EGFR
Les inhibiteurs du récepteur du facteur de croissance épidermique (EGFR) sont des composés qui bloquent la signalisation de l'EGFR, un récepteur souvent surexprimé dans divers cancers et qui joue un rôle crucial dans l'angiogenèse. Les inhibiteurs de l'EGFR sont utilisés pour prévenir la croissance tumorale et les métastases en perturbant les voies qui favorisent la formation de vaisseaux sanguins dans les tumeurs. Ces inhibiteurs sont largement utilisés dans la recherche et le traitement du cancer. Chez CymitQuimica, nous offrons une sélection diversifiée d'inhibiteurs de l'EGFR de haute qualité pour soutenir vos recherches en oncologie et angiogenèse.
587 produits trouvés pour "EGFR"
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PD168393
CAS :PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.Formule :C17H13BrN4ODegré de pureté :99.13% - 99.83%Couleur et forme :SolidMasse moléculaire :369.22Ref: TM-T6932
1mg37,00€2mg50,00€1mL*10mM (DMSO)52,00€5mg63,00€10mg94,00€25mg146,00€50mg210,00€100mg294,00€AZ7550
CAS :AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).Formule :C27H31N7O2Degré de pureté :97.07% - 99.75%Couleur et forme :SolidMasse moléculaire :485.58Epidermal Growth Factor
CAS :EGF binds EGFR, promotes cell growth & heals diabetic foot ulcers.Formule :C270H401N73O83S7Degré de pureté :97.17%Couleur et forme :SolidMasse moléculaire :6222AG-1557 hydrochloride (189290-58-2(free base))
AG-1557 hydrochloride is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).Formule :C16H15ClIN3O2Degré de pureté :98.64%Couleur et forme :SolidMasse moléculaire :443.66Tyrphostin AG 879
CAS :Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.Formule :C18H24N2OSDegré de pureté :99.05%Couleur et forme :SolidMasse moléculaire :316.46EGFR-IN-12
CAS :EGFR-IN-12 (EGFR Inhibitor) is a cell permeable and selective inhibitor of EGFR kinase (IC50: 21 nM) and blocks receptor autophosphorylation in cells.Formule :C21H18F3N5ODegré de pureté :98.3% - 99.76%Couleur et forme :SolidMasse moléculaire :413.4Ref: TM-T5168
1mg82,00€5mg159,00€1mL*10mM (DMSO)168,00€10mg259,00€25mg520,00€50mg740,00€100mg1.008,00€500mg2.015,00€CP-380736
CAS :CP-380736 (PF-00520893) inhibits EGFR, a kinase key in cancer-signaling pathways like MAPK, JNK, and Akt.Formule :C14H18N2O5Degré de pureté :99.68%Couleur et forme :White To Off-White SolidMasse moléculaire :294.3Tyrphostin 23
CAS :Tyrphostin 23 (AG18) inhibits EGFR with IC50 of 35 μM.Formule :C10H6N2O2Degré de pureté :99.7% - 99.86%Couleur et forme :Yellow-Tan SolidMasse moléculaire :186.17Osimertinib mesylate
CAS :Osimertinib mesylate (AZD-9291 mesylate) is an EGFR third-generation inhibitor. Osimertinib mesylate has antitumor activity. Cost-effective and quality-assured.
