Cyclosporin A-13C2,d4 (Major)

CAS: 59865-13-3

Ref. TR-C988901

Información del producto

• Nombre: Cyclosporin A-13C2,d4 (Major)
• Sinónimos: Cyclosporine-13C2,d4, Ciclosporin-13C2,d4, Atopica-13C2,d4, Sandimmun(e)-13C2,d4, Neoral-13C2,d4, Optimmune-13C2,d4, Restasis-13C2,d4, Cyclosporina, Cyclosporine, Cyclosporin, Restasis, cyclosporin A, Antibiotic S 7481F1, 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone, (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone, 1: PN: US6686454 SEQID: 1 claimed protein, 7: PN: WO0002548 PAGE: 30 claimed protein, Arpimune ME, Cicloral, Cicloral (antibiotic), Ciclosporin, Cipol N, Consupren, Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl], Debio088, Equoral, Gengraf, Neoplanta, Neoral, Nsc 290193, Ol 27-400, Papilock Mini, Ramihyphin A, Sandimmun, Sandimmune, Sandimmune Neoral, Sang-35, SangCyA, Sdz-Oxl 400, Sigmasporin Microoral, S-Neoral, Zinograf ME, Sandimmun Neoral

Descripción

Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),

• Marca: TRC

Propiedades químicas

• Peso molecular: 1208.62
• Fórmula: C₂C₆₀D₄H₁₀₇N₁₁O₁₂
• Color/Forma: White To Off-White
• InChI: InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1/i1+1D3,25+1D