CAS 102805-45-8

(D-P-cl-phe6,leu17)-peptide vasoactif intestinal

Formule : C₁₄₈H₂₃₉ClN₄₄O₄₂

InChI : InChI=1S/C148H238ClN43O43/c1-19-75(14)116(143(231)182-97(55-72(8)9)132(220)185-105(146(234)235)62-111(157)202)190-140(228)107(67-194)187-135(223)102(61-110(156)201)179-131(219)96(54-71(6)7)176-133(221)98(57-81-35-41-85(197)42-36-81)177-125(213)89(29-21-24-48-151)169-123(211)90(30-22-25-49-152)172-141(229)114(73(10)11)188-119(207)76(15)166-128(216)94(52-69(2)3)174-127(215)93(45-46-108(154)199)171-122(210)88(28-20-23-47-150)168-124(212)91(31-26-50-163-147(158)159)170-130(218)95(53-70(4)5)175-126(214)92(32-27-51-164-148(160)161)173-144(232)117(78(17)195)191-137(225)99(58-82-37-43-86(198)44-38-82)178-134(222)101(60-109(155)200)180-136(224)104(64-113(205)206)184-145(233)118(79(18)196)192-138(226)100(56-80-33-39-83(149)40-34-80)183-142(230)115(74(12)13)189-120(208)77(16)167-129(217)103(63-112(203)204)181-139(227)106(66-193)186-121(209)87(153)59-84-65-162-68-165-84/h33-44,65,68-79,87-107,114-118,193-198H,19-32,45-64,66-67,150-153H2,1-18H3,(H2,154,199)(H2,155,200)(H2,156,201)(H2,157,202)(H,162,165)(H,166,216)(H,167,217)(H,168,212)(H,169,211)(H,170,218)(H,171,210)(H,172,229)(H,173,232)(H,174,215)(H,175,214)(H,176,221)(H,177,213)(H,178,222)(H,179,219)(H,180,224)(H,181,227)(H,182,231)(H,183,230)(H,184,233)(H,185,220)(H,186,209)(H,187,223)(H,188,207)(H,189,208)(H,190,228)(H,191,225)(H,192,226)(H,203,204)(H,205,206)(H,234,235)(H4,158,159,163)(H4,160,161,164)/t75-,76-,77-,78+,79+,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,114-,115-,116-,117-,118-/m0/s1

Code InChI : BKPARWGQWMAALF-JPUZJAJLSA-N

SMILES : CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC3=CC=C(C=C3)Cl)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CN=CN4)N

Synonymes :

• (p-Chloro-D-Phe6,Leu17)-VIP (human, bovine, porcine, rat)
• H-His-Ser-Asp-Ala-Val-p-chloro-D-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Leu-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
• [D-P-Cl-Phe(6),Leu(17)]-Vasoactive Intestinal Peptide Human, Porcine, Rat

[D-P-CL-PHE(6),LEU(17)]-VASOACTIVE INTESTINAL PEPTIDE HUMAN, PORCINE, RAT

CAS : 102805-45-8

Formule : C₁₄₈H₂₃₉ClN₄₄O₄₂

Degré de pureté : 98%

Masse moléculaire : 3342.2039

Ref: IN-DA008RSI

[D-p-Cl-Phe6,Leu17]-VIP

CAS : 102805-45-8

Selective vasoactive intestinal peptide (VIP) receptor antagonist (IC50 = 125.8 nM). Displays no activity on glucagon, secretin or GRF receptors.

Formule : C₁₄₈H₂₃₉ClN₄₄O₄₂

Degré de pureté : 98%

Couleur et forme : Solid

Masse moléculaire : 3342.24

Ref: TM-TP2103

(p-Chloro-D-Phe6,Leu17)-VIP (human, mouse, rat) trifluoroacetate salt

CAS : 102805-45-8

VIP is a potent vasoactive neuropeptide that is found in the heart, brain, and gut. It has been shown to be a potent inhibitor of guanethidine-induced contractions in the femoral vein, as well as atrial contractions. VIP also inhibits spontaneous contractions in the fundic region of the stomach and intestinal motility. VIP has been shown to inhibit vasoactive intestinal polypeptide-induced contractions in isolated rat ileum. VIP is expressed primarily in the enteric nervous system and throughout the gastrointestinal tract.

Formule : C₁₄₈H₂₃₉ClN₄₄O₄₂

Degré de pureté : Min. 95%

Masse moléculaire : 3,342.21 g/mol

Ref: 3D-FC109522