Formule :C29H37N7O5SDegré de pureté :99.46% - >99.99%Couleur et forme :SolidMasse moléculaire :595.71RG13022
CAS :RG13022 (Tyrphostin RG13022) is a tyrosine kinase inhibitor; inhibits the autophosphorylation reaction of the EGF receptor (IC50: 4 μM).Formule :C16H14N2O2Degré de pureté :98.38%Couleur et forme :SolidMasse moléculaire :266.29RG14620
CAS :RG14620 (Tyrphostin RG14620) is an epidermal growth factor receptor (EGFR) inhibitor.Formule :C14H8Cl2N2Degré de pureté :99.82% - 99.87%Couleur et forme :SolidMasse moléculaire :275.13Naquotinib
CAS :Naquotinib (ASP8273) (ASP8273) is an orally available, mutant-selective and irreversible EGFR inhibitor; (IC50s: 8-33 nM and 230 nM toward EGFR mutants and EGFRFormule :C30H42N8O3Degré de pureté :97.49%Couleur et forme :SolidMasse moléculaire :562.71Olafertinib
CAS :Olafertinib (RX-518) is a novel mutant-selective, irreversible, orally available EGFR inhibitor. It can overcome T790M-mediated resistance in NSCLC.Formule :C29H28F2N6O2Degré de pureté :98.62% - 99.706%Couleur et forme :SolidMasse moléculaire :530.57Tucatinib
CAS :Tucatinib (ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM).Formule :C26H24N8O2Degré de pureté :99.05% - 99.96%Couleur et forme :SolidMasse moléculaire :480.52Ref: TM-T2364
2mg34,00€5mg50,00€10mg74,00€1mL*10mM (DMSO)82,00€25mg117,00€50mg177,00€100mg333,00€500mg782,00€1g1.071,00€Allitinib tosylate
CAS :Allitinib tosylate (AST-1306) is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, respectively.Formule :C31H26ClFN4O5SDegré de pureté :98.46% - 98.68%Couleur et forme :SolidMasse moléculaire :621.08EGFR/ErbB-2/ErbB-4 inhibitor-2
CAS :EGFR/ErbB-2/ErbB-4 inhibitor-2 (EGFR/ErbB2 Inhibitor) is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively)Formule :C23H21N3O3Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :387.43Ref: TM-T21954
1mg50,00€5mg94,00€1mL*10mM (DMSO)103,00€10mg140,00€25mg245,00€50mg369,00€100mg537,00€200mg712,00€HG-14-10-04
CAS :HG-14-10-04 is a potent and specific ALK inhibitor.Formule :C29H34ClN7ODegré de pureté :99.75% - >99.99%Couleur et forme :SolidMasse moléculaire :532.08Ref: TM-T4015
1mg49,00€5mg92,00€1mL*10mM (DMSO)111,00€10mg152,00€25mg222,00€50mg289,00€100mg409,00€200mg590,00€(S)-Sunvozertinib
CAS :(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.Formule :C29H35ClFN7O3Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :584.08BI-4020
CAS :BI-4020 is a fourth-generation, orally active, and non-covalent inhibitor of EGFR tyrosine kinase.Formule :C30H38N8O2Degré de pureté :97.21% - >99.99%Couleur et forme :SolidMasse moléculaire :542.68Ref: TM-T10534
1mg161,00€5mg376,00€1mL*10mM (DMSO)447,00€10mg538,00€25mg803,00€50mg1.071,00€100mg1.431,00€200mg1.953,00€Avitinib
CAS :Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor,Formule :C26H26FN7O2Degré de pureté :99.81% - >99.99%Couleur et forme :SolidMasse moléculaire :487.53FIIN-3
CAS :FIIN-3 is an irreversible inhibitor of FGFR.Formule :C34H36Cl2N8O4Degré de pureté :97.63% - 98.92%Couleur et forme :SolidMasse moléculaire :691.61Chrysophanol
CAS :Chrysophanol (Turkey Rhubarb) is an EGFR/mTOR pathway inhibitor, which can be found in rhubarb, and sorrel.Formule :C15H10O4Degré de pureté :99.44% - 99.91%Couleur et forme :Physical Description Golden Yellow Plates Or Brown Powder Melting Point 196°CMasse moléculaire :254.24Avitinib maleate
