BTK
Les inhibiteurs de la tyrosine kinase de Bruton (BTK) sont des composés qui ciblent spécifiquement et inhibent la BTK, une enzyme cruciale impliquée dans la signalisation du récepteur des cellules B et la régulation de l'angiogenèse. La BTK joue un rôle significatif dans la prolifération et la survie des cellules cancéreuses, en particulier dans les malignités hématologiques. En inhibant la BTK, ces composés peuvent perturber l'angiogenèse et la croissance tumorale, ce qui les rend précieux en thérapie anticancéreuse. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de la BTK de haute qualité pour soutenir vos recherches en oncologie, immunologie et angiogenèse.
145 produits trouvés pour "BTK"
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Tirabrutinib hydrochloride
CAS :<p>Tirabrutinib hydrochloride is a potent, highly selective, irreversible oral BTK inhibitor.Cost-effective and quality-assured.</p>Formule :C25H23ClN6O3Degré de pureté :99.04% - 99.27%Couleur et forme :SolidMasse moléculaire :490.94ARQ 531
CAS :<p>ARQ-531: potent oral BTK inhibitor, anti-cancer potential, IC50 of 0.85/0.39 nM for WT/C481S-BTK.</p>Formule :C25H23ClN4O4Degré de pureté :98.68% - 99.63%Couleur et forme :SolidMasse moléculaire :478.93MT-802
CAS :<p>MT-802 is an effective BTK degrader based on PROTAC technology (DC50: 1 nM). MT-802 has the potential to treat C481S mutant chronic lymphocytic leukemia (CLL).</p>Formule :C41H41N9O8Degré de pureté :95.93% - 97%Couleur et forme :SolidMasse moléculaire :787.82Btk inhibitor 2
CAS :<p>Btk inhibitor 2 (BGB-3111 analog) is a BTK inhibitor.</p>Formule :C24H25N5O3Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :431.49AS-1763
CAS :<p>AS-1763 is an orally available and selective BTK inhibitor with an IC50 of 0.85 nM.</p>Formule :C33H31FN6O3Degré de pureté :≥95%Couleur et forme :SolidMasse moléculaire :578.64IBT6A
CAS :<p>IBT6A is an impurity of Ibrutinib. Ibrutinib is a Btk inhibitor (IC50: 0.5 nM). IBT6A can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.</p>Formule :C22H22N6ODegré de pureté :99.8% - 99.88%Couleur et forme :SolidMasse moléculaire :386.45Rilzabrutinib
CAS :<p>Rilzabrutinib (PRN1008) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 of 1.3 nM).</p>Formule :C36H40FN9O3Degré de pureté :98.28% - 99.76%Couleur et forme :SolidMasse moléculaire :665.76Orelabrutinib
CAS :<p>Orelabrutinib (ICP-022) is an orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK).</p>Formule :C26H25N3O3Degré de pureté :97.77% - 99.54%Couleur et forme :SolidMasse moléculaire :427.49FDU73
<p>FDU73 is a potent and selective BTK PROTAC degrader with a DC50 of 2.9 nM in JeKo-1 cells. It inhibits tumor cell proliferation and exhibits antitumor activity.</p>Couleur et forme :Odour SolidBTK ligand-14
<p>BTKligand-14 is a PROTAC-targeting ligand for BTK, suitable for the synthesis of FDU73.</p>Couleur et forme :Odour SolidPROTAC BTK Degrader-5
<p>PROTAC BTK Degraders-5 (Compound 3e) is a selective Bruton's tyrosine kinase (BTK) degrader with a DC50 of 7.0 nM in JeKo-1 cells, demonstrating specificity by</p>Formule :C52H57ClFN9O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :958.52Tyrosinase-IN-16
CAS :<p>Tyrosinase-IN-16 inhibited tyrosinase.</p>Formule :C8H6BrN3SDegré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :256.12DBt-10
<p>DBt-10 is a potent Bruton's tyrosine kinase (BTK) degrader [1].</p>Formule :C68H86ClFN16O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1277.96PROTAC BTK Degrader-6
CAS :<p>PROTAC BTK Degrader-6 (Compound 15), with a DC50 of 3.18 nM, exhibits anti-inflammatory properties by inhibiting NF-κB activation and suppressing the expression</p>Formule :C45H47N11O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :837.92BTK-IN-40
CAS :<p>BTK-IN-40 (compound 375) is an inhibitor of BTK.</p>Formule :C20H25N7O2Couleur et forme :SolidMasse moléculaire :395.46FDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Couleur et forme :LiquidBTK-IN-5
CAS :<p>BTK-IN-5 is a covalent inhibitor of Bruton's tyrosine kinase (BTK) designed for the treatment of medical conditions including cardiovascular diseases,</p>Formule :C23H32N4O5Couleur et forme :SolidMasse moléculaire :444.532PROTAC BTK Degrader-2
