CAS 2559738-69-9

Formule : C24H27ClN4O3S

InChI : InChI=1S/C24H26N4O3S.ClH/c29-24(28-15-13-27(14-16-28)17-18-6-7-18)20-8-10-21(11-9-20)26-32(30,31)22-5-1-3-19-4-2-12-25-23(19)22;/h1-5,8-12,18,26H,6-7,13-17H2;1H

Code InChI : YONQEXWSPOESJA-UHFFFAOYSA-N

SMILES : C1CC1CN2CCN(CC2)C(=O)C3=CC=C(C=C3)NS(=O)(=O)C4=CC=CC5=C4N=CC=C5.Cl

Mitapivat hydrochloride

CAS : 2559738-69-9

Mitapivat (AG-348) hydrochloride is an orally active and selective allosteric activator of pyruvate kinase R (PK-R). It enhances the PK-R-catalyzed conversion of phosphoenolpyruvate to pyruvate, thereby promoting the glycolysis pathway, increasing ATP production in red blood cells, and decreasing 2,3-diphosphoglycerate (2,3-DPG) levels. Mitapivat hydrochloride is being investigated for potential use in the study of pyruvate kinase deficiency and other anemia-related disorders.

Formule : C₂₄H₂₇ClN₄O₃S

Couleur et forme : Solid

Masse moléculaire : 487.014

Ref: TM-T206172