EGFR
Les inhibiteurs du récepteur du facteur de croissance épidermique (EGFR) sont des composés qui bloquent la signalisation de l'EGFR, un récepteur souvent surexprimé dans divers cancers et qui joue un rôle crucial dans l'angiogenèse. Les inhibiteurs de l'EGFR sont utilisés pour prévenir la croissance tumorale et les métastases en perturbant les voies qui favorisent la formation de vaisseaux sanguins dans les tumeurs. Ces inhibiteurs sont largement utilisés dans la recherche et le traitement du cancer. Chez CymitQuimica, nous offrons une sélection diversifiée d'inhibiteurs de l'EGFR de haute qualité pour soutenir vos recherches en oncologie et angiogenèse.
587 produits trouvés pour "EGFR"
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(Rac)-JBJ-04-125-02
CAS :(Rac)-JBJ-04-125-02 (JBJ-04-125-02) is effective as a single agent in both in vitro and in vivo models of EGFR-mutant lung cancer.Formule :C29H26FN5O3SDegré de pureté :97.57%Couleur et forme :SolidMasse moléculaire :543.61Ref: TM-T8872
1mg100,00€5mg205,00€1mL*10mM (DMSO)249,00€10mg334,00€25mg567,00€50mg807,00€100mg1.099,00€Theliatinib tartrate
CAS :Theliatinib: oral EGFR blocker, Ki 0.05 nM, IC50 3 nM (wild-type), 22 nM (T790M/L858R), >50x kinase selectivity.Formule :C29H32N6O8Couleur et forme :SolidMasse moléculaire :592.6Osimertinib
CAS :Osimertinib (AZD-9291) is a small molecule tyrosine kinase receptor inhibitor and antineoplastic agent that is used in the therapy of selected forms of NSCLC.Formule :C28H33N7O2Degré de pureté :99.32% - >99.99%Couleur et forme :SolidMasse moléculaire :499.61Ref: TM-T2490
2mg34,00€5mg52,00€1mL*10mM (DMSO)52,00€10mg55,00€25mg67,00€50mg80,00€100mg94,00€500mg114,00€1g138,00€2g197,00€5g329,00€Almonertinib mesylate
CAS :Almonertinib mesylate: EGFR tyrosine kinase inhibitor, targets EGFR-mutant non-small cell lung cancer.Formule :C31H39N7O5SDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :621.75Ref: TM-T9865
1mg52,00€5mg110,00€1mL*10mM (DMSO)161,00€10mg177,00€25mg301,00€50mg425,00€100mg605,00€200mg797,00€Sulforaphene
CAS :Sulforaphene, from radish seeds, aids cancer cell apoptosis and inhibits migration; has an ED50 for velvetleaf at ~2x10^-4 M.Formule :C6H9NOS2Degré de pureté :97.55% - 99.67%Couleur et forme :Slightly Yellowish LiquidMasse moléculaire :175.27Ref: TM-TL0016
1mg34,00€2mg46,00€1mL*10mM (DMSO)65,00€5mg66,00€10mg92,00€25mg167,00€50mg241,00€100mg359,00€200mg525,00€Rostafuroxin
CAS :Rostafuroxin (PST 2238) has been used in trials studying the treatment of Essential Hypertension.Formule :C23H34O4Degré de pureté :98.24% - >99.99%Couleur et forme :SolidMasse moléculaire :374.51Mutant EGFR inhibitor
CAS :Selective, potent inhibitor for mutated EGFR: L858R, Exon19 deletion, T790M resistance mutants.Formule :C27H30ClN7O2Degré de pureté :98% - 99.75%Couleur et forme :SolidMasse moléculaire :520.03Ref: TM-T2705
500mgÀ demander1mg34,00€2mg49,00€5mg75,00€10mg92,00€1mL*10mM (DMSO)99,00€25mg165,00€50mg250,00€100mg359,00€Theliatinib
CAS :Theliatinib: potent, selective EGFR inhibitor, anti-tumor; Ki=0.05 nM (EGFR), IC50=3 nM (EGFR), 22 nM (T790M/L858R).Formule :C25H26N6O2Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :442.51Genistein
CAS :Genistein (NPI 031L) is a natural soy isoflavone, a multi-targeted tyrosine kinase inhibitor. Genistein has antitumor effects. Cost effective and quality assured.Formule :C15H10O5Degré de pureté :98.22% - 99.64%Couleur et forme :Rectangular Or Six-Sided Rods From 60% Alcohol Dendritic Needles From Ether SolidMasse moléculaire :270.24Olmutinib hydrochloride
