CAS 124-94-7
:Triamcinolone
Description :
Triamcinolone est un corticostéroïde synthétique aux propriétés anti-inflammatoires et immunosuppressives, couramment utilisé dans le traitement de diverses affections telles que les allergies, l'asthme et les troubles auto-immuns. Il se caractérise par sa capacité à inhiber la libération de médiateurs inflammatoires et à moduler les réponses immunitaires. La structure chimique de Triamcinolone comprend un squelette stéroïdien, qui contribue à son activité biologique et à sa pharmacocinétique. Il est généralement administré par voie topique, orale ou injectable, selon l'affection à traiter. Triamcinolone est connu pour sa puissance relativement élevée par rapport à d'autres corticostéroïdes, et peut être formulé sous diverses formes, y compris des crèmes, des pommades et des suspensions injectables. Son utilisation peut être associée à des effets secondaires, en particulier avec une utilisation à long terme, tels que la suppression surrénale, la prise de poids et un risque accru d'infections. Comme pour tout médicament, il est essentiel d'utiliser Triamcinolone sous surveillance médicale pour gérer efficacement les risques et les bénéfices potentiels.
Formule :C21H27FO6
InChI :InChI=1S/C21H27FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h5-7,13-16,23,25-26,28H,3-4,8-10H2,1-2H3/t13-,14-,15+,16-,18-,19-,20-,21-/m0/s1
Code InChI :InChIKey=GFNANZIMVAIWHM-OBYCQNJPSA-N
SMILES :F[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@](C(CO)=O)(O)[C@H](O)C3)[H])(CCC=4[C@]2(C)C=CC(=O)C4)[H]
Synonymes :- (11Beta,16Alpha)-9-Fluoro-11,16,17,21-Tetrahydroxypregna-1,4-Diene-3,20-Dione
- (11β,16α)-9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
- (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-4b-fluoro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
- (8Xi,11Beta,14Xi,16Alpha)-9-Fluoro-11,16,17,21-Tetrahydroxypregna-1,4-Diene-3,20-Dione
- 11β,16α,17α,21-Tetrahydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione
- 11β,16α,17α,21-Tetrahydroxy-9α-fluoro-Δ1,4-pregnadiene-3,20-dione
- 11β,16α,17α,21-Tetrahydroxy-9α-fluoro-Δ<sup>1,4</sup>-pregnadiene-3,20-dione
- 9-Alpha-Fluoro-11-Beta,16-Alpha,17-Alpha,21-Tetrahydroxypregna-1,4-Diene-3,20-Dione
- 9-Alpha-Fluoro-16-Alpha-Hydroxyprednisolone
- 9-Fluoro-11,16,17,21-Tetrahydroxypregna-1,4-Diene-3,20-Dione
- 9-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
- 9α-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
- 9α-Fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione
- 9α-Fluoro-16α-hydroxyprednisolone
- Acetonide
- Adcortyl
- Aristocort
- Cinolone
- Cl 19823
- Delphicort
- Fluoxiprednisolone
- Fluoxyprednisolone
- Kenacort
- Kenacort AG
- Ledercort
- Mycolog
- Nsc 13397
- Omicilon
- Polcortolon
- Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11β,16α)-
- Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,16α,17,21-tetrahydroxy-
- Rodinolone
- Triamcinlon
- Triamcinolon
- Triamcinolone Base
- Triancinolona
- Tricortale
- Voir plus de synonymes
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Triamcinolone
CAS :Formule :C21H27FO6Degré de pureté :>98.0%(HPLC)Couleur et forme :White to Almost white powder to crystalMasse moléculaire :394.44Triamcinolone
CAS :TriamcinoloneFormule :C21H27FO6Degré de pureté :99.5%Couleur et forme :White SolidMasse moléculaire :394.17917Triamcinolone
CAS :Halogenated derivatives of adrenal cortical hormonesFormule :C21H27FO6Couleur et forme :White Off-White PowderMasse moléculaire :394.1791711β,16α,17α,21-Tetrahydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione
CAS :Formule :C21H27FO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :394.4339Triamcinolone
CAS :Triamcinolone (Aristocort) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.Formule :C21H27FO6Degré de pureté :98.66% - 99.60%Couleur et forme :White SolidMasse moléculaire :394.43Triamcinolone (Triamcinolone Acetonide EP Impurity A)
CAS :Formule :C21H27FO6Masse moléculaire :394.44Triamcinolone
CAS :Formule :C21H27FO6Degré de pureté :97.5 - 102.5 %Couleur et forme :White to off-white crystalline powderMasse moléculaire :394.43Triamcinolone (Standard)
CAS :Triamcinolone (Standard) is the standard substance of Triamcinolone, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Triamcinolone (Aristocort) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry, triamcinolone binds to and activates the glucocorticoid receptor, which leads to translocation of the ligand-receptor complex to the nucleus and induces expression of glucocorticoid-responsive genes such as lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both mediators of inflammation. In addition, pro-inflammatory cytokine production, including interleukin (IL)-1and IL-6, and the activation of cytotoxic T-lymphocytes is also inhibited. T-cells are prevented from making IL-2 and proliferating. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis through increasing Ikappa-B expression and curtailing activation of nuclear factor (NF)kappa-B.Formule :C21H27FO6Couleur et forme :SolidMasse moléculaire :394.43GB/T 24800.2-2009 41 Glucocorticoids 100 µg/mL in Methanol
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Couleur et forme :MixtureTriamcinolone-d7 (Triamcinolone Acetonide EP Impurity A-d7)
CAS :Formule :C21H20FO6D7Masse moléculaire :401.49Triamcinolone
CAS :Produit contrôléTriamcinolone is a synthetic corticosteroid that reduces inflammation, suppresses the immune system, and relieves pain. It inhibits the production of cytokines and other inflammatory mediators by binding to specific receptors located in the cells of the immune system. Triamcinolone acetonide is an ester prodrug that is converted to triamcinolone in vivo. This drug has a long-term efficacy because it can be released slowly over time after intravitreal injection. The pharmacokinetic properties of triamcinolone are determined by its lipophilicity and water solubility. Triamcinolone acetonide has been shown to reduce inflammation in chronic arthritis, as well as reducing symptoms of eye disorders such as uveitis or glaucoma. This drug also prevents tumor growth by inhibiting protein synthesis and gene expression at the level of transcription, which leads to decreased cell proliferation or apoptosis.Formule :C21H27FO6Degré de pureté :Min. 97 Area-%Couleur et forme :White PowderMasse moléculaire :394.43 g/mol
