immunol. Methods., 177, 251 (1994), Stone, R., et al.: Science, 265, 308 (1994), Tacey, R., et al.: J. Pharm. Biomed. Anal., 2, 1303 (1994),<br></p>Fórmula:C24H29D3O8Forma y color:NeatPeso molecular:451.526α-Methyl-9α-fluoro-11β,17α-dihydroxyprogesterone
CAS:Producto controlado<p>Applications 6α-Methyl-9α-fluoro-11β,17α-dihydroxyprogesterone is an impurity of Fluorometholone (F593145), a glucocorticoid; anti-inflammatory.<br>References Kupferman, A., et al.: Arch. Ophthlmol., 640, 100 (1982), Tokunaga H., et al.: Chem. Pharm. Bull., 32, 4012 (1984),<br></p>Fórmula:C22H31FO4Forma y color:NeatPeso molecular:378.4817α-Estradiol-16,16,17-d3
CAS:Producto controlado<p>Applications Labelled Estradiol. Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-Εstradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer’s disease and ischemic stroke.<br>References Salole, E.G., Anal. Profiles Drug Subs., 15, 283 (1986), Lievertz, R.W., et al.: Am. J. Obstret. Gynecol., 156, 1289 (1987), Kuhnz, W., et al.: Arzneim.-Forsch., 43, 966 (1993),<br></p>Fórmula:C18H21D3O2Forma y color:NeatPeso molecular:275.42,3-Dichloro-5,6-dicyanobenzoquinone
CAS:<p>Applications An oxidizing agent, especially in steroid synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Fórmula:C8Cl2N2O2Forma y color:NeatPeso molecular:227.0Bexarotene
CAS:Producto controlado<p>Applications Bexarotene is a selective retinoid X receptor (RXR) agonist and an antineoplastic agent (1,2,3).<br>References (1) Boehm, M.F., et al.: J. Med. Che., 37,2930 (1994) (2) Gottardis, M.M., et al.: Cancer Res., 56, 5566 (1996) (3) Mukherjee, R., et al.: Nature, 386, 407 (1997)<br></p>Fórmula:C24H28O2Forma y color:NeatPeso molecular:348.48
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