BTK
Les inhibiteurs de la tyrosine kinase de Bruton (BTK) sont des composés qui ciblent spécifiquement et inhibent la BTK, une enzyme cruciale impliquée dans la signalisation du récepteur des cellules B et la régulation de l'angiogenèse. La BTK joue un rôle significatif dans la prolifération et la survie des cellules cancéreuses, en particulier dans les malignités hématologiques. En inhibant la BTK, ces composés peuvent perturber l'angiogenèse et la croissance tumorale, ce qui les rend précieux en thérapie anticancéreuse. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de la BTK de haute qualité pour soutenir vos recherches en oncologie, immunologie et angiogenèse.
168 produits trouvés pour "BTK".
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JS25
CAS :JS25, a selective BTK inhibitor, inactivates it with a 5.8 nM IC50, halts cancer cell growth, induces death, and aids against lymphoma.Formule :C29H24N4O4SCouleur et forme :SolidMasse moléculaire :524.59BLK degrader 1
CAS :BLK degrader 1 is a BLK degrader with anticancer activity for cancer research.Formule :C32H25F3N6O2Degré de pureté :99.22% - 99.24%Couleur et forme :SolidMasse moléculaire :582.58BTK-IN-22
CAS :BTK-IN-22 is a selective BTK inhibitor with IC50 of 0.9 nM; also targets BLX, BMX (IC50s: 1.4, 1.2 nM); better selectivity than Ibrutinib.Formule :C26H26N6O2Couleur et forme :SolidMasse moléculaire :454.52BTK-IN-23
CAS :BTK-IN-23: BTK inhibitor, IC50=12.8 nM; also blocks BLX (35.6 nM), BMX (5.7 nM); better selectivity than Ibrutinib.Formule :C27H28N6O2Couleur et forme :SolidMasse moléculaire :468.55BI-1622
CAS :BI-1622, an oral HER2 inhibitor, IC50: 7 nM, >25x selectivity over EGFR, shows effective in vivo antitumor activity.Formule :C26H24N10O2Couleur et forme :SolidMasse moléculaire :508.53JAK3/BTK-IN-6
CAS :JAK3/BTK-IN-6: potent BTK (0.6 nM) & JAK3 (0.4 nM) inhibitor, stable in human liver, for blood/immune research.Formule :C21H17BF3N5O3Couleur et forme :SolidMasse moléculaire :455.2(R)-Elsubrutinib
CAS :(R)-Elsubrutinib ((R)-ABBV-105) is a Btk inhibitor and an isomer of Elsubrutinib, suitable for inflammation research.Formule :C17H19N3O2Degré de pureté :99.05%Couleur et forme :Yellow SolidMasse moléculaire :297.35Ref: TM-T72653
1mg145,00€5mg250,00€1mL*10mM (DMSO)268,00€10mg340,00€25mg573,00€50mg879,00€100mg1.314,00€BLK-IN-1
CAS :BLK-IN-1 selectively blocks BLK and BTK with IC50s of 18.8 and 20.5 nM, used in cancer research.Formule :C29H23F3N6O3Couleur et forme :SolidMasse moléculaire :560.53Spebrutinib besylate
CAS :Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a Btk kinase activity inhibitor (IC50<0.5 nM, Kinact/Ki=7.69×104 M-1s-1s).Formule :C28H28FN5O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :581.62PF-06465469
CAS :PF-06465469, a covalent ITK and BTK inhibitor (IC₅₀ = 2 nM), suppresses CXCL12-mediated migration and decreases PD-1/LAG-3 for leukemia and lymphoma research.Formule :C30H33N7O2Degré de pureté :98%Couleur et forme :White SolidMasse moléculaire :523.63JAK3/BTK-IN-1
CAS :JAK3/ BTk-in-1 is a dual JAK3/BTK inhibitor that specifically targets and inhibits Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), two importantFormule :C25H28N8ODegré de pureté :97.89%Couleur et forme :White SolidMasse moléculaire :456.54PF-06658607
CAS :PF-06658607 is an alkynylated irreversible Brutons tyrosine kinase (BTK) inhibitor.Formule :C27H24N6O2Couleur et forme :SolidMasse moléculaire :464.52JNJ-64264681
