TAPI 2

CAS: 689284-12-6

Ref. 3D-PCB28412

Información del producto

• Nombre: TAPI 2

Descripción

TAPI 2 is a potent and selective inhibitor of the enzyme, pyruvate dehydrogenase kinase (PDK). PDK regulates the transition from aerobic to anaerobic metabolism. TAPI 2 binds to the active site of PDK and prevents it from phosphorylating and inactivating pyruvate dehydrogenase (PDH), which is essential for ATP production. TAPI 2 also has been shown to inhibit the respiratory chain complexes I, III, and IV. This inhibition has been shown to be reversible by scavenging or binding at a different site on the enzyme. In addition, TAPI 2 inhibits DNA replication by preventing DNA polymerases from interacting with DNA-dependent RNA polymerase. This drug has been shown to have a potent inhibitory effect on tumor cell viability in vitro and in vivo.

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 415.54 g/mol
• Fórmula: C₁₉H₃₇N₅O₅
• Pureza: Min. 95%