EGFR
Les inhibiteurs du récepteur du facteur de croissance épidermique (EGFR) sont des composés qui bloquent la signalisation de l'EGFR, un récepteur souvent surexprimé dans divers cancers et qui joue un rôle crucial dans l'angiogenèse. Les inhibiteurs de l'EGFR sont utilisés pour prévenir la croissance tumorale et les métastases en perturbant les voies qui favorisent la formation de vaisseaux sanguins dans les tumeurs. Ces inhibiteurs sont largement utilisés dans la recherche et le traitement du cancer. Chez CymitQuimica, nous offrons une sélection diversifiée d'inhibiteurs de l'EGFR de haute qualité pour soutenir vos recherches en oncologie et angiogenèse.
590 produits trouvés pour "EGFR".
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Mutated EGFR-IN-1
CAS :Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activatingFormule :C25H31N7ODegré de pureté :98.91%Couleur et forme :SolidMasse moléculaire :445.56Barecetamab
CAS :Barecetamab (ISU-104) is a humanized monoclonal antibody against tyrosine protein kinase ErbB3 with anticancer activity.Degré de pureté :97.1% (SDS-PAGE); 96.4% (SEC-HPLC) - 97.1% (SDS-PAGE); 96.4% (SEC-HPLC)Couleur et forme :Transparent LiquidMasse moléculaire :143.86 kDaGancotamab
CAS :Gancotamab (MM-302) is a polyethylene glycolated liposome targeting HER2 with antitumor activity for the study of advanced HER2-positive breast cancer.Degré de pureté :96.7% (SDS-PAGE); 98.4% (SEC-HPLC) - 96.7% (SDS-PAGE); 98.4% (SEC-HPLC)Couleur et forme :Transparent LiquidMasse moléculaire :25.79 kDaIntetumumab
CAS :Intetumumab (CNTO 95) is a fully humanized anti-α(v)-integrin monoclonal antibody that is a radiosensitizer for xenograft tumor-bearing mice.Degré de pureté :97.6% (SDS-PAGE); 97.1% (SEC-HPLC) - 97.6% (SDS-PAGE); 97.1% (SEC-HPLC)Couleur et forme :Transparent LiquidMasse moléculaire :145.56 kDaLapatinib Ditosylate
CAS :Lapatinib Ditosylate (Tykerb ditosylate) is an effective EGFR and ErbB2 inhibitor (IC50: 10.8/9.2 nM for EGFR/ErbB2).Formule :C29H26ClFN4O4S·2C7H8O3SDegré de pureté :99.41%Couleur et forme :White SolidMasse moléculaire :925.46Mevastatin
CAS :Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.Formule :C23H34O5Degré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :390.51LCH-7749944
CAS :LCH-7749944 suppresses human gastric cancer cell growth, induces apoptosis, and inhibits PAK4 with IC50 of 14.93 μM.Formule :C20H22N4O2Degré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :350.41Gefitinib
CAS :Gefitinib (ZD1839) is an EGFR first-generation inhibitor with oral activity that inhibits the EGFR 19 Del and L858R mutations.Formule :C22H24ClFN4O3Degré de pureté :99.92% - >99.99%Couleur et forme :White SolidMasse moléculaire :446.90AV-412
CAS :AV-412 (MP412) is an EGFR inhibitor (EGFR, EGFR T790M, EGFR L858R, EGFR L858R/T790M and ErbB2 with IC50s of 0.75, 0.79, 0.5, 2.3, 19 nM).Formule :C41H44ClFN6O7S2Degré de pureté :99.85% - 99.92%Couleur et forme :SolidMasse moléculaire :851.41Ref: TM-T10419
1mg42,00€2mg55,00€5mg90,00€1mL*10mM (DMSO)129,00€10mg137,00€25mg240,00€50mg403,00€100mg582,00€Tyrphostin RG 13022
CAS :Formule :C16H14N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :266.2946Losatuxizumab