CAS :JNJ-64264681 is a potent, orally active, selective, and irreversible covalent inhibitor of Bruton's tyrosine kinase (BTK).Formule :C27H30N6O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :518.63CHMFL-BTK-01
CAS :CHMFL-BTK-01 is an irreversible inhibitor of BTK (IC50: 7 nM) and also potently inhibits BTK Y223 auto-phosphorylation.Formule :C38H41N5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :647.76ACP-5862
CAS :ACP-5862, active metabolite of Acalabrutinib, is a BTK inhibitor with an IC50 of 5.0 nM.Formule :C26H23N7O3Couleur et forme :SolidMasse moléculaire :481.51SB-633825
CAS :SB-633825 can inhibit cancer cell growth and angiogenesis.Formule :C28H25N3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :483.58Tilfrinib
CAS :Tilfrinib is an effective and selective inhibitor of breast tumor kinase(Brk, IC50 = 3.15 nM) which displays anti-proliferative and anti-tumor activities.Formule :C17H13N3ODegré de pureté :99.54%Couleur et forme :Yellow SolidMasse moléculaire :275.3Ref: TM-T17098
1mg43,00€2mg56,00€5mg93,00€1mL*10mM (DMSO)93,00€10mg130,00€25mg243,00€50mg439,00€100mg645,00€500mg1.333,00€Larotinib
CAS :Larotinib is an orally active, potent, and broad-spectrum tyrosine kinase inhibitor (TKI) with an IC50 of 0.6 nM for EGFR.Formule :C24H26ClFN4O4Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :488.94Sunvozertinib
CAS :Sunvozertinib (DZD9008) is a potent ErbBs and BTK inhibitor, with inhibitory effects on EGFR, Her2.Cost-effective and quality-assured.Formule :C29H35ClFN7O3Degré de pureté :98.11% - 99.63%Couleur et forme :SolidMasse moléculaire :584.08Ref: TM-T64124
1mg34,00€5mg60,00€10mg85,00€25mg124,00€1mL*10mM (DMSO)150,00€50mg200,00€100mg353,00€500mg1.314,00€CHMFL-EGFR-202
CAS :CHMFL-EGFR-202 is a potent, irreversible inhibitor of EGFR mutant kinase (IC50s: 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases).Formule :C25H24ClN7O2Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :489.96Ref: TM-T10802
1mg109,00€2mg163,00€5mg241,00€1mL*10mM (DMSO)289,00€10mg355,00€25mg532,00€50mg745,00€100mg1.018,00€(R)-Zanubrutinib
CAS :(R)-Zanubrutinib ((R)-BGB-3111) is a selective inhibitor of Bruton tyrosine kinase (BTK).Formule :C27H29N5O3Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :471.55Ref: TM-T13447
1mg37,00€5mg80,00€1mL*10mM (DMSO)85,00€10mg133,00€25mg215,00€50mg323,00€100mg442,00€200mg615,00€(±)-Zanubrutinib
CAS :(±)-Zanubrutinib ((±)-BGB-3111) is a potent and orally available Bruton's tyrosine kinase (Btk) inhibitor that demonstrates superior oral bioavailability,Formule :C27H29N5O3Degré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :471.55Ref: TM-TQ0039
1mg47,00€5mg92,00€1mL*10mM (DMSO)101,00€10mg145,00€25mg256,00€50mg409,00€100mg587,00€500mg1.215,00€NX-2127
CAS :NX-2127 (ETX2514 Triethylamine) is an orally active BTK inhibitor that induces degradation of mutant BTKC481S in cells.NX-2127 has potent antiproliferativeFormule :C39H45N9O5Degré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :719.83BTK inhibitor 13
CAS :BTK inhibitor 13 (compound 8) is an effective and selective BTK inhibitor(IC50: 1.2 nM).Formule :C29H26FN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :511.55BTK inhibitor 20
CAS :BTK inhibitor 20 is a potent BTK inhibitor with an IC 50 of 8 nM .Formule :C37H42N8O4Couleur et forme :SolidMasse moléculaire :662.78BTK-IN-19
CAS :BTK-IN-19 is a reversible BTK inhibitor with an IC 50 of <0.001 μM .Formule :C21H22Cl2N6OCouleur et forme :SolidMasse moléculaire :445.35(Rac)-PF-06250112
