Desmethylanethol trithione

CAS: 18274-81-2

Ref. TM-T3560

Información del producto

• Nombre: Desmethylanethol trithione
• Sinónimos: ADT-OH, 4-Hydroxyanethole trithione, Desmethyl-adt, Desmethylanethol dithiolthione, 3H-1,2-Dithiole-3-thione, 5-(4-hydroxyphenyl)-, 4-(5-sulfanyl-3H-1,2-dithiol-3-ylidene)cyclohexa-2,5-dien-1-one
• CAS: 18274-81-2

Descripción

Desmethylanethol trithione (ADT-OH) is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, Desmethylanethol trithione markedly attenuated tPA-enhanced Akt activation and VEGF expression in brain microvascular endothelial cells. Finally, Desmethylanethol trithione improved functional outcomes in mice subjected to MCAO and tPA infusion. H2S donors reduced tPA-induced cerebral hemorrhage by possibly inhibiting the Akt-VEGF-MMP9 cascade. Administration of H2S donors has potential as a novel modality to improve the safety of tPA following the stroke.

• Marca: Targetmol

Propiedades químicas

• Peso molecular: 226.34
• Fórmula: C₉H₆OS₃
• Pureza: 98.23%
• Color/Forma: Solid