CAS 3070346-91-4

Formule : C54H70N8O7S2

InChI : InChI=1S/C54H70N8O7S2/c1-34-43(59-53(68)69-41-17-13-12-14-18-41)27-39(31-55-34)38-25-26-42-45(28-38)71-52(58-42)61-47(65)20-16-11-9-7-6-8-10-15-19-46(64)60-49(54(3,4)5)51(67)62-32-40(63)29-44(62)50(66)56-30-36-21-23-37(24-22-36)48-35(2)57-33-70-48/h21-28,31,33,40-41,44,49,63H,6-20,29-30,32H2,1-5H3,(H,56,66)(H,59,68)(H,60,64)(H,58,61,65)/t40-,44+,49-/m1/s1

Code InChI : KVDLSQZBDWJNSG-VINRIKPSSA-N

SMILES : CC1=C(C=C(C=N1)C2=CC3=C(C=C2)N=C(S3)NC(=O)CCCCCCCCCCC(=O)N[C@H](C(=O)N4C[C@@H](C[C@H]4C(=O)NCC5=CC=C(C=C5)C6=C(N=CS6)C)O)C(C)(C)C)NC(=O)OC7CCCCC7

R1-ICR-5

CAS : 3070346-91-4

R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1). Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.

Formule : C₅₄H₇₀N₈O₇S₂

Couleur et forme : Solid

Masse moléculaire : 1007.31

Ref: TM-T206654