CAS :(Rac)-PF-0625011 is a racemic mix, orally active, selective BTK inhibitor, also targeting BMX and TEC kinases.Formule :C22H20F2N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :438.43Cinsebrutinib
CAS :Cinsebrutinib, a Bruton's tyrosine kinase inhibitor, holds potential for research in cancer treatment.Formule :C22H26FN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :383.46BTK-IN-18
CAS :BTK-IN-18 is a potent, reversible inhibitor of Bruton's tyrosine kinase (BTK) with an inhibitory concentration (IC50) of 0.002 µM.Formule :C20H22Cl2N6OCouleur et forme :SolidMasse moléculaire :433.33Rocbrutinib
CAS :Rocbrutinib (LP-168) is a selective BTK kinase inhibitor that is effective against both wild-type and mutant forms , and has anti-tumor effects.Formule :C42H51N9O5Degré de pureté :99.87%Couleur et forme :Yellow SolidMasse moléculaire :761.91Edralbrutinib
CAS :Edralbrutinib (TG-1701) is a potent BTK inhibitor with anticancer activity and is used in the treatment of tumors, immune system disorders, and blood andFormule :C26H21F2N5O3Degré de pureté :99.41%Couleur et forme :White SolidMasse moléculaire :489.47BTK-IN-17
BTK-IN-17: selective, oral BTK inhibitor, IC50=13.7 nM, reduces p-BTK Y223/p-PLCγ2 Y1217, anti-inflammatory.Formule :C26H23N7O2Couleur et forme :SolidMasse moléculaire :465.51BTK-IN-11
CAS :BTK-IN-11: potent BTK inhibitor; may research autoimmune, inflammatory diseases, cancer. (Patent WO2022063101A1, Z2)Formule :C26H22ClN5O3Couleur et forme :SolidMasse moléculaire :487.94Pirtobrutinib
CAS :Pirtobrutinib: a selective, non-covalent BTK inhibitor effective against BTK C481 mutations, causing tumor regression in lymphoma models.Formule :C22H21F4N5O3Degré de pureté :99.76% - 99.94%Couleur et forme :SolidMasse moléculaire :479.43Ref: TM-T36287
1mg34,00€5mg74,00€1mL*10mM (DMSO)79,00€10mg119,00€25mg268,00€50mg411,00€100mg605,00€500mg1.288,00€PF-303
CAS :PF-303, a reversible covalent BTK inhibitor, shows potential for cancer and autoimmune therapy.Formule :C22H21ClN6O2Couleur et forme :SolidMasse moléculaire :436.89BMX-IN-1
CAS :BMX-IN-1 (BMX kinase inhibitor) is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton’s tyrosineFormule :C29H24N4O4SDegré de pureté :98.38%Couleur et forme :SolidMasse moléculaire :524.59PF-06250112
CAS :PF-06250112 is an effective and highly selective BTK inhibitor (IC50: 0.5 nM.Formule :C22H20F2N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :438.43DDa-1
CAS :DDa-1 is a potent (kinase degrader) [1].Formule :C60H77Cl2N13O3SCouleur et forme :SolidMasse moléculaire :1131.31TAK-020
CAS :TAK-020 is a potent covalent inhibitor of Btk with potential antitumor activity for the study of rheumatoid arthritis and immune-related diseases.Formule :C18H17N5O3Degré de pureté :98.66%Couleur et forme :SolidMasse moléculaire :351.36Ref: TM-T9529
1mg138,00€5mg334,00€1mL*10mM (DMSO)358,00€10mg597,00€25mg1.234,00€50mg1.908,00€100mg2.952,00€BMS-935177
CAS :BMS-935177 is a reversible BTK inhibitor with IC50 value of 3 nM.Formule :C31H26N4O3Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :502.56BGB-8035
CAS :BGB-8035 is a BTK inhibitor with antitumor activity that inhibits BTK, TEC, and EGFR.BGB-8035 is used in the study of tumors and autoimmune diseases.Formule :C24H31N5O4Degré de pureté :96.74%Couleur et forme :SolidMasse moléculaire :453.53BTK inhibitor 1
CAS :BTK inhibitor 1 (Compound 27) is a BTK inhibitor (IC50: 0.11 nM) with an inhibitory effect on B-cell activation in hWB with an IC50 of 2 nM.
