CAS 3074990-47-6

Formule : C23H18ClF3N2O2

InChI : InChI=1S/C23H18ClF3N2O2/c1-14-10-15(19-13-29(8-9-30)20-6-7-28-22(24)21(19)20)12-18(11-14)31-17-4-2-16(3-5-17)23(25,26)27/h2-7,10-13,30H,8-9H2,1H3

Code InChI : ZSCUPUNDYXWNOA-UHFFFAOYSA-N

SMILES : CC1=CC(=CC(=C1)OC2=CC=C(C=C2)C(F)(F)F)C3=CN(C4=C3C(=NC=C4)Cl)CCO

TEAD-IN-23

CAS : 3074990-47-6

TEAD-IN-23 (Compound 22) is a potent pan-TEAD inhibitor with an IC₅₀ of 10 nM. It exhibits strong antiproliferative activity against NCI-H226 and MSTO-211H cell lines. In the MSTO-211H xenograft tumor model, TEAD-IN-23 causes complete tumor regression. This compound is suitable for research on mesothelioma and hepatocellular carcinoma.

Formule : C₂₃H₁₈ClF₃N₂O₂

Masse moléculaire : 446.85

Ref: TM-T214277