CAS 42553-65-1

Crocin

Description :

Crocin est un pigment caroténoïde principalement dérivé de la plante de safran, Crocus sativus. Il est connu pour sa couleur jaune-orange vibrante et est responsable de la teinte caractéristique du safran. Chimiquement, Crocin est un dérivé glycosylé de la crocétine, consistant en un squelette d'acide dicarboxylique avec plusieurs moitiés de sucre attachées, ce qui améliore sa solubilité dans l'eau. Crocin présente diverses activités biologiques, y compris des effets antioxydants, anti-inflammatoires et des effets neuroprotecteurs potentiels, ce qui le rend intéressant tant dans l'industrie alimentaire que pharmaceutique. Il est souvent étudié pour ses applications thérapeutiques potentielles, en particulier dans le contexte des maladies neurodégénératives et des troubles de l'humeur. De plus, Crocin est reconnu pour son rôle en tant que colorant naturel dans les produits alimentaires, offrant une alternative sûre aux colorants synthétiques. Sa stabilité et sa biodisponibilité sont des facteurs importants dans son application, et la recherche en cours continue d'explorer sa gamme complète de bienfaits et d'utilisations pour la santé.

Formule : C₄₄H₆₄O₂₄

InChI : InChI=1S/C44H64O24/c1-19(11-7-13-21(3)39(59)67-43-37(57)33(53)29(49)25(65-43)17-61-41-35(55)31(51)27(47)23(15-45)63-41)9-5-6-10-20(2)12-8-14-22(4)40(60)68-44-38(58)34(54)30(50)26(66-44)18-62-42-36(56)32(52)28(48)24(16-46)64-42/h5-14,23-38,41-58H,15-18H2,1-4H3/b6-5+,11-7+,12-8+,19-9+,20-10+,21-13+,22-14+/t23-,24-,25-,26-,27-,28-,29-,30-,31+,32+,33+,34+,35-,36-,37-,38-,41-,42-,43+,44+/m1/s1

Code InChI : InChIKey=SEBIKDIMAPSUBY-RTJKDTQDSA-N

SMILES : C(O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H]2O[C@@H](OC(/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C(O[C@@H]3O[C@H](CO[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)=O)\C)\C)/C)/C)=O)[C@H](O)[C@@H](O)[C@@H]2O

Synonymes :

• 6-O-β-D-glucopyranosyl-1-O-[(2E,4E,6E,8E,10Z,12E,14Z)-16-{[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]methyl}-2,6,11,15-tetramethylheptadeca-2,4,6,8,10,12,14,16-octaenoyl]-β-D-glucopyranose
• 8,8′-Diapo-ψ,ψ-carotenedioic acid, bis(6-O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-β-<smallcap>D</span>-glucopyranosyl) ester
• Crocetin bis(gentiobiosyl) ester
• Crocetin di(β-<span class="text-smallcaps">D</span>-gentiobiosyl) ester
• Crocetin di-β-gentiobiosyl ester
• Crocetin digentiobioside
• Crocin
• Crocin (gardenia fruit
• Crocin 1
• Crocin 4
• Crocin A
• Kiriyasu Oil Yellow GY
• Saffron
• Saffron (Natural)
• Trans-crocin-1
• all-trans-Crocetin di-β-<span class="text-smallcaps">D</span>-gentiobiosyl ester
• bis[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl] (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioate (non-preferred name)
• trans-Crocetin di(β-<span class="text-smallcaps">D</span>-gentiobiosyl) ester
• α-Crocin
• β-<span class="text-smallcaps">D</smallcap>-Glucopyranose, 6-O-β-<smallcap>D</span>-glucopyranosyl-, 1,1′-[(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate]
• 8,8′-Diapo-ψ,ψ-carotenedioic acid, bis(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl) ester

Crocin (Gardenia Fruits Extract)

CAS : 42553-65-1

Formule : C₄₄H₆₄O₂₄

Degré de pureté : multi component mixture(HPLC)

Couleur et forme : Light yellow to Brown powder to crystal

Masse moléculaire : 976.97

Ref: 3B-C1527

Crocin

CAS : 42553-65-1

Crocin

Formule : C₄₄H₆₄O₂₄

Degré de pureté : 98%

Couleur et forme : Solid

Masse moléculaire : 976.97

Ref: 54-OR1026433

Crocin

CAS : 42553-65-1

Crocin: a water-soluble carotenoid in saffron, used for flavoring, coloring, and in Chinese medicine; inhibits TNF-alpha-induced apoptosis in cells.

Formule : C₄₄H₆₄O₂₄

Degré de pureté : 98.13% - 99.74%

Couleur et forme : Red Solid

Masse moléculaire : 976.9646

Ref: TM-T2823

Crocin

CAS : 42553-65-1

Crocin

Formule : C₄₄H₆₄O₂₄

Degré de pureté : 99.5%

Couleur et forme : Solid

Masse moléculaire : 976.96

Ref: 54-BUP00203

Crocin I, 98%

CAS : 42553-65-1

Formule : C₄₄H₆₄O₂₄

Degré de pureté : (HPLC) ≥ 98.0%

Couleur et forme : Orange to dark red powder

Masse moléculaire : 976.97

Ref: 7W-GY1779

Crocin (Standard)

CAS : 42553-65-1

Crocin (Standard) is the standard substance of Crocin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Crocin (Gardenia Yellow) is a water-soluble carotenoid pigment of saffron (Crocus sativus L. ) that has been used as a spice for flavoring and coloring food preparations, and in Chinese traditional medicine as an anodyne or tranquilizer. Crocin suppresses tumor necrosis factor (TNF)alpha-induced apoptosis of pheochromocytoma (PC12) cells by modulating mRNA expressions of Bcl-2 family proteins, which trigger downstream signals culminating in caspase-3 activation followed by cell death. Crocin prevented the activation of nSMase by enhancing the transcription of gamma-glutamylcysteinyl synthase, which contributes to a stable glutathione supply that blocks the activity of nSMase.

