CAS 3070346-91-4

R1-ICR-5

CAS : 3070346-91-4

R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1). Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.

Formule : C₅₄H₇₀N₈O₇S₂

Couleur et forme : Solid

Masse moléculaire : 1007.31

Ref: TM-T206654