Bcr-Abl
Les inhibiteurs de Bcr-Abl sont des thérapies ciblées qui inhibent la protéine de fusion Bcr-Abl, formée à la suite de la translocation du chromosome Philadelphie et moteur de la leucémie myéloïde chronique (LMC). Cette protéine influence également l'angiogenèse, contribuant à la progression tumorale. Les inhibiteurs de Bcr-Abl sont cruciaux dans le traitement de la LMC et sont explorés pour leur potentiel à inhiber l'angiogenèse dans divers cancers. Chez CymitQuimica, nous offrons des inhibiteurs de Bcr-Abl de haute qualité pour soutenir vos recherches en biologie du cancer, angiogenèse et thérapies ciblées.
119 produits trouvés pour "Bcr-Abl".
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SNIPER(ABL)-024
CAS :SNIPER(ABL)-024, a compound that conjugates GNF5 (ABL inhibitor) to an LCL161 derivative (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels,Formule :C52H61F3N8O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1031.15SIAIS100
SIAIS100, a potent BCR-ABL PROTAC degrader, demonstrates a DC50 value of 2.7 nM, highlighting its efficacy.Formule :C44H50ClF2N9O5SCouleur et forme :SolidMasse moléculaire :890.44BCR-ABL-IN-9
BCR-ABL-IN-9 (Compound B1) is an inhibitor of BCR-ABL that achieves sustained suppression through the formation of stable covalent bonds with the ABL kinase. It effectively inhibits the activity of ABL kinase (IC50 = 1.2 nM) and possesses anticancer activity.Formule :C22H20N4O3Couleur et forme :SolidMasse moléculaire :388.42TG-100435
CAS :TG-100435 is a novel multi-target oral protein tyrosine kinase inhibitor. The metabolic flux of TG100435 is entirely inhibited by methimazole and ketoconazole. In human liver microsomes or recombinant P450, the formation of TG100435 increases with the activity of cytochrome P450 reductase, suggesting that cytochrome P450 reductase may be involved.Formule :C26H25Cl2N5OCouleur et forme :SolidMasse moléculaire :494.42HG-7-85-01-NH2
CAS :HG-7-85-01-NH2, as the ligand for SNIPER(ABL)-033, effectively induces the reduction of BCR-ABL protein. This is achieved through SNIPER(ABL)-033, which connects HG-7-85-01 (an ABL inhibitor) to an LCL161 derivative (an IAP ligand) using a linker, demonstrating a DC50 value of 0.3 μM [1].Formule :C27H27F3N6OSCouleur et forme :SolidMasse moléculaire :540.6c-ABL-IN-1
CAS :C-ABL-IN-1 is a new and specific inhibitor of the c-Abl protein, which effectively prevents the progression of neurodegeneration observed in Parkinson's diseaseFormule :C17H16Cl2FN3OSCouleur et forme :SolidMasse moléculaire :400.29Asciminib hydrochloride
CAS :Asciminib hydrochloride is a STAMP inhibitor targeting the ABL myristoyl pocket, applied in Ph+ CML research for selective oncogenic signaling modulation.Formule :C20H19Cl2F2N5O3Degré de pureté :99.91%Couleur et forme :White SolidMasse moléculaire :486.3Ref: TM-T63226
1mg57,00€5mg130,00€1mL*10mM (DMSO)138,00€10mg177,00€25mg289,00€50mg409,00€100mg620,00€Agerafenib
CAS :Agerafenib (CEP32496) is a highly potent inhibitor of BRAF.Formule :C24H22F3N5O5Degré de pureté :95.78% - 99.23%Couleur et forme :White SolidMasse moléculaire :517.46Ref: TM-T2070
1mg39,00€1mL*10mM (DMSO)90,00€5mg93,00€10mg124,00€25mg219,00€50mg358,00€100mg530,00€200mg757,00€GNF-7
CAS :GNF-7 is Bcr-Abl WT and Bcr-Abl T315I inhibitor with IC50 of 133 nM and 61 nM, respectively.Formule :C28H24F3N7O2Degré de pureté :97.05% - 99.7%Couleur et forme :SolidMasse moléculaire :547.53Degrasyn