CAS :Olmutinib is a third-gen EGFR inhibitor for T790M-positive lung cancer, blocking phosphorylation and tumor pathways. Approved in Korea (2016).Formule :C26H28Cl2N6O2SCouleur et forme :SolidMasse moléculaire :559.51SU5204
CAS :SU5204 (3-[(2-Ethoxyphenyl)methylidene]-1H-indol-2-one), an analogue of SU5025, pharmacologically inhibits VEGFR2(IC50s of 4 and 51.5 μM for FLK-1 (VEGFR-2) andFormule :C17H15NO2Degré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :265.31NRC-2694
CAS :NRC-2694 is an antagonist of the epidermal growth factor receptor (EGFR). It has anti-cancer and anti-proliferative properties.Formule :C24H26N4O3Degré de pureté :99.90%Couleur et forme :SolidMasse moléculaire :418.49Ref: TM-T16343
1mg56,00€5mg105,00€1mL*10mM (DMSO)116,00€10mg170,00€25mg281,00€50mg371,00€100mg537,00€200mg712,00€ZD-4190
CAS :ZD-4190 blocks VEGFR2 and EGFR, aiding cancer treatment.Formule :C19H16BrFN6O2Degré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :459.27Ref: TM-T5475
1mg80,00€5mg173,00€1mL*10mM (DMSO)175,00€10mg261,00€25mg414,00€50mg567,00€100mg767,00€200mg1.018,00€Methyl 2,5-dihydroxycinnamate
CAS :Methyl 2,5-dihydroxycinnamate is an EGF receptor-associated tyrosine kinases inhibitor.Formule :C10H10O4Degré de pureté :99.60%Couleur et forme :CrystallineMasse moléculaire :194.18PP2
CAS :PP2 (AG 1879,AGL 1879) is a effective inhibitor of Lck/Fyn (IC50:4/5 nM) , ~100-fold less potent to EGFR, inactive for ZAP-70, PKA and JAK2.Formule :C15H16ClN5Degré de pureté :98% - 98.21%Couleur et forme :White SolidMasse moléculaire :301.77Ref: TM-T6266
2mg44,00€5mg65,00€1mL*10mM (DMSO)71,00€10mg110,00€25mg178,00€50mg304,00€100mg482,00€200mg687,00€Tyrphostin AG30
CAS :Tyrphostin AG30 (AG30) (AG30) is a potent protein tyrosine kinases (PTK) inhibitor.Formule :C10H7NO4Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :205.17PD-161570
CAS :PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.Formule :C26H35Cl2N7ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :532.51Ref: TM-T23127
1mg34,00€5mg96,00€1mL*10mM (DMSO)118,00€10mg141,00€25mg289,00€50mg465,00€100mg662,00€200mg888,00€Lazertinib
CAS :Lazertinib (GNS-1480) is a potent, selective, irreversible EGFR-TKI; IC50: 1.7-76 nM for various EGFR mutations.Formule :C30H34N8O3Degré de pureté :98.7% - 99.90%Couleur et forme :SolidMasse moléculaire :554.64Ref: TM-T4485
1mg46,00€2mg59,00€5mg96,00€1mL*10mM (DMSO)104,00€10mg130,00€25mg215,00€50mg309,00€100mg444,00€200mg655,00€Leptomycin B
CAS :Leptomycin B: potent CRM1 inhibitor, blocks protein nuclear export and cell cycle, antifungal, modifies cysteine.Formule :C33H48O6Degré de pureté :97.10% - 99.04%Couleur et forme :White Crystalline SolidMasse moléculaire :540.73Ref: TM-T15735
1mg192,00€1mL*10mM (DMSO)268,00€2mg324,00€5mg587,00€10mg835,00€25mg1.251,00€50mg1.684,00€100mg2.277,00€Gefitinib hydrochloride
CAS :Obtustatin triacetate is an integrin derived from the venom of Vipera lebetina obtusa and is an α1β1 integrin and in vivo angiogenesis inhibitor.Formule :C22H25Cl2FN4O3Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :483.36Cavutilide
CAS :Cavutilide has antiarrhythmic activity, inhibits hERG K(+) channels, and can be used to study heart failure and persistent atrial fibrillation.Formule :C22H26FN3O3Degré de pureté :99.82% - 99.85%Couleur et forme :SolidMasse moléculaire :399.458BMS-690514
CAS :BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR. It has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.Formule :C19H24N6O2Degré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :368.43Almonertinib hydrochloride