Formule :C24H23FN8O2Degré de pureté :98.24% - 98.91%Couleur et forme :SolidMasse moléculaire :474.49BTK-IN-10
CAS :BTK-IN-10 is a potent inhibitor of BTK, acting on wild-type BTK (IC50<5 nM) or mutant BTK (C481S) (IC50<5 nM).Formule :C25H24F2N4O2Couleur et forme :SolidMasse moléculaire :450.48JAK3/BTK-IN-3
CAS :JAK3/BTK-IN-3: strong dual JAK3/BTK suppressor, promising for autoimmune disease research.Formule :C22H28N8OCouleur et forme :SolidMasse moléculaire :420.51Brefeldin A 4-O-nicotinate
CAS :Brefeldin A 4-O-nicotinate (CHNQD-01228) is a dual inhibitor of Arf1 and BMX proteins with an IC50 value of 0.22 μM for T24 cell proliferation. It also suppresses T24 cell migration and colony formation in a dose-dependent manner, induces G1 phase arrest, and triggers apoptosis. By targeting BMX proteins, it inhibits the AKT/p-AKT and STAT3/p-STAT3 signaling pathways, while also inhibiting Arf1 proteins to eliminate bladder cancer stem cells and activate antitumor immunity, thus exhibiting anticancer activity. Brefeldin A 4-O-nicotinate is applicable in research related to bladder cancer.Formule :C22H27NO5Couleur et forme :SolidMasse moléculaire :385.453BTK inhibitor 18
BTK inhibitor 18 is a selective, potent, covalent, orally active Btk inhibitor (IC50: 142 nM) that exhibits anti-inflammatory effects.Formule :C29H25N5O4S2Couleur et forme :SolidMasse moléculaire :571.67RET-IN-14
CAS :RET-IN-14 inhibits RET (IC50: <0.51-9.3 nM) & BTK (C481S) (IC50: 9.2-15 nM), promising for tumor research.Formule :C24H23FN8O4Couleur et forme :SolidMasse moléculaire :506.49JAK3/BTK-IN-7
CAS :JAK3/BTK-IN-7 (XL-12), characterized as a JAK3/BTK inhibitor, exhibits IC 50 values of 2 nM and 14 nM for JAK3 and BTK respectively. This compound demonstrates anti-inflammatory properties and is applicable in research related to rheumatoid arthritis [1].Formule :C29H30N8O4Couleur et forme :SolidMasse moléculaire :554.6BTK-IN-15
BTK-IN-15: Oral BTK inhibitor, IC50 0.7 nM, induces cancer cell apoptosis, selective with anti-tumor effects.Formule :C28H24FN5O2Couleur et forme :SolidMasse moléculaire :481.52BMS-986143
CAS :BMS-986143: oral BTK inhibitor, IC50=0.26 nM, potential for autoimmune research, also targets TEC, BLK, BMX, TXK, YES1, ITK.Formule :C31H24Cl2N4O4Couleur et forme :SolidMasse moléculaire :587.45
