(S)-(+)-Camptothecin

CAS: 7689-03-4

Ref. TR-C175150

Información del producto

• Nombre: (S)-(+)-Camptothecin
• Sinónimos: 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (4S)-, 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-, Camptothecine (7CI), (+)-Camptothecin, (+)-Camptothecine, (4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 20(S)-Camptothecin, 20(S)-Camptothecine, Campathecin, Camptothecin, MAG-CPT, NSC 94600, S-CKD 602
• Marca: TRC
• Descripción: Impurity Topotecan USP Related Compound CApplications Antitumor alkaloid. Binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the packageReferences Potmesil, M., et al.: Cancer Res., 54, 1431 (1994), Desai, S.D., et al.: J. Biol. Chem., 272, 24159 (1997), Fan, Y., et al.: J. Med. Chem., 41, 2216 (1998), Kaufmann, S.H., et al.: Biochim. Biophys. Acta, 1400, 195 (1998),

Propiedades químicas

• Peso molecular: 348.35
• Fórmula: C₂₀H₁₆N₂O₄
• Color/Forma: Beige To Yellow
• InChI: InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1
• Clave InChI: InChIKey=VSJKWCGYPAHWDS-FQEVSTJZSA-N
• SMILES: CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3ccccc3nc2-1