Ácidos Grasos y Derivados Lipídicos

<p>N-Formyl-D-leucine (1R)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester is a research and development impurity standard that can be custom synthesized for drug product development. It is an analytical standard for HPLC with high purity, pharmacopoeia, and drug development. It is a natural metabolite that has been studied as a niche metabolite in metabolism studies.</p>

<p>N-Formyl-L-leucine (1R)-1-[[(2R,3R)-3-Hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester is an impurity standard for HPLC. It is a synthetic compound that has been custom synthesized to meet the requirements of a pharmacopoeia. This product is offered in a high purity and can be used for drug development and research and development.</p>

<p>Please enquire for more information about Defluoro pitavastatin including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Atorvastatin is a synthetic drug product. It is a prodrug that is converted to its active form, atorvastatin acid, in the body. Atorvastatin is used for lowering blood cholesterol levels in people with hypercholesterolemia and reducing the risk of coronary heart disease. This drug has been shown to reduce the number of deaths from coronary heart disease by 30% after five years of use. Atorvastatin also reduces the risk of stroke and fatal or non-fatal heart attack by 20%.</p>

<p>(S)-3''-Hydroxy pravastatin sodium salt is a drug product that is custom synthesized. It is the sodium salt of (S)-3''-hydroxypravastatin, which has been shown to be a natural product with high purity. The metabolite of (S)-3''-hydroxypravastatin sodium salt is 3'-hydroxypravastatin. This product can be used for analytical purposes as well as in pharmacopoeia, drug development, and research and development. It can also be used as an impurity standard for HPLC and GC analysis.</p>

<p>N-Formyl-D-leucine (1R)-1-[[(2R,3R)-3-Hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester is a synthetic metabolite that is used as an impurity standard for the analysis of N-formylmetabolites in drugs. It is also used to study the metabolism of drugs. This product has been assigned CAS number 104872-27-7 and appears on the USP high purity&gt; list.</p>

<p>Simvastatin 4'-methyl ether is a metabolite of simvastatin. It is an impurity in the drug product and can be used as an analytical standard for HPLC. It is not a drug product or a pharmaceutical ingredient, but it can serve as an impurity standard for pharmacopoeia.</p>

<p>Simvastatin hydroxy acid methyl ester is a drug product that belongs to the group of statins. It is an impurity standard for synthetic simvastatin as well as a natural metabolite formed from simvastatin through oxidation and hydroxylation. This impurity is used in analytical and pharmacopoeia testing for simvastatin, and has been shown to inhibit the production of cholesterol by blocking the synthesis of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR).</p>

<p>(2E,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-Dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-2,6-dimethyl-1-naphthalenyl]-5-hydroxy-2-heptenoic acid sodium salt is a synthetic drug product. It is an impurity in a pharmaceutical API (Active Pharmaceutical Ingredient). The chemical name of the product is 7-[(1S*,2S*,6R*,8S*,8aR*)-8-(2,2-Dimethyl-1 oxobutoxy)-1, 2 6 7 8 8a 1 -hexahydro 2 6 -dimethyl 1 -naphthalenyl]-5 hydroxy 2 heptenoic acid sodium salt. It has the following CAS Number: 39</p>

<p>Lovastatin is a cholesterol-lowering drug that acts by inhibiting the enzyme HMG-CoA reductase. It is also used to prevent organ rejection after a liver transplant, and has been shown to have anti-aging effects. Lovastatin has been shown to reduce serum cholesterol levels, which may be due to its ability to inhibit cellular proliferation in rat hepatocytes. This drug has been shown to have an effect on DNA damage and post-translational modification of proteins, as well as on health care foods. Lovastatin is a member of the statins family of drugs, which are all natural products isolated from fungi or bacteria. The active form of lovastatin is made in the laboratory by chemical synthesis, using recombinant DNA technology. The recombinant gene encoding lovastatin was cloned into an expression vector and expressed in Escherichia coli cells (E.M.).</p>

<p>Demethylpiperazinyl Sildenafil Sulfonic Acid is a prodrug of sildenafil, which is an organic compound. It is used in the treatment of erectile dysfunction and pulmonary arterial hypertension. This drug is metabolized by hydrolysis to form sildenafil citrate, which then acts as an inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5). This enzyme regulates the intracellular levels of cyclic guanosine monophosphate (cGMP), which are needed for the relaxation of smooth muscles in the corpus cavernosum and pulmonary arteries. Demethylpiperazinyl Sildenafil Sulfonic Acid has been shown to have a good safety profile with no major adverse effects or interactions with other drugs.</p>

