CAS 3076446-44-8

Formule : C29H35N3O4

InChI : InChI=1S/C29H35N3O4/c1-3-7-22-20-26(33)36-28-23(22)11-12-25(35-19-18-31-16-14-30(2)15-17-31)27(28)29(34)32-13-6-9-21-8-4-5-10-24(21)32/h4-5,8,10-12,20H,3,6-7,9,13-19H2,1-2H3

Code InChI : LNTXOIHSBUUKNJ-UHFFFAOYSA-N

SMILES : CCCC1=CC(=O)OC2=C1C=CC(=C2C(=O)N3CCCC4=CC=CC=C43)OCCN5CCN(CC5)C

Topobexin

CAS : 3076446-44-8

Topobexin (Topobexin 9) is a highly selective TOP2B inhibitor. It selectively inhibits TOP2B in vitro and stabilizes TOP2B on DNA. Topobexin offers significant protection to cardiomyocytes against DAU-induced damage. In rabbit models, Topobexin prevents anthracycline-induced cardiotoxicity and the decrease in left ventricular contractile function caused by DAU.

Formule : C₂₉H₃₅N₃O₄

Masse moléculaire : 489.61

Ref: TM-T211232