CAS 2304947-71-3

Formule : C19H18BrIN4O2

InChI : InChI=1S/C19H18BrIN4O2/c20-15-2-1-3-16-17(15)23-19(27)25(16)14-8-10-24(11-9-14)18(26)22-13-6-4-12(21)5-7-13/h1-7,14H,8-11H2,(H,22,26)(H,23,27)

Code InChI : FZLKVWWPFOLPKF-UHFFFAOYSA-N

SMILES : C1CN(CCC1N2C3=C(C(=CC=C3)Br)NC2=O)C(=O)NC4=CC=C(C=C4)I

4-(4-Bromo-2-Oxo-2,3-Dihydro-1H-Benzo[d]Imidazol-1-Yl)-N-(4-Iodophenyl)Piperidine-1-Carboxamide

CAS : 2304947-71-3

4-(4-Bromo-2-Oxo-2,3-Dihydro-1H-Benzo[d]Imidazol-1-Yl)-N-(4-Iodophenyl)Piperidine-1-Carboxamide

Formule : C₁₉H₁₈BrIN₄O₂

Degré de pureté : 99%

Masse moléculaire : 541.18

Ref: 54-OR1023008

TH5487

CAS : 2304947-71-3

TH5487

Formule : C₁₉H₁₈BrIN₄O₂

Degré de pureté : ≥95%

Masse moléculaire : 541.18

Ref: 54-BUP09023

TH 5487

CAS : 2304947-71-3

Formule : C₁₉H₁₈BrIN₄O₂

Degré de pureté : 99%

Couleur et forme : Solid

Masse moléculaire : 541.1803

Ref: IN-DA01KL47

TH5487

CAS : 2304947-71-3

TH5487 is an potent inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1)( IC50 of 342 nM)

Formule : C₁₉H₁₈BrIN₄O₂

Degré de pureté : 98.38% - 98.73%

Couleur et forme : Solid

Masse moléculaire : 541.18

Ref: TM-T8119

TH 5487

CAS : 2304947-71-3

Specific inhibitor of 8-oxoguanine glycosylase OGG1 with IC50 in submicromolar range. The compound inhibits binding of OGG1 to its substrate 8-oxoguanine, a guanine analog generated in the presence of reactive oxygen species (ROS). It was shown that TH5487 decreases inflammation level by inhibiting the base excision DNA repair in mice and altering the OGG1 chromatin dynamics. The compound also has implications in cancer biology since OGG1 inhibitors sensitise tumours to chemotherapy.

Formule : C₁₉BrH₁₈IN₄O₂

Degré de pureté : Min. 95%

Couleur et forme : Solid

Masse moléculaire : 541.18 g/mol

Ref: 3D-BT168024

4-(4-Bromo-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-(4-iodophenyl)piperidine-1-carboxamide

CAS : 2304947-71-3

Degré de pureté : 98%

Masse moléculaire : 541.1870117

Ref: 10-F866930