Pregnenolone Carbonitrile

CAS: 1434-54-4

Ref. TR-P712240

Información del producto

• Nombre: Pregnenolone Carbonitrile
• Sinónimos: 3β-Hydroxy-20-oxo-pregn-5-ene-16α-carbonitrile, 16α-Cyanopregnenolone, 3β-Hydroxy-20-oxo-5-pregnen-16α-carbonitrile, 3β-Hydroxy-20-oxopregn-5-ene-16α-carbonitrile, 5-Pregnen-3β-ol-20-one-16α-carbonitrile, PCN, Pregn-5-ene-3β-ol-20-oxo-16α-carbonitrile, Pregnenolone 16α-Carbonitrile, SC 4674, (3S,8S,9S,10R,13S,14S,16R,17S)-17-Acetyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-16-carbonitrile, (3Beta,16Alpha)-3-Hydroxy-20-Oxopregn-5-Ene-16-Carbonitrile, (3β,16α)-3-Hydroxy-20-oxopregn-5-ene-16-carbonitrile, 3beta-Hydroxy-20-oxo-5-pregnene-16alpha-carbonitrile, Ccris 9224, Pregn-5-ene-16-carbonitrile, 3-hydroxy-20-oxo-, (3beta,16alpha)-, Pregn-5-ene-16-carbonitrile, 3-hydroxy-20-oxo-, (3β,16α)-, Pregn-5-ene-16α-carbonitrile, 3β-hydroxy-20-oxo-, Pregnenolone 16alpha-carbonitrile, Pregnenolone 16α-carbonitrile, Pregnenolone carbonitrile, Sc 4674
• CAS: 1434-54-4

Descripción

Applications Pregnenolone Carbonitrile is a glucocorticoid receptor antagonist that induces the expression of the CYP3A family of steroid hydroxylases and modulates sterol and bile acid biosynthesis in vivo. Pregnenolone Carbonitrile is an an activator of rat pregnane X receptor (PXR).
References Kliewer, S.A., et. al.: Cell, 92, 73 (1998); Savas, U., et. al.: Drug Metab. Dispos., 28, 529 (2000)

• Marca: TRC

Propiedades químicas

• Peso molecular: 341.49
• Fórmula: C₂₂H₃₁NO₂
• Color/Forma: White to Pale Beige Solid
• InChI: InChI=1S/C10H9N3/c1-3-7-11-9(5-1)13-10-6-2-4-8-12-10/h1-8H,(H,11,12,13)
• Clave InChI: InChIKey=HMMPCBAWTWYFLR-UHFFFAOYSA-N
• SMILES: c1ccc(Nc2ccccn2)nc1