CAS 3104736-80-0

Formule : C39H34Cl2F3N5O8S

InChI : InChI=1S/C39H34Cl2F3N5O8S/c40-23-10-16-32(30(20-23)48-58(55,56)25-13-14-28(41)27(21-25)39(42,43)44)57-24-11-8-22(9-12-24)35(51)46-19-4-2-1-3-18-45-29-7-5-6-26-34(29)38(54)49(37(26)53)31-15-17-33(50)47-36(31)52/h5-14,16,20-21,31,45,48H,1-4,15,17-19H2,(H,46,51)(H,47,50,52)

Code InChI : RFHLRRLBVWDPOD-UHFFFAOYSA-N

SMILES : C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCCCCCNC(=O)C4=CC=C(C=C4)OC5=C(C=C(C=C5)Cl)NS(=O)(=O)C6=CC(=C(C=C6)Cl)C(F)(F)F

LUF7996

CAS : 3104736-80-0

LUF7996 is a CCR2-targeting PROTAC degrader with a DC50 of 2.6 μM, designed to degrade CCR2 effectively. It binds simultaneously to CCR2 and the E3 ligase cereblon, demonstrating sustained and concentration-dependent degradation of CCR2. The compound induces CCR2 degradation via the lysosomal pathway and effectively inhibits monocyte migration in vitro.

Formule : C₃₉H₃₄Cl₂F₃N₅O₈S

Masse moléculaire : 860.68

Ref: TM-T215953