CAS 1228817-38-6

9-Cyclopentyl-2-((2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl)amino)-5-methyl-5,7,8,9-tetrahydro-6H-pyrimido[4,5-b][1,4]diazepin-6-one

CAS : 1228817-38-6

9-Cyclopentyl-2-((2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl)amino)-5-methyl-5,7,8,9-tetrahydro-6H-pyrimido[4,5-b][1,4]diazepin-6-one

Degré de pureté : 98%

Masse moléculaire : 480.61g/mol

Ref: 54-OR1073979

Mps1-IN-2

CAS : 1228817-38-6

Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor.

Formule : C₂₆H₃₆N₆O₃

Degré de pureté : 96.24% - 99.75%

Couleur et forme : Solid

Masse moléculaire : 480.6

Ref: TM-T1839

Mps1-IN-2

CAS : 1228817-38-6

Mps1-IN-2 is a potent and selective inhibitor of the mitotic kinase Mps1. It binds to the ATP-binding site of Mps1 and inhibits its activity, leading to cell death by apoptosis or necrosis. Mps1-IN-2 has shown anti-tumor activity against cancer cells in vitro and in vivo without any significant side effects, making it an attractive candidate for cancer therapy. The crystal structure of Mps1-IN-2 bound to the kinase domain revealed that it binds to a pocket with high affinity, where ATP binding leads to conformational changes that affect the other domains of the enzyme. This study has also shown that Mps1-IN-2 inhibits spindle formation and cellular proliferation in cancer cells.

Formule : C₂₆H₃₆N₆O₃

Degré de pureté : Min. 95%

Masse moléculaire : 480.6 g/mol

Ref: 3D-DZB81738