CAS :Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation.Formule :C30H36ClN7O2Degré de pureté :98.01% - 98.12%Couleur et forme :SolidMasse moléculaire :562.1Canertinib dihydrochloride
CAS :Canertinib dihydrochloride (PD-183805 dihydrochloride) is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic andFormule :C24H27Cl3FN5O3Degré de pureté :99.13% - >99.99%Couleur et forme :SolidMasse moléculaire :558.86Naquotinib mesylate
CAS :Naquotinib mesylate (ASP8273 (mesylate)) is an orally available, mutant-selective and irreversible inhibitor of EGFR(iC50s of 8-33 nM and 230 nM for toward EGFRFormule :C31H46N8O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :658.81Izalontamab
CAS :Izalontamab (SI-B001) is a bispecific EGFR/HER3 monoclonal antibody that binds to both EGFR×EGFR homodimers and EGFR×HER3 heterodimers.Degré de pureté :95%+ - 95.3% (SDS-PAGE); 99.2% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :197.21 kDaZalutumumab
CAS :Zalutumumab is a high-affinity fully human monoclonal antibody ,the extracellular domain of the EGFR squamous cell carcinoma of the head and neck (SCCHN).Degré de pureté :95%Couleur et forme :LiquidMasse moléculaire :146.63 kDaElgemtumab
CAS :Elgemtumab (LJM716) is a fully humanised monoclonal antibody targeting HER3/ERBB3, acting as an antagonist to block HER3/Akt phosphorylation antitumour.Degré de pureté :95%Couleur et forme :LiquidMasse moléculaire :144.15 kDaSerclutamab
CAS :Serclutamab, a humanized chimeric monoclonal antibody of the IgG1-κ isotype, selectively targets the epidermal growth factor receptor (EGFR).Degré de pureté :98%Couleur et forme :LiquidAnbenitamab
CAS :Anbenitamab (KN-026) is a bispecific HER2 antibody for metastatic breast cancer research, blocking HER2 pathways and mediating ADCC.Couleur et forme :LiquidZanidatamab
CAS :Zanidatamab (ZW25) is a bispecific, humanized monoclonal antibody that targets two distinct epitopes (ECD2 and ECD4) of the HER2 receptor, exhibiting anti-tumorDegré de pureté :95%Couleur et forme :LiquidBecotatug
CAS :Becotatug (JMT101) is a humanised monoclonal antibody targeting EGFR, antitumour when combined with Osimertinib for treating EGFR-mutated advanced NSCLC.Degré de pureté :95% - 99.1% (SDS-PAGE); 98.1% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :145.52 kDaEGFR T790M/L858R-IN-8
CAS :EGFRT790M/L858R-IN-8 (compound 9) is a potent inhibitor of EGFR, specifically targeting the EGFRT790M/L858R mutations with an IC50 of 56.8 μM. This compound does not show significant antiproliferative effects on cancer cell lines A549, A431, and NHI-H1975.Formule :C16H11BrN2O3Couleur et forme :SolidMasse moléculaire :359.17EGFR vIII Protein, Human, Recombinant (hFc)
EGFR vIII Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag.Couleur et forme :Lyophilized PowderMasse moléculaire :90-120 KDa (reducing condition)Ref: TM-TMPJ-00647
5µg90,00€10µg130,00€20µg193,00€50µg381,00€100µg600,00€200µg947,00€500µg1.765,00€1mg2.535,00€Fidasimtamab
CAS :Fidasimtamab, a recombinant human IgG1 bispecific antibody, targets both HER2 and PD-1, bridging T cells and tumor cells to modulate immune responses.Degré de pureté :95% - 98.0% (SDS-PAGE); 98.3% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :144.72 kDaFutuximab
CAS :Futuximab is a chimeric monoclonal antibody targeting EGFR, commonly used in combination with zatuximab to form Sym004.Degré de pureté :95% - 97.5% (SDS-PAGE); 96.3% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :146.28 kDaImgatuzumab
CAS :Imgatuzumab (RG 7160) is a humanized anti-EGFR monoclonal antibody and immunomodulator for cancer research.
