Tafenoquine Succinate

CAS: 106635-81-8

Ref. TR-T004760

Información del producto

• Nombre: Tafenoquine Succinate
• Sinónimos: Butanedioic acid, compd. with N4-[2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]-8-quinolinyl]-1,4-pentanediamine (1:1), 1,4-Pentanediamine, N4-[2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]-8-quinolinyl]-, butanedioate (1:1) (9CI), 8-[(4-Amino-1-methylbutyl)amino]-2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinoline succinate, SB 252263, SB 252263AX, WR 238605 succinate, SB-252263-AX, Tafenoquine succinate, Etaquine, Sb-252263, (±)-2,6-Dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]primaquine succinate, (±)-N4-[2,6-Dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]-8-quinolinyl]-1,4-pentanediamine butanedioate
• CAS: 106635-81-8

Descripción

Applications Tatenoquine is a new 8-aminoquinoline with an improved therapeutic index and safety profile as compared to primaquine (P733500).Tafenoquine has the potential to become a widely used drug in the prevention and treatment of malaria infection and could replace some currently used drugs as resistant strains of Plasmodium species increase.
References McIntyre, J. A., et al.: Drugs. Future., 28, 859 (2003); LaMontagne, M.P., et al.: J. Medn. Chem., 32, 1728 (1989);

• Marca: TRC

Propiedades químicas

• Peso molecular: 581.58
• Fórmula: C₂₄H₂₈F₃N₃O₃•C₄H₆O₄
• Color/Forma: Pale Yellow to Light Brown Solid
• InChI: InChI=1S/C24H28F3N3O3.C4H6O4/c1-14-11-20(32-4)30-22-18(29-15(2)7-6-10-28)13-19(31-3)23(21(14)22)33-17-9-5-8-16(12-17)24(25,26)27;5-3(6)1-2-4(7)8/h5,8-9,11-13,15,29H,6-7,10,28H2,1-4H3;1-2H2,(H,5,6)(H,7,8)
• Clave InChI: InChIKey=CQBKFGJRAOXYIP-UHFFFAOYSA-N
• SMILES: COc1cc(C)c2c(Oc3cccc(C(F)(F)F)c3)c(OC)cc(NC(C)CCCN)c2n1.O=C(O)CCC(=O)O