Moduladores de enzimas
Los moduladores enzimáticos son compuestos que pueden aumentar o inhibir la actividad de las enzimas, regulando así la velocidad de las reacciones bioquímicas. Estos moduladores juegan un papel crítico en el control de las vías metabólicas, la señalización celular y diversos procesos fisiológicos. Los moduladores enzimáticos se utilizan ampliamente en la investigación y el desarrollo de fármacos para estudiar las funciones enzimáticas y desarrollar agentes terapéuticos. En CymitQuimica, ofrecemos una gama completa de moduladores enzimáticos de alta calidad para apoyar su investigación en la regulación enzimática y el descubrimiento de fármacos.
Subcategorías de "Moduladores de enzimas"
Se han encontrado 693 productos de "Moduladores de enzimas"
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Lumiracoxib - Bio-X ™
CAS:Producto controladoLumiracoxib is a COX-2 selective non-steroidal anti-inflammatory drug that is used for the treatment of osteoarthritis. This drug inhibits prostaglandin synthesis via inhibition of COX-2.Fórmula:C15H13ClFNO2Pureza:Min. 95%Forma y color:PowderPeso molecular:293.72 g/molDovitinib base
CAS:Receptor tyrosine kinase inhibitor; anti-angiogenesis; anti-oncogenesisFórmula:C21H21FN6OPureza:Min. 98 Area-%Forma y color:PowderPeso molecular:392.43 g/molAfatinib - Bio-X ™
CAS:Afatinib is a small molecule that inhibits the activity of cellular kinases that are involved in the progression of cancer. It is an Irreversible inhibitor of three members of the ErbB family. This molecule binds covalently to cysteine 797 residue in HER2 and blocks downstream cellular signalling which inhibits cellular growth and promotes apoptosis. It has been researched for the treatment of non-small cell lung cancer (NSCLC), breast cancer, pancreatic cancer and colorectal cancer.Fórmula:C24H25ClFN5O3Pureza:Min. 95%Forma y color:PowderPeso molecular:485.94 g/molCamostat mesylate - Bio-X ™
CAS:Camostat is a serine protease inhibitor that is used for the treatment of chronic pancreatitis. This drug has shown to reduce inflammation and pain. Studies have shown that Camostat has also inhibited the entry of SARS-CoV-2 in lung cells by inhibiting the priming process of S-protein, necessary for the viral entry into host cells.Fórmula:C20H22N4O5•CH4O3SPureza:Min. 95%Forma y color:PowderPeso molecular:494.52 g/molLOXO-305
CAS:LOXO-305 is a small molecule inhibitor, which is a synthesized chemical compound designed to selectively target specific enzymes or pathways. Its source is rooted in medicinal chemistry and pharmacological research aimed at elucidating pathways involved in oncogenesis.
Fórmula:C22H21F4N5O3Pureza:Min. 95%Forma y color:PowderPeso molecular:479.43 g/molBIO
CAS:Specific inhibitor of glycogen synthase kinase 3 (GSK-3) with IC50 in low nanomolar range. Studies showed that BIO maintains self-renewal in embryonic stem cells (ESCs) as well as increases activity of β-catenin. In neonatal cardiomyocytes, BIO promotes cell cycle by stimulating cell entry into S phase as well as cytokinesis. In germline stem cells from female mice (FGSCs), BIO promoted proliferation and maintenance of FGSCs by activating β-catenin and up-regulating E-cadherin.Fórmula:C16H10BrN3O2Pureza:Min. 95%Forma y color:Red To Dark Red SolidPeso molecular:356.17 g/molAnastrozole - Bio-X ™
CAS:Producto controladoAnastrozole is a non-steroidal drug that belongs to the class of aromatase inhibitors. It inhibits the production of estrogen by blocking the conversion of androgens to estrogens in peripheral tissues. The drug has been shown to be effective in treating breast cancer in postmenopausal women. In vitro assays have shown that Anastrozole can inhibit tumor growth as well as induce apoptosis in human serum cells, which suggests that it may be effective against a variety of cancers.
Fórmula:C17H19N5Pureza:Min. 95%Forma y color:PowderPeso molecular:293.37 g/molBrivanib alaninate
CAS:VEGFR2 a tyrosine kinase receptor inhibitor; antineoplasticFórmula:C22H24FN5O4Pureza:Min. 95%Forma y color:PowderPeso molecular:441.18123Ulixertinib
CAS:Inhibitor of ERK1 and ERK2 kinasesFórmula:C21H22Cl2N4O2Pureza:Min. 95%Forma y color:White PowderPeso molecular:433.33 g/molGefitinib hydrochloride
CAS:RIPK2 protein kinase inhibitor; EGFR inhibitorFórmula:C22H24ClFN4O3·HClPureza:Min. 95%Forma y color:PowderPeso molecular:483.36 g/molCrenolanib
CAS:Inhibits type III tyrosine kinases (PDGFRα, PDGFRβ, FLT3)Fórmula:C26H29N5O2Pureza:Min. 95%Forma y color:White To Yellow SolidPeso molecular:443.54 g/molBMS 754807
CAS:A reversible inhibitor of IGF-1R kinase and insulin receptor. Has anti-growth effects in mesenchymal, epithelial and hematopoietic tumor types. Synergistic with other cytotoxic, hormonal and targeted anti-cancer therapy.
