CAS 432531-71-0

(E/Z)-Necrosulfonamide

CAS : 432531-71-0

N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide

Formule : C₁₈H₁₅N₅O₆S₂

Degré de pureté : 98%

Masse moléculaire : 461.47

Ref: IN-DG01145517

(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide

CAS : 432531-71-0

Formule : C₁₈H₁₅N₅O₆S₂

Degré de pureté : 98%

Couleur et forme : Solid

Masse moléculaire : 461.4716

Ref: IN-DA00DF2R

(E/Z)-Necrosulfonamide

CAS : 432531-71-0

(E/Z)-Necrosulfonamide

Formule : C₁₈H₁₅N₅O₆S₂

Degré de pureté : ≥95%

Masse moléculaire : 461.47

Ref: 54-BUP09704

(E/Z)-Necrosulfonamide

CAS : 432531-71-0

(E/Z)-Necrosulfonamide is a novel inhibitor of MLKL.

Formule : C₁₈H₁₅N₅O₆S₂

Degré de pureté : 97.62% - 98%

Couleur et forme : Solid

Masse moléculaire : 461.47

Ref: TM-T7129

Necrosulfonamide

Produit contrôlé

CAS : 432531-71-0

Applications Necrosulfonamide specifically blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation. RIP3 is a key signalling molecule in the programmed necrosis (necroptosis) pathway.
References Sun, L. et al.: Cell, 148, 213 (2012);

Formule : C₁₈H₁₅N₅O₆S₂

Couleur et forme : Neat

Masse moléculaire : 461.47

Ref: TR-N388600

MLKL Inhibitor, Necrosulfonamide

CAS : 432531-71-0

Necrosulfonamide is a chemical inhibitor of MLKL, a protein that is involved in apoptosis and necroptosis. Necrosulfonamide has been shown to inhibit the kinase activity of MLKL and induce cell death by apoptosis or necroptosis. It has also been shown to inhibit cancer cell growth and suppress tumor development in animal models. Necrosulfonamide binds to MLKL and prevents its interaction with other proteins, inhibiting mitochondrial functions and leading to necrosis or necroptosis. Necrosulfonamide has also shown anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis.

Formule : C₁₈H₁₅N₅O₆S₂

Degré de pureté : Min. 95%

Masse moléculaire : 461.47 g/mol

Ref: 3D-HSA53171