CAS :Avitinib maleate is a pyrrolopyrimidine-based irreversible epidermal growth factor receptor (EGFR) inhibitor.Formule :C30H30FN7O6Degré de pureté :98% - 99.74%Couleur et forme :SolidMasse moléculaire :603.61AEE788
CAS :AEE788 (NVP-AEE 788) has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.Formule :C27H32N6Degré de pureté :98% - >99.99%Couleur et forme :SolidMasse moléculaire :440.58Ref: TM-T2116
2mg47,00€5mg70,00€1mL*10mM (DMSO)77,00€10mg103,00€25mg188,00€50mg325,00€100mg490,00€500mg1.103,00€SU 4313
CAS :SU 4313 is a bioactive chemical.Formule :C18H17NODegré de pureté :99.51% - 99.89%Couleur et forme :SolidMasse moléculaire :263.33Ref: TM-T3568
1mg34,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg92,00€25mg167,00€50mg236,00€100mg353,00€200mg517,00€AG490
CAS :AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.Formule :C17H14N2O3Degré de pureté :98.6% - 99.85%Couleur et forme :Yellow SolidMasse moléculaire :294.3WHI-P180
CAS :WHI-P180 (Janex 3) is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.Formule :C16H15N3O3Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :297.31Alflutinib mesylate
CAS :Alflutinib mesylate (AST2818 mesylate) ,is an irreversible tyrosine kinase inhibitor that selectively inhibits EGFR mutations, especially T790M.Formule :C29H35F3N8O5SDegré de pureté :97.94% - 99.63%Couleur et forme :SolidMasse moléculaire :664.70Alflutinib
CAS :Alflutinib (ASK120067) is an inhibitor of EGFR, and its targets including EGFR activating mutations and T790M, thus leading to tumor growth inhibition.Formule :C28H31F3N8O2Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :568.59Ref: TM-T22254
1mg57,00€5mg120,00€1mL*10mM (DMSO)152,00€10mg177,00€25mg356,00€50mg537,00€100mg707,00€200mg1.009,00€(E)-AG 556
CAS :AG 556 is a selective inhibitor of EGFR and blocks LPS-induced TNF-α production.
Formule :C20H20N2O3Degré de pureté :99.93%Couleur et forme :Light Yellow PowderMasse moléculaire :336.38NSC 228155
CAS :NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.Formule :C11H6N4O4SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :290.25Ref: TM-T6908
2mg34,00€5mg48,00€1mL*10mM (DMSO)50,00€10mg63,00€25mg117,00€50mg178,00€100mg334,00€200mg469,00€TX1-85-1
CAS :TX1-85-1: irreversible Her3 inhibitor (IC50: 23 nM), degrades Her3 protein, disrupts signaling, binds Cys721 covalently.Formule :C32H36N8O3Degré de pureté :97.16% - 98.72%Couleur et forme :SolidMasse moléculaire :580.68Afatinib Dimaleate
CAS :Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the EGFR family, with antineoplastic activity.Formule :C32H33ClFN5O11Degré de pureté :98.11% - 99.87%Couleur et forme :SolidMasse moléculaire :718.08AZ-5104
CAS :AZ5104 is a potent EGFR inhibitor.Formule :C27H31N7O2Degré de pureté :98.40% - 99.59%Couleur et forme :Solid PowderMasse moléculaire :485.58PD-089828
CAS :PD 089828 inhibits FGFR1, PDGFRβ, EGFR (IC50s: 0.15-5.47 μM), and c-Src (IC50: 0.18 μM).Formule :C18H18Cl2N6ODegré de pureté :97.39%Couleur et forme :SolidMasse moléculaire :405.28Nazartinib
CAS :Nazartinib (EGF816) (EGF816, NVS-816) is a covalent, irreversible, mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt (Formule :C26H31ClN6O2Degré de pureté :98.63% - ≥95%Couleur et forme :Solid PowderMasse moléculaire :495.02Ref: TM-T3506
