Pirtobrutinib

CAS: 2101700-15-4

Ref. TM-T36287

Información del producto

• Nombre: Pirtobrutinib
• Sinónimos: LOXO-305
• CAS: 2101700-15-4

Descripción

Pirtobrutinib (LOXO-305) is an advanced BTK inhibitor that displays high selectivity and operates through a non-covalent mechanism. This compound effectively inhibits various BTK C481 substitution mutations, leading to tumor regression in BTK-dependent lymphoma tumors in mouse xenograft models. Furthermore, Pirtobrutinib exhibits remarkable selectivity for BTK, with more than a 300-fold difference compared to 370 other kinases tested. Notably, at a concentration of 1 μM, Pirtobrutinib demonstrates no significant inhibition of non-kinase off-targets.

• Marca: Targetmol

Propiedades químicas

• Peso molecular: 479.43
• Fórmula: C₂₂H₂₁F₄N₅O₃
• Pureza: 99.89%
• Color/Forma: Solid