CAS 2752441-61-3

APL-4098

CAS : 2752441-61-3

APL-4098 is an orally active, selective, ATP-competitive GCN2 inhibitor with a Ki of 4.39 nM and a Kd of 2.9 nM. It reduces the phosphorylation levels of eIF2α and the expression of ATF4. APL-4098 impairs mitochondrial function and exhibits cytotoxicity against primary acute myeloid leukemia cells. It is applicable in studies related to acute myeloid leukemia.

Formule : C₁₇H₁₂ClFN₆O₃S

Masse moléculaire : 434.83

Ref: TM-T218287