Moduladores de enzimas
Los moduladores enzimáticos son compuestos que pueden aumentar o inhibir la actividad de las enzimas, regulando así la velocidad de las reacciones bioquímicas. Estos moduladores juegan un papel crítico en el control de las vías metabólicas, la señalización celular y diversos procesos fisiológicos. Los moduladores enzimáticos se utilizan ampliamente en la investigación y el desarrollo de fármacos para estudiar las funciones enzimáticas y desarrollar agentes terapéuticos. En CymitQuimica, ofrecemos una gama completa de moduladores enzimáticos de alta calidad para apoyar su investigación en la regulación enzimática y el descubrimiento de fármacos.
Subcategorías de "Moduladores de enzimas"
Se han encontrado 693 productos de "Moduladores de enzimas"
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Seratrodast - Bio-X ™
CAS:Seratrodast is a thromboxane receptor antagonist that is used to treat asthma. However, this drug does not affect thrombus formation as other thromboxane synthase inhibitors do such as ozagrel.Fórmula:C22H26O4Pureza:Min. 95%Forma y color:PowderPeso molecular:354.44 g/molA 939572 - Bio-X ™
CAS:A 939572 is an inhibitor of stearoyl-CoA desaturase 1 (SCD1). It exhibits anticancer activity as it inhibits cell growth and promotes cell death in human non-small cell lung carcinoma cells.Fórmula:C20H22ClN3O3Pureza:Min. 95%Forma y color:PowderPeso molecular:387.86 g/molAminopterin
CAS:Aminopterin is an antineoplastic agent and antifolate, which is a synthetic derivative of pteroylglutamic acid. It functions as a chemotherapeutic agent by inhibiting dihydrofolate reductase, an enzyme crucial in the folic acid pathway, thereby preventing the conversion of dihydrofolate to tetrahydrofolate. This disruption leads to impaired synthesis of purine nucleotides and thymidylate, which are essential for DNA synthesis and cell division.Fórmula:C19H20N8O5Pureza:Min. 97 Area-%Forma y color:Slightly Yellow PowderPeso molecular:440.41 g/molFluvastatin sodium
CAS:Fluvastatin is a statin that lowers blood cholesterol and triglycerides by inhibiting HMG-CoA reductase, an enzyme that plays a critical role in the synthesis of cholesterol. Fluvastatin has also been shown to reduce the incidence of myocardial infarction, and to reduce atherosclerotic lesions in animal models, reducing the incidence of cardiovascular disease. Fluvastatin also has been shown to inhibit the activation of toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS), which may be related to its anti-inflammatory effects. Furthermore, through lowering blood cholesterol, Fluvastatin also inhibits tubulointerstitial injury and prevents renal damage caused by high concentrations of the lipid.
Fórmula:C24H25FNNaO4Pureza:Min. 98%Forma y color:Off-White PowderPeso molecular:433.45 g/molApixaban - Bio-X ™
CAS:Apixaban is an anticoagulant agent used for the prophylaxis of stroke and deep vein thrombosis leading to pulmonary embolism. This drug is an inhibitor of factor Xa and prothrominase. As a result, this prevents the formation of a thrombus.Fórmula:C25H25N5O4Pureza:Min. 95%Forma y color:PowderPeso molecular:459.5 g/molRosuvastatin calcium - Bio-X ™
CAS:Rosuvastatin is a drug that belongs to the group of statins. It is used for the treatment of high cholesterol and as an adjunct therapy for patients with coronary heart disease. Rosuvastatin reduces serum cholesterol by inhibiting HMG-CoA reductase, which is the rate-limiting enzyme in the production of cholesterol. Furthermore, this drug has been shown to have anti-inflammatory properties, which may be due to its ability to inhibit prostaglandin synthesis.Fórmula:C22H27FN3O6SCaPureza:(%) Min. 95%Forma y color:PowderPeso molecular:500.57 g/molMethotrexate sodium