CAS :<p>PROTAC BTK Degrader-2, a potent degrader of BTK through the PROTAC mechanism, effectively diminishes BTK protein levels [1].</p>Formule :C47H54F2N8O13Couleur et forme :SolidMasse moléculaire :976.97GBD-9
CAS :<p>GBD-9, a dual-mechanism degrader, effectively promotes the degradation of BTK and GSPT1 through recruitment of E3 ligase cereblon (CRBN).</p>Formule :C44H47N9O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :797.9Acalabrutinib enantiomer
CAS :<p>R-Acalabrutinib, a BTK inhibitor,enantiomer, is researched for cancer, autoimmune diseases, and inflammation.</p>Formule :C26H23N7O2Degré de pureté :97.27%Couleur et forme :SolidMasse moléculaire :465.51CNX-500
CAS :<p>CNX-500: covalent Btk inhibitor linked to biotin, IC50 0.5 nM, low effect on EGFR and Src kinases.</p>Formule :C48H68N10O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :961.18evobrutinib
CAS :<p>Evobrutinib(M2951) , also known as M-2951 and MSC-2364447C, is a highly selective inhibitor of the Bruton's tyrosine kinase (BTK), which is important in the</p>Formule :C25H27N5O2Degré de pureté :98.03% - 99.58%Couleur et forme :SolidMasse moléculaire :429.51BRK inhibitor P21d hydrochloride
CAS :<p>BRK inhibitor P21d HCl targets breast tumor kinase with 30 nM IC50, suppresses p-SAM68 at 52 nM, useful for in vivo breast cancer research.</p>Formule :C23H23ClFN7O2Couleur et forme :SolidMasse moléculaire :483.93PTD10
CAS :<p>PTD10, a highly potent PROTAC BTK degrader, exhibits a DC50 of 0.5 nM and a KD of 2.28 nM.</p>Formule :C49H51N11O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :922BTK inhibitor 17
CAS :<p>BTK inhibitor 17 is a potent irreversible BTK inhibitor (IC50 = 2.1 nM). BTK inhibitor 17 can be used in rheumatoid arthritis studies.</p>Formule :C25H24N6O3Degré de pureté :99.57% - 99.88%Couleur et forme :SolidMasse moléculaire :456.5PCI-33380
CAS :<p>PCI-33380 is an irreversible inhibitor of Bruton's Tyrosine Kinase.</p>Formule :C46H52BF2N11O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :855.8Ibrutinib-biotin
CAS :<p>Ibrutinib-biotin probe links Ibrutinib to biotin, with IC50 0.755-1.02 nM for BTK (patent WO2014059368A1).</p>Formule :C56H80N12O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1097.39TLT8
<p>TLT8 is a ByeTAC protein degrader that targets BTK. It induces BTK degradation by non-covalently binding to Rpn-13 and BTK. TLT8 is applicable in research on chronic lymphocytic leukemia.</p>Couleur et forme :Odour SolidDD 03-171
CAS :<p>Potent BTK Degrader, IC50=5.1nM, CRBN-dependent, suppresses MCL; degrades Ibrutinib-resistant BTK, no kinases binding, reduces tumors in models.</p>Formule :C55H62N10O8Couleur et forme :SolidMasse moléculaire :991.163BTK inhibitor 19
CAS :<p>BTK inhibitor 19 is a highly selective, covalent BTK inhibitor ( IC 50 = 2.7 nM).</p>Formule :C25H24F3N7O3Couleur et forme :SolidMasse moléculaire :527.508PROTAC BTK Degrader-12
CAS :<p>PROTAC BTK Degrader-12 (EXAMPLE 19) is a PROTAC-based BTK degrader, featuring a structure where the BTK ligand and linker are highlighted in pink and black, the linker in black, and the VHL ligand in blue.</p>Formule :C47H54N12O4Couleur et forme :SolidMasse moléculaire :851.01PROTAC BTK Degrader-10
CAS :<p>PROTAC BTK Degrader-10 (Example 1P) is a PROTAC compound that targets BTK for degradation. It is applicable in the research of chronic lymphocytic leukemia (CLL). [Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase Cereblon].</p>Formule :C42H49N11O4Couleur et forme :SolidMasse moléculaire :771.91PROTAC BTK Degrader-13
<p>PROTAC BTK Degrader-13 (Compound 25) is a targeted BTK PROTAC degrader with a DC50 of 0.27 μM. It inhibits BTK activity with an IC50 of 0.44 μM and suppresses IL-2-induced T cell kinase (ITK) with an IC50 of 2.16 μM. This compound also inhibits the p38 MAPK signaling pathway, thereby blocking the activation of the BCR (B cell receptor) signaling pathway. [Pink: ligand for target protein BTK ligand 15; Black: linker; Blue: ligand for E3 ligase cereblon]</p>Formule :C33H30N6O7Couleur et forme :SolidMasse moléculaire :622.63PROTAC BTK Degrader-1
CAS :<p>Potent, selective oral PROTAC BTK Degrader-1; IC50: 34.51 nM (WT), 64.56 nM (BTK-481S); reduces BTK protein, inhibits tumors.</p>Formule :C43H43N9O4Couleur et forme :SolidMasse moléculaire :749.86PROTAC BTK Degrader-8