Fórmula:C23H24FN9OPureza:Min. 95%Forma y color:PowderPeso molecular:461.49 g/molAceclofenac - Bio-X ™
CAS:Acecelofenac is a non-steroidal anti-inflammatory drug that is used in the treatment of osteoarthritis, arthritis, and ankylosing spondylitis. This drug is also a cyclooxygenase inhibitor and works by inhibiting this enzyme so that pain and inflammation is reduced.Fórmula:C16H13Cl2NO4Pureza:Min. 95%Forma y color:PowderPeso molecular:354.18 g/molIrsogladine maleate - Bio-X ™
CAS:Irsogladine is a gastroprotective drug that is used for the treatment of GERD and gastric ulcers. This drug also has antioxidant properties. Irsogladine is a phosphodiesterase-4 inhibitor and increases levels of cAMP. It helps to prevent and heal damage to the stomach lining.Fórmula:C13H11Cl2N5O4Pureza:Min. 95%Forma y color:PowderPeso molecular:372.16 g/molMGCD 265
CAS:Inhibits MET, VEGFR1-3, Tie and Ron tyrosine kinases; antineoplasticFórmula:C26H20FN5O2S2Pureza:Min. 95%Peso molecular:517.60 g/molThioglycosyl Naphthalimide
CAS:Thioglycosyl Naphthalimide is a highly potent human O-GlcNAcase (hOGA) inhibitor with good selectivity against human β-N-acetylhexosaminidase B (HsHexB).Fórmula:C30H40N4O7SPureza:Min. 95%Peso molecular:600.73 g/mol(-)-Huperzine A
CAS:Acetylcholinesterase inhibitor; therapy for Alzheimer's diseaseFórmula:C15H18N2OPureza:(%) Min. 98%Forma y color:PowderPeso molecular:242.32 g/molLY 411575
CAS:Potent inhibitor of γ-secretase. LY 411575 inhibited production of amyloid β (Aβ) peptides with IC50 of 0.078 nM in vitro as well as decreased levels of Aβ40 and Aβ42 amyloids in brain of a mouse model for Alzheimer’s disease. In vitro studies confirmed that LY 411575 inhibited cleavage of Notch receptor at S3 site with IC50 of 0.39 nM, which blocked Notch activation and downstream signalling, leading to apoptosis in primary and immortalized Kaposi's sarcoma cells.Fórmula:C26H23F2N3O4Pureza:Min. 95%Forma y color:SolidPeso molecular:479.48 g/molMRK 560
CAS:γ-secretase inhibitor; reduces amyloid-β in brainÂ
Fórmula:C19H17ClF5NO4S2Pureza:Min. 95%Peso molecular:517.92 g/molGNE 6776
CAS:Specific inhibitor of the ubiquitin specific protease-7 (USP7), which is a validated deubiquitinase of the E3 ubiquitin-protein ligase MDM2. The compound inhibits the USP7 deubiquitinase activity by binding to acidic amino acid residues important for the interaction with ubiquitin. Induces tumor cell death and enhances cytotoxicity of chemotherapeutic agents.Fórmula:C20H20N4O2Pureza:Min. 95%Peso molecular:348.4 g/molIdelalisib
CAS:Idelalisib is a pharmaceutical drug that functions as a PI3Kδ inhibitor, developed through synthetic chemical processes. Its mode of action involves selectively targeting and inhibiting phosphatidylinositol 3-kinase delta (PI3Kδ), a lipid kinase that plays a crucial role in the signaling pathways responsible for cell proliferation, survival, and differentiation. By inhibiting this enzyme, Idelalisib effectively impedes pathways that are often hyperactivated in certain hematologic malignancies, thereby exerting antitumor effects.Fórmula:C22H18FN7OPureza:Min. 95%Forma y color:PowderPeso molecular:415.42 g/molSRT1720 hydrochloride
CAS:SIRT1 activatorFórmula:C25H23N7OS·xHClPureza:Min. 98 Area-%Forma y color:PowderPeso molecular:469.56 g/molAG 221
