Dérivés d'acides aminés

Desmopressin (DDAVP), as the first vasopressin analog with a very high and very specific antidiuretic effect, has been widely used for different therapeutic purposes. DDAVP also improves human learning and memory processes. CAS Number (desmopressin acetate): 62288-83-9.

Antiinflammatory peptide with high homology to somatostatin.

<p>Bachem ID: 4096175.</p>

<p>Bachem ID: 4095553.</p>

Muramyl dipeptide (MDP) inhibits HIV replication in CD4⁺ H9 lymphocytes..

Deltorphin B, a selective δ-opioid receptor agonist isolated from the skin of Phyllomedusa bicolor.

Ac-DEVD-AFC is a sensitive fluorescent substrate for the assay of caspase-3 activity. The trifluoromethyl substituent of the fluorophore improves the membrane permeability of the substrate. CAS-Number (net) 141258-58-4 .

Glucagon sulfoxide shows the same maximal glucose mobilizing activity in rat hepatocytes as native glucagon, but it is less potent, suggesting a crucial role of methionine in the binding of glucagon to its hepatic receptor.

<p>Bachem ID: 4013891.</p>

Caloxin 2A1 is a selective extracellular inhibitor of the plasma membrane Ca²⁺-pump.

AFP-pNA, substrate for prolyl tripeptidyl aminopeptidases from the periodontal pathogens Porphyromonas gingivalis and Prevotella nigrescens.

<p>Bachem ID: 4034491.</p>

Bombesin-like peptide from porcine spinal cord; exhibits a potent stimulant effect on smooth muscle of rat uterus. Neuromedin C microinjected into the amygdala inhibited feeding in rats.

GRF antagonist.

Substrate for human plasma carboxypeptidase N and membrane-bound carboxypeptidase D.

Tetraproline. PPPP was used as an internal standard in the quantitative determination of the antihypertensive (ACE-inhibiting) peptides IPP and VPP in cheese by HPLC-MS³.

FAM-HIV-1 Tat 47-57 was used as a fluorescent probe for studying the interaction between the p53 tetramerization domain and HIV-1 Tat protein.

The pentapeptide TRSAW, a highly conserved sequence within the pTH-related protein, is a potent inhibitor of osteoclastic bone resorption in vitro (EC₅₀ = 10⁻¹⁵ M).

GRF is the hypothalamic peptide hormone that specifically stimulates synthesis and release of the growth hormone by somatotropic cells of the anterior pituitary gland.

<p>Bachem ID: 4014443.</p>

A hypothalamic neuropeptide which stimulates the release of LH and FSH. CAS Number (gonadorelin acetate): 34973-08-5.

Gluten Exorphin C, isolated from the pepsin-trypsin-chymotrypsin digest of wheat gluten, was considered as a δ-opioid receptor-selective ligand. The hydrophobicity of Ile³ seems to be important for the expression of the opioid activity of gluten exorphin C. Moreover, this peptide appears to be quite different from any of the endogenous and exogenous opioid peptides ever reported as the N-terminal Tyr is the only aromatic amino acid in the structure.

γ₁-MSH has been located in the cryptic region of the ACTH/β-lipotropin precursor protein from the intermediate lobe of bovine pituitary.

CPP for gene delivery.

Former CAS-number 26469-81-8.

Specific chromogenic substrate for cathepsin H.

Diacetyl-Lys-D-Ala-D-Ala (DALAA) is a substrate for penicillin-sensitive D-alanine carboxypeptidases (DD-carboxypeptidases).

V.Paspaliaris et al. showed that daily administration of pTHrP (1-34) to rats was anabolic on bone by increasing bone formation. This treatment could inhibit the rapid decline in bone formation due to denervation.

<p>Bachem ID: 4030885.</p>

<p>Bachem ID: 4014853.</p>

Deamidation product of glucagon.

A hypothalamic opioid peptide related to Leu-enkephalin and dynorphin A with potent activity in the guinea-pig ileum assay.

CRF (corticotropin-releasing factor) is a 41-peptide produced mainly in the hypothalamus. The peptide hormone stimulates ACTH release from the anterior lobe of the pituitary gland. CRH plays an important role in the endocrine, behavioral, and immune response to stress and probably as well in the regulation of energy balance. The human sequence EEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEII amide also corresponds to the sequence of canine, feline, murine, and porcine CRH.

µ-Conotoxin GIIIA from the Conus geographus L. venom blocks with very high selectivity the muscle subtype of sodium channels.

<p>Bachem ID: 4011476.</p>

Glucagon antagonist.

Deamidation product of glucagon.

<p>Bachem ID: 4012222.</p>

Potential degradation product of exenatide resulting from aspartimide formation and cleavage.

Potential impurity of exenatide.

<p>Bachem ID: 4034554.</p>

The amyloidogenic peptide hormone amylin 1-37 (or Islet Amyloid Polypeptide, IAPP), KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY amide, has been isolated from the amyloid-rich pancreases of diabetic patients. hIAPP forms fibrillar peptide deposits in the pancreatic islets of Langerhans, which may be related to death of the insulin-producing islet β-cells in type 2 diabetes mellitus.

Peptide YY (3-36) and peptide YY are both synthesized by the gastrointestinal tract and released into the circulation after a meal. Peptide YY (3-36) is a Y₂ receptor subtype agonist, whereas peptide YY is non-selective for Y₁ and Y₂ receptor subtypes. It has been suggested that Y₁ and Y₂ receptor subtype binding affinities depend on their secondary and tertiary solution state structures.

Glucagon-Like Peptide 1 (GLP-1) is synthesized by posttranslational processing of proglucagon in the intestine and pancreas and plays an important role in metabolic homeostasis. Among the different molecular forms, such as GLP-1 (7-36) amide and GLP-1 (7-37), the function of GLP-1 (1-37) has been unclear. GLP-1 (1-37) was shown to convert intestinal epithelial cells into insulin-producing cells. These observations turned GLP-1 (1-37) into a new promising therapeutic compound for the treatment of diabetes mellitus. In animal models of dilated cardiomyopathy, hypertensive heart failure, and myocardial infarction, GLP-1 has shown a remarkable cardioprotective activity.

Potent glucagon-like peptide 1 (GLP-1) receptor antagonist.

<p>Bachem ID: 4068086.</p>

Human IAPP (8-37), ATQRLANFLVHSSNNFGAILSSTNVGSNTY-amide, readily forms fibrils in vitro.

The pentadecapeptide BPC-157 (GEPPPGKPADDAGLV) shows a protective effect on stomach and duodenum when administered to stress ulcers, cysteamine-duodenal ulcers and ethanol lesions. Application of BPC 157 improved tendon healing.

pTHrP (7-34) amide is a potent antagonist of the effects of pTH-related protein (1-34) in vitro and in vivo.