Moduladores de enzimas
Subcategorías de "Moduladores de enzimas"
Se han encontrado 691 productos para "Moduladores de enzimas".
Bafilomycin A1
CAS:Inhibitor of vacuolar-type proton pumpFórmula:C35H58O9Pureza:Min. 95 Area-%Forma y color:White PowderPeso molecular:622.83 g/molRepSox
CAS:Selective inhibitor of the transforming growth factor beta receptor TGFβ1. RepSox can replace Sox, a transcriptional factor required for cell self-renewal, in reprogramming of adult cells to induced pluripotent stem cells (iPSCs). In the cloned interspecies embryos, RepSox induced expression of pluripotency regulatory genes Oct4 and Nanog, improved viability and developmental potential of embryos in the pre-implantation stage.
Fórmula:C17H13N5Pureza:Min. 95%Forma y color:PowderPeso molecular:287.32 g/molCapmatinib
CAS:Selective c-Met kinase inhibitor
Fórmula:C23H17FN6OPureza:Min. 95 Area-%Forma y color:Slightly Yellow PowderPeso molecular:412.42 g/molCHIR 99021
CAS:Potent and selective inhibitor of the glycogen synthase kinase GSK-3. Promotes cell renewal in embryonic stem cells by modulating Notch, MAPK and TGF-β signalling pathways, which are involved in pluripotency. It also affects the Wnt/β-catenin pathway and alters expression of genes coding for proteins, epigenetic regulatory elements and non-coding RNAs. The combination of CHIR 99021 and basic fibroblast growth factor (bFGF) allows long-term self-renewal in adult mouse retinal progenitor cells.Fórmula:C22H18Cl2N8Pureza:Min. 95%Forma y color:PowderPeso molecular:465.34 g/mol(Z)-Mycophenolic acid
CAS:(Z)-Mycophenolic acid is an immunosuppressive agent derived from the fermentation of fungi, primarily from the Penicillium species. It functions by inhibiting inosine monophosphate dehydrogenase (IMPDH), an enzyme crucial for de novo purine synthesis. This selective blockade of IMPDH specifically affects lymphocyte proliferation due to their heavy reliance on this pathway for DNA synthesis, thereby exerting its immunosuppressive effects.Fórmula:C17H20O6Pureza:Min. 98 Area-%Forma y color:PowderPeso molecular:320.34 g/molAfatinib - Bio-X ™
CAS:Afatinib is a small molecule that inhibits the activity of cellular kinases that are involved in the progression of cancer. It is an Irreversible inhibitor of three members of the ErbB family. This molecule binds covalently to cysteine 797 residue in HER2 and blocks downstream cellular signalling which inhibits cellular growth and promotes apoptosis. It has been researched for the treatment of non-small cell lung cancer (NSCLC), breast cancer, pancreatic cancer and colorectal cancer.Fórmula:C24H25ClFN5O3Pureza:Min. 95%Forma y color:PowderPeso molecular:485.94 g/molBIO
CAS:Specific inhibitor of glycogen synthase kinase 3 (GSK-3) with IC50 in low nanomolar range. Studies showed that BIO maintains self-renewal in embryonic stem cells (ESCs) as well as increases activity of β-catenin. In neonatal cardiomyocytes, BIO promotes cell cycle by stimulating cell entry into S phase as well as cytokinesis. In germline stem cells from female mice (FGSCs), BIO promoted proliferation and maintenance of FGSCs by activating β-catenin and up-regulating E-cadherin.Fórmula:C16H10BrN3O2Pureza:Min. 95%Forma y color:Red To Dark Red SolidPeso molecular:356.17 g/molMotesanib
CAS:Inhibitor of VEGFR, PDGR, c-Kit and Ret; inhibitor of angiogenesisFórmula:C22H23N5OPureza:Min. 95%Peso molecular:373.45 g/molSB 239063
CAS:Inhibits p38 MAP kinase; anti-inflammatory; neuroprotectiveFórmula:C20H21FN4O2Pureza:Min. 95%Forma y color:PowderPeso molecular:368.4 g/molCrizotinib - Bio-X ™
CAS:Crizotinib is a drug that belongs to the group of tyrosine kinase inhibitors. It is used in the treatment of cancers, including non-small cell lung cancer, small cell lung cancer, and other types of solid tumours. Crizotinib inhibits the activity of the tyrosine kinase ALK or anaplastic lymphoma kinase, which is involved in many signalling pathways and biological processes. The inhibition of this enzyme leads to decreased energy metabolism, reduced mitochondrial membrane potential and increased susceptibility to apoptosis.
