Sales y derivados de API
Las sales de los Ingredientes Farmacéuticos Activos (API) son compuestos formados por la reacción de un ácido con una base, resultando en un equilibrio iónico. Estas sales suelen mejorar la solubilidad y estabilidad de los APIs, facilitando su absorción en el cuerpo. Los derivados de API son variantes químicas de un principio activo que pueden tener propiedades mejoradas o modificadas para optimizar su eficacia terapéutica. Las sales de APIs se utilizan en la formulación de medicamentos orales, inyectables y tópicos. Además, los derivados de APIs pueden mejorar la farmacocinética de los fármacos, como la liberación controlada de activos.
En CymitQuimica contamos con sales y derivados de APIs con la pureza y calidad necesarias para investigación y desarrollo de formulaciones farmacéuticas.
Se han encontrado 79382 productos de "Sales y derivados de API"
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Dechloro-Rivaroxaban
CAS:Producto controlado<p>Applications Dechloro-Rivaroxaban is an impurity of Rivaroxaban (R538000), which is a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Fórmula:C19H19N3O5SForma y color:NeatPeso molecular:401.44Edoxaban 4-Carboxylic Acid Hydrochloride
CAS:Producto controladoFórmula:C22H25ClN6O5S·xHClForma y color:NeatPeso molecular:520.99 + x(36.46)4a-Hydroxy Ivermectin
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications 4a-Hydroxy Ivermectin is an impurity of Ivermectin (I940800), an antiparasitic drug that is active against a wide variety of nematode and arthropod parasites and is used to treat scabies and lice in humans. An invitro inhibitor of SARS-CoV-2/ Covid-19.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Campbell, W., et al.: Science, 221, 823 (1983); Glaziou, P., et al.: Trop. Med. Parasitol., 45, 253 (1994); Meinking, T., et al.: New Engl. J. Med., 333, 26 (1995); Caly, L., et al.: Antivir. Res., 178<br></p>Fórmula:C48H74O15Forma y color:NeatPeso molecular:891.09(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane Hydrochloride
CAS:Producto controladoFórmula:C12H17NO2·ClHForma y color:NeatPeso molecular:243.73Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
CAS:<p>Applications Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate is an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.<br>References Vallu, V., et. al.: Anal. Chem. Indian J., 14, 339 (2014); Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)<br></p>Fórmula:C18H20N2O3SForma y color:NeatPeso molecular:344.432-(9H-Carbazol-1-yl)acetic Acid
CAS:Producto controladoFórmula:C14H11NO2Forma y color:NeatPeso molecular:225.243(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate
CAS:<p>Applications (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine is an intermediate in the preparation of orally active reversible P2Y12 receptor antagonists such as Ticagrelor (T437700)for the prevention of thrombosis.<br>References Springthorpe, B. et al.: Bioorg. Med. Chem. Lett., 17, 6013 (2007);<br></p>Fórmula:C9H9F2N·C8H8O3Forma y color:NeatPeso molecular:321.32Diclofenac Isopropyl Ester
CAS:<p>Impurity Diclofenac Isopropyl Ester Impurity<br>Applications Diclofenac Isopropyl Ester can be synthesized as one of the five esters of diclofenac with different alcohols as pro-drugs and can be evaluated for anti-inflammatory activity by carrageenan induced rat hand paw method.<br>References Suryawanshi, S. B., et al.: Chem Sci Trans, 3, 562 (2014);<br></p>Fórmula:C17H17Cl2NO2Forma y color:NeatPeso molecular:338.23(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol
CAS:<p>Stability Hygroscopic<br>Applications (3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol was used to preapare AZD6140 as an orally active reversible P2Y12 receptor antagonist for prevention of thrombosis.<br>References Zhang, H., et al.: Bioorg. Med. Chem. Lett., 22, 3598 (2012);<br></p>Fórmula:C8H15NO3Forma y color:NeatPeso molecular:173.214-Hydroxythiobenzamide
CAS:<p>Applications 4-Hydroxythiobenzamide is used in the synthesis of PPARα agonists used in increasing HDLc levels. Also used in the synthesis of potent CDK5 inhibitors in the treatment of Alzheimer’s disease.<br>References Sierra, M. et al.: J. Med. Chem., 50, 685 (2007); Zhong, W. et al.: Bioorg. Med. Chem. Lett., 17, 5384 (2007);<br></p>Fórmula:C7H7NOSForma y color:NeatPeso molecular:153.2Methylamine Hydrochloride
CAS:Producto controlado<p>Applications Methanamine Hydrochloride is used in the synthesis of betaine-homocysteine S-methyltransferase. Also used in the synthesis of novel oxazinones as polymerase inhibitors.<br>References Picha, J. et al.: Eur. J. Med. Chem., 65, 256 (2013); Gangloff, A. et al.: Bioorg. Med. Chem. Lett., 23, 4501 (2013);<br></p>Fórmula:CH5N·HClForma y color:White To Off-WhitePeso molecular:67.518
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