<p>PROTACBTK Degrader-8 (compound 3) is an efficient PROTAC BTK degrader with a linker that can couple with ADC antibodies to form PAC.</p>Formule :C80H94F2N14O20P2Masse moléculaire :1670.62121PROTAC BTK Degrader-9
<p>PROTACBTK Degrader-9 (compound 23) is a potent PROTACs degrader that specifically targets BTK. It effectively downregulates the RANKL-activated BTK-PLCγ2-Ca2+-NFATc1 signaling pathway. Consequently, PROTACBTK Degrader-9 inhibits osteoclastogenesis and reduces alveolar bone resorption in a mouse model of periodontitis.</p>Formule :C46H52FN13O5Masse moléculaire :885.41984Ibrutinib dimer
CAS :<p>Ibrutinib dimer is an impurity of Ibrutinib. IIbrutinib dimer is a Dimer of Ibrutinib. Ibrutinib is an irreversible Btk inhibitor (IC50: 0.5 nM).</p>Formule :C50H48N12O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :880.99SJF620 hydrochloride
CAS :<p>SJF620 hydrochloride is a PROTAC that utilizes a lenalidomide analog to recruit CRBN and ligands to target Btk, exhibiting a DC50 of 7.9 nM [1].</p>Formule :C41H45ClN8O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :797.3NRX-0492
CAS :<p>NRX-0492: orally active BTK degrader, induces ubiquitylation/proteasomal breakdown, potent with DC50 ≤0.2 nM, DC90 ≤0.5 nM, disrupts BCR signaling.</p>Formule :C43H51N11O6Couleur et forme :SolidMasse moléculaire :817.94BIIB091
CAS :<p>BIIB091 is a highly selective, reversible BTK inhibitor for treating autoimmune diseases.</p>Formule :C28H34N10O2Couleur et forme :SolidMasse moléculaire :542.648BCPyr
CAS :<p>BCPyr is a new candidate BTK degrader ( DC 50 = 800 nM).</p>Formule :C58H65F2N11O8Couleur et forme :SolidMasse moléculaire :1082.224GDC-0834
CAS :<p>GDC-0834 inhibits BTK with an in vitro IC50 of 5.9 and 6.4 nM in biochemical and cellular assays, respectively, and in vivo IC50 of 1.1 and 5.6 μM in mouse and</p>Formule :C33H36N6O3SCouleur et forme :SolidMasse moléculaire :596.74Elsubrutinib
CAS :<p>Elsubrutinib (ABBV-105) is a highly active, potent, and selective orally-administered inhibitor of Bruton's tyrosine kinase (BTK). It irreversibly inhibits the catalytic domain of BTK with an IC50 value of 0.18 μM. Elsubrutinib holds potential for the advancement of research on inflammatory diseases.</p>Formule :C17H19N3O2Couleur et forme :SolidMasse moléculaire :297.358IBT6A hydrochloride
CAS :<p>IBT6A hydrochloride: Ibrutinib impurity, Btk inhibitor IC50: 0.5 nM, used in dimer/adduct synthesis.</p>Formule :C22H23ClN6OCouleur et forme :SolidMasse moléculaire :422.91Anti-BTK Antibody (3G585)
<p>Anti-BTK Antibody (3G585) is an antibody targeting BTK. Anti-BTK Antibody (3G585) can be used in ELISA, IHC.</p>Couleur et forme :Odour LiquidN-piperidine Ibrutinib hydrochloride
CAS :<p>N-piperidine Ibrutinib hydrochloride is a BTK inhibitor that inhibits WT BTK and C481S BTK , which inhibits the growth and proliferation of cancer cells.</p>Formule :C22H23ClN6ODegré de pureté :98.83%Couleur et forme :SolidMasse moléculaire :422.91NX-5948
CAS :<p>NX-5948 (BTK-IN-24) is a PROTAC-type BTK degrader with anti-inflammatory and anticancer activities, inhibiting B cell activation.</p>Formule :C42H54N12O5Degré de pureté :98.29%Couleur et forme :SolidMasse moléculaire :806.96Poseltinib
CAS :<p>Poseltinib is an oral, irreversible BTK inhibitor (IC50 1.95 nM) with higher selectivity over BMX, TEC, and TXK, blocking BCR, FcR, and TLR signaling.</p>Formule :C26H26N6O3Couleur et forme :SolidMasse moléculaire :470.52(S)-Sunvozertinib
CAS :<p>(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.</p>Formule :C29H35ClFN7O3Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :584.08Tolebrutinib
CAS :<p>Tolebrutinib is an oral, selective BTK inhibitor, effective for MS research, with brain penetration and IC50s of 0.4/0.7 nM in cells.</p>Formule :C26H25N5O3Degré de pureté :98.4% - 98.82%Couleur et forme :SolidMasse moléculaire :455.51(Z)-LFM-A13
CAS :<p>(Z)-LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.</p>Formule :C11H8Br2N2O2Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :360Fenebrutinib