CAS :Degrasyn (WP1130) inhibits DUBs (USP5, UCH-L1, USP9x, USP14, UCH37) and Bcr/Abl without affecting the 20S proteasome.Formule :C19H18BrN3ODegré de pureté :98.32% - 99.98%Couleur et forme :SolidMasse moléculaire :384.27Ref: TM-T6300
2mg39,00€5mg57,00€1mL*10mM (DMSO)63,00€10mg96,00€25mg178,00€50mg306,00€100mg477,00€200mg672,00€Nocodazole
CAS :Nocodazole: synthetic microtubule polymerization blocker, also impedes Abl with low IC50; binds to beta-tubulin.Formule :C14H11N3O3SDegré de pureté :98% - 99.91%Couleur et forme :Yellow SolidMasse moléculaire :301.32Ref: TM-T2802
5mg34,00€1mL*10mM (DMSO)38,00€10mg52,00€25mg94,00€50mg165,00€100mg268,00€200mg399,00€500mg647,00€Rebastinib
CAS :DCC-2036 (Rebastinib (DCC-2036)) is a conformational control Bcr-Abl inhibitor for Abl1(WT, IC50: 0.8 nM) and Abl1(T315I, IC50: 4 nM), also inhibits LYN, SRC,Formule :C30H28FN7O3Degré de pureté :99.53% - 99.79%Couleur et forme :SolidMasse moléculaire :553.59SGX-523
CAS :SGX-523 is a selective Met inhibitor (IC50: 4 nM), no inhibitory to Abl, BRAFV599E, p38α, and c-Raf.Formule :C18H13N7SDegré de pureté :99% - >99.99%Couleur et forme :SolidMasse moléculaire :359.41Ref: TM-T2293
1mg34,00€2mg46,00€5mg84,00€1mL*10mM (DMSO)87,00€10mg114,00€25mg219,00€50mg349,00€100mg557,00€200mg790,00€Ponatinib
CAS :Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor (IC50s: 0.37/1.1/1.5/2.2/5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectivelyFormule :C29H27F3N6ODegré de pureté :98% - 99.60%Couleur et forme :SolidMasse moléculaire :532.56NVP-BAW2881
CAS :NVP-BAW2881 (BAW2881) is a potent and selective VEGFR inhibitor with activity to inhibit chronic and acute skin inflammation.Formule :C22H15F3N4O2Degré de pureté :98.19% - 99.97%Couleur et forme :White SolidMasse moléculaire :424.38Ref: TM-T3641
1mg34,00€2mg48,00€1mL*10mM (DMSO)69,00€5mg71,00€10mg109,00€25mg200,00€50mg324,00€100mg470,00€500mg1.054,00€AT9283
CAS :AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).Formule :C19H23N7O2Degré de pureté :99.83% - 99.98%Couleur et forme :White SolidMasse moléculaire :381.43Ref: TM-T3068
2mg39,00€5mg75,00€1mL*10mM (DMSO)84,00€10mg111,00€25mg231,00€50mg371,00€100mg595,00€200mg833,00€Multi-kinase inhibitor 1
CAS :Multi-kinase inhibitor 1 (Multi-kinase inhibitor I) is a Multi-kinase inhibitor.Formule :C20H17F3N4O3Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :418.37Ref: TM-T4191
1mg37,00€2mg52,00€5mg79,00€1mL*10mM (DMSO)87,00€10mg101,00€25mg177,00€50mg268,00€100mg385,00€Flumatinib
CAS :Flumatinib (HHGV678) is an orally bioavailable tyrosine kinase inhibitor flumatinib, with potential antineoplastic activity.Formule :C29H29F3N8ODegré de pureté :99.39% - 99.95%Couleur et forme :White SolidMasse moléculaire :562.59Ref: TM-T4320
1mg34,00€5mg63,00€10mg82,00€1mL*10mM (DMSO)82,00€25mg120,00€50mg155,00€100mg259,00€200mg388,00€500mg642,00€AG1024
CAS :AG1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).Formule :C14H13BrN2ODegré de pureté :98% - 99.37%Couleur et forme :SolidMasse moléculaire :305.17Olverembatinib dimesylate
CAS :Olverembatinib dimesylate (GZD824 Dimesylate) is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I).Formule :C29H27F3N6O·2CH4O3SDegré de pureté :97.66% - >99.99%Couleur et forme :SolidMasse moléculaire :724.77Ref: TM-T2429
1mg37,00€5mg79,00€10mg113,00€1mL*10mM (DMSO)114,00€25mg216,00€50mg289,00€100mg378,00€200mg552,00€
