CAS 1241902-40-8

Formule : C21H31NO3

InChI : InChI=1S/C21H31NO3/c1-4-5-15-6-8-16(9-7-15)17-10-12-18(13-11-17)20(23)22-19(14(2)3)21(24)25/h10-16,19H,4-9H2,1-3H3,(H,22,23)(H,24,25)/t15?,16?,19-/m0/s1

Code InChI : SKMKUWKJBZSEJH-RJYAGPCLSA-N

SMILES : CCCC1CCC(CC1)C2=CC=C(C=C2)C(=O)N[C@@H](C(C)C)C(=O)O

GNE-0439

CAS : 1241902-40-8

GNE-0439

Formule : C₂₁H₃₁NO₃

Degré de pureté : ≥98%

Masse moléculaire : 345.48

Ref: 54-BUP22796

GNE-0439

CAS : 1241902-40-8

Ref: IN-DA024X9D

GNE-0439

CAS : 1241902-40-8

GNE-0439 is a small molecule that inhibits the activity of the sodium channel. It binds to the extracellular domain of the alpha subunit and blocks voltage-gated sodium channels, which are necessary for action potential propagation. GNE-0439 is a potent inhibitor of neuronal and cardiomyocyte Na(+) current, with an IC50of 2 nM in rat neurons and 1 μM in human atrial myocytes. In addition, GNE-0439 inhibits voltage-gated potassium channels (IC50 = 200 nM) and glutamate receptors (IC50 = 2 μM). GNE-0439 is a high purity compound that has been synthesized according to Good Manufacturing Practices (GMP). It is >98% pure as determined by HPLC analysis.

Formule : C₂₁H₃₁NO₃

Degré de pureté : Min. 95%

Masse moléculaire : 345.5 g/mol

Ref: 3D-RZB90240

GNE-0439

CAS : 1241902-40-8

GNE-0439 is a Nav1.7-selective inhibitor (IC50 0.34 μM), also targeting Nav1.5 and mutant N1742K channels, valuable for ion channel research.

Formule : C₂₁H₃₁NO₃

Degré de pureté : 99.60%

Couleur et forme : White Solid

Masse moléculaire : 345.48

Ref: TM-T11437