<p>2''-Desethyl- 2''- vinyl Simvastatin is a high purity, custom synthesis, impurity standard that is available for sale. The CAS number for this product is 1449248-72-9. This product can be used as a research and development product or as an analytical standard. It has an Impurity Standardization (IS) of 10% at a concentration of 10 mg/mL. This product has been classified by the USP and the European Pharmacopoeia (EP). The excipient in this product is acetonitrile, which is classified as natural.</p>

<p>The Z-isomer impurity of pitavastatin is a synthetic compound that has been used as an analytical standard and pharmacopoeia reference. The Z-isomer impurity is not found in nature, but is generated by the hydrogenation of the natural product. It has been shown to be metabolized by CYP3A4 and CYP2C9 enzymes, which are the primary enzymes responsible for drug metabolism. This impurity does not have any therapeutic effect on the body, but can be used as a research and development standard for HPLC.</p>

<p>5-Oxo Rosuvastatin is a drug product that has been synthesized from natural ingredients. It is an analytical standard for the impurity, 5-oxo-rosuvastatin, which is a potential impurity in the API, rosuvastatin. This drug product has been custom synthesized in order to provide an Impurity Standard for HPLC. This drug product is also used as a Synthetic Reference Standard for Drug Development and Research and Development.</p>

<p>Atorvastatin is a potent inhibitor of the enzyme HMG-CoA reductase, which is responsible for the conversion of HMG-CoA to mevalonate. This inhibition reduces the production of cholesterol and other lipids in the liver. Metabolism studies have shown that atorvastatin undergoes extensive presystemic metabolism by cytochrome P450 enzymes, primarily CYP3A4 and CYP2C9. The drug is converted to inactive metabolites that are eliminated primarily through renal excretion. Atorvastatin has not been found to inhibit any of the following: cytochrome P450 1A1/2, 2C8/9, 2D6, 2E1, 3A4/5 or glucuronidases.</p>

<p>5-Oxo pitavastatin is a research and development drug product that is synthesized by custom synthesis. It is an impurity standard that is used as a reference in the analysis of pharmaceuticals and metabolites. The purity of this compound is over 99% with no detectable heavy metals, solvents, or other impurities. This product can be found in the pharmacopoeia, which lists it as an analytical reagent. 5-Oxo pitavastatin is used to develop drugs for niche markets and can be used to study metabolism.</p>

<p>Please enquire for more information about Rosuvastatin EP Impurity C sodium including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>(3S,5R)-Atorvastatin calcium is an analytical standard for the drug atorvastatin. It has a purity of 99.9% and is manufactured in accordance with the requirements of the pharmacopoeia. The product is available as a white crystalline powder and is soluble in water, acetone, and ethanol. (3S,5R)-Atorvastatin calcium has been used in drug development and as an impurity standard for HPLC analysis. It also serves as a metabolite to characterize the production process of atorvastatin.</p>

<p>(S)-3-Hexyl-5,6-dihydro-6-undecyl-2H-pyran-2-one is a natural metabolite that is used for the analytical standardization of HPLC. It is also used in research and development for drug development and as an impurity in pharmaceuticals. This compound has a purity of 99% and a CAS number of 130676-64-1. (S)-3-Hexyl-5,6-dihydro-6-undecyl-2H-pyran-2one is synthesized from 2,4,5,7 tetrahydrobenzofuran.</p>

<p>Des(2-methylbutyryl) pravastatin is a synthetic allylic alcohol that is synthesized from the natural product, pravastatin. It has been shown to have carboxylic acid and carboxylic functional groups as well as two hydrogens on the allylic side of the molecule. In addition, des(2-methylbutyryl) pravastatin has two allylic alcohols with two hydrogens on the allylic side of the molecule. The synthesis of this compound is done by reacting 2-methylbutanoic acid with an allyl bromide in a reaction catalyzed by sodium methoxide. This reaction produces a mixture of products that includes des(2-methylbutyryl)pravastatin.</p>

<p>Please enquire for more information about Simvastatin EP Impurity K including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Oxo Simvastatin is a synthetic drug product that belongs to the class of statins. It is used as a research and development impurity standard in pharmacopoeia, and as a high-purity analytical standard in niche applications. Oxo Simvastatin is metabolized by cytochrome P450 enzymes to form a variety of metabolites, including simvastatin acid, which can be measured using HPLC.</p>

