CAS 115956-12-2

Dolasétron

Description :

Dolasetron is an antagonist of the serotonin (5-HT) receptor subtype 5-HT 3 (K i = 20 nM). 1 It is selective for 5-HT 3 receptors over 5-HT 1A , 5-HT 1B , 5-HT 2 , dopamine D 2 , α 1 -, α 2 -, β-adrenergic, M 1-5 muscarinic acetylcholine, and neurokinin-1 (NK 1 ) receptors (IC 50 s = >10 μM for all). 2 Dolasetron inhibits 5-HT-induced membrane currents in NG 108-15 cells (IC 50 = 3.8 nM). 1 It increases the latency to emesis and reduces the number of vomiting and retching episodes induced by cisplatin (Item No. 13119 ) in ferrets when administered at doses of 0.5 or 2 mg/kg. 2 Formulations containing dolasetron have been used in the prevention of postoperative or chemotherapy-induced nausea.

Formule : C₁₉H₂₀N₂O₃

InChI : InChI=1/C19H20N2O3/c22-17-10-21-13-5-12(17)6-14(21)8-15(7-13)24-19(23)18-16-4-2-1-3-11(16)9-20-18/h1-4,12-15H,5-10H2

Code InChI : InChIKey=UKTAZPQNNNJVKR-MMUVGSQPNA-N

SMILES : O(C(=O)C=1C=2C(NC1)=CC=CC2)[C@@H]3C[C@]4([N@]5[C@](CC(C4)C(=O)C5)(C3)[H])[H]

Synonymes :

• (2alpha,6alpha,8alpha,9abeta)-Octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl-1H-indole-3-carboxylate
• (6R)-3-oxooctahydro-2H-2,6-methanoquinolizin-8-yl 1H-indole-3-carboxylate
• 1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, (2α,6α,8α,9aβ)-
• 1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, stereoisomer
• 1H-indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester
• 2,6-Methano-2H-quinolizine, 1H-indole-3-carboxylic acid deriv.
• 3-oxooctahydro-2H-2,6-methanoquinolizin-8-yl 1H-indole-3-carboxylate
• 3-oxooctahydro-2H-2,6-methanoquinolizin-8-yl 1H-isoindole-3-carboxylate
• Anemet
• Mdl 73147
• Dolasetron
• 1H-Indole-3-carboxylicacid, octahydro-3-oxo-2,6-Methano-2H-quinolizin-8-yl ester, stereoisoMer
• Dolasteron
• Unii-82wi2L7Q6e
• 1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, (2alpha,6alpha,8alpha,9abeta)-
• Octahydro-3-oxo-2,6-Methano-2H-quinolizin-8-yl Ester
• rel-(5s,6R,8r,9aS)-3-Oxooctahydro-1H-2,6-methanoquinolizin-8-yl 1H-indole-3-carboxylate
• 1H-Indole-3-carboxylic Acid 3-Oxooctahydro-2H-2,6-methanoquinolizin-8-yl Ester
• Hsdb 7565
• dolasetron USP/EP/BP
• Dolasetronum [inn-latin]
• (2a,6a,8a,9ab)-1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester
• Dolasetronum

Dolasetron

CAS : 115956-12-2

Formule : C₁₉H₂₀N₂O₃

Degré de pureté : >98.0%(HPLC)

Couleur et forme : White to Almost white powder to crystaline

Masse moléculaire : 324.38

Ref: 3B-D5820

Dolasteron

CAS : 115956-12-2

Dolasteron

Formule : C₁₉H₂₀N₂O₃

Degré de pureté : 98%

Couleur et forme : Solid

Masse moléculaire : 324.37

Ref: 54-OR1026379

Dolasetron

CAS : 115956-12-2

Formule : C₁₉H₂₀N₂O₃

Couleur et forme : Off-White Solid

Masse moléculaire : 324.38

Ref: 4Z-D-097001

Dolasetron

CAS : 115956-12-2

Dolasetron

Formule : C₁₉H₂₀N₂O₃

Degré de pureté : ≥98%

Masse moléculaire : 324.37

Ref: 54-BUP13263

Dolasetron

CAS : 115956-12-2

Formule : C₁₉H₂₀N₂O₃

Masse moléculaire : 324.37

Ref: 7W-GP2323

Dolasetron-d4 (Indole-d4)

CAS : 115956-12-2

Formule : C₁₉H₁₆D₄N₂O₃

Couleur et forme : Off-White Solid

Masse moléculaire : 328.40

Ref: 4Z-D-097012

Dolasetron

CAS : 115956-12-2

Formule : C₁₉H₂₀N₂O₃

Degré de pureté : 98%

Couleur et forme : Solid

Masse moléculaire : 324.3737

Ref: IN-DA000H7X

Dolasetron

Produit contrôlé

CAS : 115956-12-2

Applications Bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist. Antiemetic.
References Boeijinga, P.H., et al.: Eur. J. Pharmacol., 219, 9 (1992), Miller, R.C., et al., Drug Dev. Res., 28, 87 (1993), Fauser, A.A., et al.: Eur. J. Cancer, 32, 1523 (1996), Graczyk, S.G., et al.: Anesth. Analg., 84, 325 (1997),

Formule : C₁₉H₂₀N₂O₃

Couleur et forme : Neat

Masse moléculaire : 324.37

Ref: TR-D528500

Dolasetron

CAS : 115956-12-2

Dolasetron (MDL-73147)(MDL-73147) is a serotonin 5-HT3 receptor antagonist. Dolasetron is used to treat nausea and vomiting following chemotherapy.

Formule : C₁₉H₂₀N₂O₃

Degré de pureté : 99.84% - 99.86%

Couleur et forme : Solid

Masse moléculaire : 324.3737

Ref: TM-T4568

Dolasetron

CAS : 115956-12-2

rel-(5s,6R,8r,9aS)-3-Oxooctahydro-1H-2,6-methanoquinolizin-8-yl 1H-indole-3-carboxylate

Formule : C₁₉H₂₀N₂O₃

Degré de pureté : 98%

Masse moléculaire : 324.37

Ref: IN-DG235697

Dolasetron

CAS : 115956-12-2

Formule : C₁₉H₂₀N₂O₃

Masse moléculaire : 324.4

Ref: BE-RMCD210000

Octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester

CAS : 115956-12-2

Dolasetron mesylate is a mesylate of the biologically active form of dolasetron, which is an octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester. Dolasetron has been shown to be effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy or radiation therapy. It has been approved for use in adults with cancer who have not responded to other treatments. Dolasetron is rapidly absorbed from the gastrointestinal tract and is then distributed throughout the body, including into the brain. The elimination half life of dolasetron mesylate is about 2 hours and it binds to plasma proteins. Dolasetron mesylate specifically binds to serotonin receptors, which are found on cells in the gut. This binding inhibits serotonin induced contraction of bowel smooth muscle cells.

Formule : C₁₉H₂₀N₂O₃

Degré de pureté : Min. 95%

Couleur et forme : White To Off-White To Grey Solid

Masse moléculaire : 324.37 g/mol

Ref: 3D-FD22592

Dolasetron

CAS : 115956-12-2

Formule : C₁₉H₂₀N₂O₃

Masse moléculaire : 324.38

Ref: ST-EA-CP-D39000