CAS :Losatuxizumab (ABT-806) is an anti-EGFR monoclonal antibody with potential anti-tumor activity for the study of advanced malignant solid tumors.Degré de pureté :97.3% (SDS-PAGE); 95.1% (SEC-HPLC) - 97.3% (SDS-PAGE); 95.1% (SEC-HPLC)Couleur et forme :Transparent LiquidMasse moléculaire :144.85 kDaPropanedinitrile,2-[(4-methoxyphenyl)methylene]-
CAS :Formule :C11H8N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :184.1940Panitumumab
CAS :Panitumumab is a fully human IgG2 monoclonal antibody targeting the epidermal growth factor receptor EGFR).Degré de pureté :95% - 98.1% (SDS-PAGE); 99.4% (SEC-HPLC)Couleur et forme :Transparent LiquidMasse moléculaire :144.31 kDaG7-18NATE
CAS :G7-18NATE, a peptide inhibitor of Grb7, exhibits micromolar affinity (K D = 18.1 μM) for binding to the Grb7-SH2 domain. It effectively inhibits cell proliferation, motility, invasion, and 3D culture formation in various cancer cell lines [1] [2].Formule :C67H80N14O19SCouleur et forme :SolidMasse moléculaire :1417.5EGFR/PI3Kα-IN-1
EGFR/PI3Kα-IN-1 (compound 30k), a dual EGFR/PI3Kα inhibitor, exhibits potent activity with IC 50 values of 3.6 nM (EGFRL858R/T790M) and 30 nM (PI3Kα). It effectively inhibits tumor cell proliferation and demonstrates significant anticancer activity.Formule :C50H49N11O5SCouleur et forme :SolidMasse moléculaire :916.06JBJ-09-063 TFA
JBJ-09-063 TFA, an EGFR inhibitor selective for EGFR mutations, IC50s: 0.147-0.396 nM, blocks EGFR/Akt/ERK signaling, for EGFR-mutant lung cancer research.Formule :C33H30F4N4O5SCouleur et forme :SolidMasse moléculaire :670.67SJF 1521
CAS :SJF 1521 is an EGFR degrader belonging to the PROTAC class that selectively degrades EGFR while preserving HER2.Formule :C57H61ClFN7O9SDegré de pureté :99.20%Couleur et forme :SolidMasse moléculaire :1074.65DS06652923
DS06652923 is an orally active inhibitor targeting EGFR triple mutations. It exhibits growth-inhibitory effects on Ba/F3EGFRdel19/T90M/C795S cells, with a GI50 value of 9.4 nM. Additionally, DS06652923 induces tumor regression in the Ba/F3 syngeneic transplantation model.Couleur et forme :Odour SolidEGFR-IN-76
CAS :EGFR-IN-76 is a potent EGFR inhibitor.Formule :C30H30ClFN6O2Degré de pureté :97.02% - 97.72%Couleur et forme :SolidMasse moléculaire :561.05OK2
OK2, a specific inhibitor of the CCN2/EGFR interaction, effectively disrupts this interaction by binding to the CT domain of CCN2.Formule :C42H62N14O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :907.03Lumretuzumab
CAS :Lumretuzumab (RG-7116) is a humanized anti-HER3 monoclonal antibody with antitumor activity.Degré de pureté :95.3% (SDS-PAGE); 96.4% (SEC-HPLC) - 95.3% (SDS-PAGE); 96.4% (SEC-HPLC)Couleur et forme :Transparent LiquidMasse moléculaire :146.9 kDaMM-151
CAS :MM-151 is a humanized IgG1 monoclonal antibody targeting EGFR. It binds to multiple regions of the EGFR extracellular domain (ECD) and decreases mutations in circulating free tumor DNA associated with EGFR resistance. MM-151 significantly inhibits EGFR signaling and cell growth and is applicable in research on resistant cancers such as colorectal cancer, non-small cell lung cancer, and triple-negative breast cancer.Couleur et forme :LiquidMS9427
CAS :MS9427: PROTAC EGFR degrader, 7.1 nM (WT), 4.3 nM (L858R); targets mutant via UPS and autophagy; inhibits NSCLC cell growth; anticancer research.Formule :C48H58ClFN8O12Couleur et forme :SolidMasse moléculaire :993.47HER2-IN-14