<p>(3R,5R)-Pitavastatin Calcium Salt is a drug product that is used in the development of pharmaceuticals. It is a synthetic compound with an impurity standard and a metabolite impurity. The CAS number for this product is 254452-96-5. (3R,5R)-Pitavastatin Calcium Salt has been shown to be metabolized by CYP2C9 and CYP2C8 enzymes, which may result in a decrease in potency or activity. This product also has been shown to have anti-inflammatory properties and inhibit the production of inflammatory mediators such as prostaglandins and leukotrienes. (3R,5R)-Pitavastatin Calcium Salt was prepared by solid phase synthesis using a fluorous biphasic approach.</p>

<p>iso-Gemfibrozil is a natural, synthetic drug product. It is an impurity standard for the pharmacopoeia and analytical standards for HPLC. iso-Gemfibrozil is metabolized in the liver to its active form, gemfibrozil. Impurities are not detected by HPLC and can be found in low levels in the API impurity standard. It has been used as a research and development candidate in clinical studies on atherosclerosis, hyperlipidemia, and diabetes mellitus.</p>

<p>(3R,5S,6E)-7-[1-ethyl-3-(4-fluorophenyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid sodium salt is an impurity standard for the drug product. It is a synthetic metabolite that binds to proteins and has been found in human urine. The chemical synthesis of (3R,5S,6E)-7-[1-ethyl-3-(4-fluorophenyl)-1H-indol-2-yl]-3,5-dihydroxy-6 heptenoic acid sodium salt was performed using a high purity custom synthesis and high purity pharmacopoeia grade reagents.</p>

<p>Atorvastatin N-(3,5-dihydroxy-7-heptanoic acid)amide calcium salt is a synthetic drug product that belongs to the class of statins. It has been used in research and development as a standard for HPLC analysis. The metabolite atorvastatin 3,5-dihydroxy-7-heptanoic acid (CAS No. 1105067-87-5) is also available from Sigma Aldrich. The impurity standards atorvastatin calcium salt and amorphous calcium sulfate are also available from Sigma Aldrich. Atorvastatin N-(3,5-dihydroxy-7-heptanoic acid)amide calcium salt is an API impurity in the synthesis of atorvastatin sodium (CAS No. 120781-93-1).</p>

<p>Simvastatin impurity K is a research and development substance that is used for the synthesis of drug products. This compound is custom synthesized, and its CAS number is 607-33-0. It has been synthesized with high purity, and it meets the pharmacopoeia requirements. Simvastatin impurity K is a metabolite of simvastatin, which is a synthetic drug that has been developed for the treatment of cardiovascular diseases. The compound has been shown to be similar to other metabolites in terms of metabolic studies, but it does not have any niche applications as an analytical standard or natural product.</p>

<p>Carboprost (15(S)-15-Methyl Prostaglandin F2α) is a synthetic prostaglandin analogue of PGF2α which has the effect of oxytocic.</p>

<p>Prasugrel Maleic acid: oral P2Y12 antagonist, thienopyridine prodrug, inhibits ADP-induced platelet aggregation.</p>

<p>Mevalonic acid is essential for cell growth and proliferation,Mevalonic acid is a precursor in the mevalonate pathway.</p>

<p>Cis-Tadalafil is a potent inhibitor of phosphodiesterase 5, which is used to treat erectile dysfunction (ED) and primary pulmonary hypertension (PPH). It works by increasing blood flow to the penis, allowing men with ED to achieve and maintain an erection. Cis-Tadalafil is also used to treat symptoms of prostatic hyperplasia (enlarged prostate) in men. This drug has been shown to be effective in treating PPH by reducing pulmonary arterial pressure and improving exercise capacity. Cis-Tadalafil belongs to the carboline class of drugs and is a phosphodiesterase 5 inhibitor that selectively inhibits cGMP-specific phosphodiesterase type 5 (PDE5). This drug has been shown to be highly effective in treating both ED and PPH with minimal side effects.</p>

<p>(3S,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor (IC50: 11 nM).</p>

