CAS 23720-80-1
:Nardosinone
Description :
Nardosinone est un composé sesquiterpénique naturel principalement dérivé de la plante Nardostachys jatamansi, communément connue sous le nom de spikenard. Il se caractérise par sa structure bicyclique complexe, qui contribue à ses propriétés chimiques uniques. Nardosinone présente une gamme d'activités biologiques, y compris des effets anti-inflammatoires, antimicrobiens et des effets neuroprotecteurs potentiels, ce qui le rend intéressant pour la recherche pharmacologique. Le composé se trouve généralement dans des huiles essentielles et des extraits de la plante, et sa présence est souvent associée à des pratiques médicinales traditionnelles. En termes de solubilité, Nardosinone est généralement plus soluble dans des solvants organiques que dans l'eau, ce qui est courant pour de nombreux terpènes. Sa structure moléculaire comprend plusieurs groupes fonctionnels qui peuvent participer à diverses réactions chimiques, améliorant ses applications potentielles tant en chimie des produits naturels qu'en développement thérapeutique. Dans l'ensemble, Nardosinone représente un composé significatif dans le domaine des produits naturels, avec des études en cours visant à élucider son éventail complet d'effets biologiques et d'utilisations potentielles en médecine.
Formule :C15H22O3
InChI :InChI=1S/C15H22O3/c1-9-6-5-7-10-11(16)8-12-13(15(9,10)4)14(2,3)18-17-12/h7,9,12-13H,5-6,8H2,1-4H3/t9-,12-,13+,15+/m1/s1
Code InChI :InChIKey=KXGHHSIMRWPVQM-JWFUOXDNSA-N
SMILES :C[C@@]12[C@]3([C@@](CC(=O)C1=CCC[C@H]2C)(OOC3(C)C)[H])[H]
Synonymes :- (3aR,9R,9aR,9bS)-1,1,9,9a-tetramethyl-1,3a,4,7,8,9,9a,9b-octahydro-5H-naphtho[2,1-c][1,2]dioxol-5-one
- (3aR,9R,9aR,9bS)-1,3a,4,7,8,9,9a,9b-Octahydro-1,1,9,9a-tetramethyl-5H-naphtho[2,1-c][1,2]dioxol-5-one
- 5H-Naphtho[2,1-c][1,2]dioxol-5-one, 1,3a,4,7,8,9,9a,9b-octahydro-1,1,9,9a-tetramethyl-, (3aR,9R,9aR,9bS)-
- 5H-Naphtho[2,1-c][1,2]dioxol-5-one, 1,3a,4,7,8,9,9a,9b-octahydro-1,1,9,9a-tetramethyl-, [3aR-(3aα,9α,9aα,9bα)]-
- Nardosinon
- Nardosinone
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(3aR,9R,9aR,9bS)-1,1,9,9a-Tetramethyl-3a,4,7,8,9,9a-hexahydro-1H-naphtho[2,1-c][1,2]dioxol-5(9bH)-one
CAS :Formule :C15H22O3Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :250.3334Nardosinone
CAS :Nardosinone is an enhancer of nerve growth factor and possesses a wide range of pharmacological effects, including sedative, adaptogen-like, anti-depressive, anti-leukemic, anti-tumorous, and anti-trypanosomal activities. It has a wide spectrum of targets including PI3K,Akt,MEK,ERK, PKA, MAPK.Formule :C15H22O3Degré de pureté :95%~99%Masse moléculaire :250.338Nardosinone (Standard)
CAS :Nardosinone (Standard) is a reference standard for research and analysis in studies involving Nardosinone. 1. Nardosinone has inhibitory effect on Ang II-induced hypertrophy in H9c2 cells, might be mediated by targeting PI3K/Akt and MEK/ERK signaling pathways. 2. Nardosinone could protect against the neuronal injury exposed to OGD, which may be relevant to the promotion of PKA and ERK signaling pathway. 3. Nardosinone enhances staurosporine- or dbcAMP-induced neurite outgrowth from PC12D cells, probably by amplifying both the MAP kinase-dependent and -independent signaling pathways of dbcAMP and staurosporine. 4. The enhancement of NGF-induced neurite outgrowth from PC12D cells by Nardosinone involves activation of a down-stream step of the MAP kinase-dependent cascade of NGF coupled with PKC.Formule :C15H22O3Masse moléculaire :250.3334Nardosinone
CAS :Produit contrôléApplications Nardosinone reduces neuronal injury and protects H9c2 cardiac cells from angiotensin II-induced hypertrophy which may give rise to heart failure. Enhancer of nerve growth factor (NGF).
References Du, M. et al.: J. Huazhong Uni. Sci. Tech. Med. Serv., 33, 822 (2013); Li, P. et al.: Dev. Brain Res., 145, 177 (2003);Formule :C15H22O3Couleur et forme :NeatMasse moléculaire :250.33(3aR,9R,9aR,9bS)-1,1,9,9a-Tetramethyl-3a,4,7,8,9,9a-hexahydro-1H-naphtho[2,1-c][1,2]dioxol-5(9bH)-one
CAS :Formule :C15H22O3Degré de pureté :99%Masse moléculaire :250.33Nardosinone
CAS :Nardosinone inhibits H9c2 cell hypertrophy, protects neurons from OGD, and boosts neurite outgrowth by modifying key signaling pathways.Formule :C15H22O3Degré de pureté :98.82% - 99%Couleur et forme :SolidMasse moléculaire :250.3334Nardosinone
CAS :Oxygen-heterocyclic compoundFormule :C15H22O3Degré de pureté :≥ 98.0 % (HPLC)Couleur et forme :CrystalsMasse moléculaire :250.34Nardosinone
CAS :Produit contrôléNardosinone is a secoiridoid compound, which is a natural product derived from the roots of the plant Nardostachys jatamansi, commonly known as spikenard. The source of Nardosinone is a flowering plant that is native to the Himalayan region and has been traditionally used in Ayurvedic medicine for its therapeutic properties. The mode of action of Nardosinone involves modulation of neurotransmitter systems, inhibition of neuroinflammation, and protection against oxidative damage, contributing to its neuroprotective effects. Nardosinone exhibits potential applications in the treatment of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, due to its ability to improve cognitive function and mitigate neuronal damage. Additionally, it is being investigated for its potential role in mood regulation and anti-anxiety effects. Given its intriguing pharmacological profile, Nardosinone is the subject of ongoing research aimed at understanding its comprehensive mechanisms and potential therapeutic benefits in neuroscience.Formule :C15H22O3Degré de pureté :Min. 95%Couleur et forme :SolidMasse moléculaire :250.33 g/mol
![(3aR,9R,9aR,9bS)-1,1,9,9a-Tetramethyl-3a,4,7,8,9,9a-hexahydro-1H-naphtho[2,1-c][1,2]dioxol-5(9bH)-…](https://static.cymitquimica.com/products/IN/thumb/DA00C4G3.jpg)