1mg34,00€5mg74,00€1mL*10mM (DMSO)82,00€10mg113,00€25mg177,00€50mg334,00€100mg500,00€500mg1.099,00€Oritinib mesylate
CAS :Oritinib mesylate (SH-1028), an oral pyrimidine EGFR blocker with 18 nM IC50, targets both sensitive and T790M resistant mutations.Formule :C32H41N7O5SCouleur et forme :SolidMasse moléculaire :635.78PD153035
CAS :PD153035 (NSC-669364) hydrochloride is an effective and selective inhibitor of EGFR (Ki/IC50: 5.2/29 pM, in cell-free assays); little inhibitory against FGFR,Formule :C16H14BrN3O2Degré de pureté :98.47% - 99.29%Couleur et forme :SolidMasse moléculaire :360.21PKI-166 hydrochloride
CAS :EGFR-kinase inhibitor, IC50 0.7 nM, >3000x selective, cuts metastasis and angiogenesis in mice, antihypertensive, oral use.Formule :C20H19ClN4OCouleur et forme :SolidMasse moléculaire :366.85NRC-2694 hydrochloride
CAS :NRC-2694 hydrochloride is an epidermal growth factor receptor (EGFR) antagonist potentially for the treatment of solid tumors.Formule :C24H27ClN4O3Couleur et forme :SolidMasse moléculaire :454.95JCN037
CAS :JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).Formule :C16H11BrFN3O2Degré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :376.18Dacomitinib
CAS :Dacomitinib (PF299) is an oral selective inhibitor of EGFR, ERBB2, ERBB4 with IC50s: 6, 45.7, 73.7 nM.Formule :C24H25ClFN5O2Degré de pureté :99.4% - 99.72%Couleur et forme :SolidMasse moléculaire :469.94Ref: TM-T2483
1mg35,00€2mg50,00€5mg74,00€1mL*10mM (DMSO)74,00€10mg120,00€25mg170,00€50mg215,00€100mg334,00€200mg421,00€500mg692,00€Tyrphostin A9
CAS :Tyrphostin A9 (SF 6847) is an Agricultural acaricide, now superseded. Tyrphostin A9 is firstly designed as an EGFR inhibitorFormule :C18H22N2ODegré de pureté :98.21% - 99.87%Couleur et forme :Yellow SolidMasse moléculaire :282.38Poziotinib hydrochloride
CAS :Oral poziotinib HCl targets EGFR/HER mutants, inhibiting cancer cell growth.Formule :C23H22Cl3FN4O3Degré de pureté :99.69% - 99.81%Couleur et forme :SolidMasse moléculaire :527.8PP 3
CAS :PP 3 is a Negative control for the Src kinase inhibitor PP 2Formule :C11H9N5Degré de pureté :98.61%Couleur et forme :Whit To Off-White SolidMasse moléculaire :211.22Afatinib
CAS :Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.Formule :C24H25ClFN5O3Degré de pureté :98.56% - 99.9%Couleur et forme :Off-White SolidMasse moléculaire :485.94Ref: TM-T21312
5mg34,00€10mg49,00€1mL*10mM (DMSO)50,00€25mg81,00€50mg109,00€100mg137,00€200mg168,00€500mg284,00€SYR127063
CAS :SYR127063 (BDBM-92454) (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive conformation.Formule :C23H20ClF3N4O3Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :492.88(E)-AG 99
CAS :(E)-AG 99 ((E)-Tyrphostin AG 99) is an inhibitor of EGFR kinase (IC50: 10 μM in the human epidermoid carcinoma cell line A431).Formule :C10H8N2O3Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :204.18CUDC-101
CAS :CUDC-101 is a potent inhibitor of HDAC, EGFR and HER2 with IC50s of 4.4, 2.4 and 15.7 nM, respectively.Formule :C24H26N4O4Degré de pureté :95.76% - 99.17%Couleur et forme :SolidMasse moléculaire :434.49Mobocertinib
CAS :Mobocertinib (tak788) is a potent inhibitor of epidermal growth factor receptor (EGFR) and an antineoplastic agentFormule :C32H39N7O4Degré de pureté :99.47% - 99.97%Couleur et forme :SolidMasse moléculaire :585.7(Rac)-JBJ-04-125-02