CAS :<p>Fenebrutinib (GDC-0853) is a selective and noncovalent Btk inhibitor (Ki: 0.91 nM).</p>Formule :C37H44N8O4Degré de pureté :98.26% - 98.94%Couleur et forme :SolidMasse moléculaire :664.8Ibrutinib
CAS :<p>Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation.</p>Formule :C25H24N6O2Degré de pureté :98% - 99.93%Couleur et forme :SolidMasse moléculaire :440.5PCI 29732
CAS :<p>PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.</p>Formule :C22H21N5ODegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :371.43Remibrutinib
CAS :<p>Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood.</p>Formule :C27H27F2N5O3Degré de pureté :99.5% - 99.81%Couleur et forme :SolidMasse moléculaire :507.53BIIB068
CAS :<p>BIIB068 is an selective, reversible and orally active BTK inhibitor (IC50 = 1 nM, Kd = 0.3 nM). BIIB068 is 400 times more selective for BTK than other kinases.</p>Formule :C23H29N7O2Degré de pureté :97.98%Couleur et forme :SolidMasse moléculaire :435.52Ibrutinib deacryloylpiperidine
CAS :<p>Ibrutinib deacryloylpiperidine (IBT4A) is a highly selective Bruton’s tyrosine kinase (BTK) irreversible inhibitor with an IC50 of 0.5 nM.</p>Formule :C17H13N5ODegré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :303.32CHMFL-BMX-078
CAS :<p>CHMFL-BMX-078 is a highly potent and selective type II irreversible BMX kinase inhibitor with an IC50 of 11 nM.</p>Formule :C33H35N7O6Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :625.67N-piperidine Ibrutinib
CAS :<p>N-piperidine Ibrutinib is a potent BTK inhibitor with IC50s of 51.0 for WT BTK and 30.7 nM for C481S BTK respectively.</p>Formule :C22H22N6ODegré de pureté :96.65%Couleur et forme :SolidMasse moléculaire :386.45zanubrutinib
CAS :<p>Zanubrutinib (BGB-3111) is an inhibitor of Bruton tyrosine kinase (BTK).</p>Formule :C27H29N5O3Degré de pureté :98.42% - 99.76%Couleur et forme :SolidMasse moléculaire :471.55BMS-986142
CAS :<p>BMS-986142 is a potent and highly selective reversible BTK inhibitor (IC50: 0.5 nM).</p>Formule :C32H30F2N4O4Degré de pureté :98.7% - 99.76%Couleur et forme :SolidMasse moléculaire :572.6Acalabrutinib
CAS :<p>Acalabrutinib (ACP-196), also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.</p>Formule :C26H23N7O2Degré de pureté :98.94% - 99.64%Couleur et forme :SolidMasse moléculaire :465.51(Rac)-IBT6A
CAS :<p>(Rac)-IBT6A is a racemate of IBT6A. IBT6A is an impurity of Ibrutinib and can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.</p>Formule :C22H22N6ODegré de pureté :99.24%Couleur et forme :SolidMasse moléculaire :386.45TL-895
CAS :<p>TL-895 is a potent, selective ATP-competitive BTK inhibitor (IC50 = 1.5 nM, Ki = 11.9 nM).</p>Formule :C25H26FN5O2Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :447.5Spebrutinib
CAS :<p>Spebrutinib (LMK-435) is an orally bioavailable, selective inhibitor of Bruton's agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic</p>Formule :C22H22FN5O3Degré de pureté :97.02% - >99.99%Couleur et forme :SolidMasse moléculaire :423.44ONO-4059 analog
CAS :<p>ONO-4059 analog (ONO-WG-307)ue is an analogue of ONO-4059, which is a highly potent and selective oral BTK inhibitor with IC50 of 23.9 nM. Phase 1.</p>Formule :C25H24N6O3Degré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :456.5RN486
CAS :<p>RN486 is an effective and specific BTK inhibitor (IC50: 4 nM).</p>Formule :C35H35FN6O3Degré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :606.69Branebrutinib
CAS :<p>Branebrutinib (BMS986195) is a potent, covalent inhibitor of Bruton's tyrosine kinase (BTK), >5,000-fold selective over all kinases outside of the Tec family.</p>Formule :C20H23FN4O2Degré de pureté :95.86% - 99.31%Couleur et forme :SolidMasse moléculaire :370.42Larotinib mesylate hydrate
CAS :<p>Larotinib mesylate hydrate is a potent, broad-spectrum, and orally active tyrosine kinase inhibitor (TKI), primarily targeting EGFR with an IC50 value of 0.6 nM</p>Formule :C26H36ClFN4O11S2Couleur et forme :SolidMasse moléculaire :699.17CNX-774
CAS :<p>CNX-774 is a highly specific, irreversible, and orally active BTK inhibitor (IC50<1 nM).</p>Formule :C26H22FN7O3Degré de pureté :97.35% - 99.11%Couleur et forme :SolidMasse moléculaire :499.5CGI-1746
CAS :<p>CGI1746 is a potent and highly selective small-molecule Btk inhibitor with IC50 of 1.9 nM.</p>Formule :C34H37N5O4Degré de pureté :97.69% - 97.88%Couleur et forme :SolidMasse moléculaire :579.69Avitinib
