PDGF R beta/CD140b Protein, Canine, Recombinant (His)

Ref. TM-TMPK-01050

Información del producto

• Nombre: PDGF R beta/CD140b Protein, Canine, Recombinant (His)
• Sinónimos: JTK12, PDGF R β, PDGFR-β, PDGFR, PDGFRB, PDGF R beta, PDGF R β/CD140b, PDGFR1, CD140B, PDGFR-2

Descripción

PDGF is a major serum mitogen that can exist as a homo or hetero-dimeric protein consisting of disulfide-linked PDGF-A and PDGF-B chains. The PDGF-AA,PDGF-BB and PDGF-AB isoforms have been shown to bind to two distinct cell surface PDGF receptors with different affinities. Where as PDGF R alpha binds all three PDGF isoforms with high affinity, PDGF R beta binds PDGF-BB only with high-affinity. PDGF R plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites.

• Marca: Targetmol

Propiedades químicas

• Peso molecular: The protein has a predicted MW of 57.25 kDa. Due to glycosylation, the protein migrates to 70-100 kDa based on Tris-Bis PAGE result.
• Color/Forma: Solid