CAS:Inhibitor of isocitrate dehydrogenase 2Fórmula:C19H17F6N7OPureza:Min. 95%Forma y color:PowderPeso molecular:473.38 g/molDCC 2036
CAS:Inhibits multiple tyrosine kinases (Abl1, Src family kinases, Tie-2 and VEGFR-2)Fórmula:C30H28FN7O3Pureza:Min. 95%Forma y color:PowderPeso molecular:553.59 g/molPeiminine
CAS:Inhibitor of TGF-α, CTGF, ERK1/2, NF-κB and FasL; anti-inflammatoryFórmula:C27H43NO3Pureza:Min. 98 Area-%Peso molecular:429.64 g/molSGC AAK1 1
CAS:Dual inhibitor of the adaptor protein 2-associated kinase 1 (AAK1) and BMP2-inducible kinase (BMP2K) with IC50 values of 270 nM and 1 μM, respectively. In a recent study, SGC AAK1 1 stabilised β-catenin, inhibited phosphorylation of the AP2 complex subunit mu protein (AP2M1) and activated Wnt signalling in in vitro experiments._x000D_Fórmula:C21H25N5O3SPureza:Min. 95%Forma y color:SolidPeso molecular:427.52 g/molEbselen
CAS:Ebselen is a non-toxic organoselenium compound with antioxidant, anti-inflammatory and cytoprotective properties. Ebselen is an inhibitor of lipoxygenases, nitric oxide (NO) synthases, protein kinase C, H+/K+-ATPase, thioredoxin reductase and NADPH oxidase. Recently, ebselen has been identified by several studies as a covalent inhibitor of the main protease Mpro from coronaviruses. For the SARS-CoV-2 main protease Mpro, the IC50 value is 0.67 μM and EC50 is 4.57 μM.Fórmula:C13H9NOSePureza:Min. 98 Area-%Forma y color:PowderPeso molecular:274.18 g/molNilotinib HCl monohydrate - Bio-X ™
CAS:Nilotinib is a kinase inhibitor that is used for the treatment of Chronic Myeloid Leukemia (CML). This drug is also used for the treatment of CML that is resistant to imatinib. Nilotinib inhibits the tyrosine kinase activity of the BCR-ABL protein. It also inhibits PDGFR and c-kit.
Fórmula:C28H22F3N7O•HCl•H2OPureza:Min. 95%Forma y color:PowderPeso molecular:583.99 g/molLY 2886721
CAS:Inhibitor of BACE1 proteaseFórmula:C18H16F2N4O2SPureza:Min. 98 Area-%Forma y color:PowderPeso molecular:390.41 g/molZileuton- Bio-X ™
CAS:Zileuton is an inhibitor of the 5-lipoxygenase enzyme, thus preventing the leukotrienes LTE4, LDT4, LTB4 and LTC4 from being formed. This in turn reduces inflammation, bronchoconstriction and mucus secretion in the airways. As a result, Zileuton can be used in the treatment and management of asthma and allergic rhinitis. Studies have shown that Zileuton has the potential to reverse dementia-related brain damage.Fórmula:C11H12N2O2SPureza:(%) Min. 95%Forma y color:PowderPeso molecular:236.29 g/molMalotilate - Bio-X ™
CAS:Malotilate is a pharmacological agent that is used to treat symptoms of hepatitis, bowel disease, and collagen diseases. This drug reduces collagen synthesis and cell migration activity of fibroblasts in vitro. It also has been shown to facilitate liver regeneration in rats.Fórmula:C12H16O4S2Pureza:(%) Min. 95%Forma y color:PowderPeso molecular:288.39 g/molKenpaullone
CAS:Inhibitor of glycogen synthase 3 (GSK-3) and cyclin-dependent kinases CDK1, CDK2 and CDK5. Kenpaullone can substitute transcription factor Klf4 in reprogramming of fibroblast to induced pluripotent stem cells when using the method of ectopic expression of transcriptional factors. In an in vitro model for Alzheimer’s disease, kenpaullone decreased production of amyloid beta peptides Aβ40 and Aβ42.
