Péptidos

Bz-Ala-OMe is a reactive mercuric chloride that undergoes hydrolysis to form reactive mercuric acetate. It has been shown that the activation energy of the reaction is high and the reaction can be initiated by soybean trypsin. The reactive site of Bz-Ala-OMe is composed of chloride atoms and sephadex g-100. This compound reacts with serine proteases, such as trypsin or chymotrypsin, to form an amide intermediate. This intermediate reacts with n-acetyl-l-tyrosine to produce a chloromethyl ketone which then undergoes a nucleophilic attack by histidine to produce histamine in the presence of H2O2 or O2. Histamine binds to H1 receptors in the body, leading to an inflammatory response.

DBCO-dPEG®12-Carboxyfluorescein is a PEG compound containing a fluorescein dye used for tagging biomolecules, and serving as fluorescent probe for bioimaging applications.

Boc-Leu-Ser-Thr-Arg-pNA acetate hydrate is a substrate for enteropeptidase. It has an acid sequence of Gly-Phe-Lys and an amino acid sequence of Arg-Pro-Gly. Enteropeptidase cleaves the peptide bond between the N and C termini of the peptides with Lys or Arg at the P1 position.

This Haptoglobin Light Tryptic Peptide Standard has the potential for use in proteomics studies and in the identification and quantitation of proteins. Haptoglobin is involved in the removal of free hemoglobin and also in neutralizing oxidative damage.

HIST1H2AG, H2AFP, HIST1H2AI, H2AFC, HIST1H2AK, H2AFD, HIST1H2AL, and H2AFN are histone proteins that are components of the nucleosome. They are involved in regulating gene expression. Histones can be analyzed by a proteomics technique known as TrypTides to identify modifications to the protein's amino acid sequence. The Proteomics Tools Kit provides a number of tools for performing peptide enrichment and analysis of proteins extracted from cells or tissues. In this kit is an MS Calibrator-2 (25nmol) which is used to calibrate mass spectrometers with different capabilities.

Schizophrenia Related Peptide is a research tool that can be used to study ion channels and receptors. It is an artificial peptide that has the same amino acid sequence as the part of the human brain that is believed to be responsible for schizophrenia. The Schizophrenia Related Peptide can bind to cell membranes and inhibit protein interactions, which may lead to new pharmacological treatments for schizophrenia.

Neuromedin U Precursor-Related Peptide 33 (Rat, Mouse) is a research tool that can be used to study the effects of neuromedin U on the activation of receptors. This peptide is a ligand for the receptor and has been shown to inhibit ion channels. Neuromedin U Precursor-Related Peptide 33 (Rat, Mouse) may also be used as an antibody or in protein interactions studies. This product is made from high purity materials and can be used in pharmacology and life science experiments.

A Cholesterol Ester Transfer Protein (CETP) heavy tryptic peptide standard responsible for use in protein identification and quantitation studies. CETP is an enzyme which moves cholesterol esters from high density lipoproteins (HDL) to apolioprotein B-containing particles. This action lowers the amount of HDL which may increase the risk of the disease atherosclerosis.

ANP (Rat, 3-28) is a peptide that is a potent inhibitor of protein interactions. This peptide binds to the ligand-binding domain of the receptor and blocks the binding of the ligand. ANP (Rat, 3-28) also has high purity and can be used as a research tool or an antibody in life science studies.

The IL-3R is a cytokine receptor that binds to the interleukin 3 (IL-3) molecule. The protein has a molecular weight of approximately 40 kDa and consists of two extracellular immunoglobulin-like domains, a transmembrane domain, and an intracellular tyrosine kinase domain. The IL-3R is expressed on hematopoietic stem cells, progenitor cells, erythrocytes, mast cells, neutrophils, lymphocytes and macrophages.

Hydroxy-dPEG®8-t-Butyl Ester is a PEG polymer categorised as monofunctional (OH-PEG-X). Used as a linker, hydroxy-dPEG®8-t-Butyl Ester is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.

Please enquire for more information about H-2kb tetramer peptide - Q7 including the price, delivery time and more detailed product information at the technical inquiry form on this page

m-dPEG®12-Amine is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®12-Amine is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

CRF is a human antibody that is used as a research tool. It has reactivity with cells that are activated by CRF, and binds to the receptor on these cells. CRF is also known as a ligand, which can bind to the receptor and trigger changes in the cell, such as ion channels or protein interactions. CRF is an activator of G-protein coupled receptors.