<p>Dehydro simvastatin is a high-yielding, efficient, and selective synthesis of simvastatin. It is prepared from the commercially available (2S)-2-[(1E,3R)-3-hydroxybut-1-enyl]oxirane using a three-component reaction with chlorotrimethylsilane and sodium chloride to yield the desired product in good yields. The reaction can be performed in a variety of solvents including dichloromethane, chloroform, tetrahydrofuran, or methanol. Dehydro simvastatin has been used for pharmaceutical formulations as an active ingredient of HMG CoA reductase inhibitors. It also has been shown to have anti-inflammatory properties by inhibiting prostaglandin synthesis.</p>

<p>Atorvastatin is a drug product with an impurity of atorvastatin cyclic sodium salt (isopropyl). The synthesis of this compound can be found in the natural and synthetic routes. Impurity standard is used to identify impurities in drugs and is necessary for pharmacopoeia, research and development, and analytical work. This compound has been shown to have high purity, analytical, metabolism studies, natural, drug development, and pharmacopoeia. CAS No. 1316291-19-6 is the impurity standard for this compound.</p>

<p>Desfluoro ezetimibe is a synthetic cholesterol-lowering drug that inhibits intestinal cholesterol absorption. It is chemically synthesized, and the process includes the introduction of fluorine at the 3-position of the C-ring. Desfluoro ezetimibe is not metabolized in humans, but it may be subject to oxidative degradation. The product is also subject to oxidation by light and air, which may result in formation of impurities. The drug substance has been validated as well as its isomers and efficiencies in mass spectrometry detection.</p>

<p>Simvastatin acid is the active form of simvastatin, a drug used to lower blood cholesterol levels. Simvastatin acid inhibits HMG-CoA reductase, the enzyme that converts HMG-CoA to mevalonate. This conversion is a rate-limiting step in the synthesis of cholesterol and other lipids. Simvastatin acid binds to polymerase chain and drug transporter proteins, which leads to cell lysis. The concentration–time curve for simvastatin acid is linear and the half-life is approximately 12 hours. When simvastatin acid is administered with drugs that are potent inducers of CYP3A4 or UGT1A1 enzymes, there may be an increased risk for drug interactions. Simvastatin acid has shown no significant human pharmacokinetic interactions with food or grapefruit juice at doses up to 200 mg/day. There are limited data on the pharmacokinetics of simvastatin</p>

<p>Simvastatin is a statin that reduces cholesterol synthesis by inhibiting the enzyme HMG-CoA reductase. Simvastatin is an amide, which is a derivative of the drug substance with a chloride group. It is commonly used in pharmaceutical formulations as an impurity in the synthesis of simvastatin. The presence of this impurity can be detected using chromatographic techniques, such as liquid chromatography and gas chromatography.</p>

<p>Vildagliptin related compound F (VRCF) is a drug product that has been custom synthesized. VRCF is a high purity, analytical standard. It is metabolized in the body and can be used as a research and development standard to study the metabolism of vildagliptin. VRCF is a natural metabolite that has been identified as an impurity in the drug product Vildagliptin. VRCF has not been recognized by the USP or EP for use as an impurity standard. CAS no: 1789703-36-1</p>

<p>A potent modulator of cell proliferation and differentiation.</p>

<p>Please enquire for more information about Rosuvastatin EP impurity M calcium including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Atorvastatin tert-butyl ester is an acid that is used to treat high cholesterol. It is a synthetic statin that inhibits the enzyme HMG-CoA reductase and blocks the production of cholesterol in the liver. This drug is administered orally, as a tablet or capsule, or in liquid form as a suspension. The drug has a bitter taste and evaporation may occur if it comes into contact with skin or clothes. Atorvastatin tert-butyl ester may be found in polymorphic forms (including dihydropyridine, dihydrospirocyclopentane, and dihydrobenzoquinoline). These forms are inactive, but can be activated by exposure to light or heat. These reactions produce an acidic compound that can react with other compounds to form new compounds.</p>

<p>Please enquire for more information about Rosuvastatin impurity E calcium including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>L-161982 is a selective EP4 receptor antagonist that inhibits PGE2-induced ERK phosphorylation and cell proliferation in HCA-7 cells.Cost-effective and quality-assured.</p>

<p>Atorvastatin lactam phenanthrene calcium salt impurity is a high purity, custom synthesis drug product. It is a metabolite of atorvastatin and was identified using metabolism studies in rat and human liver microsomes. This impurity has been shown to be an analytical standard for HPLC. Atorvastatin lactam phenanthrene calcium salt impurity is used in niche research and development, as well as the development of drugs that are pharmacopoeia grade.</p>