CAS :(Rac)-JBJ-04-125-02 (JBJ-04-125-02) is effective as a single agent in both in vitro and in vivo models of EGFR-mutant lung cancer.Formule :C29H26FN5O3SDegré de pureté :97.57%Couleur et forme :SolidMasse moléculaire :543.61Ref: TM-T8872
1mg100,00€5mg205,00€1mL*10mM (DMSO)249,00€10mg334,00€25mg567,00€50mg807,00€100mg1.099,00€Theliatinib tartrate
CAS :Theliatinib: oral EGFR blocker, Ki 0.05 nM, IC50 3 nM (wild-type), 22 nM (T790M/L858R), >50x kinase selectivity.Formule :C29H32N6O8Couleur et forme :SolidMasse moléculaire :592.6Osimertinib
CAS :Osimertinib (AZD-9291) is a small molecule tyrosine kinase receptor inhibitor and antineoplastic agent that is used in the therapy of selected forms of NSCLC.Formule :C28H33N7O2Degré de pureté :99.32% - >99.99%Couleur et forme :SolidMasse moléculaire :499.61Ref: TM-T2490
2mg34,00€5mg52,00€1mL*10mM (DMSO)52,00€10mg55,00€25mg67,00€50mg80,00€100mg94,00€500mg114,00€1g138,00€2g197,00€5g329,00€Almonertinib mesylate
CAS :Almonertinib mesylate: EGFR tyrosine kinase inhibitor, targets EGFR-mutant non-small cell lung cancer.Formule :C31H39N7O5SDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :621.75Ref: TM-T9865
1mg52,00€5mg110,00€1mL*10mM (DMSO)161,00€10mg177,00€25mg301,00€50mg425,00€100mg605,00€200mg797,00€Sulforaphene
CAS :Sulforaphene, from radish seeds, aids cancer cell apoptosis and inhibits migration; has an ED50 for velvetleaf at ~2x10^-4 M.Formule :C6H9NOS2Degré de pureté :97.55% - 99.67%Couleur et forme :Slightly Yellowish LiquidMasse moléculaire :175.27Ref: TM-TL0016
1mg34,00€2mg46,00€1mL*10mM (DMSO)65,00€5mg66,00€10mg92,00€25mg167,00€50mg241,00€100mg359,00€200mg525,00€Rostafuroxin
CAS :Rostafuroxin (PST 2238) has been used in trials studying the treatment of Essential Hypertension.Formule :C23H34O4Degré de pureté :98.24% - >99.99%Couleur et forme :SolidMasse moléculaire :374.51Mutant EGFR inhibitor
CAS :Selective, potent inhibitor for mutated EGFR: L858R, Exon19 deletion, T790M resistance mutants.Formule :C27H30ClN7O2Degré de pureté :98% - 99.75%Couleur et forme :SolidMasse moléculaire :520.03Ref: TM-T2705
500mgÀ demander1mg34,00€2mg49,00€5mg75,00€10mg92,00€1mL*10mM (DMSO)99,00€25mg165,00€50mg250,00€100mg359,00€Theliatinib
CAS :Theliatinib: potent, selective EGFR inhibitor, anti-tumor; Ki=0.05 nM (EGFR), IC50=3 nM (EGFR), 22 nM (T790M/L858R).Formule :C25H26N6O2Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :442.51Genistein
CAS :Genistein (NPI 031L) is a natural soy isoflavone, a multi-targeted tyrosine kinase inhibitor. Genistein has antitumor effects. Cost effective and quality assured.Formule :C15H10O5Degré de pureté :98.22% - 99.64%Couleur et forme :Rectangular Or Six-Sided Rods From 60% Alcohol Dendritic Needles From Ether SolidMasse moléculaire :270.24Olmutinib hydrochloride
CAS :Olmutinib is a third-gen EGFR inhibitor for T790M-positive lung cancer, blocking phosphorylation and tumor pathways. Approved in Korea (2016).Formule :C26H28Cl2N6O2SCouleur et forme :SolidMasse moléculaire :559.51SU5204
CAS :SU5204 (3-[(2-Ethoxyphenyl)methylidene]-1H-indol-2-one), an analogue of SU5025, pharmacologically inhibits VEGFR2(IC50s of 4 and 51.5 μM for FLK-1 (VEGFR-2) andFormule :C17H15NO2Degré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :265.31NRC-2694