Couleur et forme :LiquidMasse moléculaire :145.0 (kDa)Ponezumab
CAS :Ponezumab (PF-04360365), a humanized IgG2 antibody, lowers Aβ in the CNS & boosts mice memory. Used in Alzheimer's research.Couleur et forme :LiquidRunimotamab
Runimotamab, an IgG1-κ humanized chimeric antibody, targets CD3E and HER2 [1].Couleur et forme :Odour LiquidTyrphostin AG 494
CAS :Formule :C16H12N2O3Degré de pureté :>98.0%(HPLC)(N)Couleur et forme :Light yellow to Amber to Dark green powder to crystalMasse moléculaire :280.28IGF-1R modulator 1
CAS :IGF-1Rmodulator 1 (Example 5) is an IGF-1R modulator featuring an EC50 of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), and 0.39 μM (TrkB). This compound is useful in research on diseases characterized by impaired signaling of neurotrophic and/or other trophic factors, such as Alzheimer's disease.Formule :C22H17N3O4Couleur et forme :SolidMasse moléculaire :387.39Icotinib
CAS :Icotinib (Conmana) is an orally available quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity.Formule :C22H21N3O4Degré de pureté :99.76% - 99.94%Couleur et forme :SolidMasse moléculaire :391.42ZM323881 hydrochloride
CAS :ZM323881 hydrochloride (ZM 323881 HCl) is a potent and selective VEGFR2 inhibitor.Formule :C22H19ClFN3O2Degré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :411.86Ref: TM-T1991
1mg34,00€5mg66,00€1mL*10mM (DMSO)69,00€10mg96,00€25mg225,00€50mg369,00€100mg550,00€200mg780,00€lavendustin A
CAS :lavendustin A (RG-14355) is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.Formule :C21H19NO6Degré de pureté :98%Couleur et forme :Off-White SolidMasse moléculaire :381.38Icotinib Hydrochloride
CAS :Icotinib Hydrochloride, an oral EGFR inhibitor (BPI-2009H), may halt cancer growth by blocking EGFR signaling.Formule :C22H22ClN3O4Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :427.88TAK-285
CAS :TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc.Formule :C26H25ClF3N5O3Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :547.96Ref: TM-T6039
1mg38,00€5mg80,00€1mL*10mM (DMSO)96,00€10mg120,00€25mg216,00€50mg354,00€100mg512,00€200mg727,00€EGFR-IN-31
CAS :EGFR-IN-31: Potent EGFR inhibitor, targets mutations & overexpression in NSCLC; potential cancer research compound. (WO2021185298A1, 2)Formule :C32H36FN7O2Couleur et forme :SolidMasse moléculaire :569.67EGFR-IN-49
CAS :EGFR-IN-49 selectively inhibits EGFR mutations T790M (IC50: 65 nM) & T790M/L858R (IC50: 13.6 nM), triggering apoptosis dose-dependently.Formule :C22H15N5O2SCouleur et forme :SolidMasse moléculaire :413.45EGFR-IN-55
CAS :"EGFR-IN-55 targets EGFRWT (70 nM IC50) & EGFRL858R/T790M (3.9 nM IC50), halts NCI-H1975 cell cycle in G0/G1, showing anticancer properties."Formule :C25H25Cl2N7O2Couleur et forme :SolidMasse moléculaire :526.42(E/Z)-AG490
CAS :(E/Z)-AG490 is a racemic mix of (E)- and (Z)-isomers; it inhibits tyrosine kinase, EGFR, Stat-3, and JAK2/3.Formule :C17H14N2O3Couleur et forme :SolidMasse moléculaire :294.3