Formule : C₄₄H₆₄O₂₄

Masse moléculaire : 976.9646

Ref: TM-TMSM-0823

Crocin

CAS : 42553-65-1

Formule : C₄₄H₆₄O₂₄

Degré de pureté : 95%

Couleur et forme : Solid

Masse moléculaire : 976.9646

Ref: IN-DA00BXRM

Crocin I

CAS : 42553-65-1

Crocin is a water-soluble carotenoid pigment of saffron (Crocus sativus L.), it has been used as a spice for flavoring and coloring food preparations. Crocin has anti-inflammatory, anti-oxidative, anti-apoptotic, anti-asthma, anti-cancer, and hypolipidemic effects. Crocin improves toxic effects of diazinon via reducing lipid peroxidation and restoring altered contractile and relaxant responses in rat aorta; it also protects retinal photoreceptors against light-induced cell death. Crocin can also promote ovarian cancer HO-8910 cell apoptosis, most likely by increasing p53 and Fas/APO-1 expression, and then activating the apoptotic pathway regulated by Caspase-3.

Formule : C₄₄H₆₄O₂₄

Degré de pureté : 95%~99%

Masse moléculaire : 976.972

Ref: BP-BP0406

Crocin

CAS : 42553-65-1

Stability Light Sensitive
Applications Crocin, is a natural carotenoid derived the flowers crocus and gardenia. Crocin has been shown to be a potent antioxidant. It has also been shown to have an antiproliferative action against cancer cells in vitro, and also possessing possible antidepressant properties.
References Zheng, Y. Q., et al.: Brain Res., 1138, 86 (2006); Hosseinzadeh, H., et al.: PTR, 24 (5), 726 (2010); Ochiai, T., et al.: Biochim. Biophys. Acta., 1770(4), 578 (2006);

Formule : C₄₄H₆₄O₂₄

Couleur et forme : Neat

Masse moléculaire : 976.96

Ref: TR-C794945

Crocin

CAS : 42553-65-1

(2E,4E,6E,8E,10E,12E,14E)-Bis((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl) 2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioate

Formule : C₄₄H₆₄O₂₄

Degré de pureté : 95%

Masse moléculaire : 976.96

Ref: IN-DG38996

Crocin

CAS : 42553-65-1

Natural glycoside

Formule : C₄₄H₆₄O₂₄

Degré de pureté : ≥ 95.0 % (HPLC)

Couleur et forme : Powder

Masse moléculaire : 976.98

Ref: 5G-80391

Crocin I

CAS : 42553-65-1

Formule : C₄₄H₆₄O₂₄

Couleur et forme : Solid

Masse moléculaire : 977.0

Ref: BE-BePure-21470

CrocinⅠ

CAS : 42553-65-1

Formule : C₄₄H₆₄O₂₄

Couleur et forme : Solid

Masse moléculaire : 977.0

Ref: BE-RMT19100

Crocin

CAS : 42553-65-1

Degré de pureté : 95%

Masse moléculaire : 976.972

Ref: 10-F979316

Crocin I

CAS : 42553-65-1

Crocin is a pharmaceutical product which is an antipyretic and analgesic medication, primarily composed of paracetamol (acetaminophen). It is synthesized through chemical processes originally derived from coal tar, although modern production predominantly utilizes petrochemical sources. The mode of action of Crocin involves the inhibition of cyclooxygenase (COX) enzymes, particularly COX-2, in the central nervous system. This action leads to a decrease in the synthesis of prostaglandins, which are responsible for pain and fever.

Formule : C₄₄H₆₄O₂₄

Degré de pureté : Min. 98.0 Area-%

Couleur et forme : Powder

Masse moléculaire : 976.96 g/mol

Ref: 3D-OC08286

Crocin - microscopy grade

CAS : 42553-65-1

Crocin is a carotenoid found in the fruit of Crocus sativus. It has been shown to have potential anticancer activity, as well as antioxidant and anti-inflammatory properties. Crocin has demonstrated significant cytotoxicity against cancer cells in vitro. The mechanism of action is not fully understood, but it may be due to its ability to inhibit oxidative injury and receptor activity. Crocin has also been shown to have an effect on eye disorders such as retinitis pigmentosa and macular degeneration, which may be due to its antioxidant properties. The analytical method for crocin is high performance liquid chromatography (HPLC). HPLC separation is achieved using a reversed-phase column with gradient elution using water, acetonitrile and methanol. Preparative HPLC is used for isolation from natural sources.

Formule : C₄₄H₆₄O₂₄

Degré de pureté : Min. 95%

Couleur et forme : Powder

Masse moléculaire : 976.96 g/mol

Ref: 3D-FC158408