Alamandine is a complex heterocyclic molecule. It has been shown to activate ion channels and ligand-gated ion channels, such as nicotinic acetylcholine receptors and serotonin receptors. Alamandine also has an inhibitory effect on the release of neurotransmitters. Alamandine has been observed to bind to a number of proteins that are involved in signal transduction pathways, including protein kinases and transcription factors.

Delta Sleep-Inducing Peptide (DSIP) is a neuropeptide that induces delta sleep in mammals. Studies have shown that DSIP plasma concentrations and the human circadian rhythm are correlated and that DSIP concentrations are dependent on the initiation of sleep. Interestingly DSIP has the ability to cross the blood-brain barrier and can be absorbed from the gut.  This neuropeptide is found in plasma, peripheral organs and neurons and its functions extend beyond inducing sleep. For example it has the ability to affect levels of hormones, neurotransmitters and psychological performance. It has also been found that schizophrenia and depression patients have lower concentrations of DSIP in their cerebrospinal fluid and plasma. Clinically DFSIP has already been used to treat opioid and alcohol withdrawal in reducing symptoms felt by patients.

EGF is a protein that belongs to the epidermal growth factor family. It has been shown to be an activator of the receptor tyrosine kinase, and binds to the extracellular domain of the receptor with high affinity. EGF is a ligand for the epidermal growth factor receptor (EGFR), and it has been shown that there are many other receptors that can bind to EGF, including insulin-like growth factor 1 receptor (IGF1R), insulin-like growth factor 2 receptor (IGF2R), platelet-derived growth factor A receptor alpha chain (PDGFRα), c-met proto-oncogene, fibroblast growth factor receptor 3 (FGFR3), and nerve growth factor receptor (NGFR). EGF also activates ion channels such as TRPC6 and TRPV4, which are involved in cell proliferation and differentiation.

This product is a Substance P antagonist in the Hydrochloride salt from and as a 0.5mg vial. Substance P is a neuropeptide that acts as a neurotransmitter and neuromodulator. It is best known for its role in nociception or pain perception. Substance P is also involved in other biological processes such as the regulation of gastrointestinal motility and the inflammatory response. As a tachykinin neuropeptide, substance P acts through binding to its specific neurokinin 1 receptor (NK-1R). NK-1R is present in neurons and on glial cell types. Substance P is also involved in: increased inflammation in the lungs, gastrointestinal tract and the skin and neuroinflammation. Interestingly the levels of Substance P are raised in inflammatory bowel diseases and through its involvement in cytokine release, it contributes to asthma pathology. These diverse selection of functions makes substance P a target for therapeutic research.

Monobiotin is a pharmacological substance that has been used as an activator of protein kinase C (PKC) and for the inhibition of ion channels. It is also responsible for the phosphorylation of proteins such as glycogen synthase kinase-3β, which are involved in cell proliferation and differentiation. Monobiotin can be used as a research tool to study PKC activation and ion channel inhibition.

MAL-dPEG®4-Glu(TFP Ester)-NH-dPEG®4-Glu(TFP Ester)-NH-m-dPEG®24 is a peptide containing polyethylene glycol (PEG) as spacer to alter their pharmacokinetic properties and pharmodynamics.

Dendrotoxin I is a synthetic black mamba snake toxin sourced from the block mamba, Dendroaspis polylepis polylepis and is a voltage-dependent K+ channel blocker. This product has disulfide bonds between Cys7-Cys57, Cys16-Cys40, and Cys32-Cys53 and is available as a 0.1mg vial.

DNP-Pro-Leu-Gly is a synthetic substrate of carboxypeptidase A. It is a peptide that has been shown to have potential as an anti-ulcer agent in animal studies. DNP-Pro-Leu-Gly is able to activate the enzyme carboxypeptidase A by binding to its active site and mimicking the natural substrate, tryptophan. The peptide has also been shown to inhibit collagen degradation in vitro, which may be due to its ability to bind collagen and inhibit the activity of collagenase enzymes.

A synthetic peptide for use as a blocking control in assays to test for specificity of PCDHA10 antibody, catalog no. 70R-6166

A synthetic peptide for use as a blocking control in assays to test for specificity of ZNF791 antibody, catalog no. 70R-8149

Amyloid β-Protein (Human, 1-38) is a peptide that is a major constituent of the amyloid plaques found in the brains of people with Alzheimer's disease. It has been shown to inhibit ion channels and ligand-activated ion channels. The receptor for this protein is unknown, but it may be involved in cell signaling or neurotransmitter release. Amyloid β-Protein (Human, 1-38) can be used as a research tool to study proteins and their interactions with other proteins, as well as to study how these interactions affect the function of cells. It can also be used to study how antibody molecules bind to specific proteins and how these antibodies interact with other molecules.