CAS 3092208-36-8

Formule : C44H46N10O5

InChI : InChI=1S/C44H46N10O5/c45-40-38-39(28-6-13-33(14-7-28)59-32-4-2-1-3-5-32)49-54(41(38)47-26-46-40)30-10-8-29(9-11-30)51-20-18-50(19-21-51)23-27-24-52(25-27)31-12-15-34-35(22-31)44(58)53(43(34)57)36-16-17-37(55)48-42(36)56/h1-7,12-15,22,26-27,29-30,36H,8-11,16-21,23-25H2,(H2,45,46,47)(H,48,55,56)

Code InChI : MSDFCFUNLHSPFM-UHFFFAOYSA-N

SMILES : C1CC(CCC1N2CCN(CC2)CC3CN(C3)C4=CC5=C(C=C4)C(=O)N(C5=O)C6CCC(=O)NC6=O)N7C8=NC=NC(=C8C(=N7)C9=CC=C(C=C9)OC1=CC=CC=C1)N

DFCI-002-06

CAS : 3092208-36-8

DFCI-002-06 is an orally active dual-targeted HCK/BTK PROTAC degrader, demonstrating DC₅₀ values of 1.3 nM for HCK and 4.5 nM for BTK. It retains superior antitumor activity compared to dual-targeted HCK/BTK inhibitors and induces apoptosis in cancer cells. DFCI-002-06 is applicable in studies of MYD88-mutant B-cell malignancies.

Formule : C₄₄H₄₆N₁₀O₅

Masse moléculaire : 794.92

Ref: TM-T217183