CAS:Inhibitor of folate synthesis; folic acid analogueFórmula:C20H22N8O5•NaxPureza:Min. 95%Peso molecular:476.42 g/molAfatinib - Bio-X ™
CAS:Afatinib is a small molecule that inhibits the activity of cellular kinases that are involved in the progression of cancer. It is an Irreversible inhibitor of three members of the ErbB family. This molecule binds covalently to cysteine 797 residue in HER2 and blocks downstream cellular signalling which inhibits cellular growth and promotes apoptosis. It has been researched for the treatment of non-small cell lung cancer (NSCLC), breast cancer, pancreatic cancer and colorectal cancer.Fórmula:C24H25ClFN5O3Pureza:Min. 95%Forma y color:PowderPeso molecular:485.94 g/molTenatoprazole
CAS:H+/K+ ATPase inhibitorFórmula:C16H18N4O3SPureza:Min. 95%Forma y color:PowderPeso molecular:346.41 g/molCamostat mesylate - Bio-X ™
CAS:Camostat is a serine protease inhibitor that is used for the treatment of chronic pancreatitis. This drug has shown to reduce inflammation and pain. Studies have shown that Camostat has also inhibited the entry of SARS-CoV-2 in lung cells by inhibiting the priming process of S-protein, necessary for the viral entry into host cells.Fórmula:C20H22N4O5•CH4O3SPureza:Min. 95%Forma y color:PowderPeso molecular:494.52 g/molPentoxifylline
CAS:Producto controladoPhosphodiesterase inhibitorFórmula:C13H18N4O3Pureza:Min. 95%Forma y color:White PowderPeso molecular:278.31 g/mol3-(4-Phenylbutyl)-4-propyloxetan-2-one
CAS:Cis/trans-form of GK 563 [2351820-19-2]Fórmula:C16H22O2Pureza:Min. 95%Forma y color:SolidPeso molecular:246.34 g/molMK 4827
CAS:Inhibitor of PARP1 and PARP2 enzymes
Fórmula:C19H20N4OPureza:Min. 96 Area-%Forma y color:White PowderPeso molecular:320.39 g/molRucaparib camsylate
CAS:Inhibitor of poly (ADP-ribose) polymerase enzyme; antineoplasticFórmula:C19H18FN3O•C10H16O4SPureza:Min. 95%Forma y color:Off-White To Yellow SolidPeso molecular:555.66 g/molDiacerein - Bio-X ™
CAS:Diacerein is a slow-onset anthraquinone IL-1 inhibitor that is used in the treatment of joint diseases such as osteoarthritis. This drug is also being studied for the treatment of insulin resistance and diabetes mellitus. Diacerein works to decrease inflammation and cartilage destruction by reducing the level of interleukin-1.Fórmula:C19H12O8Pureza:Min. 95%Forma y color:PowderPeso molecular:368.29 g/molCetilistat - Bio-X ™
CAS:Cetilistat is a drug that is used to treat obesity. This drug inhibits the enzyme pancreatic lipase and so it prevents triglycerides from being hydrolyzed into absorbable free fatty acids.Fórmula:C25H39NO3Pureza:Min. 95%Forma y color:PowderPeso molecular:401.58 g/molBrivanib alaninate
CAS:VEGFR2 a tyrosine kinase receptor inhibitor; antineoplasticFórmula:C22H24FN5O4Pureza:Min. 95%Forma y color:PowderPeso molecular:441.18123SU 0268
CAS:Inhibitor of 8-oxoguanine DNA glycosylase OGG1 with IC50 of 0.059 μM and excellent specificity over other DNA repair enzymes. OGG1 and its substrate 8-oxoguanine are involved in mutagenesis, genotoxicity, inflammation and cancer. The compound can cause accumulation of 8-oxoguanine in DNA in vitro and is a potent tool for the study of OGG1 biology.Fórmula:C26H25N3O4SPureza:Min. 95%Forma y color:White PowderPeso molecular:475.56 g/molArbutin - Synthetic origin
CAS:Inhibitor of tyrosinase in melanocytes: skin whitener
Fórmula:C12H16O7Pureza:Min. 98 Area-%Forma y color:White PowderPeso molecular:272.25 g/molPF 670462
CAS:Casein kinase (CK1ε and CK1ÎŽ) inhibitorFórmula:C19H20FN5•(HCl)2Pureza:Min. 95%Peso molecular:410.32 g/molLicofelone
CAS:Dual COX/5-LO inhibitor; anti-inflammatory; analgesic
Fórmula:C23H22ClNO2Pureza:Min. 95%Forma y color:PowderPeso molecular:379.88 g/molGefitinib hydrochloride