Fórmula:C16H11BrN2OPureza:Min. 95%Forma y color:Yellow To Dark Yellow SolidPeso molecular:326.00548GSK 2606414
CAS:Inhibitor of EIF2AK3/PERK kinasesFórmula:C24H20F3N5OPureza:Min. 95%Forma y color:PowderPeso molecular:451.44 g/mol(S)-Mephenytoin - Bio-X ™
CAS:(S)-Mephenytoin is a substrate of cytochrome P450 enzyme CYP2C19 (a hydroxylase). It is an effective anticonvulsant that improves control of seizures in patients. According to studies, the drug exhibits a genetic polymorphism in CYP2C19 that results in reduced metabolism in some individuals.Fórmula:C12H14N2O2Pureza:Min. 97 Area-%Forma y color:White PowderPeso molecular:218.25 g/mol3-(4-Phenylbutyl)-4-propyloxetan-2-one
CAS:Cis/trans-form of GK 563 [2351820-19-2]Fórmula:C16H22O2Pureza:Min. 95%Forma y color:SolidPeso molecular:246.34 g/molEtodolac - Bio-X ™
CAS:Etodolac is a non-steroidal anti-inflammatory drug (NSAID) used to treat osteoarthritis and rheumatoid arthritis. It is also used to treat acute pain. This drug works by inhibiting prostaglandin synthesis from the inhibition of the enzyme cyclooxygenase.Fórmula:C17H21NO3Pureza:Min. 95%Forma y color:PowderPeso molecular:287.35 g/molDMAT
CAS:Inhibitor of protein kinase CK2
Fórmula:C9H7Br4N3Pureza:Min. 95%Forma y color:White PowderPeso molecular:476.79 g/mol6-Thioguanine - Bio-X ™
CAS:6-Thioguanine is a purine analog used in the therapy for leukemia and for remission consolidation in patients with acute nonlymphocytic anemia. This drug also has antimetabolite action. It replaces guanine during DNA replication. This substitution disrupts the accurate pairing of DNA bases, leading to errors in DNA replication and hinders cell division.Fórmula:C5H5N5SPureza:Min. 95%Forma y color:PowderPeso molecular:167.19 g/molML 210
CAS:Inhibitor of glutathione peroxidase GPX4Fórmula:C22H20Cl2N4O4Pureza:Min. 95%Forma y color:SolidPeso molecular:475.32 g/molTriptolide
CAS:Inhibits RNAPII-mediated trasncription; immunosuppressant; anti-inflammatoryFórmula:C20H24O6Pureza:Min. 97 Area-%Forma y color:PowderPeso molecular:360.4 g/molBRD 6989
CAS:A small molecule inhibitor with high selectivity for CDK8 over CDK19. Increases IL-10 production in stimulated human and murine macrophages and dendritic cells. Modulatory action on inflammatory responses has therapeutic potential.Fórmula:C16H16N4Pureza:Min. 95%Forma y color:SolidPeso molecular:264.33 g/molA 769662
CAS:Allosteric activator of AMP-activated protein kinase (AMPK) acting on the AMPK-β subunit with therapeutic potential in metabolic disorders such as diabetes, obesity, etc. A769662 also blocks the differentiation of mouse embryonic stem cells (mESCs) and maintains the mESCs in naïve state even in the absence of leukemia inhibitory factor (2i/L).Fórmula:C20H12N2O3SPureza:Min. 95%Forma y color:SolidPeso molecular:360.39 g/molTacrolimus - Bio-X ™
CAS:Tacrolimus is a calcineurin inhibitor drug that is used for the prevention of rejection after an organ transplant. This drug can also be used in the treatment of severe atopic dermatitis. Tacrolimus’ mechanism of action is not well known however it is understood that this drug inhibits T-lymphocyte activation by binding to an intracellular protein called FKBP-12. This drug also has anti-inflammatory properties.
Fórmula:C44H69NO12Pureza:Min. 95%Forma y color:White Off-White PowderPeso molecular:804.02 g/molAZD 9291
CAS:A potent inhibitor of EGFR with sensitizing and T790M resistance mutations, selective over the wild-type form of the receptor. Causes tumour regression in EGFR mutant T790M transgenic and xenograft models in vivo.Fórmula:C28H33N7O2Pureza:Min. 97%Forma y color:SolidPeso molecular:499.61 g/molRamipril - Bio-X ™
CAS:Ramipril is an angiotensin-converting enzyme (ACE) inhibitor. It is used in the treatment of high blood pressure, congestive heart failure and other cardiovascular diseases. Ramipril inhibits the conversion of angiotensin I to angiotensin II by blocking ACE, which lowers blood pressure and reduces fluid retention.This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Fórmula:C23H32N2O5Pureza:Min. 95%Forma y color:PowderPeso molecular:416.51 g/molR-Rolipram
CAS:Inhibitor of PDE4 enzyme; anti-inflammatory
Fórmula:C16H21NO3Pureza:Min. 95%Forma y color:PowderPeso molecular:275.34 g/molVolitinib
CAS:Inhibitor of c-Met kinaseFórmula:C17H15N9Pureza:Min. 95%Forma y color:White PowderPeso molecular:345.36 g/molFeprazone
CAS:Anti-inflammatory; inducer of P450 II B familyFórmula:C20H20N2O2Pureza:Min. 95%Forma y color:PowderPeso molecular:320.39 g/molBKM 120
CAS:Inhibitor of pan-class I PI3K family of lipid kinases; antineoplastic
Fórmula:C18H21O2N6F3Pureza:Min. 95%Forma y color:White PowderPeso molecular:410.39 g/mol