CAS :<p>Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor,</p>Formule :C26H26FN7O2Degré de pureté :99.81% - >99.99%Couleur et forme :SolidMasse moléculaire :487.53BTK IN-1
CAS :<p>BTK IN-1 (SNS062 analog) (SNS062 analog) is an effective BTK inhibitor (IC50: <100 nM).</p>Formule :C19H21ClN6ODegré de pureté :97.38%Couleur et forme :SolidMasse moléculaire :384.86BTK Protein, Human, Recombinant (His)
<p>Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling.</p>Degré de pureté :90%Couleur et forme :Lyophilized PowderMasse moléculaire :78.3 kDa (predicted)Ibrutinib-d5
CAS :<p>Ibrutinib D5 is a deuterium-labeled Ibrutinib. Ibrutinib is an irreversible Btk inhibitor.</p>Formule :C25H24N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :445.53JAK3/BTK-IN-5
CAS :<p>JAK3/BTK-IN-5 is a potent dual inhibitor targeting JAK3 and BTK with synergistic effects, valuable for related autoimmune disease research.</p>Formule :C19H22ClN7O2Couleur et forme :SolidMasse moléculaire :415.88BLK-IN-2
CAS :<p>BLK-IN-2为一种高效、选择性且不可逆的B-淋巴酪氨酸激酶(BLK)抑制剂，具有5.9 nM的IC50值。该化合物亦能抑制BTK，其IC50值为202.0 nM。BLK-IN-2在多种淋巴瘤细胞中展现出显著的抗增殖作用。</p>Formule :C39H41N9O3Couleur et forme :SolidMasse moléculaire :683.8EGFR-IN-40
CAS :<p>EGFR-IN-40 (compound 3z) is a potent inhibitor of BTK (IC50: 1.2 nM), EGFR (IC50: 5.3 nM) and ITK (IC50: 46.1 nM).</p>Formule :C23H20N6O3Couleur et forme :SolidMasse moléculaire :428.44GDC-0834 Racemate
CAS :<p>GDC-0834 Racemate is the racemate form of GDC-0834, which is an effective and selective BTK inhibitor</p>Formule :C33H36N6O3SCouleur et forme :SolidMasse moléculaire :596.74BTK inhibitor 10
CAS :<p>BTK inhibitor 10, an oral drug from patent WO2018145525, may treat rheumatoid arthritis.</p>Formule :C25H23N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :441.48SJF620
CAS :<p>SJF620 is a potent degrader of PROTAC BTK(DC50 : 7.9 nM).</p>Formule :C41H44N8O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :760.84Ibrutinib-MPEA
CAS :<p>Ibrutinib-MPEA is ibrutinib derivative. Ibrutinib is a covalent and irreversible BTK inhibitor that has been used to treat hematological malignancies.</p>Formule :C32H39N9O2Couleur et forme :SolidMasse moléculaire :581.71JNJ-64264681
CAS :<p>JNJ-64264681 is a potent, orally active, selective, and irreversible covalent inhibitor of Bruton's tyrosine kinase (BTK).</p>Formule :C27H30N6O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :518.63(R)-Elsubrutinib
CAS :<p>(R)-Elsubrutinib ((R)-ABBV-105), a Btk inhibitor, is used in research on immune diseases and cancer.</p>Formule :C17H19N3O2Couleur et forme :SolidMasse moléculaire :297.35DPPY
CAS :<p>DPPY inhibits EGFR, BTK, JAK3 (IC50<10 nM), curbs B-cell lymphoma growth, and may be studied for IPF treatment.</p>Formule :C25H26ClN7O3Couleur et forme :SolidMasse moléculaire :507.97SB-633825
CAS :<p>SB-633825 can inhibit cancer cell growth and angiogenesis.</p>Formule :C28H25N3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :483.58Spebrutinib besylate
CAS :<p>Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a Btk kinase activity inhibitor (IC50<0.5 nM, Kinact/Ki=7.69×104 M-1s-1s).</p>Formule :C28H28FN5O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :581.62ACP-5862
CAS :<p>ACP-5862, active metabolite of Acalabrutinib, is a BTK inhibitor with an IC50 of 5.0 nM.</p>Formule :C26H23N7O3Couleur et forme :SolidMasse moléculaire :481.51CHMFL-BTK-01
CAS :<p>CHMFL-BTK-01 is an irreversible inhibitor of BTK (IC50: 7 nM) and also potently inhibits BTK Y223 auto-phosphorylation.</p>Formule :C38H41N5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :647.76JAK3/BTK-IN-6
CAS :<p>JAK3/BTK-IN-6: potent BTK (0.6 nM) & JAK3 (0.4 nM) inhibitor, stable in human liver, for blood/immune research.</p>Formule :C21H17BF3N5O3Couleur et forme :SolidMasse moléculaire :455.2BI-1622
CAS :<p>BI-1622, an oral HER2 inhibitor, IC50: 7 nM, >25x selectivity over EGFR, shows effective in vivo antitumor activity.</p>Formule :C26H24N10O2Couleur et forme :SolidMasse moléculaire :508.53BLK-IN-1
CAS :<p>BLK-IN-1 selectively blocks BLK and BTK with IC50s of 18.8 and 20.5 nM, used in cancer research.</p>Formule :C29H23F3N6O3Couleur et forme :SolidMasse moléculaire :560.53BTK-IN-23