CAS :HER2-IN-14 (Compound 34) is a potent inhibitor of HER2, achieving an inhibitory concentration (IC50) of 18 nM.Formule :C26H23ClF2N8O3Couleur et forme :SolidMasse moléculaire :568.96EP26
EP26 is an orally active and potent inhibitor of EGFR and PD-L1, with IC50 values of 48.6 nM and 1.77 µM, respectively. It reduces the protein expression of p-EGFR and induces cell cycle arrest at the G0/G1 phase. EP26 shows potential for glioblastoma research.Formule :C42H42ClFN4O5Couleur et forme :SolidMasse moléculaire :736.28278EGFR-IN-118
EGFR-IN-118 (Compound 4a) is an inhibitor of the tyrosine kinase EGFR. It exhibits anticancer properties, effectively inhibiting the proliferation of MCF-7 and PC3 cells, with IC50 values of 2.53 and 3.25 µg/ml, respectively. Additionally, EGFR-IN-118 demonstrates antioxidant activity by inhibiting DPPH free radicals, with an IC50 of 10.04 µg/ml.Formule :C26H23N3O2SCouleur et forme :SolidMasse moléculaire :441.1511EGFR-TK-IN-2
EGFR-TK-IN-2 (compound 10b) is an EGFR-TK inhibitor with an IC50 value of 0.16 μM, and it suppresses cell proliferation.Formule :C22H19N3O3Couleur et forme :SolidMasse moléculaire :373.14264HLX-22
CAS :HLX-22 is a humanized monoclonal antibody targeting HER2. When used in combination with trastuzumab, HLX-22 can induce apoptosis in HER2-overexpressing breast and gastric cancer cells. It also exhibits potent antitumor activity against advanced solid tumors.AZ14133346
AZ14133346 (compound 36) is a potent and selective inhibitor of EGFR exon 20 insertion, with an IC50 of 85 nM. It plays a significant role in cancer research.Formule :C29H27N5O2Couleur et forme :SolidMasse moléculaire :477.21648Varlitinib
CAS :Varlitinib (ASLAN001) is a potent, reversible, small molecule pan-EGFR inhibitor with IC50s of 7, 2, 4 nM for HER1, HER2 and HER4, respectively.Formule :C22H19ClN6O2SDegré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :466.94MC-Val-Cit-PAB-Amide-TLR7 agonist 4
CAS :MC-Val-Cit-PAB-Amide-TLR7 agonist 4 Conjugate is a conjugate formed by linking MC-Val-Cit-PAB-Amide and TLR7 agonist 4, useful for cancer research.Formule :C52H72N12O11Degré de pureté :97.70%Couleur et forme :White SolidMasse moléculaire :1041.2HER2-IN-13
CAS :HER2-IN-13 (Compound 33) serves as an effective HER2 inhibitor, exhibiting an IC50 value of 8 nM, and additionally demonstrates inhibition of wt-EGFR with anFormule :C26H23ClF2N8O3Couleur et forme :SolidMasse moléculaire :568.96Gefitinib N-oxide hydrochloride
Gefitinib N-oxide hydrochloride is an N-oxide of EGFR inhibitor Gefitinib with IC50 of 2-37 nM.Formule :C22H24ClFN4O41·5HClCouleur et forme :SolidMasse moléculaire :517.59EGFR-IN-42
EGFR-IN-42 (17b) is a potent EGFR inhibitor with nanomolar efficacy, merging tamoxifen/endoxifen and gefitinib, exhibiting enhanced anti-cancer action.Formule :C49H53ClFN5O5Couleur et forme :SolidMasse moléculaire :846.43EGFR-IN-43
EGFR-IN-43 (17c) is a potent EGFR inhibitor with ER antagonist action, tamoxifen/endoxifen+gefitinib linkage, and strong anticancer activity.Formule :C50H55ClFN5O5Couleur et forme :SolidMasse moléculaire :860.45EGFR-TK-IN-5
EGFR-TK-IN-5 (Compound NCE 2) is a thiazolyl pyrazoline derivative with significant inhibitory activity and stability against EGFR. It is applicable in tumor research.Formule :C26H20ClFN4OSCouleur et forme :SolidMasse moléculaire :490.98EGFR-IN-22
