Pirtobrutinib

CAS : 2101700-15-4

Ref. TM-T36287

Informations sur le produit

• Nom: Pirtobrutinib
• Synonymes: LOXO-305
• CAS: 2101700-15-4

Description

Pirtobrutinib (LOXO-305) is an advanced BTK inhibitor that displays high selectivity and operates through a non-covalent mechanism. This compound effectively inhibits various BTK C481 substitution mutations, leading to tumor regression in BTK-dependent lymphoma tumors in mouse xenograft models. Furthermore, Pirtobrutinib exhibits remarkable selectivity for BTK, with more than a 300-fold difference compared to 370 other kinases tested. Notably, at a concentration of 1 μM, Pirtobrutinib demonstrates no significant inhibition of non-kinase off-targets.

• Marque: Targetmol

Propriétés chimiques

• Masse moléculaire: 479.43
• Formule: C₂₂H₂₁F₄N₅O₃
• Degré de pureté: 99.89%
• Couleur/Forme: Solid