CAS:RIPK2 protein kinase inhibitor; EGFR inhibitorFórmula:C22H24ClFN4O3·HClPureza:Min. 95%Forma y color:PowderPeso molecular:483.36 g/molAZD 1152
CAS:AZD 1152 is an Aurora kinase inhibitor, which is a type of small-molecule therapeutic agent. It is derived from the pharmaceutical research conducted by AstraZeneca. Its primary mode of action involves the selective inhibition of Aurora B kinase, an enzyme crucial for the regulation of mitosis. By interfering with this enzyme, AZD 1152 disrupts the normal progression of cell division, leading to the inhibition of proliferation and induction of apoptosis in rapidly dividing cells.Fórmula:C26H31FN7O6PPureza:Min. 97 Area-%Forma y color:Slightly Yellow PowderPeso molecular:587.54 g/molCerivastatin sodium
CAS:An inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase that reduces total cholesterol and low-density lipoprotein (LDL). Cerivastatin is cardioprotective and anti-atherosclerotic. Cerivastatin inhibits the expression of the atherosclerotic genes monocyte chemoattractant protein-1 (MCP-1) and C-C chemokine receptor type 2 (CCR2), whilst inducing the expression of Kruppel-like factor 2 (KLF2).Fórmula:C26H33FNNaO5Pureza:Min. 98 Area-%Forma y color:PowderPeso molecular:481.53 g/molSU 11274
CAS:MET tyrosine kinase inhibitor; anti-proliferative; pro-apoptoticFórmula:C28H30ClN5O4SPureza:Min. 95%Forma y color:Yellow To Orange SolidPeso molecular:568.09 g/molOmeprazole - Bio-X ™
CAS:Omeprazole is a proton pump inhibitor (PPI) that inhibits the production of gastric acid in the stomach. This is due to Omeprazole binding through a stable disulphide bond to the H+/K+ ATPase enzyme found on parietal cells, and preventing hydrogen ion transport. Consequently, gastric acid secretion is supressed. As a PPI, Omerprazole can be used to treat disorders where gastric acid is over-secreted. Examples of these disorders are gastroesophageal reflux disease (GERD) and peptic ulcer disease.Fórmula:C17H19N3O3SPureza:Min. 95%Forma y color:PowderPeso molecular:345.42 g/molAceclofenac - Bio-X ™
CAS:Acecelofenac is a non-steroidal anti-inflammatory drug that is used in the treatment of osteoarthritis, arthritis, and ankylosing spondylitis. This drug is also a cyclooxygenase inhibitor and works by inhibiting this enzyme so that pain and inflammation is reduced.Fórmula:C16H13Cl2NO4Pureza:Min. 95%Forma y color:PowderPeso molecular:354.18 g/molUNC 4203
CAS:Potent and specific inhibitor of the tyrosine protein kinase Mer precursor (MERTK) with 38-fold selectivity over the FMS-like protein kinase FLT3. UNC 4203 inhibits MERTK with an IC50 value of 2.4 nM and shows favourable pharmacokinetic properties. In vivo experiments in mice showed that UNC 4203 dramatically decreased the phosphorylation of MERTK in bone marrow leukemia cells.Fórmula:C30H44N6OPureza:Min. 95%Forma y color:Yellow PowderPeso molecular:504.71 g/molIrsogladine maleate - Bio-X ™
CAS:Irsogladine is a gastroprotective drug that is used for the treatment of GERD and gastric ulcers. This drug also has antioxidant properties. Irsogladine is a phosphodiesterase-4 inhibitor and increases levels of cAMP. It helps to prevent and heal damage to the stomach lining.Fórmula:C13H11Cl2N5O4Pureza:Min. 95%Forma y color:PowderPeso molecular:372.16 g/molChymostatin
CAS:Inhibitor of chymotrypsinFórmula:C31H41N7O6Forma y color:White To Yellowish SolidPeso molecular:607.7 g/molBAY 607550
CAS:A selective and potent inhibitor of phosphodiesterase 2 (PDE2). Raises cAMP and cGMP levels in neurons, improves social recognition and object memory in murine animals. Reverses anxiolytic effects induced by oxidative stress in mice by blocking cGMP-PKG signaling.
