Methyl indole-5-carboxylate
CAS: 1011-65-0
Ref. 3D-FM25514
25g | 136,00 € | ||
50g | 195,00 € | ||
100g | 337,00 € | ||
250g | 645,00 € | ||
500g | 1.047,00 € |
Información del producto
- 5-(Methoxycarbonyl)indoleH-Indole-5-carboxylic acid methyl ester5-(Methoxycarbonyl)-1H-indole
- Indole-5-carboxylic acid methyl ester
- methyl 1H-indole-5-carboxylate
- 1H-Indole-5-carboxylic acid, methyl ester
Methyl indole-5-carboxylate is a hdac inhibitor that has been shown to have anticancer activity. It has been shown to inhibit the growth of hCT116 cells and xenograft tumors in mice. Methyl indole-5-carboxylate is also an active analog for other anticancer agents, such as 5-azacytidine and 5-aza-2'-deoxycytidine. The drug is cytotoxic to L6 cells and increases the expression of p21 protein, which inhibits tumor cell proliferation. This compound is metabolized by cytochrome P450 enzymes into methyl indole carboxylate, which can be further converted into a reactive intermediate that binds DNA.
Propiedades químicas
Consulta técnica sobre: 3D-FM25514 Methyl indole-5-carboxylate
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