Fórmula:C21H22Cl2FN5OPureza:Min. 95%Forma y color:PowderPeso molecular:450.34 g/molSivelestat
CAS:Inhibitor of human neutrophil elastase
Fórmula:C20H22N2O7SPureza:Min. 95%Peso molecular:434.46 g/molBenazepril HCl - Bio-X ™
CAS:Benazepril is a nonsteroidal anti-inflammatory drug that can be used to treat hypertension, heart failure and renal failure. It is an angiotensin-converting enzyme (ACE) inhibitor that blocks the conversion of angiotensin I to angiotensin II. This inhibition prevents the vasoconstrictive effects of this peptide, which are mediated through activation of the renin-angiotensin system.Fórmula:C24H28N2O5•HClPureza:Min. 95%Forma y color:PowderPeso molecular:460.95 g/molCZC 25146
CAS:Inhibitor of leucine-rich repeat kinase LRRK2Â
Fórmula:C22H25FN6O4SPureza:Min. 98 Area-%Forma y color:PowderPeso molecular:488.54 g/molGNE 6776
CAS:Specific inhibitor of the ubiquitin specific protease-7 (USP7), which is a validated deubiquitinase of the E3 ubiquitin-protein ligase MDM2. The compound inhibits the USP7 deubiquitinase activity by binding to acidic amino acid residues important for the interaction with ubiquitin. Induces tumor cell death and enhances cytotoxicity of chemotherapeutic agents.Fórmula:C20H20N4O2Pureza:Min. 95%Peso molecular:348.4 g/molPD 169316
CAS:Inhibitor of p38 kinase
Fórmula:C20H13FN4O2Pureza:Min. 95%Forma y color:PowderPeso molecular:360.34 g/molMethotrexate
CAS:Methotrexate is a chemotherapeutic and immunosuppressive medication, which is a synthetic analog of folic acid. Its source is through chemical synthesis, mimicking the structure of dihydrofolate in order to exert its effects. Methotrexate acts primarily by inhibiting the enzyme dihydrofolate reductase (DHFR), leading to a decrease in tetrahydrofolate production. This disruption in folate metabolism results in the inhibition of DNA, RNA, and protein synthesis, which affects rapidly dividing cells.Methotrexate is employed broadly in clinical oncology as an antineoplastic agent, particularly in the treatment of leukemias, lymphomas, breast cancer, and osteosarcoma. Additionally, it serves as a cornerstone for managing autoimmune diseases such as rheumatoid arthritis and psoriasis, where it helps modulate the aberrant immune response. The dual role of Methotrexate in oncology and immunosuppression underscores its versatility and critical importance in therapeutic regimens. However, its use demands careful monitoring due to potential adverse effects on non-cancerous cells and organ systems, necessitating precise dosage management and patient evaluation.Fórmula:C20H22N8O5Forma y color:Yellow PowderPeso molecular:454.44 g/molGC376 sodium
CAS:GC 376 is an inhibitor of the main protease Mpro (3CLpro) in coronaviruses as well as picornaviruses. This broad-spectrum antiviral compound has been used as investigational veterinary drug for treatment of feline infectious peritonitis virus (FIPV) infections. Recent studies also showed that GC 376 inhibits the main protease Mpro (3CLpro) from SARS-CoV-2 with IC50 of 0.03 μM and EC50 of 3.37 μM.
Fórmula:C21H30N3NaO8SPureza:Min. 95 Area-%Forma y color:White PowderPeso molecular:507.53 g/molNilotinib HCl monohydrate - Bio-X ™
CAS:Nilotinib is a kinase inhibitor that is used for the treatment of Chronic Myeloid Leukemia (CML). This drug is also used for the treatment of CML that is resistant to imatinib. Nilotinib inhibits the tyrosine kinase activity of the BCR-ABL protein. It also inhibits PDGFR and c-kit.
Fórmula:C28H22F3N7O•HCl•H2OPureza:Min. 95%Forma y color:PowderPeso molecular:583.99 g/molPF 06409577
CAS:Potent agonist of a1β1γ1 5′-adenosine monophosphate-activated protein kinase (AMPK). It binds to the allosteric drug and metabolite (ADaM) site at the α- and β- subunit interface of AMPK. It has potential for the treatment of diabetic nephropathy. PF 06409577 reduces infections caused by flaviviruses, mediated by changes in the metabolism of lipids in host cells.
Fórmula:C19H16ClNO3Pureza:Min. 95%Forma y color:White/Off-White SolidPeso molecular:341.79 g/molQ-VD-OPH
CAS:Inhibitor of caspases; broad spectrumFórmula:C26H25F2N3O6Pureza:Min. 98.00 Area-%Forma y color:PowderPeso molecular:513.49 g/mol