CAS :<p>BTK-IN-23: BTK inhibitor, IC50=12.8 nM; also blocks BLX (35.6 nM), BMX (5.7 nM); better selectivity than Ibrutinib.</p>Formule :C27H28N6O2Couleur et forme :SolidMasse moléculaire :468.55PF-06465469
CAS :<p>PF-06465469 is a covalent ITK inhibitor(IC50: 2 nM).</p>Formule :C30H33N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :523.63VA5 TG2 inhibitor
CAS :<p>VA5 inhibits transamidase and GTP-binding by locking protein in an open state, disabling GTPase.</p>Formule :C31H34N4O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :590.62BTK-IN-22
CAS :<p>BTK-IN-22 is a selective BTK inhibitor with IC50 of 0.9 nM; also targets BLX, BMX (IC50s: 1.4, 1.2 nM); better selectivity than Ibrutinib.</p>Formule :C26H26N6O2Couleur et forme :SolidMasse moléculaire :454.52CGI560
CAS :<p>CGI560 is a potent BTK inhibitor with IC50 = 400 nM for BTK.</p>Formule :C29H27N5OCouleur et forme :SolidMasse moléculaire :461.56BLK degrader 1
CAS :<p>BLK degrader 1 is a BLK degrader with anticancer activity for cancer research.</p>Formule :C32H25F3N6O2Degré de pureté :99.22% - 99.24%Couleur et forme :SolidMasse moléculaire :582.58HZ-A-005
CAS :<p>HZ-A-005 is a selective, potent, covalent inhibitor of Bruton's tyrosine kinase (BTK). HZ-A-005 significantly inhibits tumour growth in a xenograft mouse model.</p>Formule :C25H23ClN6O2Couleur et forme :SolidMasse moléculaire :474.94JS25
CAS :<p>JS25, a selective BTK inhibitor, inactivates it with a 5.8 nM IC50, halts cancer cell growth, induces death, and aids against lymphoma.</p>Formule :C29H24N4O4SCouleur et forme :SolidMasse moléculaire :524.59GDC-0834 S-enantiomer
CAS :<p>GDC-0834, the S-enantiomer, is a potent and selective inhibitor of Bruton's tyrosine kinase (BTK).</p>Formule :C33H36N6O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :596.74CHMFL-EGFR-202
CAS :<p>CHMFL-EGFR-202 is a potent, irreversible inhibitor of EGFR mutant kinase (IC50s: 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases).</p>Formule :C25H24ClN7O2Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :489.96Tilfrinib
CAS :<p>Tilfrinib is an effective and selective inhibitor of breast tumor kinase(Brk, IC50 = 3.15 nM) which displays anti-proliferative and anti-tumor activities.</p>Formule :C17H13N3ODegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :275.3NX-2127
CAS :<p>NX-2127 (ETX2514 Triethylamine) is an orally active BTK inhibitor that induces degradation of mutant BTKC481S in cells.NX-2127 has potent antiproliferative</p>Formule :C39H45N9O5Degré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :719.83(±)-Zanubrutinib
CAS :<p>(±)-Zanubrutinib ((±)-BGB-3111) is a potent and orally available Bruton's tyrosine kinase (Btk) inhibitor that demonstrates superior oral bioavailability,</p>Formule :C27H29N5O3Degré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :471.55(R)-Zanubrutinib
CAS :<p>(R)-Zanubrutinib ((R)-BGB-3111) is a selective inhibitor of Bruton tyrosine kinase (BTK).</p>Formule :C27H29N5O3Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :471.55(Rac)-PF-06250112
CAS :<p>(Rac)-PF-0625011 is a racemic mix, orally active, selective BTK inhibitor, also targeting BMX and TEC kinases.</p>Formule :C22H20F2N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :438.43BTK-IN-19
CAS :<p>BTK-IN-19 is a reversible BTK inhibitor with an IC 50 of <0.001 μM .</p>Formule :C21H22Cl2N6OCouleur et forme :SolidMasse moléculaire :445.35BTK inhibitor 20
CAS :<p>BTK inhibitor 20 is a potent BTK inhibitor with an IC 50 of 8 nM .</p>Formule :C37H42N8O4Couleur et forme :SolidMasse moléculaire :662.78BTK-IN-18
CAS :<p>BTK-IN-18 is a potent, reversible inhibitor of Bruton's tyrosine kinase (BTK) with an inhibitory concentration (IC50) of 0.002 µM.</p>Formule :C20H22Cl2N6OCouleur et forme :SolidMasse moléculaire :433.33BTK-IN-17
<p>BTK-IN-17: selective, oral BTK inhibitor, IC50=13.7 nM, reduces p-BTK Y223/p-PLCγ2 Y1217, anti-inflammatory.</p>Formule :C26H23N7O2Couleur et forme :SolidMasse moléculaire :465.51BTK-IN-11
CAS :<p>BTK-IN-11: potent BTK inhibitor; may research autoimmune, inflammatory diseases, cancer. (Patent WO2022063101A1, Z2)</p>Formule :C26H22ClN5O3Couleur et forme :SolidMasse moléculaire :487.94PF-303