CAS :NRC-2694 is an antagonist of the epidermal growth factor receptor (EGFR). It has anti-cancer and anti-proliferative properties.Formule :C24H26N4O3Degré de pureté :99.90%Couleur et forme :SolidMasse moléculaire :418.49Ref: TM-T16343
1mg56,00€5mg105,00€1mL*10mM (DMSO)116,00€10mg170,00€25mg281,00€50mg371,00€100mg537,00€200mg712,00€ZD-4190
CAS :ZD-4190 blocks VEGFR2 and EGFR, aiding cancer treatment.Formule :C19H16BrFN6O2Degré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :459.27Ref: TM-T5475
1mg80,00€5mg173,00€1mL*10mM (DMSO)175,00€10mg261,00€25mg414,00€50mg567,00€100mg767,00€200mg1.018,00€Methyl 2,5-dihydroxycinnamate
CAS :Methyl 2,5-dihydroxycinnamate is an EGF receptor-associated tyrosine kinases inhibitor.Formule :C10H10O4Degré de pureté :99.60%Couleur et forme :CrystallineMasse moléculaire :194.18PP2
CAS :PP2 (AG 1879,AGL 1879) is a effective inhibitor of Lck/Fyn (IC50:4/5 nM) , ~100-fold less potent to EGFR, inactive for ZAP-70, PKA and JAK2.Formule :C15H16ClN5Degré de pureté :98% - 98.21%Couleur et forme :White SolidMasse moléculaire :301.77Ref: TM-T6266
2mg44,00€5mg65,00€1mL*10mM (DMSO)71,00€10mg110,00€25mg178,00€50mg304,00€100mg482,00€200mg687,00€Tyrphostin AG30
CAS :Tyrphostin AG30 (AG30) (AG30) is a potent protein tyrosine kinases (PTK) inhibitor.Formule :C10H7NO4Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :205.17PD-161570
CAS :PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.Formule :C26H35Cl2N7ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :532.51Ref: TM-T23127
1mg34,00€5mg96,00€1mL*10mM (DMSO)118,00€10mg141,00€25mg289,00€50mg465,00€100mg662,00€200mg888,00€Lazertinib
CAS :Lazertinib (GNS-1480) is a potent, selective, irreversible EGFR-TKI; IC50: 1.7-76 nM for various EGFR mutations.Formule :C30H34N8O3Degré de pureté :98.7% - 99.90%Couleur et forme :SolidMasse moléculaire :554.64Ref: TM-T4485
1mg46,00€2mg59,00€5mg96,00€1mL*10mM (DMSO)104,00€10mg130,00€25mg215,00€50mg309,00€100mg444,00€200mg655,00€Leptomycin B
CAS :Leptomycin B: potent CRM1 inhibitor, blocks protein nuclear export and cell cycle, antifungal, modifies cysteine.Formule :C33H48O6Degré de pureté :97.10% - 99.04%Couleur et forme :White Crystalline SolidMasse moléculaire :540.73Ref: TM-T15735
1mg192,00€1mL*10mM (DMSO)268,00€2mg324,00€5mg587,00€10mg835,00€25mg1.251,00€50mg1.684,00€100mg2.277,00€Gefitinib hydrochloride
CAS :Obtustatin triacetate is an integrin derived from the venom of Vipera lebetina obtusa and is an α1β1 integrin and in vivo angiogenesis inhibitor.Formule :C22H25Cl2FN4O3Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :483.36Cavutilide
CAS :Cavutilide has antiarrhythmic activity, inhibits hERG K(+) channels, and can be used to study heart failure and persistent atrial fibrillation.Formule :C22H26FN3O3Degré de pureté :99.82% - 99.85%Couleur et forme :SolidMasse moléculaire :399.458BMS-690514
CAS :BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR. It has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.Formule :C19H24N6O2Degré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :368.43Almonertinib hydrochloride
CAS :Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation.Formule :C30H36ClN7O2Degré de pureté :98.01% - 98.12%Couleur et forme :SolidMasse moléculaire :562.1Canertinib dihydrochloride