Fórmula:C27H32N4O4Pureza:Min. 95%Forma y color:PowderPeso molecular:476.24236Zotarolimus
CAS:Inhibitor of immunophilin FKBP12 and mTOR signalling with immunosuppressant activity. Zotarolimus inhibits proliferation of endothelial cells and smooth muscle cells and is employed in vascular interventional therapies.Fórmula:C52H79N5O12Pureza:Min. 95%Forma y color:White PowderPeso molecular:966.21 g/molRebamipide - Bio-X ™
CAS:Rebamipide is a gastroprotective agent that is used to treat various gastrointestinal disorders such as gastric ulcers and GERD. This drug’s mechanism of action is not fully understood however, it is thought to exert its effects by promoting the secretion of protective mucus in the stomach and intestine, which helps to create a barrier against stomach acid and other irritants. Additionally, it has antioxidant and anti-inflammatory properties that can help reduce tissue damage.Fórmula:C19H15ClN2O4Pureza:Min. 95%Forma y color:PowderPeso molecular:370.79 g/molThioglycosyl Naphthalimide
CAS:Thioglycosyl Naphthalimide is a highly potent human O-GlcNAcase (hOGA) inhibitor with good selectivity against human β-N-acetylhexosaminidase B (HsHexB).Fórmula:C30H40N4O7SPureza:Min. 95%Peso molecular:600.73 g/molGilteritinib
CAS:Inhibitor of FLT3 and AXL tyrosine kinasesFórmula:C29H44N8O3Pureza:Min. 95%Forma y color:PowderPeso molecular:552.71 g/mol(-)-Huperzine A
CAS:Acetylcholinesterase inhibitor; therapy for Alzheimer's diseaseFórmula:C15H18N2OPureza:(%) Min. 98%Forma y color:PowderPeso molecular:242.32 g/molLY 411575
CAS:Potent inhibitor of γ-secretase. LY 411575 inhibited production of amyloid β (Aβ) peptides with IC50 of 0.078 nM in vitro as well as decreased levels of Aβ40 and Aβ42 amyloids in brain of a mouse model for Alzheimer’s disease. In vitro studies confirmed that LY 411575 inhibited cleavage of Notch receptor at S3 site with IC50 of 0.39 nM, which blocked Notch activation and downstream signalling, leading to apoptosis in primary and immortalized Kaposi's sarcoma cells.Fórmula:C26H23F2N3O4Pureza:Min. 95%Forma y color:SolidPeso molecular:479.48 g/molLovastatin - Bio-X ™
CAS:Lovastatin is an HMG-CoA reductase inhibitor that is used to lower LDL cholesterol levels and to aid in the management of cardiovascular diseases. Animal studies have demonstrated that this drug has vasculoprotective properties.Fórmula:C24H36O5Pureza:Min. 95%Forma y color:PowderPeso molecular:404.54 g/molMRK 560
CAS:γ-secretase inhibitor; reduces amyloid-β in brainÂ
Fórmula:C19H17ClF5NO4S2Pureza:Min. 95%Peso molecular:517.92 g/molTacrolimus
CAS:Antirheumatic; immunosuppressant; neuroprotective; neuroregenerativeFórmula:C44H69NO12Pureza:Min. 98 Area-%Forma y color:White PowderPeso molecular:804.02 g/molGNE 6776
CAS:Specific inhibitor of the ubiquitin specific protease-7 (USP7), which is a validated deubiquitinase of the E3 ubiquitin-protein ligase MDM2. The compound inhibits the USP7 deubiquitinase activity by binding to acidic amino acid residues important for the interaction with ubiquitin. Induces tumor cell death and enhances cytotoxicity of chemotherapeutic agents.Fórmula:C20H20N4O2Pureza:Min. 95%Peso molecular:348.4 g/molEN 6