CAS :<p>PF-303, a reversible covalent BTK inhibitor, shows potential for cancer and autoimmune therapy.</p>Formule :C22H21ClN6O2Couleur et forme :SolidMasse moléculaire :436.89BTK inhibitor 13
CAS :<p>BTK inhibitor 13 (compound 8) is an effective and selective BTK inhibitor(IC50: 1.2 nM).</p>Formule :C29H26FN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :511.55Pirtobrutinib
CAS :<p>Pirtobrutinib: a selective, non-covalent BTK inhibitor effective against BTK C481 mutations, causing tumor regression in lymphoma models.</p>Formule :C22H21F4N5O3Degré de pureté :99.76% - 99.94%Couleur et forme :SolidMasse moléculaire :479.43Cinsebrutinib
CAS :<p>Cinsebrutinib, a Bruton's tyrosine kinase inhibitor, holds potential for research in cancer treatment.</p>Formule :C22H26FN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :383.46Edralbrutinib
CAS :<p>Edralbrutinib (TG-1701) is a potent BTK inhibitor with anticancer activity and is used in the treatment of tumors, immune system disorders, and blood and</p>Formule :C26H21F2N5O3Degré de pureté :99.41%Couleur et forme :SolidMasse moléculaire :489.47BMX-IN-1
CAS :<p>BMX-IN-1 (BMX kinase inhibitor) is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton’s tyrosine</p>Formule :C29H24N4O4SDegré de pureté :98.38%Couleur et forme :SolidMasse moléculaire :524.59PF-06250112
CAS :<p>PF-06250112 is an effective and highly selective BTK inhibitor (IC50: 0.5 nM.</p>Formule :C22H20F2N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :438.43TAK-020
CAS :<p>TAK-020 is a potent covalent inhibitor of Btk with potential antitumor activity for the study of rheumatoid arthritis and immune-related diseases.</p>Formule :C18H17N5O3Degré de pureté :98.79%Couleur et forme :SolidMasse moléculaire :351.36BTK inhibitor 1
CAS :<p>BTK inhibitor 1 (Compound 27) is a BTK inhibitor (IC50: 0.11 nM) with an inhibitory effect on B-cell activation in hWB with an IC50 of 2 nM.</p>Formule :C24H23FN8O2Degré de pureté :98.24% - 98.91%Couleur et forme :SolidMasse moléculaire :474.49BMS-935177
CAS :<p>BMS-935177 is a reversible BTK inhibitor with IC50 value of 3 nM.</p>Formule :C31H26N4O3Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :502.56WS-11
CAS :<p>WS-11 is a non-covalent reversible inhibitor of BTK, with IC50 values of 3.9 nM for the wild-type and 2.2 nM for the C481S mutant BTK. In addition to strong hydrogen bonding, WS-11 also forms robust π-π interactions with PHE540, and p-π interactions with LYS430 within the active pocket.</p>Formule :C26H22FN9O2Couleur et forme :SolidMasse moléculaire :511.51BTK-IN-38
CAS :<p>BTK-IN-38 (Example 125) is an efficacious inhibitor of BTK. It effectively suppresses the proliferation of DOHH2 and BT474 cells, with IC50 values of 114 nM and 340 nM, respectively.</p>Formule :C27H26F2N4O2Couleur et forme :SolidMasse moléculaire :476.52JAK3/BTK-IN-4
CAS :<p>JAK3/BTK-IN-4, a dual inhibitor for JAK3/BTK, shows synergy in autoimmune disease treatment. (Patent WO2021147953A1, compound 003)</p>Formule :C21H25ClN8OCouleur et forme :SolidMasse moléculaire :440.93GNE-431
CAS :<p>GNE-431: potent, selective noncovalent Btk inhibitor, IC50=3.2 nM; effective against C481R, T474I, T474M mutants, may counter ibrutinib resistance.</p>Formule :C30H32N10O2Couleur et forme :SolidMasse moléculaire :564.64BIIB129
CAS :<p>BIIB129 is a selective and brain-penetrant BTK covalent inhibitor used to study B-cell proliferation-related diseases.</p>Formule :C19H22N6O2Degré de pureté :98.56%Couleur et forme :SolidMasse moléculaire :366.42BTK-IN-15
<p>BTK-IN-15: Oral BTK inhibitor, IC50 0.7 nM, induces cancer cell apoptosis, selective with anti-tumor effects.</p>Formule :C28H24FN5O2Couleur et forme :SolidMasse moléculaire :481.52RET-IN-14
CAS :<p>RET-IN-14 inhibits RET (IC50: <0.51-9.3 nM) & BTK (C481S) (IC50: 9.2-15 nM), promising for tumor research.</p>Formule :C24H23FN8O4Couleur et forme :SolidMasse moléculaire :506.49BMS-986143
CAS :<p>BMS-986143: oral BTK inhibitor, IC50=0.26 nM, potential for autoimmune research, also targets TEC, BLK, BMX, TXK, YES1, ITK.</p>Formule :C31H24Cl2N4O4Couleur et forme :SolidMasse moléculaire :587.45BTK-IN-16