CAS :Canertinib dihydrochloride (PD-183805 dihydrochloride) is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic andFormule :C24H27Cl3FN5O3Degré de pureté :99.13% - >99.99%Couleur et forme :SolidMasse moléculaire :558.86Naquotinib mesylate
CAS :Naquotinib mesylate (ASP8273 (mesylate)) is an orally available, mutant-selective and irreversible inhibitor of EGFR(iC50s of 8-33 nM and 230 nM for toward EGFRFormule :C31H46N8O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :658.81Izalontamab
CAS :Izalontamab (SI-B001) is a bispecific EGFR/HER3 monoclonal antibody that binds to both EGFR×EGFR homodimers and EGFR×HER3 heterodimers.Degré de pureté :95%+ - 95.3% (SDS-PAGE); 99.2% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :197.21 kDaZalutumumab
CAS :Zalutumumab is a high-affinity fully human monoclonal antibody ,the extracellular domain of the EGFR squamous cell carcinoma of the head and neck (SCCHN).Degré de pureté :95%Couleur et forme :LiquidMasse moléculaire :146.63 kDaElgemtumab
CAS :Elgemtumab (LJM716) is a fully humanised monoclonal antibody targeting HER3/ERBB3, acting as an antagonist to block HER3/Akt phosphorylation antitumour.Degré de pureté :95%Couleur et forme :LiquidMasse moléculaire :144.15 kDaSerclutamab
CAS :Serclutamab, a humanized chimeric monoclonal antibody of the IgG1-κ isotype, selectively targets the epidermal growth factor receptor (EGFR).Degré de pureté :98%Couleur et forme :LiquidAnbenitamab
CAS :Anbenitamab (KN-026) is a bispecific HER2 antibody for metastatic breast cancer research, blocking HER2 pathways and mediating ADCC.Couleur et forme :LiquidZanidatamab
CAS :Zanidatamab (ZW25) is a bispecific, humanized monoclonal antibody that targets two distinct epitopes (ECD2 and ECD4) of the HER2 receptor, exhibiting anti-tumorDegré de pureté :95%Couleur et forme :LiquidBecotatug
CAS :Becotatug (JMT101) is a humanised monoclonal antibody targeting EGFR, antitumour when combined with Osimertinib for treating EGFR-mutated advanced NSCLC.Degré de pureté :95% - 99.1% (SDS-PAGE); 98.1% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :145.52 kDaEGFR T790M/L858R-IN-8
CAS :EGFRT790M/L858R-IN-8 (compound 9) is a potent inhibitor of EGFR, specifically targeting the EGFRT790M/L858R mutations with an IC50 of 56.8 μM. This compound does not show significant antiproliferative effects on cancer cell lines A549, A431, and NHI-H1975.Formule :C16H11BrN2O3Couleur et forme :SolidMasse moléculaire :359.17EGFR vIII Protein, Human, Recombinant (hFc)
EGFR vIII Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag.Couleur et forme :Lyophilized PowderMasse moléculaire :90-120 KDa (reducing condition)Ref: TM-TMPJ-00647
5µg90,00€10µg130,00€20µg193,00€50µg381,00€100µg600,00€200µg947,00€500µg1.765,00€1mg2.535,00€Fidasimtamab
CAS :Fidasimtamab, a recombinant human IgG1 bispecific antibody, targets both HER2 and PD-1, bridging T cells and tumor cells to modulate immune responses.Degré de pureté :95% - 98.0% (SDS-PAGE); 98.3% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :144.72 kDaFutuximab
CAS :Futuximab is a chimeric monoclonal antibody targeting EGFR, commonly used in combination with zatuximab to form Sym004.Degré de pureté :95% - 97.5% (SDS-PAGE); 96.3% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :146.28 kDaImgatuzumab
CAS :Imgatuzumab (RG 7160) is a humanized anti-EGFR monoclonal antibody and immunomodulator for cancer research.
