CAS 3119435-52-5

Formule : C16H13Cl2N3O4

InChI : InChI=1S/C16H13Cl2N3O4/c17-10-5-8(25-16(3-4-16)15-21-19-7-24-15)6-11(18)13(10)9-1-2-12(22)20-14(9)23/h5-7,9H,1-4H2,(H,20,22,23)

Code InChI : OHNLXFGXOGKALQ-UHFFFAOYSA-N

SMILES : C1CC(=O)NC(=O)C1C2=C(C=C(C=C2Cl)OC3(CC3)C4=NN=CO4)Cl

NEK7 degrader-3

CAS : 3119435-52-5

NEK7degrader-3 is an orally active NEK7 molecular glue degrader capable of crossing the blood-brain barrier, with a DC50 of 31.1 nM. It facilitates the interaction between NEK7 and the E3 ligase cereblon, promoting NEK7 proteasomal degradation and reducing inflammation mediated by the NLRP3 inflammasome. NEK7degrader-3 inhibits caspase-1 activity, releases cytokines IL-1β, IL-1α, and IL-18, and decreases pyroptosis-related plasma membrane permeability. It shows anti-inflammatory effects in an LPS-induced neuroinflammation mouse model and is useful for studying neuroinflammation.

Formule : C₁₆H₁₃Cl₂N₃O₄

Masse moléculaire : 382.20

Ref: TM-T218506