CAS :<p>BTK-IN-16 is a potential inhibitor of wild-type BTK and C481S mutants.BTK-IN-16 can be used to study various autoimmune diseases and cancers caused by BTK.</p>Formule :C15H14N4O2Degré de pureté :99.04%Couleur et forme :SoildMasse moléculaire :282.3BTK inhibitor 18
<p>BTK inhibitor 18 is a selective, potent, covalent, orally active Btk inhibitor (IC50: 142 nM) that exhibits anti-inflammatory effects.</p>Formule :C29H25N5O4S2Couleur et forme :SolidMasse moléculaire :571.67G-744
CAS :<p>G-744 is a selective and orally active inhibitor of Btk (IC50: 2 nM).</p>Formule :C29H29N5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :527.64JAK3/BTK-IN-3
CAS :<p>JAK3/BTK-IN-3: strong dual JAK3/BTK suppressor, promising for autoimmune disease research.</p>Formule :C22H28N8OCouleur et forme :SolidMasse moléculaire :420.51BTK-IN-10
CAS :<p>BTK-IN-10 is a potent inhibitor of BTK, acting on wild-type BTK (IC50<5 nM) or mutant BTK (C481S) (IC50<5 nM).</p>Formule :C25H24F2N4O2Couleur et forme :SolidMasse moléculaire :450.48HDHD4-IN-1
CAS :<p>HDHD4-IN-1 (compound 3) is an inhibitor of N-acetylneuraminate-9-phosphate phosphatase (HDHD4) with an IC50 value of 11 μM. It is utilized in the research of neurological disorders.</p>Formule :C12H22NO11PCouleur et forme :SolidMasse moléculaire :387.28JAK3/BTK-IN-7
CAS :<p>JAK3/BTK-IN-7 (XL-12), characterized as a JAK3/BTK inhibitor, exhibits IC 50 values of 2 nM and 14 nM for JAK3 and BTK respectively. This compound demonstrates anti-inflammatory properties and is applicable in research related to rheumatoid arthritis [1].</p>Formule :C29H30N8O4Couleur et forme :SolidMasse moléculaire :554.6Brefeldin A 4-O-nicotinate
CAS :<p>Brefeldin A 4-O-nicotinate (CHNQD-01228) is a dual inhibitor of Arf1 and BMX proteins with an IC50 value of 0.22 μM for T24 cell proliferation. It also suppresses T24 cell migration and colony formation in a dose-dependent manner, induces G1 phase arrest, and triggers apoptosis. By targeting BMX proteins, it inhibits the AKT/p-AKT and STAT3/p-STAT3 signaling pathways, while also inhibiting Arf1 proteins to eliminate bladder cancer stem cells and activate antitumor immunity, thus exhibiting anticancer activity. Brefeldin A 4-O-nicotinate is applicable in research related to bladder cancer.</p>Formule :C22H27NO5Couleur et forme :SolidMasse moléculaire :385.453BTK-IN-8
<p>BTK-IN-8: potent, selective covalent BTK inhibitor; IC50=0.22 nM, Kd=0.91 nM; effective in blood CD69 cells (IC50=0.029 μM).</p>Formule :C26H36N6O3Couleur et forme :SolidMasse moléculaire :480.6BTK-IN-6
<p>BTK-IN-6, a potent BTK inhibitor, may treat immune, cardiac, cancer, viral, inflammatory, metabolic, and neurological disorders.</p>Formule :C23H22FN5O3Couleur et forme :SolidMasse moléculaire :435.45Ibrutinib Racemate
CAS :<p>Ibrutinib is a selective, irreversible Btk inhibitor (IC50: 0.5 nM). Ibrutinib Racemate is the racemate of Ibrutinib.</p>Formule :C25H24N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :440.5Dihydrodiol-Ibrutinib
CAS :<p>PCI 45227 is an active metabolite of the Bruton's tyrosine kinase inhibitor ibrutinib .1PCI 45227 is formed from ibrutinib by the cytochrome P450 (CYP) isoform CYP3A.<br>1.Veeraraghavan, S., Viswanadha, S., Thappali, S., et al.Simultaneous quantification of lenalidomide, ibrutinib and its active metabolite PCI-45227 in rat plasma by LC-MS/MS: Application to a pharmacokinetic studyJ. Pharm. Biomed. Anal.107151-158(2015)</p>Formule :C25H26N6O4Couleur et forme :SolidMasse moléculaire :474.521BTK-IN-25
CAS :<p>BTK-IN-25 (compound 71) is a potent BTK inhibitor, demonstrating an IC50 of 0.77 nM against BTK(C481S) and achieving an IC50 of 1 nM in DOHH2 cells [1].</p>Formule :C28H27F2N3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :523.53JDB175
CAS :<p>JDB175, a selective BTK inhibitor with oral bioavailability, demonstrates excellent penetration through the blood-brain barrier.</p>Formule :C26H21F3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :478.47BTK-IN-27
CAS :<p>BTK-IN-27 (example 8), a potent BTK inhibitor with an IC50 of 0.2 nM, demonstrates anti-proliferative effects in TMD8 cells with an IC50 of less than 5 nM.</p>Formule :C31H35N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :537.66
