Dérivés d'acides aminés

<p>gamma-L-Glutamyl hydrazide</p>

<p>This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci</p>

<p>L-Histidine methyl ester dihydrochloride is used to prepare optically pure L-(+)-ergothioneine. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar prod</p>

<p>Endogenous opioid neurotransmitter that is an agonist at mu- and delta-opioid receptors</p>

A hypothalamic opioid peptide related to Leu-enkephalin and dynorphin A with potent activity in the guinea-pig ileum assay.

The peptide hormone osteocalcin is involved not only in bone formation, it also plays an important role in glucose metabolism and could regulate testosteron. In mice, only the completely decarboxylated form of the peptide shows the latter hormonal activities, whereas in humans, osteocalcin, partially decarboxylated osteocalcins, and the uncarboxylated peptide seem to be involved. Generally, obese individuals have been shown to have lower osteocalcin(s) levels than non-obese controls, and type 2 diabetic individuals have lower plasma osteocalcin than non-diabetic individuals.

Potential degradation product of exenatide resulting from aspartimide formation and cleavage.

Deamidation product of glucagon.

GLP-1 (7-36) amide is secreted from the lower small intestine and shows a strong insulinotropic effect. GLP-1 (7-36) amide is considered as the most important incretin hormone. Its action is mediated by receptors expressed by the endocrine pancreatic B-cells. Considerable interest has focused on the development of this peptide as a therapeutic strategy for non-insulin-dependent (type 2 ) diabetes mellitus and associated neuropathy.

µ-Conotoxin GIIIA from the Conus geographus L. venom blocks with very high selectivity the muscle subtype of sodium channels.

GRF is the hypothalamic peptide hormone that specifically stimulates synthesis and release of the growth hormone by somatotropic cells of the anterior pituitary gland.

<p>Bachem ID: 4012222.</p>

Potential impurity of exenatide.

<p>Bachem ID: 4034554.</p>

Antagonist of human MC1, MC3 and MC4 receptors.

Substrate for assays of aminopeptidase M and leucine aminopeptidase. Its use for histochemical purposes has been described.

A synthetic chromogenic substrate for the determination of serinic and thiol proteases, e.g. urokinase, trypsin, cathepsin B, cathepsin L, and papain.

<p>Bachem ID: 4029233.</p>

Ac-DEVD-AFC is a sensitive fluorescent substrate for the assay of caspase-3 activity. The trifluoromethyl substituent of the fluorophore improves the membrane permeability of the substrate. CAS-Number (net) 141258-58-4 .

Deltorphin B, a selective δ-opioid receptor agonist isolated from the skin of Phyllomedusa bicolor.

Former CAS-number 26469-81-8.

Glucagon-Like Peptide 1 (GLP-1) is synthesized by posttranslational processing of proglucagon in the intestine and pancreas and plays an important role in metabolic homeostasis. Among the different molecular forms, such as GLP-1 (7-36) amide and GLP-1 (7-37), the function of GLP-1 (1-37) has been unclear. GLP-1 (1-37) was shown to convert intestinal epithelial cells into insulin-producing cells. These observations turned GLP-1 (1-37) into a new promising therapeutic compound for the treatment of diabetes mellitus. In animal models of dilated cardiomyopathy, hypertensive heart failure, and myocardial infarction, GLP-1 has shown a remarkable cardioprotective activity.

Most circulating ghrelin is des-octanoyl ghrelin. The non-acylated ghrelin was considered inactive at first, though biological activities such as stimulation of adipogenesis and control of cell growth could be demonstrated more recently. Both ghrelin and the more abundant endogenous form des-octanoyl ghrelin could play a role in the paracrine regulation of vascular tone in humans.

Tos-GPK-AMC, a fluorogenic substrate for trypsin, gingipain K, and cathepsin L.

The oxytocin antagonist OVTA shows enhanced affinity for rat uterine oxytocin receptors after iodination.

Substrate for porcine cathepsin A and acid carboxypeptidases from A. niger.and A. kawachii.

Peptide YY has been isolated from human colonic extracts. It is identical in sequence to porcine PYY except for two amino acid replacements.

Substrate for dipeptidyl aminopeptidase I (cathepsin C).

<p>Bachem ID: 4003763.</p>

Cyclo(His-Pro), a diketopiperazine showing various biological effects in the CNS, as well as endocrine effects, has been isolated from several mammalian tissues. In some cases, it has been identified as a degradation product of thyrotropin-releasing hormone (TRH). In the presence of zinc ions, cyclo(His-Pro) showed hypoglycemic effects and induced body weight reduction in rats.

The chromogenic substrate Z-GGL-pNA is used alone or in combination with other substrates as Suc-LLVY-AMC for measuring the chymotrypsin-like activity of the proteasome. Z-GGL-pNA is also cleaved by proteinase yscE (kexin), subtilisins, and neutral endopeptidase 24.5.

Specific inhibitor of thimet oligopeptidase (soluble metalloendopeptidase, EC 3.4.24.15) (Ki = 0.027 ± 0.003 µM). Neprilysin (Endopeptidase-2, EC 3.4.24.11) converts Cpp-AAF-pAb into a potent inhibitor of angiotensin-converting enzyme (ACE).

Chimeric rabies virus glycoprotein fragment peptide (RVG-9R peptide) was able to bind and transduce siRNA to neuronal cells in vitro, resulting in efficient gene silencing. Repeated administration of RVG-9R-bound siRNA did not induce inflammatory cytokines nor anti-peptide antibodies.

N-terminal amino acid of expressed proteins. The formyl moiety is removed enzymatically.

KALA amphipathic peptide, a low-molecular weight cationic amphipathic peptide was able to bind to DNA, to destabilize membranes and to mediate transfection of plasmid DNA in various cell lines. Thus, KALA provides a starting point for a family of peptides that incorporate other functions to improve DNA delivery systems.

Educt for the synthesis of proteasome inhibitors. Z-LL activates the ClpP protease from M. tuberculosis.

<p>Bachem ID: 4039552.</p>

Chromogenic substrate for gingipain K.

Amylin (20-29) (or hIAPP 20-29) forms fibrils that are ultrastructurally identical to amyloid fibrils seen in pancreatic islets. The region SNNFGAILSS appears to be the most important amyloidogenic sequence of hIAPP (human islet amyloid polypeptide).

Substrate for aminopeptidase M, also used in histochemistry.