N-(4-Chloro-2-pyrimidinyl)-2,3-dimethyl-2H-indazol-6-amine

CAS: 1226499-97-3

Ref. TR-C472230

Información del producto

• Nombre: N-(4-Chloro-2-pyrimidinyl)-2,3-dimethyl-2H-indazol-6-amine
• Sinónimos: (4-Chloro-pyrimidin-2-yl)-(2,3-dimethyl-2H-indazol-6-yl)-amine

Descripción

Applications N-(4-Chloro-2-pyrimidinyl)-2,3-dimethyl-2H-indazol-6-amine is an intermediate in the synthesis of 5-((2-((2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino)pyrimidin-4-yl)amino)-2-methylbenzenesulfonamide Hydrochloride (D474433) which is an impurity of Pazopanib (P210925), which is an oral angiogenesis inhibitor targeting VEGFR and PDGFR.
References Olaussen, K., et al.: Oncogen., 28, 4249 (2009), Sleijfer, S., et al.: J. Clin. Oncol., 27, 3126 (2009), Chan, A., et al.: Drugs, 69, 167 (2009),

• Marca: TRC

Propiedades químicas

• Peso molecular: 273.72
• Fórmula: C₁₃H₁₂ClN₅
• Color/Forma: Neat
• InChI: InChI=1S/C13H12ClN5/c1-8-10-4-3-9(7-11(10)18-19(8)2)16-13-15-6-5-12(14)17-13/h3-7H,1-2H3,(H,15,16,17)
• Clave InChI: InChIKey=MIXMRKPSOXIOPX-UHFFFAOYSA-N
• SMILES: Cc1c2ccc(Nc3nccc(Cl)n3)cc2nn1C