CAS:Autophagy activator that acts through targeting the ATP6V1A subunit of vATPaseFórmula:C19H14F2N4O2Pureza:Min. 95%Forma y color:White To Yellow To Beige SolidPeso molecular:368.34 g/molIdelalisib
CAS:Idelalisib is a pharmaceutical drug that functions as a PI3Kδ inhibitor, developed through synthetic chemical processes. Its mode of action involves selectively targeting and inhibiting phosphatidylinositol 3-kinase delta (PI3Kδ), a lipid kinase that plays a crucial role in the signaling pathways responsible for cell proliferation, survival, and differentiation. By inhibiting this enzyme, Idelalisib effectively impedes pathways that are often hyperactivated in certain hematologic malignancies, thereby exerting antitumor effects.Fórmula:C22H18FN7OPureza:Min. 95%Forma y color:PowderPeso molecular:415.42 g/molBKM 120
CAS:Inhibitor of pan-class I PI3K family of lipid kinases; antineoplastic
Fórmula:C18H21O2N6F3Pureza:Min. 95%Forma y color:White PowderPeso molecular:410.39 g/molSRT1720 hydrochloride
CAS:SIRT1 activatorFórmula:C25H23N7OS·xHClPureza:Min. 98 Area-%Forma y color:PowderPeso molecular:469.56 g/molPimasertib
CAS:A selective inhibitor of MEK1/2 kinase. Anti-proliferative and pro-apoptotic in multiple myeloma (MM) cells via G0/G1 cell cycle arrest and caspase 3 and PARP cleavage, respectively. Synergistic with other anti-MM therapies. Has anti-tumor effects in some solid tumors, such as in K-ras mutated colorectal cancer.Fórmula:C15H15FIN3O3Pureza:Min. 95%Forma y color:White To Yellow SolidPeso molecular:431.2 g/molJNJ 10198409
CAS:Selective inhibitor of the platelet derived growth factor receptor PDGFRβ with IC50 value of 4.2 nM. JNJ 10198409 inhibits the PDGFRβ kinase activity and its downstream signalling leading to anti-proliferative and anti-angiogenic effects, which were confirmed in various tumoral cell lines.Fórmula:C18H16FN3O2Pureza:Min. 95%Forma y color:SolidPeso molecular:325.34 g/molA 939572
CAS:Inhibitor of stearoyl-CoA desaturase SCD1 with IC50 of 6.3 nM, as measured in the SCD1-expressing human microsomes. A 939572 exhibited anticancer activity as it reduced cell proliferation and triggered cell killing in human non-small cell lung carcinoma cells. A 939572 inhibited tumour growth in an in vivo model for gastric carcinoma and reduced the oleic acid:stearic acid ratio in mouse liver and plasma.Fórmula:C20H22ClN3O3Pureza:Min. 95%Forma y color:PowderPeso molecular:387.86 g/molKU-0063794
CAS:Inhibits mTORC1 and mTORC2 serine/threonine kinasesFórmula:C25H31N5O4Pureza:Min. 95%Forma y color:White To Beige To Yellow SolidPeso molecular:465.54 g/molGefitinib - Bio-X ™
CAS:Gefitinib is an inhibitor of the epidermal growth factor receptor (EGFR) protein. This inhibition is on the EGFR tyrosine kinase domain, where Gefitinib bindings to the ATP-binding site. As a a tyrosine kinase inhibitor, Gefitinib blocks tumor growth and has led to its use in slowing the progression of non-small cell lung cancer. Gefitinib also inhibits invasion and metastasis through inhibition of macrophage receptor interacting protein kinase 2 (RIPK2), rather than EGFR.Fórmula:C22H24ClFN4O3Pureza:Min. 98 Area-%Forma y color:PowderPeso molecular:446.9 g/mol