Couleur et forme :LiquidMasse moléculaire :145.0 (kDa)Ponezumab
CAS :Ponezumab (PF-04360365), a humanized IgG2 antibody, lowers Aβ in the CNS & boosts mice memory. Used in Alzheimer's research.Couleur et forme :LiquidRunimotamab
Runimotamab, an IgG1-κ humanized chimeric antibody, targets CD3E and HER2 [1].Couleur et forme :Odour LiquidTyrphostin AG 494
CAS :Formule :C16H12N2O3Degré de pureté :>98.0%(HPLC)(N)Couleur et forme :Light yellow to Amber to Dark green powder to crystalMasse moléculaire :280.28IGF-1R modulator 1
CAS :IGF-1Rmodulator 1 (Example 5) is an IGF-1R modulator featuring an EC50 of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), and 0.39 μM (TrkB). This compound is useful in research on diseases characterized by impaired signaling of neurotrophic and/or other trophic factors, such as Alzheimer's disease.Formule :C22H17N3O4Couleur et forme :SolidMasse moléculaire :387.39Icotinib
CAS :Icotinib (Conmana) is an orally available quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity.Formule :C22H21N3O4Degré de pureté :99.76% - 99.94%Couleur et forme :SolidMasse moléculaire :391.42ZM323881 hydrochloride
CAS :ZM323881 hydrochloride (ZM 323881 HCl) is a potent and selective VEGFR2 inhibitor.Formule :C22H19ClFN3O2Degré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :411.86Ref: TM-T1991
1mg34,00€5mg66,00€1mL*10mM (DMSO)69,00€10mg96,00€25mg225,00€50mg369,00€100mg550,00€200mg780,00€lavendustin A
CAS :lavendustin A (RG-14355) is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.Formule :C21H19NO6Degré de pureté :98%Couleur et forme :Off-White SolidMasse moléculaire :381.38Icotinib Hydrochloride
CAS :Icotinib Hydrochloride, an oral EGFR inhibitor (BPI-2009H), may halt cancer growth by blocking EGFR signaling.Formule :C22H22ClN3O4Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :427.88TAK-285
CAS :TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc.Formule :C26H25ClF3N5O3Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :547.96Ref: TM-T6039
1mg38,00€5mg80,00€1mL*10mM (DMSO)96,00€10mg120,00€25mg216,00€50mg354,00€100mg512,00€200mg727,00€EGFR-IN-31
CAS :EGFR-IN-31: Potent EGFR inhibitor, targets mutations & overexpression in NSCLC; potential cancer research compound. (WO2021185298A1, 2)Formule :C32H36FN7O2Couleur et forme :SolidMasse moléculaire :569.67EGFR-IN-49
CAS :EGFR-IN-49 selectively inhibits EGFR mutations T790M (IC50: 65 nM) & T790M/L858R (IC50: 13.6 nM), triggering apoptosis dose-dependently.Formule :C22H15N5O2SCouleur et forme :SolidMasse moléculaire :413.45EGFR-IN-55
CAS :"EGFR-IN-55 targets EGFRWT (70 nM IC50) & EGFRL858R/T790M (3.9 nM IC50), halts NCI-H1975 cell cycle in G0/G1, showing anticancer properties."Formule :C25H25Cl2N7O2Couleur et forme :SolidMasse moléculaire :526.42(E/Z)-AG490
CAS :(E/Z)-AG490 is a racemic mix of (E)- and (Z)-isomers; it inhibits tyrosine kinase, EGFR, Stat-3, and JAK2/3.Formule :C17H14N2O3Couleur et forme :SolidMasse moléculaire :294.3