CAS :EGFR-IN-22: potent for EGFR (IC50: 4.91 nM) & L858R/T790M/C797S mutation (IC50: 0.54 nM).Formule :C38H47BrFN10O2PCouleur et forme :SolidMasse moléculaire :805.72Inetetamab
Inetetamab is a recombinant humanized antibody targeting HER2 receptor domain IV, with anticancer activity, inducing pyroptosis in lung adenocarcinoma.Degré de pureté :96.54% (SEC-HPLC) - 96.54% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :145.1 kDaEGFR-IN-15
CAS :EGFR-IN-15 (compound I-005) is a potent EGFR inhibitor, exhibiting an IC50 value of 4 nM. This compound holds potential for oncological research applications.Formule :C24H25BrN6O2Couleur et forme :SolidMasse moléculaire :509.408BMS-599626
CAS :BMS-599626 (AC480) has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.Formule :C27H27FN8O3Degré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :530.55EGFR kinase inhibitor 2
EGFR kinase inhibitor 2 (compound A-7) is a potent EGFR inhibitor targeting the mutations EGFRL858R/T790M/C797S and EGFRDel19/T790M/C797S. This compound shows potential in addressing acquired resistance in the treatment of non-small cell lung cancer.Formule :C39H40N6O5Couleur et forme :SolidMasse moléculaire :672.30602EGFR-IN-140
EGFR-IN-140 (Compound 31) is an inhibitor of EGFR, effectively targeting both wild-type EGFR and the EGFRL858R/T790M/C797S mutant, with Ki values of 0.95 nM and 2.1 nM, respectively. Additionally, it inhibits EGFRdel19/T790M/C797S in Ba/F3 cells with an IC50 of 56.9 nM and demonstrates antitumor activity in mouse models.Formule :C27H37FN8O2Couleur et forme :SolidMasse moléculaire :524.633EGFR-IN-127
EGFR-IN-127 is an ATP-competitive inhibitor targeting EGFR, with IC50 values of 136.3 nM for EGFRdel19 and 161.2 nM for EGFRdel19/T790M/C797S. This compound holds potential for the study of non-small cell lung cancer (NSCLC).Couleur et forme :Odour SolidMatuzumab
CAS :Matuzumab (EMD 72000) is a humanized monoclonal antibody targeting EGFR that can be used to study non-small cell lung cancer.Degré de pureté :95%Couleur et forme :LiquidMasse moléculaire :145.9 kDaEGFR-IN-124
EGFR-IN-124 (compound 10A) is an EGFR inhibitor with an IC50 value of 0.54 μM, utilized in cancer research.Couleur et forme :Odour SolidJAK 3 inhibitor IV
CAS :JAK 3 inhibitor IV (ZM 39923 hydrochloride) is a JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found toFormule :C16H19NODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :241.33DP-C-4
DP-C-4 is a Cereblon-based dual PROTAC for simultaneous degradation of EGFR and PARP[1].Couleur et forme :SolidAZ14240475
AZ14240475 is a potent, selective, brain-penetrant inhibitor of EGFREx20Ins mutants (EGFREx20Ins mutants) with a pIC50 of 7.6, playing a significant role in cancer research.Formule :C23H15ClF2N6O2Couleur et forme :SolidMasse moléculaire :480.854Depatuxizumab MMAF
Depatuxizumab-MMAF, an antibody-drug conjugate (ADC), comprises an EGFR-targeted antibody linked to McMMAF and is utilized in glioblastoma research.Couleur et forme :LiquidMasse moléculaire :148.24 kDaEGFR-IN-7
CAS :EGFR-IN-7 (TQB3804) is a selective and potent EGFR kinase inhibitor.Formule :C32H41BrN9O2PDegré de pureté :98.2% - 99.49%Couleur et forme :White SolidMasse moléculaire :694.6
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