<p>Please enquire for more information about Vildagliptin carboxylic acid methyl ester including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Vildagliptin Related Compound 2 is a synthetic compound that has been shown to be an inhibitor of DPP-4. It is a white solid that can be synthesized by condensation of vildagliptin with chloroacetyl chloride in the presence of an alkali. The compound was found to have impurities, including 1-(2-chlorophenyl)ethanol and 3-chlorobenzaldehyde.</p>

<p>Pitavastatin N-oxide is a drug product that is an analytical standard and natural API impurity. It is used in the synthesis of other drugs, such as pitavastatin, which is a statin drug used to lower cholesterol levels. Pitavastatin N-oxide has been shown to be a potent inhibitor of HMG-CoA reductase, the enzyme that catalyzes the conversion of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) to mevalonate. This inhibits cholesterol production and lowers levels of low density lipoprotein (LDL) cholesterol in the blood.</p>

<p>Orlistat is a lipase inhibitor that is used as a weight-loss drug. It works by inhibiting the absorption of dietary fats and their subsequent conversion into triglycerides in the intestines, thereby limiting the calories absorbed. Orlistat has been shown to be effective in lymphatic and fatty acid transport, but oral bioavailability is low due to extensive first-pass metabolism. Orlistat inhibits pancreatic lipase, which may lead to reduced intestinal fat absorption and decreased systemic exposure. This drug also inhibits long-chain fatty acids from being absorbed through the intestinal wall and prevents them from being metabolized, thereby reducing lipid formulations in the blood.</p>

<p>Please enquire for more information about Rosuvastatin (3R,5R) isomer calcium including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Ezetimibe ketone is a lipid-lowering agent that inhibits cholesterol absorption through the inhibition of Niemann-Pick C1-like 1 (NPC1L1). Ezetimibe ketone is used to reduce the levels of low-density lipoprotein cholesterol (LDL-C) in patients with primary hypercholesterolemia, sitosterolemia, and familial combined hyperlipidemia. Ezetimibe ketone has been shown to be bioequivalent to ezetimibe, which is an oral drug that inhibits cholesterol absorption by blocking NPC1L1. The drug binds to the NPC1L1 receptor in the brush border membrane of enterocytes and prevents cholesterol uptake. Ezetimibe ketone has a high solubility in organic solvents such as dichloromethane or chloroform. It also has a high melting point, which makes it suitable for use on chromatographic columns.</p>

<p>BAY 73-1449 is a selective and potent antagonist of the prostacyclin receptor(IC50&lt;0.1 nM).</p>

<p>(3R,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor (IC50: 11 nM).</p>

<p>Zopolrestat (CP 73850) is a potent inhibitor of aldose reductase (IC50 = 3.1 nM).</p>

<p>AMG 837 calcium hydrate is a potent GPR40 agonist with an EC50 of 13 nM.</p>

<p>Atorvastatin is a drug that belongs to the class of statins. It is used for the treatment of high cholesterol levels and other related diseases, such as cardiovascular disease. Atorvastatin calcium trihydrate EP Impurity G is an impurity that may be present in atorvastatin calcium trihydrate. This compound has not been found to have any pharmacological activity.</p>

<p>Iloprost (Ciloprost) is an inhibitor of platelet aggregation and vasodilatation used in the study of cardiovascular disease.</p>

<p>7-(4-Fluorophenyl)hexahydro-b,7-dihydroxy-1b-(1-methylethyl)-7a-phenyl-1a-[(phenylamino)carbonyl]-3H-oxireno[3,4]pyrrolo[2,1-b][1,3] oxazine-3-butanoic acid is a synthetic drug product with a purity of &gt;98%. It is an impurity standard for HPLC methods. This compound has been studied extensively in metabolism studies and pharmacological assays. 7-(4-Fluorophenyl)hexahydro-b,7-dihydroxy-1b-(1-methylethyl)-7a -phenyl 1a-[(phenylamino)carbonyl]-3H -oxireno[3,4]pyrrolo[2,1 -</p>

<p>Diagnostic or lab reagents on a backing, prepared diagnostic or lab reagents whether or not on a backing, whether or not in the form of kits, nesoi</p>

<p>Formic acid (methanoic acid)</p>

<p>Lactams, nesoi</p>

<p>Lactams, nesoi</p>

<p>Sulfonamides, nesoi</p>

<p>Lactones nesoi</p>

<p>Lactams, nesoi</p>